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    TUMOR ANTIGEN PEPTIDE
    4.
    发明申请
    TUMOR ANTIGEN PEPTIDE 审中-公开

    公开(公告)号：US20170360911A1

    公开(公告)日：2017-12-21

    申请号：US15534315

    申请日：2015-12-08

    申请人： Sapporo Medical University ,  Sumitomo Dainippon Pharma Co., Ltd.

    发明人： Noriyuki Sato ,  Toshihiko Torigoe ,  Yoshihiko Hirohashi ,  Takayuki Kanaseki ,  Sho Miyamoto ,  Vitaly Kochin ,  Masashi Goto

    IPC分类号： A61K39/00 ,  C07K7/06 ,  G01N33/574 ,  C07K16/30 ,  C12N5/0783 ,  G01N33/50 ,  C12Q1/68 ,  C07K16/28

    摘要： The purpose of the present invention is to provide: a detection agent for specifically detecting a cancer stem cell; a tumor antigen peptide specifically presented by cancer stem cells; a medicinal composition useful in preventing and/or treating cancer, said medicinal composition comprising the aforementioned tumor antigen peptide as an active ingredient; a method for screening the tumor antigen peptide; etc. To achieve the above-mentioned purpose, provided are: peptides represented by YO-XO-ZO; a polyepitope peptide consisting of a plurality of epitope peptides connected together, said polyepitope peptide containing at least one of the above-mentioned peptides as one of the epitope peptides; a polynucleotide encoding the aforementioned peptides and/or polyepitope peptide; a medicinal composition comprising the same as an active ingredient; a prophylactic and/or therapeutic agent for cancer characterized by inducing CTL; etc.

    Neurogenic baroreflex sensitivity measurement device, neurogenic baroreflex sensitivity measurement program and neurogenic baroreflex sensitivity measurement method
    5.
    发明授权
    Neurogenic baroreflex sensitivity measurement device, neurogenic baroreflex sensitivity measurement program and neurogenic baroreflex sensitivity measurement method 有权

    公开(公告)号：US09826909B2

    公开(公告)日：2017-11-28

    申请号：US14775827

    申请日：2014-03-28

    申请人： SAPPORO MEDICAL UNIVERSITY

    发明人： Yuichi Kato

    IPC分类号： A61B5/02 ,  A61B5/021 ,  A61B5/00 ,  A61B5/024 ,  A61B5/026

    CPC分类号： A61B5/02125 ,  A61B5/02416 ,  A61B5/0261 ,  A61B5/4035 ,  A61B5/7246 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/7278 ,  A61B2562/0238

    摘要： [Problem] To provide a neurogenic baroreflex sensitivity measurement device, neurogenic baroreflex sensitivity measurement program and neurogenic baroreflex sensitivity measurement method capable of easily and objectively measuring neurogenic baroreflex sensitivity that is not dependent on vascular hardness without using blood pressure or pulsations in the diameter of the carotid artery.[Solution] The neurogenic baroreflex sensitivity measurement device comprises: a pulse wave data-acquiring unit (41) for acquiring pulse wave data of an artery; a normalized pulse wave volume-calculating unit (42) for calculating a normalized pulse wave volume on the basis of the pulse wave data; a pulse interval-acquiring unit (43) for acquiring pulse intervals corresponding to the pulse wave data; a baroreflex series-detecting unit (44) for detecting baroreflex series in which the normalized pulse wave volume and pulse interval both increase or decrease for at least three beats in a row; and a neurogenic baroreflex sensitivity-calculating unit (45) for calculating the slope of a regression line representing the correlation between the normalized pulse wave volume and the pulse interval in a baroreflex series as the neurogenic baroreflex sensitivity, which is an index representing the neurogenic baroreflex function.

    CELL GROWTH METHOD AND PHARMACEUTICAL PREPARATION FOR TISSUE REPAIR AND REGENERATION
    6.
    发明申请
    CELL GROWTH METHOD AND PHARMACEUTICAL PREPARATION FOR TISSUE REPAIR AND REGENERATION 审中-公开

    公开(公告)号：US20170266234A1

    公开(公告)日：2017-09-21

    申请号：US15617571

    申请日：2017-06-08

    申请人： Sapporo Medical University

    发明人： Osamu Honmou

    IPC分类号： A61K35/28

    CPC分类号： A61K35/28 ,  A61K35/12 ,  A61K35/16 ,  A61K2035/124 ,  C12N5/0663 ,  C12N2500/84 ,  C12N2501/91

    摘要： The present invention relates to a method for growing, rapidly and massively ex vivo, cells collected from a living subject to provide a safe and effective pharmaceutical preparation for biological tissue repair/regeneration. Specifically, the present invention relates to a method for growing cells in a sample collected from a living subject by culturing the cells in a medium containing allogeneic (including autogenic) serum. Preferably the allogeneic serum has been determined as being negative for a serum tumor marker and/or an infectious factors, and the amount of the anticoagulant (e.g., heparin, a heparin derivative, or a salt thereof) added to the collected sample is less than 5 U/mL with respect to the volume of the sample or the amount of the anticoagulant in the medium at the start of culture is less than 0.5 U/mL. The present invention further relates to use of the method.

    MOLECULAR MARKER FOR CANCER STEM CELL
    8.
    发明申请
    MOLECULAR MARKER FOR CANCER STEM CELL 有权
    癌症干细胞分子标记

    公开(公告)号：US20140044686A1

    公开(公告)日：2014-02-13

    申请号：US13967410

    申请日：2013-08-15

    申请人： Dainippon Sumitomo Pharma Co. Ltd. ,  Sapporo Medical University

    发明人： Toshihiko Torigoe ,  Yoshihiko Hirohashi ,  Noriyuki Satoh ,  Kenjiro Kamiguchi ,  Rena Morita ,  Satoshi Nishizawa ,  Akari Takahashi

    IPC分类号： C12N5/0783 ,  C07K7/06

    CPC分类号： A61K38/177 ,  C07K7/06 ,  C12N5/0638 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5017 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/705

    摘要： A molecular marker for detecting a cancer stem cell in a cell mass which is a subject of interest, wherein the molecular marker can be detected in a cancer stem cell contained in the subject of interest but cannot be detected in a normal cell and a cancer cell that is different from a cancer stem cell; a method for determining the presence or absence of a cancer stem cell in a subject of interest by using the molecular marker as an measure; a kit for determining the presence or absence of a cancer stem cell, which comprises at least a reagent for detecting the molecular marker; a polypeptide encoded by the molecular marker; an antibody capable of recognizing an epitope of an expression product of a gene derived from the molecular marker; a nucleic acid capable of inhibiting the expression of the molecular marker; and a nucleic acid vaccine comprising a gene derived from the molecular marker.

    摘要翻译： 用于检测作为感兴趣的受试者的细胞块中的癌干细胞的分子标记，其中可以在感兴趣的受试者所含的癌干细胞中检测分子标记，但在正常细胞和癌细胞中不能检测到 这与癌症干细胞不同; 通过使用分子标记作为测量来确定感兴趣对象中癌干细胞的存在或不存在的方法; 用于确定癌干细胞的存在或不存在的试剂盒，其包含至少一种用于检测分子标记的试剂; 由分子标记编码的多肽; 能够识别来自分子标记物的基因的表达产物的表位的抗体; 能够抑制分子标记物的表达的核酸; 和包含衍生自分子标记的基因的核酸疫苗。

    LIGATOR AND LIGATION METHOD
    9.
    发明申请
    LIGATOR AND LIGATION METHOD 有权
    仪器和仪器方法

    公开(公告)号：US20130267965A1

    公开(公告)日：2013-10-10

    申请号：US13878502

    申请日：2011-10-05

    申请人： Toru Mizuguchi ,  Koichi Hirata ,  Masaki Kawamoto ,  Makoto Meguro

    发明人： Toru Mizuguchi ,  Koichi Hirata ,  Masaki Kawamoto ,  Makoto Meguro

    IPC分类号： A61B17/12

    CPC分类号： A61B17/12013 ,  A61B2017/00349

    摘要： A ligator for ligating body duct(s), said ligator enabling quick, easy and damage-free repetition of ligation and release of one or more body ducts in a body cavity through an operation outside the body cavity, and having an excellent performance of blocking the flow of a body fluid such as blood or lymph in a body duct. In an abdominal surgery, the ligator can be provided at such a position as not disturbing the surgery per se or hindering the vision during the surgery, while leaving the back-end thereof outside the body cavity, and can be operated outside the body cavity. In an endoscopic surgery, the ligator can be inserted from an opening that is a surgical wound while leaving the back-end thereof outside the body cavity, and can be operated outside the body cavity.

    摘要翻译： 用于结扎身体导管的结扎器，所述结扎器能够通过体腔外的操作快速，容易且无损伤地重复连接和释放体腔中的一个或多个身体导管，并且具有优异的阻塞性能 身体管道中的体液如血液或淋巴液的流动。 在腹部手术中，可以在不妨碍手术本身或者在手术期间阻碍视力的同时将结扎器设置在身体腔外部的后端，并且可以在体腔外部进行操作。 在内窥镜手术中，可以从作为手术伤口的开口插入结扎器，同时将其后端留在体腔外部，并且可以在体腔外部进行操作。