公开(公告)号：US08712702B2

公开(公告)日：2014-04-29

申请号：US13167585

申请日：2011-06-23

申请人： Takeshi Takagi ,  Koji Okumura ,  Tatsuo Kamata

发明人： Takeshi Takagi ,  Koji Okumura ,  Tatsuo Kamata

IPC分类号： G06F19/00 ,  G01N1/10

CPC分类号： G01N1/38 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N27/3271 ,  G01N2021/054 ,  G01N2035/1018

摘要： A measuring apparatus for measuring a predetermined physical property of a liquid measuring sample comprises a preparing unit in which a plurality of materials including at least a liquid material are mixed; a supply route which supplies the liquid material to the preparing unit; a withdrawing unit which withdraws the measuring sample from the preparing unit into the supply route, the measuring sample being prepared to contain the liquid material supplied to the preparing unit via the supply route; and a measuring unit which measures the predetermined physical property of the measuring sample withdrawn into the supply route by the withdrawing unit.

摘要翻译： 用于测量液体测量样品的预定物理性能的测量装置包括其中混合至少包含液体材料的多种材料的制备单元; 将液体材料供给到制备单元的供给路径; 所述取出单元将所述测量样品从所述准备单元抽出到所述供给路径中，所述测量样品准备容纳经由所述供给路径供给到所述准备单元的液体材料; 以及测量单元，其测量由所述抽出单元抽出到所述供给路径中的所述测量样本的预定物理属性。

公开(公告)号：US20100200432A1

公开(公告)日：2010-08-12

申请号：US12449732

申请日：2008-02-24

申请人： Tatsuo Kamata ,  Takeshi Takagi

发明人： Tatsuo Kamata ,  Takeshi Takagi

IPC分类号： G01N27/26 ,  C01B21/08

CPC分类号： C12Q1/006 ,  C12Q1/28

摘要： The present invention relates to a method, a reagent and an apparatus for determining a substrate concentration based on an amount of hydrogen peroxide generated from a substrate. In the present invention, a suppressing agent for suppressing a reaction between the hydrogen peroxide and an inhibitor is added. As the suppressing agent, an azide compound such as sodium azide or a nitrite compound such as sodium nitrite is used. In the invention, a supporting electrolyte, such as sodium chloride or potassium chloride may be further added.

摘要翻译： 本发明涉及一种基于从基底产生的过氧化氢量来确定底物浓度的方法，试剂和装置。 在本发明中，添加抑制过氧化氢与抑制剂的反应的抑制剂。 作为抑制剂，可以使用叠氮化钠等叠氮化合物，亚硝酸钠等亚硝酸酯化合物。 在本发明中，可以进一步添加氯化钠或氯化钾等担载电解质。

公开(公告)号：US09429579B2

公开(公告)日：2016-08-30

申请号：US12311175

申请日：2007-09-20

申请人： Koji Sugiyama ,  Tatsuo Kamata ,  Takeshi Takagi

发明人： Koji Sugiyama ,  Tatsuo Kamata ,  Takeshi Takagi

IPC分类号： G01N33/00 ,  G01N35/00 ,  G01N33/66 ,  G01N33/72 ,  G01N35/02 ,  A61B5/145 ,  G01N30/88

CPC分类号： G01N33/66 ,  A61B5/14532 ,  G01N33/723 ,  G01N35/026 ,  G01N2030/8822 ,  G01N2800/042

摘要： The present invention relates to a blood analysis apparatus X for measuring concentrations of glucose and glycohemoglobin in blood. The blood analysis apparatus X is configured to perform the concentration measurement of the glucose and the glycohemoglobin by one sampling of blood 13. The blood analysis apparatus X is preferably configured to simultaneously carry out sample preparations for concentration measurement of the glucose and the glycohemoglobin by one sample preparation. The blood analysis apparatus X may be configured to perform dilution of a blood sample for measuring the glycohemoglobin and dilution of a blood sample for measuring the glucose using the same diluent.

摘要翻译： 血液分析装置技术领域本发明涉及用于测定血液中葡萄糖和糖血红蛋白浓度的血液分析装置X. 血液分析装置X构成为通过血液13的一次取样来进行葡萄糖和糖血红蛋白的浓度测定。血液分析装置X优选同时进行葡萄糖和糖血红蛋白的浓度测定用样品制剂1 样品制备。 血液分析装置X可以被配置为执行用于测量糖血红蛋白的血液样品的稀释和用于使用相同的稀释剂测量葡萄糖的血液样品的稀释。

公开(公告)号：US08535510B2

公开(公告)日：2013-09-17

申请号：US12450775

申请日：2008-04-15

申请人： Tatsuo Kamata ,  Takeshi Takagi ,  Yuki Ito

发明人： Tatsuo Kamata ,  Takeshi Takagi ,  Yuki Ito

IPC分类号： G01N27/327

CPC分类号： C12Q1/001 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  A61B2560/0223

摘要： This invention provides a substrate concentration measuring method for measuring a concentration of a substrate included in a specimen based on an output for measurement from an enzyme electrode when the enzyme electrode and the substrate are reacted with each other, the substrate concentration is calculated using an output for correction from the enzyme electrode obtained when a reference solution whose substrate concentration is known and the enzyme electrode are reacted with each other before or after the enzyme electrode and the substrate are reacted with each other. For example, the output for correction is measured by each specimen. In this method, the substrate concentration may be calculated using the output for correction for the specimen to be measured and an output for correction corresponding to the at least one other specimen and measured prior to the output for correction.

摘要翻译： 本发明提供一种基板浓度测量方法，用于当酶电极和基板彼此反应时，基于酶电极的测量输出测量样品中包含的基板的浓度，基板浓度使用输出 用于当酶底物浓度已知的参比溶液和酶电极在酶电极和底物之间彼此反应之前彼此反应的酶电极获得的酶电极校正。 例如，用于校正的输出由每个样本测量。 在该方法中，可以使用待测试样本的校正输出和与至少一个其他样本相对应的校正输出并在校正输出之前测量来计算衬底浓度。

公开(公告)号：US20100299072A1

公开(公告)日：2010-11-25

申请号：US12451085

申请日：2008-04-25

申请人： Tatsuo Kamata ,  Takeshi Takagi ,  Yuki Ito

发明人： Tatsuo Kamata ,  Takeshi Takagi ,  Yuki Ito

IPC分类号： G06F19/00 ,  G01N33/50

CPC分类号： G01N27/3274 ,  G01N30/8606 ,  G01N33/5438 ,  G01N33/721 ,  G01N33/96 ,  G01N2030/146 ,  G01N2030/8411 ,  G01N2030/8822

摘要： This invention is a method for a substrate concentration measurement method including measuring a concentration of a substrate in a blood specimen containing hemoglobin. In the method, the substrate concentration is calculated by using a measurement value correlating with a substrate concentration influenced by hemoglobin, and a hemoglobin concentration or a value correlating with the hemoglobin concentration. A substrate concentration is calculated by correcting the measurement value Re correlating with the substrate concentration based on the following Formulae 1 and 2: [Formula 1] Corrected value=100×Re/V (%), wherein V (%) represents a value with respect to plasma (a ratio of a measurement value influenced by hemoglobin with respect to a measurement value obtained by measuring plasma), and Re represents the measurement value correlating with the substrate concentration influenced by hemoglobin; [Formula 2] Value with respect to plasma V (%)=(Vmax×Re)/(Km+Re)+B, wherein Vmax represents a value obtained by subtracting an intercept (B) from the value (V) with respect to plasma which is maintained constant even when the measurement value influenced by hemoglobin increases, Km represents a value of Re at which the value V (%) with respect to plasma becomes Vmax/2, and B represents a value (constant) of V (%) with respect to plasma when Re is 0.

摘要翻译： 本发明是一种测定含有血红蛋白的血液标本中的基质浓度的基板浓度测定方法。 在该方法中，通过使用与受血红蛋白影响的底物浓度相关的测定值和血红蛋白浓度或与血红蛋白浓度相关的值来计算底物浓度。 通过基于以下公式1和2校正与底物浓度相关的测量值Re来计算底物浓度：[式1]校正值= 100×Re / V（％），其中V（％）表示与 对血浆的影响（由血红蛋白影响的测定值相对于通过测定血浆得到的测定值的比例），Re表示与由血红蛋白影响的底物浓度相关的测定值; [式2]相对于等离子体V（％）=（Vmax×Re）/（Km + Re）+ B的值，其中Vmax表示通过从相对于（V）的值（V）减去截距（B） 即使当受血红蛋白影响的测量值增加时，也保持恒定的等离子体，Km表示相对于等离子体的值V（％）为Vmax / 2的Re值，B表示V（％）的值（常数） ）相对于等离子体。

公开(公告)号：US20120094367A1

公开(公告)日：2012-04-19

申请号：US12311175

申请日：2007-09-20

申请人： Koji Sugiyama ,  Tatsuo Kamata ,  Takeshi Takagi

发明人： Koji Sugiyama ,  Tatsuo Kamata ,  Takeshi Takagi

IPC分类号： C12M1/40

CPC分类号： G01N33/66 ,  A61B5/14532 ,  G01N33/723 ,  G01N35/026 ,  G01N2030/8822 ,  G01N2800/042

摘要： The present invention relates to a blood analysis apparatus X for measuring concentrations of glucose and glycohemoglobin in blood. The blood analysis apparatus X is configured to perform the concentration measurement of the glucose and the glycohemoglobin by one sampling of blood 13. The blood analysis apparatus X is preferably configured to simultaneously carry out sample preparations for concentration measurement of the glucose and the glycohemoglobin by one sample preparation. The blood analysis apparatus X may be configured to perform dilution of a blood sample for measuring the glycohemoglobin and dilution of a blood sample for measuring the glucose using the same diluent.

摘要翻译： 血液分析装置技术领域本发明涉及用于测定血液中葡萄糖和糖血红蛋白浓度的血液分析装置X. 血液分析装置X构成为通过血液13的一次取样来进行葡萄糖和糖血红蛋白的浓度测定。血液分析装置X优选同时进行葡萄糖和糖血红蛋白的浓度测定用样品制剂1 样品制备。 血液分析装置X可以被配置为执行用于测量糖血红蛋白的血液样品的稀释和用于使用相同的稀释剂测量葡萄糖的血液样品的稀释。

公开(公告)号：US20120015388A1

公开(公告)日：2012-01-19

申请号：US13166575

申请日：2011-06-22

申请人： Takeshi Takagi ,  Toshikatsu Sakai ,  Chiaki Miyamoto ,  Takefumi Asami ,  Tatsuo Kamata ,  Takuya Yotani ,  Takayuki Oka

发明人： Takeshi Takagi ,  Toshikatsu Sakai ,  Chiaki Miyamoto ,  Takefumi Asami ,  Tatsuo Kamata ,  Takuya Yotani ,  Takayuki Oka

IPC分类号： C12Q1/54 ,  C12M1/40

CPC分类号： C12Q1/006 ,  G01N33/66 ,  G01N33/723 ,  G01N33/726

摘要： The ionic strength of a diluent for preparing an analytical sample is set to be 0.06 to 0.16. The analytical sample prepared by using the diluent having the ionic strength within this range can be subjected to both for analyzing a first object in a test sample by electrode method and for analyzing a second object in the test sample by liquid chromatography method, and high-precision measurement can be attained. The analytical sample is especially useful for preparing a sample for measurement used both for measuring glucose concentration in a blood sample by enzyme electrode method and for measuring glycohemoglobin concentration in the blood sample by liquid chromatography method.

摘要翻译： 用于制备分析样品的稀释剂的离子强度设定为0.06至0.16。 通过使用离子强度在该范围内的稀释剂制备的分析样品可以通过电极法分析测试样品中的第一个物体，并通过液相色谱法分析测试样品中的第二个物体， 可以进行精度测量。 分析样品特别适用于制备用于通过酶电极法测量血液样品中的葡萄糖浓度并通过液相色谱法测量血液样品中的糖血红蛋白浓度的测量样品。

公开(公告)号：US20100288650A1

公开(公告)日：2010-11-18

申请号：US12450775

申请日：2008-04-15

申请人： Tatsuo Kamata ,  Takeshi Takagi ,  Yuki Ito

发明人： Tatsuo Kamata ,  Takeshi Takagi ,  Yuki Ito

IPC分类号： G01N27/27

CPC分类号： C12Q1/001 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  A61B2560/0223

摘要： This invention provides a substrate concentration measuring method for measuring a concentration of a substrate included in a specimen based on an output for measurement from an enzyme electrode when the enzyme electrode and the substrate are reacted with each other, the substrate concentration is calculated using an output for correction from the enzyme electrode obtained when a reference solution whose substrate concentration is known and the enzyme electrode are reacted with each other before or after the enzyme electrode and the substrate are reacted with each other. For example, the output for correction is measured by each specimen. In this method, the substrate concentration may be calculated using the output for correction for the specimen to be measured and an output for correction corresponding to the at least one other specimen and measured prior to the output for correction.

摘要翻译： 本发明提供一种基板浓度测量方法，用于当酶电极和基板彼此反应时，基于酶电极的测量输出测量样品中包含的基板的浓度，基板浓度使用输出 用于当酶底物浓度已知的参比溶液和酶电极在酶电极和底物之间彼此反应之前彼此反应的酶电极获得的酶电极校正。 例如，用于校正的输出由每个样本测量。 在该方法中，可以使用待测试样本的校正输出和与至少一个其他样本相对应的校正输出并在校正输出之前测量来计算衬底浓度。

公开(公告)号：US20110318767A1

公开(公告)日：2011-12-29

申请号：US13159226

申请日：2011-06-13

申请人： Takeshi Takagi ,  Koji Okumura

发明人： Takeshi Takagi ,  Koji Okumura

IPC分类号： C12Q1/54 ,  G01N27/30 ,  C12M1/34 ,  G01N33/66

CPC分类号： G01N33/66 ,  C12Q1/006 ,  G01N33/726

摘要： A measurement of plasma glucose is carried out through the following steps, a sample preparation step (S101, S102) of preparing a measurement sample by hemolyzing hemocytes in blood, a step of measuring whole blood glucose (S103 to S105) of measuring a glucose concentration in whole blood with the measurement sample, and a step of calculating a liquid content ratio of whole blood (S109) of calculating a liquid content ratio of whole blood from a hemocyte/plasma ratio in the blood hemocyte and predetermined ratios of liquid components of hemocytes and of liquid components of plasma.

摘要翻译： 通过以下步骤进行血浆葡萄糖的测定，通过血液中的血细胞溶血来制备测定试样的样品制备工序（S101，S102），测定全血的葡萄糖浓度的步骤（S103〜S105） 与测量样品的全血中，计算全血中的液体含有比例（S109），从血细胞中的血细胞/血浆比计算全血的液体含有率和血细胞的液体成分的预定比例 和等离子体的液体成分。

公开(公告)号：US09251898B2

公开(公告)日：2016-02-02

申请号：US13983855

申请日：2012-02-07

申请人： Koji Katayama ,  Takeshi Takagi

发明人： Koji Katayama ,  Takeshi Takagi

IPC分类号： G11C13/00 ,  H01L27/10 ,  H01L27/102 ,  H01L49/02 ,  H01L45/00 ,  H01L27/24 ,  G11C29/50

CPC分类号： G11C13/0069 ,  G11C13/0007 ,  G11C13/004 ,  G11C29/50008 ,  G11C2013/0045 ,  G11C2013/0083 ,  G11C2213/72 ,  H01L27/101 ,  H01L27/1021 ,  H01L27/2409 ,  H01L27/2418 ,  H01L28/20 ,  H01L45/08 ,  H01L45/1233 ,  H01L45/146

摘要： A method for programming a nonvolatile memory element includes: decreasing a resistance value of a variable resistance element in an initial state, by applying an initialization voltage pulse to a series circuit in which a load resistor having a first resistance value is connected in series with the variable resistance element and a MSM diode; applying, after the decreasing, a write voltage pulse to the series circuit after the resistance value of the variable resistance element is changed to a second resistance value lower than the first resistance value; and applying, after the decreasing, an erase voltage pulse to the series circuit after the resistance value of the variable resistance element is changed to a third resistance value lower than the first resistance value.

摘要翻译： 一种用于非易失性存储元件的编程方法包括：通过向串联电路施加初始化电压脉冲来降低初始状态下的可变电阻元件的电阻值，其中具有第一电阻值的负载电阻器与 可变电阻元件和MSM二极管; 在可变电阻元件的电阻值变为低于第一电阻值的第二电阻值之后，在减小之后向串联电路施加写入电压脉冲; 以及在所述可变电阻元件的电阻值变为低于所述第一电阻值的第三电阻值之后，在所述减小之后向所述串联电路施加擦除电压脉冲。