公开(公告)号：US3950221A

公开(公告)日：1976-04-13

申请号：US490278

申请日：1974-07-22

申请人： Yoshitaka Kokusho ,  Susumu Higashi ,  Haruo Machida ,  Shinjiro Iwasaki

发明人： Yoshitaka Kokusho ,  Susumu Higashi ,  Haruo Machida ,  Shinjiro Iwasaki

IPC分类号： A23C19/032 ,  C12N9/00 ,  C12N9/52 ,  C12N9/58 ,  C07G7/02 ,  A23C19/00

CPC分类号： C12N9/58 ,  A23C19/0326 ,  C12N9/00 ,  C12N9/52 ,  Y10S435/838 ,  Y10S435/839 ,  Y10S435/911 ,  Y10S435/931 ,  Y10S435/939

摘要： A process for improving the quality of microbial rennet by inactivating cellulase impurities in microbial rennet which comprises heat-treating microbial rennet in an aqueous medium in the presence of sodium chloride.

公开(公告)号：US4283494A

公开(公告)日：1981-08-11

申请号：US900234

申请日：1978-04-26

申请人： Yoshitaka Kokusho ,  Haruo Machida ,  Shinjiro Iwasaki

发明人： Yoshitaka Kokusho ,  Haruo Machida ,  Shinjiro Iwasaki

IPC分类号： C12N9/18 ,  C12N9/20 ,  C12N1/20 ,  C12R1/05

CPC分类号： C12R1/05 ,  C12N9/18 ,  C12N9/20 ,  Y10S435/829

摘要： A microbial lipase which has (i) an optimal pH for activity of about 9.+-.0.5, (ii) an optimal temperature for activity of about 40.degree. C. to about 48.degree. C., (iii) a lipase activity to be activated by bile salts, (iv) a cholesterol esterase activity, and (v) a molecular weight of about 30.times.10.sup.4 to about 40.times.10.sup.4 ; a process for its preparation; and microbiologically pure culture therefor.

摘要翻译： 一种微生物脂肪酶，其具有（i）约9 +/- 0.5的活性的最佳pH，（ii）约40℃至约48℃的活性的最佳温度，（iii）脂肪酶活性为 由胆汁盐活化，（iv）胆固醇酯酶活性，和（v）约30×10 4至约40×10 4的分子量; 其准备过程; 和微生物纯培养物。

公开(公告)号：US5190868A

公开(公告)日：1993-03-02

申请号：US644425

申请日：1991-01-22

申请人： Yoshitaka Kokusho ,  Akio Oshima ,  Akira Tsunoda ,  Shinjiro Iwasaki

发明人： Yoshitaka Kokusho ,  Akio Oshima ,  Akira Tsunoda ,  Shinjiro Iwasaki

IPC分类号： C11C3/08 ,  C11C3/10 ,  C12P7/64

CPC分类号： C12P7/6454 ,  C11C3/08 ,  C11C3/10

摘要： Disclosed is a process for the interesterification of oil or fat by treating such oil or fat in presence of a fatty acid or fatty acid ester or different oil or fat wherein a reactor column that is packed with an alkaline high molecular weight lipase preparation containing 0 to 5% moisture is fed with a substrate solution composed of the above oil or fat and fatty acid or fatty acid ester or different oil or fat for a continuous reaction in such a manner that the substrate solution contains 100 to 1800 ppm moisture and 50 to 800 ppm moisture at the inlet and outlet, respectively, of the column.

摘要翻译： 公开了通过在脂肪酸或脂肪酸酯或不同的油或脂肪存在下处理这种油或脂肪来酯交换油脂的方法，其中装有碱性高分子量脂肪酶制剂的反应器塔包含0至 将5％的水分与上述油或脂肪组成的底物溶液和脂肪酸或脂肪酸酯或不同的油或脂肪进行连续反应，使得底物溶液含有100至1800ppm的水分和50至800 分别在塔的入口和出口处的ppm水分。

公开(公告)号：US4783402A

公开(公告)日：1988-11-08

申请号：US598697

申请日：1984-04-10

申请人： Yoshitaka Kokusho ,  Shigeaki Kato ,  Haruo Machida

发明人： Yoshitaka Kokusho ,  Shigeaki Kato ,  Haruo Machida

IPC分类号： C07F9/10 ,  C07H19/06 ,  C07H19/16 ,  C07J51/00 ,  C12N9/16 ,  C12P9/00 ,  C12P33/00 ,  C12P19/30 ,  C12P19/40

CPC分类号： C07H19/06 ,  C07F9/10 ,  C07H19/16 ,  C07J51/00 ,  C12N9/16 ,  C12P7/6481 ,  C12P9/00

摘要： A process for producing a primary or secondary alcohol derivative of a phosopholipid which comprises reacting the phospholipid with a primary or secondary alcohol in the presence of phospholipase DM.

摘要翻译： 一种用于制备磷脂的伯醇或仲醇衍生物的方法，其包括在磷脂酶DM存在下使磷脂与伯醇或仲醇反应。

公开(公告)号：US4782019A

公开(公告)日：1988-11-01

申请号：US598696

申请日：1984-04-10

申请人： Yoshitaka Kokusho ,  Shigeaki Kato ,  Haruo Machida

发明人： Yoshitaka Kokusho ,  Shigeaki Kato ,  Haruo Machida

IPC分类号： C07F9/10 ,  C07H11/04 ,  C07H15/10 ,  C07H19/06 ,  C07H19/16 ,  C12N9/16 ,  C12P7/20 ,  C12P9/00 ,  C12P13/00 ,  C12P13/02 ,  C12P17/10 ,  C12P17/12 ,  C12P17/16 ,  C12P19/02 ,  C12P19/30 ,  C12P19/32 ,  C12R1/01 ,  C12R1/03 ,  C12P17/00

CPC分类号： C07H11/04 ,  C07F9/10 ,  C07H15/10 ,  C07H19/06 ,  C07H19/16 ,  C12N9/16 ,  C12P13/02

摘要： A process for producing a sphingophospholipid derivative comprising reacting a sphingophospholipid with a specified compound having an alcoholic hydroxyl group selected from the group consisting of specified primary alcohol compounds, specified secondary alcohol compounds and specified saccharides or their phenol glycosides in the presence of phospholipase DM.

摘要翻译： 一种生产鞘磷脂衍生物的方法，其包括在磷脂酶DM的存在下，使鞘磷脂与具有选自特定伯醇化合物，特定仲醇化合物和特定糖类或其苯酚糖苷的醇羟基的指定化合物反应。

公开(公告)号：US4624919A

公开(公告)日：1986-11-25

申请号：US598699

申请日：1984-04-10

申请人： Yoshitaka Kokusho ,  Shigeaki Kato ,  Haruo Machida

发明人： Yoshitaka Kokusho ,  Shigeaki Kato ,  Haruo Machida

IPC分类号： A61K9/127 ,  C07H11/04 ,  C07H13/06 ,  C07H15/10 ,  C12N9/16 ,  C12N9/20 ,  C12P19/00 ,  C12P19/02 ,  C12P19/12 ,  C12P19/26 ,  C12P19/44 ,  C12R1/01 ,  C12R1/03 ,  C12P9/00

CPC分类号： C07H11/04 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  C07H13/06 ,  C07H15/10 ,  C12N9/16 ,  C12P19/00 ,  C12P19/26 ,  C12P19/44

摘要： A process for producing a saccharide derivative of a phospholipid, which comprises reacting a phospholipid with a monosaccharide having 5 to 7 carbon atoms, at least one primary alcohol group and at least three hydroxyl groups in total including the OH of the primary alcohol group or a disaccharide thereof, said saccharide being optionally substituted by a group selected from the class consisting of amino and acetylamino groups, or a phenol glycoside of said saccharide in the presence of phospholipase DM. The phospholipid-saccharide derivatives are useful as a liposome-forming substrate, or as an emulsifier for cosmetics, such as cream and lotion, fat solutions for transfusion and agricultural chemicals, such as pesticides and herbicides.

摘要翻译： 一种磷脂的糖衍生物的制造方法，其特征在于，使磷脂与碳原子数为5〜7的单糖，至少1个伯醇基和至少3个羟基相同，包括伯醇基的OH或 二糖，所述糖任选被选自氨基和乙酰氨基的基团取代，或在磷脂酶DM存在下由所述糖的酚糖苷取代。 磷脂糖衍生物可用作形成脂质体的底物，或用作化妆品的乳化剂，例如乳膏和洗剂，用于输血的脂肪溶液和农药如农药和除草剂。

公开(公告)号：US5153000A

公开(公告)日：1992-10-06

申请号：US437099

申请日：1989-11-16

申请人： Yoshiko Chikawa ,  Katsumi Kita ,  Mitsuharu Masuda ,  Tomihiro Kurosaki ,  Takashi Itoh ,  Noriko Inoue ,  Haruya Kato ,  Takashi Imamura ,  Yasuo Ishii ,  Yoshitaka Kokusho ,  Akira Tsunoda ,  Shigeaki Kato

发明人： Yoshiko Chikawa ,  Katsumi Kita ,  Mitsuharu Masuda ,  Tomihiro Kurosaki ,  Takashi Itoh ,  Noriko Inoue ,  Haruya Kato ,  Takashi Imamura ,  Yasuo Ishii ,  Yoshitaka Kokusho ,  Akira Tsunoda ,  Shigeaki Kato

IPC分类号： A61K8/14 ,  A61K8/55 ,  A61K9/127 ,  A61Q19/00 ,  C07F9/10 ,  C07H11/04

CPC分类号： C07H11/04 ,  A61K8/14 ,  A61K8/556 ,  A61K9/1271 ,  A61K9/1272 ,  A61Q19/00 ,  C07F9/10 ,  Y10S977/797 ,  Y10S977/904 ,  Y10S977/915 ,  Y10S977/926

摘要： A novel monophosphate and a novel diphosphate prepared by a phosphatidyl transfer reaction of a phospholipid and an alcohol in the presence of phospholipase D are disclosed. The phosphates can independently or together form small and stable liposomes which can include active components therein. Cosmetic compositions comprising these phosphates or liposomes penetrate well into the hair and the skin, and exhibit long-lasting excellent moisture-retaining, beauty, skin-activation effects.