公开(公告)号：US5814321A

公开(公告)日：1998-09-29

申请号：US758374

申请日：1996-11-29

申请人： Tokuji Miyahara ,  Kozo Takase ,  Koichi Saito ,  Yoko Kishimoto ,  Satoru Tokuyama

发明人： Tokuji Miyahara ,  Kozo Takase ,  Koichi Saito ,  Yoko Kishimoto ,  Satoru Tokuyama

IPC分类号： A61K39/39 ,  A61K45/00 ,  A61K9/107

CPC分类号： A61K39/39 ,  A61K2039/55566 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/943

摘要： A water-in-oil type oil adjuvant vaccine comprises 20 to 90% by weight of an oil phase A) which is in a liquid state at ordinary temperature; 0.5 to 30% by weight of an emulsifying agent comprising a non-ionic surfactant B) which is a partial ester derived from a polyhydric alcohol carrying at least three hydroxyl groups and a fatty acid and which is in a liquid state at 40.degree. C. and a polyoxyethylene (20 to 60 moles) hydroxy fatty acid triglyceride C); and 5 to 75% by weight of an aqueous phase D) containing a biologically acceptable and effective amount of antigens, and optionally E) 0.01 to 10% by weight of an amino acid or a salt thereof and 0.01 to 10% by weight of a non-reducing sugar or a sugar alcohol having at least 5 hydroxyl groups in the molecule. In addition, a water-in-oil-in-water type oil adjuvant vaccine comprises the foregoing water-in-oil type oil adjuvant vaccine as an internal phase and an outer aqueous phase F) comprising 0.2 to 20% by weight of an emulsifying agent which comprises a non-ionic surfactant and which has an overall HLB value of not less than 10. The oil adjuvant vaccines show a high ability to induce an antibody-production over a long period of time and are excellent in requirements for medicines such as stability and safety.

摘要翻译： 油包油型油佐剂疫苗含有20〜90重量％的油相A），其在常温下为液态; 0.5至30重量％的包含非离子表面活性剂B）的乳化剂，其为衍生自至少三个羟基和脂肪酸的多元醇的偏酯，并且在40℃处于液态。 和聚氧乙烯（20至60摩尔）羟基脂肪酸甘油三酯C）; 和5至75重量％的包含生物可接受和有效量的抗原的水相D），以及任选地E）0.01至10重量％的氨基酸或其盐和0.01至10重量％的 非还原糖或分子中具有至少5个羟基的糖醇。 此外，水包油包水型油佐剂疫苗包含上述油包水型油佐剂疫苗作为内相和外水相F），其包含0.2-20重量％的乳化剂 药物，其包含非离子表面活性剂，其总体HLB值不小于10.油佐剂疫苗显示出在长时间内诱导抗体产生的高能力，并且对药物如 稳定性和安全性。

公开(公告)号：US20050158330A1

公开(公告)日：2005-07-21

申请号：US11016389

申请日：2004-12-17

申请人： Koichi Saito ,  Yoko Kishimoto ,  Tokuji Miyahara ,  Kouzou Takase

发明人： Koichi Saito ,  Yoko Kishimoto ,  Tokuji Miyahara ,  Kouzou Takase

IPC分类号： A61K39/39 ,  A61K9/00 ,  A61K9/107 ,  A61K9/113 ,  A61K39/00 ,  A61K47/44 ,  A61K31/765

CPC分类号： A61K9/113

摘要： The present invention provides a W/O/W type oil adjuvant vaccine containing an outer aqueous phase containing 0.5 wt %-20 wt % of a polyethylene glycol derivative having a molecular weight of 400-20,000, and an inner aqueous phase containing a biologically acceptable and effective amount of an antigen. The constitution of the present invention that a polyethylene glycol derivative having a specific molecular weight is contained in the outer aqueous phase enables preparation of a W/O/W type oil adjuvant vaccine showing a high adjuvant effect, reduced side effects such as topical response, superior preparation stability and superior workability to allow a person to give an injection easily due to the lowered viscosity.

摘要翻译： 本发明提供一种W / O / W型油佐剂疫苗，其含有含有0.5重量％〜20重量％的分子量为400〜20,000的聚乙二醇衍生物的外层水相和含有生物可接受的内水相 和有效量的抗原。 在外部水相中含有特定分子量的聚乙二醇衍生物的本发明的结构能够制备显示高佐剂效果的W / O / W型油佐剂疫苗，减少副作用，如局部反应， 优异的制备稳定性和优异的加工性，使得人们由于粘度降低而容易地进行注射。

公开(公告)号：US09783852B2

公开(公告)日：2017-10-10

申请号：US12995642

申请日：2009-06-02

申请人： Noriyuki Suzuki ,  Koichi Saito ,  Satoshi Ando ,  Nobuyuki Horie

发明人： Noriyuki Suzuki ,  Koichi Saito ,  Satoshi Ando ,  Nobuyuki Horie

IPC分类号： C12N5/00 ,  C12Q1/68 ,  C12N5/073 ,  G01N33/50

CPC分类号： C12Q1/6883 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0393 ,  C12N5/0603 ,  C12Q1/6809 ,  C12Q2600/142 ,  G01N33/5014 ,  C12Q2545/113

摘要： The present invention provides a method for assessing embryotoxicity of a chemical comprising: (1) a first step of measuring the expression level of one or more genes selected from among genes each comprising any of the nucleotide sequences of SEQ ID NOs: 1 to 78 and 101 to 230 and orthologous genes thereof in a sample from a non-human mammal or mammalian cell which has come into contact with a test chemical; and (2) a second step of comparing the measured value of the expression level of the gene in the sample obtained in the first step with a control value of the expression level of the gene and based on the difference assessing the level of the embryotoxicity of the test chemical in the sample; and so on.

公开(公告)号：US09102175B2

公开(公告)日：2015-08-11

申请号：US12704477

申请日：2010-02-11

申请人： Koichi Saito ,  Katsunori Ono ,  Kenji Ozawa

发明人： Koichi Saito ,  Katsunori Ono ,  Kenji Ozawa

IPC分类号： B41N7/00 ,  B41J13/076 ,  B21C37/15 ,  B65H27/00 ,  C23C24/04 ,  F16C13/00

CPC分类号： B41J13/076 ,  B21C37/15 ,  B41N7/00 ,  B41N2207/02 ,  B41N2207/10 ,  B65H27/00 ,  B65H2401/115 ,  B65H2402/80 ,  B65H2404/13 ,  B65H2404/1351 ,  B65H2404/531 ,  C23C24/04 ,  F16C13/00

摘要： A transport roller includes: a roller body of which a pair of end surfaces face each other by a press work so as to be in a cylindrical shape; and a high friction layer which contains inorganic particles and is provided on a surface of the roller body. Here, the roller body is provided with a joining portion which is formed by separating the pair of end surfaces. In addition, an average particle diameter of the inorganic particle is larger than a distance between the pair of the end surfaces of the roller body on an outer peripheral surface side thereof.

摘要翻译： 输送辊包括：辊体，其一对端面通过压力加工而成为圆筒形; 以及包含无机颗粒并设置在辊体的表面上的高摩擦层。 这里，辊体设置有通过分离一对端面而形成的接合部。 此外，无机粒子的平均粒径大于辊体的外周面侧的一对端面之间的距离。

公开(公告)号：US08439494B2

公开(公告)日：2013-05-14

申请号：US12263092

申请日：2008-10-31

申请人： Hiroshige Owaki ,  Motonori Okumura ,  Munehide Kanaya ,  Nagamitsu Takashima ,  Yasuto Kanai ,  Koichi Saito ,  Kazuyoshi Imai ,  Hiroyuki Kamikura

发明人： Hiroshige Owaki ,  Motonori Okumura ,  Munehide Kanaya ,  Nagamitsu Takashima ,  Yasuto Kanai ,  Koichi Saito ,  Kazuyoshi Imai ,  Hiroyuki Kamikura

IPC分类号： B41J2/175

CPC分类号： B41J2/17563

摘要： A liquid ejecting head includes a head main body capable of ejecting a liquid supplied from a liquid storage unit, and a supply member provided with a liquid supply passage for supplying the liquid from the liquid storage unit to the head main body. The supply member has a filter mounting member provided with the liquid supply passage, a supply body that supplies the filter mounting member with the liquid, and a filter provided between the filter mounting member and the supply body. The supply member is provided with an outer portion that fixes the filter mounting member, the supply body, and the filter and that is formed by integral molding.

摘要翻译： 液体喷射头包括能够喷射从液体存储单元供应的液体的头主体和设置有用于将液体从液体存储单元供应到头主体的液体供给通道的供给构件。 供给构件具有设置有液体供给通道的过滤器安装构件，向过滤器安装构件供给液体的供给体以及设置在过滤器安装构件和供给体之间的过滤器。 供给部件设置有固定过滤器安装部件，供给体和过滤器并且通过一体成型而形成的外部部分。

公开(公告)号：US08314345B2

公开(公告)日：2012-11-20

申请号：US12626807

申请日：2009-11-27

申请人： Koichi Saito ,  Tetsuya Yamamoto

发明人： Koichi Saito ,  Tetsuya Yamamoto

IPC分类号： H05K1/16

CPC分类号： H01L24/03 ,  H01L24/05 ,  H01L24/11 ,  H01L24/13 ,  H01L2224/02319 ,  H01L2224/02331 ,  H01L2224/02351 ,  H01L2224/02377 ,  H01L2224/0311 ,  H01L2224/0312 ,  H01L2224/03436 ,  H01L2224/0361 ,  H01L2224/0401 ,  H01L2224/05548 ,  H01L2224/05567 ,  H01L2224/05647 ,  H01L2224/1132 ,  H01L2224/11849 ,  H01L2224/131 ,  H01L2224/94 ,  H01L2924/00013 ,  H01L2924/0002 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/351 ,  H01L2924/00014 ,  H01L2224/11 ,  H01L2224/03 ,  H01L2224/13099 ,  H01L2224/13599 ,  H01L2224/05599 ,  H01L2224/05099 ,  H01L2224/29099 ,  H01L2224/29599 ,  H01L2224/05552 ,  H01L2924/00

摘要： In a semiconductor module having the structure in which a bump electrode provided on a wiring layer is connected to a device electrode provided on a semiconductor device, connection reliability between the bump electrode and the device electrode is improved. An insulating resin layer is provided between the semiconductor device and the wiring layer. The bump electrode, formed integrally with the wiring layer and projected from the wiring layer toward the insulating resin layer, is electrically connected to the device electrode provided on the semiconductor device. Part of the height of the wiring layer on the end side in a bump connection area is lower than that of the wiring in a wiring area extending toward the side opposite to the end side.

摘要翻译： 在具有设置在布线层上的凸块电极连接到设置在半导体器件上的器件电极的结构的半导体模块中，突起电极和器件电极之间的连接可靠性得到改善。 在半导体器件和布线层之间设置绝缘树脂层。 与布线层一体形成并从布线层朝向绝缘树脂层突出的突起电极与设置在半导体器件上的器件电极电连接。 突起连接区域的端侧的布线层的高度的一部分比在与端侧相反的一侧延伸的布线区域的布线的高度的部分低。

公开(公告)号：US20120245281A1

公开(公告)日：2012-09-27

申请号：US13514190

申请日：2010-12-10

申请人： Yasuhiro Tsudo ,  Masaki Inaba ,  Koichi Saito ,  Hideaki Saito ,  Takanori Yamamoto

发明人： Yasuhiro Tsudo ,  Masaki Inaba ,  Koichi Saito ,  Hideaki Saito ,  Takanori Yamamoto

IPC分类号： C08L75/04 ,  C08L75/12

CPC分类号： C08J3/203 ,  B29C41/18 ,  B29K2075/00 ,  C08G18/10 ,  C08G18/12 ,  C08G18/42 ,  C08G18/73 ,  C08J3/12 ,  C08J3/20 ,  C08J2375/00 ,  C08J2375/04

摘要： Provided are urethane resin particles for slush molding which make it possible that inconveniences based on the slip-down of a pigment, on the aggregation of particles of the pigment, and on other causes are removed although this coloring is coloring onto the resin particle surfaces. The present invention is urethane resin particles for slush mold which contain a urethane resin and an additive, wherein the particles have a shape factor SF1 of 101 to 200, a shape factor SF2 of 120 to 240, and a central particle diameter of 20 to 500 μm. It is preferred that the urethane resin has a concentration of urea groups of 0.5 to 10% by weight, a total of the concentration of urethane groups and that of the urea groups of 4 to 20% by weight, a melting point of 160 to 260° C. and a glass transition temperature of −65 to 0° C.

摘要翻译： 提供了用于搪塑的聚氨酯树脂颗粒，这使得可能除去颜料着色到树脂颗粒表面上以来，基于颜料的滑落，颜料的颗粒聚集和其它原因的不便。 本发明是含有聚氨酯树脂和添加剂的用于糊模的聚氨酯树脂颗粒，其中颗粒的形状因子SF1为101〜200，形状因子SF2为120〜240，中心粒径为20〜500 μm。 优选的是，所述聚氨酯树脂的尿素基浓度为0.5〜10重量％，氨基甲酸酯基和尿素基的浓度的总和为4〜20重量％，熔点为160〜260 ℃，玻璃化转变温度为-65℃至0℃。

公开(公告)号：US08220920B2

公开(公告)日：2012-07-17

申请号：US12813673

申请日：2010-06-11

申请人： Koichi Saito ,  Kenji Ozawa ,  Ryoji Uesugi

发明人： Koichi Saito ,  Kenji Ozawa ,  Ryoji Uesugi

IPC分类号： B41J2/01 ,  B25F5/02 ,  F16C13/00

CPC分类号： B65H27/00 ,  B65H2401/13 ,  B65H2402/80 ,  B65H2404/13421 ,  B65H2404/1351 ,  B65H2404/182 ,  B65H2801/06

摘要： A transport device includes a transport roller that is formed into a cylindrical shape in such a manner that a pair of end surfaces thereof are matched with each other by press working, and includes a medium supporting region in a part thereof in a longitudinal direction, while the medium supporting region supporting a medium; and a bearing that pivotally supports a region of the transport roller, the region being other than the medium supporting region. The transport roller includes an opening in the region other than the medium supporting region in a seam formed by matching the pair of end surfaces with each other.

摘要翻译： 输送装置包括：输送辊，其形成为圆筒状，使得其一对端面通过冲压加工相互匹配，并且在其纵向方向的一部分中包括介质支撑区域，同时 介质支撑区域支撑介质; 以及枢转地支撑输送辊的区域的轴承，该区域不同于介质支撑区域。 传送辊在通过使一对端面彼此匹配而形成的接缝中包括在介质支撑区域之外的区域中的开口。

公开(公告)号：US20120115856A1

公开(公告)日：2012-05-10

申请号：US13322888

申请日：2010-05-28

申请人： Junichi Ishikawa ,  Koichi Saito ,  Norihisa Ohe ,  Kentaro Kobayashi

发明人： Junichi Ishikawa ,  Koichi Saito ,  Norihisa Ohe ,  Kentaro Kobayashi

IPC分类号： A61K31/428 ,  C07D403/10 ,  C07D413/10 ,  C07D413/14 ,  C07D403/14 ,  C07D417/14 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/541 ,  A61K31/5377 ,  A61P9/10 ,  A61P25/02 ,  C07D417/10

CPC分类号： A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/454 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： A compound depicted by the formula below, or a pharmaceutically acceptable salt or solvate thereof. wherein, R1 represents (1) a C3-6 alkyl group, (2) a C1-6 alkyl group substituted with one or more substituent group(s) selected from those consisting a halogen atom, etc., (3) a C3-10 non-aromatic cyclic hydrocarbon group or a 5- to 6-membered non-aromatic heterocyclic group which respectively is optionally substituted with one or more substituent group(s) selected from those consisting an oxo group, etc., (4) an aromatic cyclic hydrocarbon group substituted with one or more substituent selected from the group consisting halogen atom and C1-4 alkoxy group; X represents NH, O, or S; Y represents CH or N; Z represents N or a C—R2; R2 represents (1) hydrogen atom, (2) a C1-6 alkyl group, a C2-6 alkenyl group or a C2-6 alkynyl group that respectively is optionally substituted with one or more substituent group(s) selected from among those consisting (a) a halogen atom, etc., or (3) a C5-6 non-aromatic cyclic hydrocarbon group or a 5- to 6-membered non-aromatic heterocyclic group optionally substituted; ring A represents a benzene ring optionally substituted; ring B represents a benzene ring optionally substituted.

摘要翻译： 由下式表示的化合物或其药学上可接受的盐或溶剂化物。 其中，R1表示（1）C3-6烷基，（2）被选自卤原子等的一个或多个取代基取代的C 1-6烷基，（3）C3- 10个非芳族环状烃基或5〜6元非芳族杂环基，其分别任选被一个或多个选自氧代基等的取代基取代，（4）芳族 被一个或多个选自卤素原子和C 1-4烷氧基的取代基取代的环状烃基; X表示NH，O或S; Y表示CH或N; Z表示N或C-R2; R2表示（1）氢原子，（2）分别被一个或多个选自以下的取代基取代的C 1-6烷基，C 2-6烯基或C 2-6炔基： （a）卤素原子等，或（3）任选取代的C5-6非芳香族环状烃基或5〜6元非芳香族杂环基; 环A表示任选取代的苯环; 环B表示任选取代的苯环。

公开(公告)号：US08004204B2

公开(公告)日：2011-08-23

申请号：US12484265

申请日：2009-06-15

申请人： Takafumi Nonaka ,  Takashi Kumagai ,  Noriyuki Matsubara ,  Kazuo Ban ,  Koichi Saito

发明人： Takafumi Nonaka ,  Takashi Kumagai ,  Noriyuki Matsubara ,  Kazuo Ban ,  Koichi Saito

IPC分类号： H05B41/16

CPC分类号： H05B33/0815 ,  H02M1/32 ,  H02M3/33523 ,  H05B33/0824 ,  Y10T307/406

摘要： A series load circuit is a circuit formed by connecting a light-emitting device unit 851 (the first load circuit) and a light-emitting device unit 852 (the second load circuit) in series. A voltage generating circuit 111 generates voltage to be applied to the series load circuit. A current detecting circuit 112 detects electric current flowing through the light-emitting device unit 851. A controlling circuit 114 controls the voltage generating circuit 111 so that the electric current detected by the current detecting circuit 112 becomes a predetermined current value.

摘要翻译： 串联负载电路是通过串联连接发光器件单元851（第一负载电路）和发光器件单元852（第二负载电路）而形成的电路。 电压产生电路111产生施加到串联负载电路的电压。 电流检测电路112检测流过发光器件单元851的电流。控制电路114控制电压产生电路111，使得由电流检测电路112检测的电流变为预定电流值。