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1.发明授权Phospholipases, nucleic acids encoding them and methods for making and using them 有权磷脂酶，编码它们的核酸以及制备和使用它们的方法公开(公告)号：US07943360B2
公开(公告)日：2011-05-17
申请号：US11625765
申请日：2007-01-22
申请人： Svetlana Gramatikova , Geoff Hazlewood , David Lam , Nelson R. Barton , Blake G. Sturgis , Dan E. Robertson , Jincai Li , Joel A. Kreps , Roderick James Fielding , Robert C. Brown , Amit Vasavada , Xuqiu Tan , Adrian Badillo , Wilhelmus P. Van Hoek , Giselle Janssen , Charles Isaac , Mark J. Burk
发明人： Svetlana Gramatikova , Geoff Hazlewood , David Lam , Nelson R. Barton , Blake G. Sturgis , Dan E. Robertson , Jincai Li , Joel A. Kreps , Roderick James Fielding , Robert C. Brown , Amit Vasavada , Xuqiu Tan , Adrian Badillo , Wilhelmus P. Van Hoek , Giselle Janssen , Charles Isaac , Mark J. Burk
CPC分类号： C12N9/16 , C07K2319/00 , C12N9/18 , C12N9/20 , C12N15/8242 , C12N15/8247 , C12P7/6418 , C12P7/6445 , C12P7/6481
摘要： The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity, nucleic acids encoding them and antibodies that bind to them. Industrial methods, e.g., oil degumming, and products comprising use of these phospholipases are also provided.
摘要翻译： 本发明提供具有磷脂酶活性的新型多肽，包括例如磷脂酶A，B，C和D活性，patatin活性，脂质酰基水解酶（LAH）活性，编码它们的核酸和与它们结合的抗体。 还提供了工业方法，例如油脱胶，以及包含使用这些磷脂酶的产品。
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2.发明授权Phospholipases, nucleic acids encoding them and methods for making and using them 有权磷脂酶，编码它们的核酸以及制备和使用它们的方法公开(公告)号：US07977080B2
公开(公告)日：2011-07-12
申请号：US10592450
申请日：2005-03-08
申请人： Svetlana Gramatikova , Geoff Hazlewood , David Lam , Nelson R. Barton , Blake G. Sturgis , Dan E. Robertson , Jincai Li , Joel A. Kreps , Roderick James Fielding , Robert C. Brown , Amit Vasavada , Xuqiu Tan , Adrian Badillo , Wilhelmus P. Van Hoek , Giselle Janssen , Charles Isaac , Mark J. Burk
发明人： Svetlana Gramatikova , Geoff Hazlewood , David Lam , Nelson R. Barton , Blake G. Sturgis , Dan E. Robertson , Jincai Li , Joel A. Kreps , Roderick James Fielding , Robert C. Brown , Amit Vasavada , Xuqiu Tan , Adrian Badillo , Wilhelmus P. Van Hoek , Giselle Janssen , Charles Isaac , Mark J. Burk
CPC分类号： C12N15/8242 , C07K2319/00 , C12N9/16 , C12N9/18 , C12N9/20 , C12N15/8247 , C12P7/6418 , C12P7/6481
摘要： The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, phosphatidic acid phosphatases (PAP)) and/or lipid acyl hydrolase (LAH) activity, nucleic acids encoding them and antibodies that bind to them. Industrial methods, e.g., oil degumming, and products comprising use of these phospholipases are also provided.
摘要翻译： 本发明提供具有磷脂酶活性的新型多肽，包括例如磷脂酶A，B，C和D活性，patatin活性，磷脂酸磷酸酶（PAP））和/或脂质酰基水解酶（LAH）活性，编码它们的核酸和抗体 绑定到他们。 还提供了工业方法，例如油脱胶，以及包含使用这些磷脂酶的产品。
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3.发明申请公开(公告)号：US20090053191A1
公开(公告)日：2009-02-26
申请号：US11625765
申请日：2007-01-22
申请人： Svetlana GRAMATIKOVA , Geoff Hazlewood , David Lam , Nelson R. Barton , Blake G. Sturgis , Dan E. Robertson , Jincai Li , Joel A. Kreps , Roderick James Fielding , Robert C. Brown , Amit Vasavada , Xuqiu Tan , Adrian Badillo , Wilhelmus P. Van Hoek , Giselle Janssen , Charles Isaac , Mark J. Burk
发明人： Svetlana GRAMATIKOVA , Geoff Hazlewood , David Lam , Nelson R. Barton , Blake G. Sturgis , Dan E. Robertson , Jincai Li , Joel A. Kreps , Roderick James Fielding , Robert C. Brown , Amit Vasavada , Xuqiu Tan , Adrian Badillo , Wilhelmus P. Van Hoek , Giselle Janssen , Charles Isaac , Mark J. Burk
IPC分类号： A61K38/46 , C12N15/11 , C07H21/04 , C12P19/34 , C12P21/04 , C12N15/00 , C12N1/20 , C12N5/06 , C12N1/19 , C12N5/04 , A01K67/027 , A01H5/00 , C07H21/02 , C12N9/20 , C12N11/14 , C40B40/10 , C12N11/08 , C07K16/18 , G06F19/00 , C11D7/42 , C11D3/386 , C12N15/82 , C12P7/64 , C10G32/00 , A61K31/7088 , A61K38/00 , C12Q1/44
CPC分类号： C12N9/16 , C07K2319/00 , C12N9/18 , C12N9/20 , C12N15/8242 , C12N15/8247 , C12P7/6418 , C12P7/6445 , C12P7/6481
摘要： The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity, nucleic acids encoding them and antibodies that bind to them. Industrial methods, e.g., oil degumming, and products comprising use of these phospholipases are also provided.
摘要翻译： 本发明提供具有磷脂酶活性的新型多肽，包括例如磷脂酶A，B，C和D活性，patatin活性，脂质酰基水解酶（LAH）活性，编码它们的核酸和与它们结合的抗体。 还提供了工业方法，例如油脱胶，以及包含使用这些磷脂酶的产品。
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4.发明申请Phospholipases, Nucleic Acids Encoding Them and Methods for Making and Using Them 有权磷脂酶，编码它们的核酸及其制备和使用方法公开(公告)号：US20080317731A1
公开(公告)日：2008-12-25
申请号：US10592450
申请日：2005-03-08
申请人： Svetlana Gramatikova , Geoff Hazlewood , David Lam , Nelson R. Barton , Blake G. Sturgis , Dan E. Robertson , Jincai Li , Joel A. Kreps , Roderick Fielding , Robert C. Brown , Amit Vasavada , Xuqiu Tan , Andrian Badillo , Wilhelmus P. Van Hoek , Giselle Janssen , Charles Isaac , Mark J. Burk
发明人： Svetlana Gramatikova , Geoff Hazlewood , David Lam , Nelson R. Barton , Blake G. Sturgis , Dan E. Robertson , Jincai Li , Joel A. Kreps , Roderick Fielding , Robert C. Brown , Amit Vasavada , Xuqiu Tan , Andrian Badillo , Wilhelmus P. Van Hoek , Giselle Janssen , Charles Isaac , Mark J. Burk
IPC分类号： A61K38/43 , C12N15/11 , C12N15/00 , C12N5/06 , C12N1/20 , C12N1/19 , C12N5/04 , A01K67/027 , A01H5/00 , C12N9/99 , C12N9/20 , C12N11/00 , C40B40/10 , C07K16/18 , G01N33/573 , C12P21/04 , C12Q1/44 , G06F19/00 , A61P43/00 , A61K31/7088 , C07H1/00 , C12P19/34 , C40B50/06 , C12Q1/68 , C11C1/00 , C11D7/42 , D06M16/00 , C10G32/00 , C12P7/64
CPC分类号： C12N15/8242 , C07K2319/00 , C12N9/16 , C12N9/18 , C12N9/20 , C12N15/8247 , C12P7/6418 , C12P7/6481
摘要： The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, phosphatidic acid phosphatases (PAP)) and/or lipid acyl hydrolase (LAH) activity, nucleic acids encoding them and antibodies that bind to them. Industrial methods, e.g., oil degumming, and products comprising use of these phospholipases are also provided.
摘要翻译： 本发明提供具有磷脂酶活性的新型多肽，包括例如磷脂酶A，B，C和D活性，patatin活性，磷脂酸磷酸酶（PAP））和/或脂质酰基水解酶（LAH）活性，编码它们的核酸和抗体 绑定到他们。 还提供了工业方法，例如油脱胶，以及包含使用这些磷脂酶的产品。
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公开(公告)号：US20090176976A1
公开(公告)日：2009-07-09
申请号：US12397204
申请日：2009-03-03
申请人： Grace DESANTIS , Jennifer Ann Chaplin , Ellen Chi , Aileen Milan , Jay M. Short , David Weiner , Mark Madden , Mark J. Burk , Dan E. Robertson , Darcy Madden
发明人： Grace DESANTIS , Jennifer Ann Chaplin , Ellen Chi , Aileen Milan , Jay M. Short , David Weiner , Mark Madden , Mark J. Burk , Dan E. Robertson , Darcy Madden
IPC分类号： C12N15/11
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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公开(公告)号：US07651849B2
公开(公告)日：2010-01-26
申请号：US12397204
申请日：2009-03-03
申请人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay M. Short , David Paul Weiner , Mark Madden , Darcy Madden, legal representative , Mark J. Burk , Dan E. Robertson
发明人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay M. Short , David Paul Weiner , Mark Madden , Mark J. Burk , Dan E. Robertson
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , A61K38/00 , C07H21/04 , C12Q1/68 , C07H21/02
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
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公开(公告)号：US09321701B2
公开(公告)日：2016-04-26
申请号：US13365132
申请日：2012-02-02
申请人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Jun Sun , Robin E. Osterhout , Priti Pharkya
CPC分类号： C12P5/02 , C07C1/24 , C07C2521/04 , C07C2521/12 , C07C2521/16 , C07C2523/10 , C07C2523/28 , C07C2523/31 , C07C2523/745 , C07C2527/167 , C07C2527/173 , C12N15/52 , C12P5/026 , C12P7/04 , Y02E50/343 , C07C11/167
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.
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公开(公告)号：US09169486B2
公开(公告)日：2015-10-27
申请号：US13527440
申请日：2012-06-19
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
摘要翻译： 本发明提供具有丁二烯或巴豆醇途径的非天然存在的微生物。 本发明另外提供了使用这种生物体来生产丁二烯或巴豆醇的方法。
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9.发明授权Microorganisms for producing methacrylic acid and methacrylate esters and methods related thereto 有权用于生产甲基丙烯酸和甲基丙烯酸酯的微生物及其相关方法公开(公告)号：US09133487B2
公开(公告)日：2015-09-15
申请号：US13436811
申请日：2012-03-30
申请人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
发明人： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
摘要： The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate.
摘要翻译： 本发明提供具有甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯途径的非天然存在的微生物生物。 微生物生物体含有编码甲基丙烯酸途径中的酶的至少一种外源核酸。 本发明另外提供了生产甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的方法。 该方法可以包括培养产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯的微生物，其中微生物生物体表达至少一种编码甲基丙烯酸途径酶的外源核酸，其量足以产生甲基丙烯酸， 甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯在条件下和足够的时间以产生甲基丙烯酸，甲基丙烯酸酯，3-羟基异丁酸酯和/或2-羟基异丁酸酯。
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公开(公告)号：US08940509B2
公开(公告)日：2015-01-27
申请号：US13668117
申请日：2012-11-02
CPC分类号： C12P17/08 , C07D313/04 , C08G18/4277 , C08G63/08 , C12N5/0018 , C12N15/52 , C12N15/63 , C12N15/70 , C12P17/02
摘要： The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.
摘要翻译： 本发明提供了非天然存在的含有己内酯途径的微生物，其具有至少一种编码丁二烯途径酶的外源核酸，其表达量足以产生己内酯。 本发明另外提供了使用这种微生物生物体来制备己内酯的方法，该方法是在条件和足够的时间内培养含本文所述的己内酯途径的非天然存在的微生物生物产生己内酯。
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