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公开(公告)号：US20120152107A1
公开(公告)日：2012-06-21
申请号：US13311993
申请日：2011-12-06
申请人： Timothy Hand , Kevin Bacon , Victor Wen
发明人： Timothy Hand , Kevin Bacon , Victor Wen
IPC分类号： F15B13/02
CPC分类号： E02F9/2217 , F15B11/024 , F15B2211/3058 , F15B2211/3111 , F15B2211/3127 , F15B2211/329 , F15B2211/355 , F15B2211/40507 , F15B2211/40584 , F15B2211/41527 , F15B2211/6355 , F15B2211/7053
摘要： A hydraulic circuit capable of both a regeneration mode of operation and a full force mode of operation includes a poppet valve controlled by a control valve operating in conjunction with a shuttle valve. The opening of the poppet valve enables the regeneration mode of operation, and the closing of the poppet valve enables the full force mode of operation.
摘要翻译： 能够兼容再生操作模式和全力操作模式的液压回路包括由与梭阀一起操作的控制阀控制的提升阀。 提升阀的打开使得能够再生操作模式，并且提升阀的关闭使得能够进行全压力操作模式。
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公开(公告)号：US09127437B2
公开(公告)日：2015-09-08
申请号：US13311993
申请日：2011-12-06
申请人： Timothy Hand , Kevin Bacon , Victor Wen
发明人： Timothy Hand , Kevin Bacon , Victor Wen
IPC分类号： F15B11/08 , E02F9/22 , F15B11/024
CPC分类号： E02F9/2217 , F15B11/024 , F15B2211/3058 , F15B2211/3111 , F15B2211/3127 , F15B2211/329 , F15B2211/355 , F15B2211/40507 , F15B2211/40584 , F15B2211/41527 , F15B2211/6355 , F15B2211/7053
摘要： A hydraulic circuit capable of both a regeneration mode of operation and a full force mode of operation includes a poppet valve controlled by a control valve operating in conjunction with a shuttle valve. The opening of the poppet valve enables the regeneration mode of operation, and the closing of the poppet valve enables the full force mode of operation.
摘要翻译： 能够兼容再生操作模式和全力操作模式的液压回路包括由与梭阀一起操作的控制阀控制的提升阀。 提升阀的打开使得能够再生操作模式，并且提升阀的关闭使得能够进行全压力操作模式。
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3.发明授权Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders 有权用作CCR3拮抗剂治疗炎症和免疫疾病的芳基磺酰胺衍生物公开(公告)号：US08242118B2
公开(公告)日：2012-08-14
申请号：US12763072
申请日：2010-04-19
申请人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/535 , A61K31/44 , A61K31/195 , A61K31/275 , A01N43/40 , A01N37/12 , A01N37/44 , A01N37/34 , C07D239/02 , C07D213/00 , C07C255/00 , C07C315/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
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4.发明授权Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders 失效用作治疗炎症和免疫疾病的ccr3拮抗剂的芳基磺酰胺衍生物公开(公告)号：US07700586B2
公开(公告)日：2010-04-20
申请号：US10489029
申请日：2002-09-04
申请人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
发明人： Yingfu Li , Akihiko Watanabe , Timothy B. Lowinger , Kevin Bacon , Norihiro Kawamura , Takuya Shintani , Tetsuo Kikuchi , Toshiya Moriwaki , Klaus Urbahns , Keiko Fukushima , Noriko Nunami , Takashi Yoshino , Toshiki Murata , Megumi Yamauchi , Hiroko Yoshino
IPC分类号： A61K31/55 , A01N43/62 , A61K31/497 , C07D243/08 , C07D241/04 , C07D295/00
CPC分类号： C07D213/70 , C07C311/29 , C07C323/67 , C07D207/14 , C07D207/48 , C07D209/08 , C07D211/28 , C07D211/58 , C07D211/96 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D241/04 , C07D241/06 , C07D243/08 , C07D257/04 , C07D295/088 , C07D295/13 , C07D295/194 , C07D295/26 , C07D307/14 , C07D333/38 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.
摘要翻译： 本发明涉及可用作药物制剂活性成分的磺酰胺衍生物。 本发明的磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。
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公开(公告)号：US20080261903A1
公开(公告)日：2008-10-23
申请号：US10561570
申请日：2004-06-16
IPC分类号： A61K31/7052 , C07H21/00 , C12N15/63 , C12N5/00 , C12N9/12 , C40B40/08 , A61P35/00 , A61P11/00 , C12P21/00 , C12Q1/68 , G01N33/53 , C12Q1/48
CPC分类号： C12N9/0004
摘要： Reagents which regulate human RC Kinase activity and reagents which bind to human RC Kinase gene products can be used to regulate this protein for therapeutic effects. Such regulation is particularly useful for treating chronic obstructive pulmonary disease, asthma, cancer, and diseases in which cell signaling is defective.
摘要翻译： 调节人类RC激酶活性的试剂和与人类RC激酶基因产物结合的试剂可用于调节该蛋白质的治疗效果。 这种调节对于治疗慢性阻塞性肺疾病，哮喘，癌症和细胞信号传导有缺陷的疾病特别有用。
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6.发明申请Pyrimidine derivatives useful for the treatment of diseases mediated by crth2 有权可用于治疗由crth2介导的疾病的嘧啶衍生物公开(公告)号：US20070129355A1
公开(公告)日：2007-06-07
申请号：US10554668
申请日：2004-04-14
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/506 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译： 本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。 本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病 ，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。
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公开(公告)号：US20060275297A1
公开(公告)日：2006-12-07
申请号：US11495801
申请日：2006-07-28
申请人： Gerard Hardiman , Devora Rossi , Kevin Bacon , J. Bazan , Thomas Schall , Albert Zlotnik
发明人： Gerard Hardiman , Devora Rossi , Kevin Bacon , J. Bazan , Thomas Schall , Albert Zlotnik
IPC分类号： A61K39/395 , G01N33/567 , C07K16/24
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00 , Y10S435/81
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
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公开(公告)号：US07829685B2
公开(公告)日：2010-11-09
申请号：US10561570
申请日：2004-06-16
CPC分类号： C12N9/0004
摘要： Reagents which regulate human RC Kinase activity and reagents which bind to human RC Kinase gene products can be used to regulate this protein for therapeutic effects. Such regulation is particularly useful for treating chronic obstructive pulmonary disease, asthma, cancer, and diseases in which cell signaling is defective.
摘要翻译： 调节人类RC激酶活性的试剂和与人类RC激酶基因产物结合的试剂可用于调节该蛋白质的治疗效果。 这种调节对于治疗慢性阻塞性肺疾病，哮喘，癌症以及细胞信号传导有缺陷的疾病特别有用。
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9.发明授权Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 有权可用于治疗由CRTH2介导的疾病的嘧啶衍生物公开(公告)号：US07812160B2
公开(公告)日：2010-10-12
申请号：US10554668
申请日：2004-04-14
申请人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
发明人： Tai-wei Ly , Yuji Koriyama , Takashi Yoshino , Hiroki Sato , Kazuho Tanaka , Hiromi Sugimoto , Yoshihisa Manabe , Kevin Bacon , Klaus Urbahns , Masanori Seki , Takuya Shintani
IPC分类号： C07D239/42 , C07D239/34 , C07D239/48 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , A61K31/505 , A61K31/506 , A61P11/06
CPC分类号： C07D239/42 , C07D239/30 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
摘要翻译： 本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。 本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病 ，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。
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10.发明申请2-Phenoxy- and 2-Phenylsulfonamide Derivatives with CCR3 Antagonistic Activity for the Treatment of Inflammatory or Immunological Disorders 审中-公开具有CCR3拮抗活性的2-苯氧基 - 和2-苯基磺酰胺衍生物用于治疗炎症或免疫疾病公开(公告)号：US20090286771A1
公开(公告)日：2009-11-19
申请号：US12504606
申请日：2009-07-16
申请人： Yingfu Li , Kevin Bacon , Hiromi Sugimoto , Keiko Fukushima , Kentaro Hashimoto , Makiko Marumo , Toshiya Moriwaki , Noriko Nunami , Naoki Tsuno , Klaus Urbahns , Nagahiro Yoshida
发明人： Yingfu Li , Kevin Bacon , Hiromi Sugimoto , Keiko Fukushima , Kentaro Hashimoto , Makiko Marumo , Toshiya Moriwaki , Noriko Nunami , Naoki Tsuno , Klaus Urbahns , Nagahiro Yoshida
IPC分类号： A61K31/496 , A61K31/439 , A61K31/551 , A61K31/55 , A61P9/10 , A61P25/28 , A61P31/18
CPC分类号： C07D487/04 , A61K31/439 , C07C311/29 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/40 , C07D207/404 , C07D207/48 , C07D211/54 , C07D223/12 , C07D241/04 , C07D243/08 , C07D257/04 , C07D295/13 , C07D295/22 , C07D295/26 , C07D303/06 , C07D303/36 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D453/02 , C07D487/02 , C07D487/08
摘要： Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.
摘要翻译： 本文提供具有CCR3拮抗活性的2-苯氧基 - 和2-苯基磺酰胺衍生物。 这些化合物可用于治疗与CCR3活性相关的疾病，包括但不限于特应性皮炎，过敏性鼻炎，类风湿性关节炎，格雷夫氏病，艾滋病毒感染，阿尔茨海默病，动脉粥样硬化和其他炎症和/或免疫学疾病。
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