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公开(公告)号：US20120307035A1
公开(公告)日：2012-12-06
申请号：US13358254
申请日：2012-01-25
申请人： Zahid Yaqoob , Wonshik Choi , Toyohiko Yamauchi , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人： Zahid Yaqoob , Wonshik Choi , Toyohiko Yamauchi , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： H04N7/18
CPC分类号： G01B9/04 , G01B9/02032 , G01B9/02047 , G01B9/02064 , G01B9/0207 , G01B9/02084 , G01B9/02091 , G01N21/45 , G02B27/1086 , G02B27/50 , G03H1/0443 , G03H2001/005 , G03H2001/0456 , G03H2001/0467 , G03H2222/24
摘要： The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.
摘要翻译： 本发明涉及全场反射相位显微镜。 在优选实施例中，本发明可以组合低相干干涉测量和离轴数字全息显微镜（DHM）。 基于反射的DHM提供高灵敏度和单次成像的细胞动力学，而使用低相干源提供深度选择性测量。 该系统的优选实施例使用参考臂中的衍射光栅来产生在整个视场内虽然具有低相干光源的均匀对比度的干涉图像。 随着路径长度灵敏度的提高，本发明适用于具有亚纳米级灵敏度的活细胞膜动力学的全场测量。
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公开(公告)号：US20120035442A1
公开(公告)日：2012-02-09
申请号：US13167445
申请日：2011-06-23
申请人： Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , Michael Feld , Chae-Ryon Kong , David Feld , Alison Hearn , Jonathan Feld
发明人： Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , Michael Feld , Chae-Ryon Kong , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/4312 , A61B5/444 , A61B2560/0223 , G01J3/0208 , G01J3/0216 , G01J3/0218 , G01J3/0272 , G01J3/44 , G01N21/65 , G01N2201/129
摘要： The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.
摘要翻译： 本发明还涉及特定过滤器组合的选择，其可以提供足够的信息用于多变量校准以提取复杂生物系统中的精确分析物浓度。 本发明还描述了引起小型化设计的波长间隔选择方法。 最后，本发明提出了多种波长选择方法和小型化分光设备设计以及从一个域（波长选择）到另一个域（设计参数）映射的必要工具。 信息谱带的这种选择在使得特别采用拉曼光谱和其他光谱技术的任何临床诊断仪器的小型化方面具有广泛的范围。
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3.发明申请PORTABLE OPTICAL FIBER PROBE-BASED SPECTROSCOPIC SCANNER FOR RAPID CANCER DIAGNOSIS 审中-公开便携式光纤基于探针的光谱扫描仪用于快速诊断公开(公告)号：US20120302892A1
公开(公告)日：2012-11-29
申请号：US13338920
申请日：2011-12-28
申请人： Niyom Lue , Michael Feld , Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , David Feld , Alison Hearn , Jonathan Feld
发明人： Niyom Lue , Michael Feld , Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： A61B6/00
CPC分类号： A61B5/0091 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/42 , A61B5/4312 , G01N21/64 , G01N2021/4742 , G01N2021/656 , G01N2201/0639
摘要： A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.
摘要翻译： 用于疾病诊断的组织光谱扫描的多模式探针系统。 该系统可以使用漫反射光谱，荧光光谱和拉曼光谱法检测癌组织，如组织边缘评估。
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公开(公告)号：US20120259228A1
公开(公告)日：2012-10-11
申请号：US13464578
申请日：2012-05-04
申请人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
CPC分类号： A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要： The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译： 本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。 本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。
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公开(公告)号：US20090131802A1
公开(公告)日：2009-05-21
申请号：US12291545
申请日：2008-11-10
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/14546 , A61B5/6843
摘要： The present invention relates to an optical contact sensor for a spectroscopic probe. The sensor detects contact of the distal end of a fiber optic probe to a surface being measured. The system can be used to correct Raman spectral measurements of tissue.
摘要翻译： 本发明涉及一种用于光谱探针的光学接触传感器。 该传感器检测光纤探头的远端与被测表面的接触。 该系统可用于校正组织的拉曼光谱测量。
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公开(公告)号：US20070038124A1
公开(公告)日：2007-02-15
申请号：US11445923
申请日：2006-06-02
申请人： Stephen Fulghum , Sudha Thimmaraju , Jonathan Feld
发明人： Stephen Fulghum , Sudha Thimmaraju , Jonathan Feld
IPC分类号： A61B6/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/02007
摘要： The present invention relates to systems and methods used in the measurement of arterial tissue. Optical probes in accordance with the invention use optical fibers to deliver and collect light using a sidelooking catheter. Diffused white light and fluorescence scattering is collected and processed to provide for improved artery wall diagnosis.
摘要翻译： 本发明涉及用于测量动脉组织的系统和方法。 根据本发明的光学探针使用光纤使用侧视导管传送和收集光。 扩散的白光和荧光散射被收集和处理以提供改善的动脉壁诊断。
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