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    Apparatus for introducing fluid into microfluidic chip by using centrifugal force, a system including the apparatus, and a method of using the apparatus
    1.
    发明授权
    Apparatus for introducing fluid into microfluidic chip by using centrifugal force, a system including the apparatus, and a method of using the apparatus 有权
    用于通过离心力将流体引入微流体芯片的装置，包括该装置的系统以及使用该装置的方法

    公开(公告)号：US07641858B2

    公开(公告)日：2010-01-05

    申请号：US11846794

    申请日：2007-08-29

    申请人： Young-rok Kim ,  Jun-hong Min ,  Kak Namkoong ,  Kwang-ho Cheong ,  Chang-eun Yoo ,  Ki-woong Han ,  Ki-eun Kim

    发明人： Young-rok Kim ,  Jun-hong Min ,  Kak Namkoong ,  Kwang-ho Cheong ,  Chang-eun Yoo ,  Ki-woong Han ,  Ki-eun Kim

    IPC分类号： B01L3/14 ,  B65B3/04

    CPC分类号： B01L9/527 ,  B01L3/5021 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2300/0832 ,  B01L2400/0409 ,  C12M23/16

    摘要： An apparatus introducing a fluid using a centrifugal force includes an introduction member including a chip receiver and a fluid introduction reservoir, the chip receiver receiving a first part of a microfluidic chip, the first part including an inlet, the fluid introduction reservoir storing a fluid to be introduced to the microfluidic chip, the fluid introduction reservoir having an exit formed to correspond to the inlet of the microfluidic chip received in the chip receiver, and a support member supporting a second part of the microfluidic chip, wherein the microfluidic chip is disposed between the introduction member and the support member, the apparatus is rotatable in a state where the introduction member is closer to a center of rotation than the microfluidic chip, and the fluid is introducible from the fluid introduction reservoir through the inlet into the microfluidic chip due to a centrifugal force generated by rotation.

    摘要翻译： 使用离心力引入流体的装置包括引入构件，其包括芯片接收器和流体引入储存器，所述芯片接收器接收微流体芯片的第一部分，所述第一部分包括入口，所述流体引入储存器将流体存储到 引入到微流体芯片中，流体引入储存器具有形成为对应于接收在芯片接收器中的微流体芯片的入口的出口，以及支撑微流体芯片的第二部分的支撑构件，其中微流体芯片设置在 引导构件和支撑构件，该装置可以在导入构件比微流体芯片更靠近旋转中心的状态下旋转，并且流体可以从流体引入储存器通过入口引入到微流体芯片中，这是由于 由旋转产生的离心力。

    Method and apparatus for concentrating and amplifying nucleic acid in single micro chamber
    3.
    发明授权
    Method and apparatus for concentrating and amplifying nucleic acid in single micro chamber 有权
    在单微室中浓缩和扩增核酸的方法和装置

    公开(公告)号：US07807360B2

    公开(公告)日：2010-10-05

    申请号：US11620961

    申请日：2007-01-08

    申请人： Young-rok Kim ,  Jun-hong Min ,  In-ho Lee ,  Young-sun Lee ,  Chang-eun Yoo ,  Ki-woong Han

    发明人： Young-rok Kim ,  Jun-hong Min ,  In-ho Lee ,  Young-sun Lee ,  Chang-eun Yoo ,  Ki-woong Han

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6806 ,  B01L3/5027 ,  B01L3/5088 ,  C12Q1/686 ,  C12Q2565/629 ,  C12Q2537/149 ,  C12Q2527/125

    摘要： A method of sequentially performing concentration and amplification of nucleic acid in a single micro chamber includes: introducing a nucleic acid-containing sample and a solution including a kosmotropic salt to a micro chamber having a hydrophilic interior surface to concentrate the nucleic acid by binding the nucleic acid on the interior surface of the micro chamber; and performing a polymerase chain reaction (PCR) by adding a PCR mixture to the chamber. Since the nucleic acid is reversibly bound to the interior surface of the micro chamber, PCR yield is higher compared with a surface of aluminum oxide in which irreversible binding occurs. In addition, all processes are sequentially performed in a single micro chamber so that the number of samples, consumables, time, and labor for treatment and analysis can be reduced, detection sensitivity can be improved, and risk of sample cross contamination significantly reduced without sample loss by eliminating transporting of the sample. A complete automated system for concentration and amplification of nucleic acid is thus readily provided.

    摘要翻译： 在单个微室中依次进行核酸的浓缩和扩增的方法包括：将含核酸的样品和包含可染色盐的溶液引入具有亲水性内表面的微室中，以通过结合核酸来浓缩核酸 酸在微室的内表面上; 并通过向该室加入PCR混合物进行聚合酶链式反应（PCR）。 由于核酸可逆地结合到微室的内表面，与其中发生不可逆结合的氧化铝的表面相比，PCR产率更高。 此外，所有过程都在单个微室中顺序进行，以便可以减少样品数量，消耗品，时间和处理和分析的劳动力，可以提高检测灵敏度，并且样品交叉污染的风险在没有样品时显着降低 通过消除样品的运输而损失。 因此容易提供用于浓缩和扩增核酸的完整的自动化系统。

    Apparatus and method for separating material by size using a rotating drum having multiplex axes of rotation
    6.
    发明授权
    Apparatus and method for separating material by size using a rotating drum having multiplex axes of rotation 有权
    使用具有多个旋转轴的旋转滚筒分离材料的装置和方法

    公开(公告)号：US07727136B2

    公开(公告)日：2010-06-01

    申请号：US11682673

    申请日：2007-03-06

    申请人： Young-rok Kim ,  Kak Namkoong ,  Jun-hong Min

    发明人： Young-rok Kim ,  Kak Namkoong ,  Jun-hong Min

    IPC分类号： B04B7/12 ,  B04B13/00

    CPC分类号： B04B5/02 ,  B04B13/00 ,  G01N15/042 ,  G01N15/05 ,  G01N21/07 ,  G01N33/491

    摘要： An apparatus and method for centrifugally separating particles by both weight and size include a rotating drum rotating about a second rotating axis disposed perpendicularly to a first rotating axis, and includes an inlet, at least one rotating plate and an outlet. The inlet injects a test material. The rotating plate extends radially outward toward an inner surface of the rotating drum from the second rotating axis and has one or more configurations of protruded and recessed portions formed on a surface thereof. The rotating plate receives the test material on a surface thereof. The outlet discharges separated test material.

    摘要翻译： 用于通过重量和尺寸离心分离颗粒的装置和方法包括围绕垂直于第一旋转轴设置的第二旋转轴线旋转的旋转滚筒，并且包括入口，至少一个旋转板和出口。 入口注入测试材料。 旋转板从第二旋转轴线朝向旋转鼓的内表面径向向外延伸，并且具有形成在其表面上的突出和凹陷部分的一个或多个构造。 旋转板在其表面上接收测试材料。 出口排出分离的测试材料。

    Sensing switch and detecting method using the same
    7.
    发明授权
    Sensing switch and detecting method using the same 失效
    感应开关及使用其的检测方法

    公开(公告)号：US07510865B2

    公开(公告)日：2009-03-31

    申请号：US11347185

    申请日：2006-02-03

    申请人： Kyu-tae Yoo ,  Joon-ho Kim ,  Jun-hong Min ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kui-hyun Kim ,  Jeo-young Shim ,  Kak Namkoong

    发明人： Kyu-tae Yoo ,  Joon-ho Kim ,  Jun-hong Min ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kui-hyun Kim ,  Jeo-young Shim ,  Kak Namkoong

    IPC分类号： C12M1/34

    CPC分类号： G01N33/54373

    摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.

    摘要翻译： 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

    Sensing switch and detecting method using the same
    8.
    发明授权
    Sensing switch and detecting method using the same 有权
    感应开关及使用其的检测方法

    公开(公告)号：US07790440B2

    公开(公告)日：2010-09-07

    申请号：US12272183

    申请日：2008-11-17

    申请人： Kyu-tae Yoo ,  Joon-ho Kim ,  Jun-hong Min ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kui-hyun Kim ,  Jeo-young Shim ,  Kak Namkoong

    发明人： Kyu-tae Yoo ,  Joon-ho Kim ,  Jun-hong Min ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kui-hyun Kim ,  Jeo-young Shim ,  Kak Namkoong

    IPC分类号： C12M3/00

    CPC分类号： G01N33/54373

    摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.

    摘要翻译： 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

    Microfluidic chip and manipulating apparatus having the same
    10.
    发明授权
    Microfluidic chip and manipulating apparatus having the same 有权
    微流控芯片和操纵装置具有相同的功能

    公开(公告)号：US07465545B2

    公开(公告)日：2008-12-16

    申请号：US11341033

    申请日：2006-01-27

    申请人： Su-hyeon Kim ,  Jun-hong Min ,  Kak Namkoong

    发明人： Su-hyeon Kim ,  Jun-hong Min ,  Kak Namkoong

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2400/0409 ,  Y10T117/10

    摘要： Provided are a microfluidic chip and a microfluidic manipulating apparatus including the same. The microfluidic chip includes at least one microfluidic manipulating unit formed in a substrate. The microfluidic manipulating unit includes: a plurality of microchannels formed in the substrate; an inlet formed at a first end of the microchannel and exposed through the substrate; a trap formed at the microchannel; a chamber connected to a second end of the microchannel; and an outlet connected to the chamber and exposed through the substrate.

    摘要翻译： 提供了一种微流控芯片和包括该微流控芯片的微流控操纵装置。 微流体芯片包括形成在基板中的至少一个微流体操纵单元。 微流体操纵单元包括：形成在基板中的多个微通道; 入口，其形成在所述微通道的第一端处并暴露于所述基底; 在微通道处形成的陷阱; 连接到所述微通道的第二端的室; 以及连接到室并通过基板暴露的出口。