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    Compositions and methods for detecting cancer
    3.
    发明授权
    Compositions and methods for detecting cancer 有权
    组成和检测癌症的方法

    公开(公告)号：US07851144B2

    公开(公告)日：2010-12-14

    申请号：US11840112

    申请日：2007-08-16

    申请人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

    发明人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

    IPC分类号： C12Q1/00 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57438

    摘要： The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.

    摘要翻译： 本发明提供涉及检测受试者中癌症的存在和/或评估癌症风险的方法和组合物。 这些方法包括检测和诊断个体癌症的方法; 识别患有癌症风险的个体的方法; 和分期癌症的方法。 所述方法通常涉及检测已发现与癌症相关的帕拉丁基因核苷酸序列改变和/或检测生物样品中帕拉丁蛋白mRNA和/或蛋白质的水平。 本发明还提供了用于本发明方法的核酸探针，核酸引物和抗体，以及包含其中一种或多种的试剂盒。

    Compositions and methods for detecting cancer
    4.
    发明授权
    Compositions and methods for detecting cancer 有权
    组成和检测癌症的方法

    公开(公告)号：US09315867B2

    公开(公告)日：2016-04-19

    申请号：US12939801

    申请日：2010-11-04

    申请人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

    发明人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57438

    摘要： The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.

    摘要翻译： 本发明提供涉及检测受试者中癌症的存在和/或评估癌症风险的方法和组合物。 这些方法包括检测和诊断个体癌症的方法; 识别患有癌症风险的个体的方法; 和分期癌症的方法。 所述方法通常涉及检测已发现与癌症相关的帕拉丁基因核苷酸序列改变和/或检测生物样品中帕拉丁蛋白mRNA和/或蛋白质的水平。 本发明还提供了用于本发明方法的核酸探针，核酸引物和抗体，以及包含其中一种或多种的试剂盒。

    THERMAL MANAGEMENT IN A FUEL CELL SYSTEM
    5.
    发明申请
    THERMAL MANAGEMENT IN A FUEL CELL SYSTEM 审中-公开
    燃料电池系统中的热管理

    公开(公告)号：US20090246578A1

    公开(公告)日：2009-10-01

    申请号：US12060760

    申请日：2008-04-01

    申请人： Craig Evans ,  Evan Rege ,  Ru Chen ,  Zakiul Kabir

    发明人： Craig Evans ,  Evan Rege ,  Ru Chen ,  Zakiul Kabir

    IPC分类号： H01M8/00

    CPC分类号： H01M8/04007 ,  H01M8/0668 ,  H01M2008/1095

    摘要： Embodiments of thermally integrated HT PEM fuel cell systems are disclosed. In one disclosed embodiment, a fuel cell system comprises a fuel cell, a fuel processor configured to form a processed fuel for the fuel cell, and a thermal management system comprising a heat transfer fluid circulation loop that circulates a heat transfer fluid through the fuel cell and through the fuel processing system in a common loop.

    摘要翻译： 公开了热集成HT PEM燃料电池系统的实施例。 在一个公开的实施例中，燃料电池系统包括燃料电池，配置成形成用于燃料电池的处理燃料的燃料处理器，以及包括传热流体循环回路的热管理系统，该传热流体循环回路使传热流体循环通过燃料电池 并通过燃油处理系统进行共同循环。

    FUEL CELL MEMBRANES, GELS, AND METHODS OF FABRICATION
    6.
    发明申请
    FUEL CELL MEMBRANES, GELS, AND METHODS OF FABRICATION 审中-公开
    燃料电池膜，凝胶和制造方法

    公开(公告)号：US20080317946A1

    公开(公告)日：2008-12-25

    申请号：US12107670

    申请日：2008-04-22

    申请人： Ru Chen

    发明人： Ru Chen

    IPC分类号： B05D1/00 ,  C08K5/42

    CPC分类号： B01D71/62 ,  B01D67/0011 ,  B01D67/0016 ,  B01D69/10 ,  B01D2325/22 ,  C08J5/2256 ,  C08J2379/04 ,  C08L79/04 ,  H01M8/1027 ,  H01M8/103 ,  H01M8/1032 ,  H01M8/1048 ,  H01M8/1072 ,  H01M2300/0082 ,  Y02P70/56

    摘要： The forming of fuel cell membranes via novel intermediate gels is disclosed. One disclosed embodiment provides a method of making a fuel cell polyazole membrane comprising dissolving a polyazole with a water stable polyazole solubilizing acid thereby forming a polyazole-acid solution, applying a layer of said polyazole-acid solution to a support thereby forming a polyazole-acid film, contacting said polyazole-acid film with water thereby forming a polyazole-acid gel, and contacting said polyazole-acid gel with a doping acid thereby forming said fuel cell polyazole membrane.

    摘要翻译： 公开了通过新型中间凝胶形成燃料电池膜。 一个公开的实施方案提供了一种制备燃料电池聚唑膜的方法，其包括用耐水稳定的多唑溶解酸溶解聚唑，从而形成聚唑酸溶液，将一层所述聚唑酸溶液施加到载体上，从而形成聚唑酸 膜，使所述聚唑酸膜与水接触，从而形成聚唑酸凝胶，并使所述聚唑酸凝胶与掺杂酸接触，从而形成所述燃料电池多唑膜。

    COMPOSITIONS AND METHODS FOR DETECTING CANCER
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR DETECTING CANCER 有权
    用于检测癌症的组合物和方法

    公开(公告)号：US20110104694A1

    公开(公告)日：2011-05-05

    申请号：US12939801

    申请日：2010-11-04

    申请人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

    发明人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57438

    摘要： The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.

    摘要翻译： 本发明提供涉及检测受试者中癌症的存在和/或评估癌症风险的方法和组合物。 这些方法包括检测和诊断个体癌症的方法; 识别患有癌症风险的个体的方法; 和分期癌症的方法。 所述方法通常涉及检测已发现与癌症相关的帕拉丁基因核苷酸序列改变和/或检测生物样品中帕拉丁蛋白mRNA和/或蛋白质的水平。 本发明还提供了用于本发明方法的核酸探针，核酸引物和抗体，以及包含其中一种或多种的试剂盒。

    Rigidity & Inplane Electrolyte Mobility Enhancement for Fuel Cell Eletrolyte Membranes
    9.
    发明申请
    Rigidity & Inplane Electrolyte Mobility Enhancement for Fuel Cell Eletrolyte Membranes 审中-公开
    用于燃料电池电解质膜的刚性和电解质电解质迁移率增强

    公开(公告)号：US20100227250A1

    公开(公告)日：2010-09-09

    申请号：US12397158

    申请日：2009-03-03

    申请人： Ru Chen ,  Craig Evans ,  Evan Rege ,  Zakiul Kabir

    发明人： Ru Chen ,  Craig Evans ,  Evan Rege ,  Zakiul Kabir

    IPC分类号： H01M4/00 ,  H01M2/00

    CPC分类号： C08J5/2275 ,  C08J2327/18 ,  C08J2379/06 ,  H01M8/0258 ,  H01M8/0263 ,  H01M8/0271 ,  H01M8/1004 ,  H01M8/103 ,  H01M8/1048 ,  H01M8/106 ,  H01M8/1081 ,  H01M8/1088 ,  Y02P70/56

    摘要： Embodiments related to fuel cells and membrane-electrode assemblies for fuel cells are disclosed. In one disclosed embodiment, a membrane-electrode assembly includes a catalyzed anode material and a membrane disposed in face-sharing contact with the catalyzed anode material. The membrane comprises mutually interpenetrating first and second phases, the first phase supporting an ionic conduction through the membrane, and the second phase supporting a dimensional structure of the membrane. The membrane-electrode assembly also includes a catalyzed cathode material disposed in face-sharing contact with the membrane, opposite the catalyzed anode material. Two opposing flow plates are also provided, each flow plate configured to distribute a reactant gas to a catalyzed electrode material of the membrane-electrode assembly. Other embodiments provide variants on the membrane-electrode assembly and methods to make the membrane-electrode assembly.

    摘要翻译： 公开了与用于燃料电池的燃料电池和膜 - 电极组件相关的实施例。 在一个公开的实施例中，膜电极组件包括催化阳极材料和与催化阳极材料共面接触设置的膜。 膜包括相互互穿的第一和第二相，第一相支持通过膜的离子传导，第二相支撑膜的尺寸结构。 膜 - 电极组件还包括与膜的面共享接触设置的催化的阴极材料，与催化的阳极材料相对。 还提供了两个相对的流动板，每个流动板被配置为将反应气体分配到膜 - 电极组件的催化电极材料。 其它实施例提供了膜 - 电极组件上的变型和制造膜 - 电极组件的方法。

    COMPOSITIONS AND METHODS FOR DETECTING CANCER
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR DETECTING CANCER 有权
    用于检测癌症的组合物和方法

    公开(公告)号：US20080318225A1

    公开(公告)日：2008-12-25

    申请号：US11840112

    申请日：2007-08-16

    申请人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

    发明人： Teresa A. Brentnall ,  Ru Chen ,  Katherine L. Pogue-Geile ,  David C. Whitcomb ,  Mary Patricia Bronner ,  Carol A. Otey

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/535

    CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57438

    摘要： The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The methods generally involve detecting a palladin gene nucleotide sequence alteration that has been found to be associated with cancer and/or detecting a level of a palladin mRNA and/or protein in a biological sample. The present invention further provides nucleic acid probes, nucleic acid primers, and antibodies, as well as kits comprising one or more of the same, for use in a subject method.

    摘要翻译： 本发明提供涉及检测受试者中癌症的存在和/或评估癌症风险的方法和组合物。 这些方法包括检测和诊断个体癌症的方法; 识别患有癌症风险的个体的方法; 和分期癌症的方法。 所述方法通常涉及检测已发现与癌症相关的帕拉丁基因核苷酸序列改变和/或检测生物样品中帕拉丁蛋白mRNA和/或蛋白质的水平。 本发明还提供了用于本发明方法的核酸探针，核酸引物和抗体，以及包含其中一种或多种的试剂盒。