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公开(公告)号：US20080200347A1
公开(公告)日：2008-08-21
申请号：US11794811
申请日：2006-01-16
申请人： Yasuko Yoshida , Kazunari Yamada , Kousuke Niwa
发明人： Yasuko Yoshida , Kazunari Yamada , Kousuke Niwa
CPC分类号： C12Q1/6837 , B01J2219/00286 , B01J2219/005 , B01J2219/00527 , B01J2219/00542 , B01J2219/00545 , B01J2219/00554 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00722 , B01L3/508 , B01L2300/0636 , B01L2300/0822
摘要： The present invention provides a hybridization method suited for using a signal probe. An array of the present invention comprises: a substrate; a nucleic acid probe that is fixed to the substrate and is hybridized with a sample to have a signal change; and at least one cavity that is filled with a specific liquid containing the sample and causing the hybridization of the nucleic acid probe with the sample. The array in this arrangement effectively enhances the reproducibility and the efficiency of hybridization with the signal probe.
摘要翻译： 本发明提供了适合于使用信号探针的杂交方法。 本发明的阵列包括：基底; 固定在基底上并与样品杂交以具有信号变化的核酸探针; 以及填充有含有样品的特定液体并使核酸探针与样品杂交的至少一个空腔。 在这种布置中的阵列有效地增强了与信号探针杂交的重现性和效率。
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公开(公告)号：US20100276309A1
公开(公告)日：2010-11-04
申请号：US12747597
申请日：2008-12-12
CPC分类号： B01F13/0222 , B01F13/0059 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/04 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/0803 , B01L2300/0864 , B01L2300/0867 , B01L2400/0409 , B01L2400/0487 , Y10T137/8593
摘要： In a state where liquids are contained in a plurality of liquid container portions which are formed in a first layer and a second layer of a cartridge and which have predetermined volumes determined depending on liquids to be contained, and where the reaction vessel is connected to any one of communicating ports, when pressure is applied to act upon one of the liquid container portions which is communicated with the communicating port connected to the reaction vessel, the atmosphere is supplied to the one liquid container portion through a atmosphere flowing passage communicating with the outside, and the liquid contained in the one liquid container portion is supplied to the reaction vessel. The cartridge is rotated to connect another communicating port to the reaction vessel such that plural liquids are eventually supplied to the reaction vessel. On that occasion, since the atmosphere supplied through the atmosphere flowing passage is further supplied to the reaction vessel through the communicating port connected to the reaction vessel and the one liquid container portion, the plural liquids contained in the reaction vessel are stirred by the inflow of the atmosphere.
摘要翻译： 在液体被容纳在形成在第一层中的多个液体容器部分和盒的第二层的状态下，并且具有根据要包含的液体确定的预定体积，并且其中反应容器连接到任何 一个连通端口，当施加压力作用在与连接到反应容器的连通口连通的液体容器部分之一时，气氛通过与外部连通的大气流动通道供应到一个液体容器部分 并且容纳在一个液体容器部分中的液体被供应到反应容器。 旋转墨盒以将另一个连通口连接到反应容器，使得多个液体最终被供应到反应容器。 因此，由于通过大气流动通道供应的气氛通过连接到反应容器和一个液体容器部分的连通口进一步供应到反应容器中，所以反应容器中包含的多种液体被流入 气氛。
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公开(公告)号：US20090042734A1
公开(公告)日：2009-02-12
申请号：US11886676
申请日：2006-03-27
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00378 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00542 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , B01L3/5088 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0887 , C12Q1/6837
摘要： An object of the present invention is to provide a probe array having partitioned array regions with uniform surface chemical properties. The probe array of the present invention includes a substrate having a plurality of partitioned array regions where many probes are immobilized and a separator attached to the substrate and including partitions partitioning the array regions. The above object can be achieved by attaching the separator including the partitions capable of partitioning instead of forming hydrophobic regions on a surface of the substrate by printing or chemical treatment.
摘要翻译： 本发明的目的是提供一种具有均匀表面化学性质的分隔阵列区的探针阵列。 本发明的探针阵列包括具有多个分隔阵列区域的基底，其中许多探针被固定，并且分离器附着到基底上，并且包括分隔阵列区域的分隔物。 上述目的可以通过印刷或化学处理将包括能够分隔而不是通过印刷或化学处理形成疏水性区域的分隔体附接到基板的表面来实现。
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公开(公告)号：US20070238870A1
公开(公告)日：2007-10-11
申请号：US11572506
申请日：2005-07-29
IPC分类号： C12M1/00
CPC分类号： B01L3/502746 , B01L3/502707 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B01L2300/0887 , B01L2300/165
摘要： The hybridization device of the invention aims to attain a hybridization reaction of high reproducibility. A hybridization device 2 for a hybridization reaction of nucleic acid has a cover member 10 that defines a cavity 12, which includes a nucleic acid fixation area 6 of a substrate 4 for fixation of a nucleic acid probe and has capacity for storage of a liquid for the hybridization reaction therein. At least part of an area exposed to inside of the cavity 12 forms a hydrophobic region 18. Adequate control of the surface characteristic of the area exposed to the cavity for implementing the hybridization reaction desirably enhances the signal intensity and reduces a variation in signal intensity, thus attaining the hybridization reaction of high reproducibility.
摘要翻译： 本发明的杂交装置旨在实现高再现性的杂交反应。 用于核酸杂交反应的杂交装置2具有限定空腔12的覆盖构件10，其包括用于固定核酸探针的基底4的核酸固定区域6，并且具有用于储存用于 其中的杂交反应。 暴露于空腔12内部的区域的至少一部分形成疏水区域18。 为了实现杂交反应，暴露于空腔的区域的表面特性的适当控制期望增强信号强度并降低信号强度的变化，从而实现高再现性的杂交反应。
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公开(公告)号：US20070292853A1
公开(公告)日：2007-12-20
申请号：US10593349
申请日：2005-03-18
CPC分类号： C12Q1/6827 , C12Q2565/501 , C12Q2537/143 , C12Q2525/204
摘要： A DNA array for detecting a single nucleotide polymorphism of a gene, which comprises, on a solid support, a first probe spots group consisting of one or more probe spots each containing one or more probes hybridizable with a polynucleotide of the gene, in which the probes are exactly complementary to the first polymorphism pattern of the gene, and a second probe spots group consisting of one or more probe spots each containing one or more probes hybridizable with the polynucleotide of the gene, in which the probes are exactly complementary to the second polymorphism pattern of the gene, wherein probe lengths in the probe spots is different from each other. This DNA array enables more exact SNP detection.
摘要翻译： 一种用于检测基因的单核苷酸多态性的DNA阵列，其在固体支持物上包含由一个或多个探针点组成的第一探针斑点，每个探针点含有一个或多个与该基因的多核苷酸杂交的探针，其中 探针与基因的第一多态性模式完全互补，第二探针点组由一个或多个探针点组成，每个探针点含有一个或多个可与基因的多核苷酸杂交的探针，其中探针与第二个 基因的多态性模式，其中探针点中的探针长度彼此不同。 该DNA阵列能够进行更准确的SNP检测。
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公开(公告)号：US20080070795A1
公开(公告)日：2008-03-20
申请号：US11851865
申请日：2007-09-07
申请人： Keisuke Makino , Tsutomu Kodaki , Seiya Watanabe , Seung Pack , Mitsuru Nonogawa , Hiroo Wada , Yasuko Yoshida , Kazunari Yamada
发明人： Keisuke Makino , Tsutomu Kodaki , Seiya Watanabe , Seung Pack , Mitsuru Nonogawa , Hiroo Wada , Yasuko Yoshida , Kazunari Yamada
CPC分类号： C07D498/04 , C07H19/24 , C07H21/04
摘要： The present invention aims to provide a technique for stably immobilizing a probe on a carrier The present invention provides a linker compound represented by formula (1): wherein A represents a hydrogen atom, another substituent, a sugar, or a derivative thereof.
摘要翻译： 本发明的目的在于提供一种用于将探针稳定地固定在载体上的技术。本发明提供由式（1）表示的连接剂化合物：其中A表示氢原子，另一取代基，糖或其衍生物。
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公开(公告)号：US07200254B2
公开(公告)日：2007-04-03
申请号：US10235999
申请日：2002-09-05
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00529 , B01J2219/0054 , B01J2219/00576 , B01J2219/00677 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , G01N2035/00158 , G01N2035/0494
摘要： Technology is disclosed for highly accurate automated execution of processing for alignment of a detection area to a DNA microarray image file and processing for quantitative determination of success/failure of the alignment during DNA microarray analysis. A probe reactive chip used for the technology comprises a substrate; a spot region wherein spots for fixing a probe capable of specifically reacting to a sample marked so as to be optically detectable are formed in a matrix on a surface of the substrate; and a reference pattern area, which is arranged within the spot region or approximate to the spot region, and comprises a plurality of different alignment marks in order to correct misalignment of the spot during analysis of the sample on the surface of the substrate.
摘要翻译： 公开了用于高精度自动执行用于将检测区域与DNA微阵列图像文件对齐的处理的技术，以及用于在DNA微阵列分析期间定量确定取向成功/失败的处理。 用于该技术的探针反应性芯片包括基底; 斑点区域，其中用于固定探针的斑点能够与标记为可光学检测的样品特异性反应，形成在基底表面上的基质中; 以及布置在斑点区域内或近似于斑点区域的参考图案区域，并且包括多个不同的对准标记，以便在基底表面上的样品分析期间校正斑点的未对准。
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公开(公告)号：USD295414S
公开(公告)日：1988-04-26
申请号：US813640
申请日：1985-12-26
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公开(公告)号：US4274081A
公开(公告)日：1981-06-16
申请号：US64507
申请日：1979-08-07
申请人： Nobutaka Nomura , Hiroshi Kido , Kazunari Yamada
发明人： Nobutaka Nomura , Hiroshi Kido , Kazunari Yamada
CPC分类号： G06F3/0238
摘要： A data input apparatus comprises a display device for displaying guidance information which designates types of data to be inputted as well as the order therefor, a key set having a plurality of keys arrayed in a matrix and a corresponding number of mats defining the functions of the individual keys which can be imparted with new definitions by changing over the associated mats, and a circuit adapted to select and change the mats defining the keys so that the various types of data indicated by the guidance information can be inputted in the order given by the guidance information. The mats can thus be replaced by other proper ones automatically without resorting to manual operation.
摘要翻译： 数据输入装置包括显示装置，用于显示指定要输入的数据的类型的指导信息及其顺序，具有矩阵排列的多个键的键组和相应数量的定义 可以通过改变关联的垫子来赋予新定义的单个键，以及适于选择和改变定义键的垫的电路，使得能够以由引导信息指示的顺序输入由引导信息指示的各种类型的数据 指导信息。 因此，这些垫可以由其他适当的垫子自动更换，而无需手动操作。
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公开(公告)号：US4225565A
公开(公告)日：1980-09-30
申请号：US6293
申请日：1979-01-25
CPC分类号： C22B7/04 , Y02P10/212
摘要： In the treating of waste slags produced in the desulfurization and/or dephosphorization of molten pig iron with alkali carbonates, the alkali is recovered by extracting said waste slags with hot water while feeding carbon dioxide gas to form an extraction solution having a pH of 9.0-11.5 and recovering alkali carbonates from said extraction solution. The extraction solution contains little sulphur and silicates, from which alkali carbonates can be easily recovered with high yield therefrom.
摘要翻译： 在用碱性碳酸盐脱硫和/或脱磷脱磷生产的废渣中处理废渣时，用热水提取所述废渣并回收二氧化碳，形成pH为9.0〜 11.5并从所述提取溶液中回收碱金属碳酸盐。 提取溶液含有少量的硫和硅酸盐，碱金属碳酸盐可以从其中高收率地容易地回收。
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