利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

40 records (took 0.017 seconds)

    Digital Holographic Method of Measuring Cellular Activity and of Using Results to Screen Compounds
    3.
    发明申请
    Digital Holographic Method of Measuring Cellular Activity and of Using Results to Screen Compounds 有权
    测量细胞活性的数字全息方法和使用结果筛选化合物

    公开(公告)号：US20130096017A1

    公开(公告)日：2013-04-18

    申请号：US13704464

    申请日：2011-06-17

    Applicant: David D. Nolte ,  Kwan Jeong

    Inventor： David D. Nolte ,  Kwan Jeong

    IPC: G06F19/10

    CPC classification number: G06F19/10 ,  A61B5/0075 ,  A61B5/4845 ,  G01N21/27 ,  G03H1/0443 ,  G03H1/0866 ,  G03H1/32 ,  G03H2001/0445 ,  G03H2001/0447 ,  G03H2001/045 ,  G03H2001/0467 ,  G03H2222/24

    Abstract: Motility contrast imaging (MCI) is a depth-resolved holographic technique to extract cellular and subcellular motion inside tissue. The holographic basis of the measurement technique makes it highly susceptible to mechanical motion. The motility contrast application, in particular, preferably includes increased mechanical stability because the signal is based on time-varying changes caused by cellular motion, not to be confused with mechanical motion of the system. The use of the resulting spectrogram response signatures, or “fingerprint” data, of known compounds is disclosed to screen new compounds for leads as to those having potentially beneficial mechanisms of action. The “fingerprint” data of known toxic compounds can be used to screen new compounds for toxicity.

    Abstract translation: 运动对比成像（MCI）是一种深度分辨全息技术，用于提取组织内的细胞和亚细胞运动。 测量技术的全息基础使其非常易受机械运动的影响。 运动对比应用尤其优选地包括增加的机械稳定性，因为该信号是基于由细胞运动引起的时变变化，不会与系统的机械运动相混淆。 公开了使用已知化合物的所得光谱图响应特征或“指纹”数据，以筛选出具有潜在有益的作用机制的那些引线的新化合物。 已知有毒化合物的“指纹”数据可用于筛选新化合物的毒性。

    Method and device for wave-front sensing
    5.
    发明授权
    Method and device for wave-front sensing 失效
    用于波前感测的方法和装置

    公开(公告)号：US07659993B2

    公开(公告)日：2010-02-09

    申请号：US11200457

    申请日：2005-08-09

    Applicant: Marcus Feierabend ,  Markus Rückel ,  Winfried Denk

    Inventor： Marcus Feierabend ,  Markus Rückel ,  Winfried Denk

    IPC: G01B11/02

    CPC classification number: G01J9/00 ,  G01J9/02 ,  G01N21/6458 ,  G03H1/0443 ,  G03H2001/0458 ,  G03H2001/0467

    Abstract: A method for sensing a wave-front of specimen light scattered from an illuminated area in a specimen (10) includes the steps of focusing illumination light into the specimen (10), directing specimen light scattered in the specimen (10) to a detector device (50) having a plurality of detector elements (51) and being capable to sense light with local resolution, detecting sample light contained in the specimen light with the detector device (50), said sample light being scattered in a predetermined sample plane (11) of the specimen (10) and being selected by a time-based gating of the specimen light, locally resolved measuring phase information of the sample light, and reconstructing the wave-front of the sample light on the basis of the phase information. Furthermore, a method of microscopic imaging with adapted illumination light is described.

    Abstract translation: 用于感测从样本（10）中的照射区域散射的样本光的波前的方法包括将照射光聚焦到样本（10）中的步骤，将在样本（10）中散射的样本光引导到检测器装置 （50）具有多个检测器元件（51）并能够以局部分辨率感测光，利用检测器装置（50）检测样品光中包含的样品光，所述样品光在预定的样品平面（11 ），并且通过对样本光进行基于时间的选通来选择样本光的局部分解测量相位信息，并且基于相位信息重建样本光的波前。 此外，描述了具有适应的照明光的显微成像的方法。

    Holographic imaging
    6.
    发明授权
    Holographic imaging 失效
    全息成像

    公开(公告)号：US5796498A

    公开(公告)日：1998-08-18

    申请号：US284616

    申请日：1994-09-06

    Applicant: Paul Michael William French

    Inventor： Paul Michael William French

    IPC: G03H1/00 ,  G03H1/04 ,  G03H1/22 ,  G03H1/26

    CPC classification number: G03H1/0248 ,  G03H1/0005 ,  G03H1/04 ,  G03H1/0404 ,  G03H2001/0083 ,  G03H2001/0268 ,  G03H2001/0467 ,  G03H2001/0471 ,  G03H2001/2244 ,  G03H2222/33 ,  G03H2223/26 ,  G03H2260/54

    Abstract: A holographic imaging apparatus having a pulsed laser light source for generating an object beam and a reference beam whereby an object, obscured by a diffusing medium, is illuminated by the object beam. A real time interferogram recording medium is exposed to the coincidence of light reflected from the object and the reference beam to record an interferogram. A holographic image is then reconstructed from the interferogram and may be viewed and recorded. The pulsed laser light source generates a beam which is divided by a conventional beam splitter device into an object beam and a reference beam. The object beam is then diverged by a lens which forms a diverging object beam to illuminate the object. The reference beam is diverged through another lens to form a diverging reference beam which is directed so that it illuminates a photoreactive crystal. The coincidence of the reflected light and diverging reference beam generates a pattern of interference fringes known as an interferogram which is recorded by the crystal. The apparatus can use time-gating in the holographic medium to use ballistic and snake-like light, which arrives before scattered light, to construct a holographic image. The apparatus can also obtain depth information for 3-D images by using the time-gating technique to obtain the image bearing light from a 3-D object. The apparatus also may record light-in-flight images of the object, to record different depths of the object separately, by using an optical delay assembly.

    Abstract translation: PCT No.PCT / GB93 / 00316 Sec。 371日期：1994年9月6日 102（e）1994年9月6日PCT PCT 1993年2月15日PCT公布。 出版物WO93 / 16419 日期1993年8月19日具有用于产生物体光束的脉冲激光光源和参考光束的全息成像装置，由此漫射介质遮蔽的物体被物体光束照射。 实时干涉图记录介质暴露于从物体和参考光反射的光的一致记录干涉图。 然后从干涉图重建全息图像，并且可以查看和记录全息图像。 脉冲激光光源产生由传统光束分离器装置划分为物体光束和参考光束的光束。 物体光束然后被形成发散物体光束的透镜发散，以照射物体。 参考光束通过另一个透镜发散以形成发散的参考光束，其被引导为使其照亮光反应晶体。 反射光和发散参考光束的一致产生被称之为由晶体记录的干涉图的干涉条纹图案。 该设备可以在全息介质中使用时间选通，使用到达散射光之前的弹道和蛇状光来构造全息图像。 该装置还可以通过使用时间选通技术获得3D图像的图像承载光，从而获得3-D图像的深度信息。 该装置还可以记录物体的飞行中的图像，以通过使用光学延迟组件来单独记录物体的不同深度。

    Method and arrangement for short coherence holography
    8.
    发明授权
    Method and arrangement for short coherence holography 有权
    短相干全息术的方法和布置

    公开(公告)号：US09175954B2

    公开(公告)日：2015-11-03

    申请号：US14110100

    申请日：2011-12-23

    Applicant: Klaus Koerner ,  Giancarlo Pedrini ,  Christof Pruss ,  Wolfgang Osten

    Inventor： Klaus Koerner ,  Giancarlo Pedrini ,  Christof Pruss ,  Wolfgang Osten

    IPC: G01B9/021 ,  G01B11/02 ,  G01B11/24 ,  G03H1/04 ,  G03H1/08 ,  G03H1/00

    CPC classification number: G01B11/2441 ,  G02F2203/54 ,  G02F2203/56 ,  G03H1/0443 ,  G03H1/0866 ,  G03H2001/0033 ,  G03H2001/045 ,  G03H2001/0467 ,  G03H2210/62 ,  G03H2222/13 ,  G03H2222/22 ,  G03H2222/23 ,  G03H2222/24 ,  G03H2222/33

    Abstract: The invention relates to a method and arrangement for short coherence holography for distance measurement, for profile detection and/or for 3D detection of one or more object elements and/or object areas and/or objects or for readout of holographic volume memories with a holographic interferometer and with at least one short coherence light source. For each optically detected object element in the hologram the holographic interferometer has an optical path difference clearly unequal to zero. At least one spectrally integrally detecting, rastered detector is arranged. The short coherence light source with frequency comb is designed with the optical delay length Y1. Detected holograms are digitally reconstructed. Relative distances of object elements are digitally calculated from the hologram reconstructions, so that a 3D point cloud of object elements and/or object areas and/or objects is produced. Data can be read out optically in parallelized form from holographic volume memories or three-dimensionally structured signatures.

    Abstract translation: 本发明涉及一种用于距离测量的短相干全息术的方法和装置，用于轮廓检测和/或用于一个或多个对象元件和/或物体区域和/或物体的3D检测或用于全息存储的全息体积存储器的读出 干涉仪和至少一个短相干光源。 对于全息图中的每个光学检测的对象元件，全息干涉仪具有明显不等于零的光程差。 至少一个光谱整体检测，被检测器被布置。 具有频率梳的短相干光源设计有光延迟长度Y1。 检测到的全息图经数字重建。 对象元素的相对距离由全息图重建数字计算，从而产生对象元素和/或对象区域和/或对象的3D点云。 数据可以从全息体积存储器或三维结构的签名以光学方式读出。

    Method and apparatus for motility contrast imaging
    9.
    发明授权
    Method and apparatus for motility contrast imaging 有权
    运动对比成像的方法和装置

    公开(公告)号：US08886295B2

    公开(公告)日：2014-11-11

    申请号：US12874855

    申请日：2010-09-02

    Applicant: David D. Nolte ,  John J. Turek ,  Kwan Jeong

    Inventor： David D. Nolte ,  John J. Turek ,  Kwan Jeong

    IPC: G01B9/02 ,  G03H1/08 ,  G03H1/04

    CPC classification number: G01B9/02091 ,  G01B9/02032 ,  G01B9/02082 ,  G03H1/0443 ,  G03H1/08 ,  G03H2001/0445 ,  G03H2001/045 ,  G03H2001/0467 ,  G03H2210/62 ,  G03H2222/33 ,  G03H2223/20 ,  H01L27/146

    Abstract: A system for motility contrast imaging a biological target within tissue comprising a CCD array; an illumination source for generating an incoming beam; a first beam splitter for receiving the incoming beam and producing an object beam and a reference beam; a second beam splitter for illuminating a multitude of biological targets with the object beam and for directing backscattered object beams towards the CCD array; a computer-controlled delay stage for zero-path-matching the reference beam to the backscattered object beams; a reference beam that intersects the backscattered object beams at an angle to produce a series of interference fringes that modulate Fourier-domain information; and a computer for receiving a time series of Fourier-domain information. The interference fringes between the backscattered object beam and the reference beam are recorded by the CCD array and passed to the computer which constructs a digital hologram at successive times.

    Abstract translation: 一种用于对包含CCD阵列的组织内的生物靶进行运动对比成像的系统; 用于产生进入光束的照明源; 用于接收入射光束并产生物体光束和参考光束的第一分束器; 第二分束器，用于用物体光束照射多个生物靶，并用于将反向散射的物体光束引向CCD阵列; 计算机控制的延迟级，用于将参考光束与背散射物体光束零路径匹配; 参考光束以一角度与后向散射物体光束相交，以产生一系列调制傅立叶域信息的干涉条纹; 以及用于接收傅立叶域信息的时间序列的计算机。 后向散射物体光束和参考光束之间的干涉条纹由CCD阵列记录并传递到连续构建数字全息图的计算机。

Patent Agency Ranking