公开(公告)号：US20240226003A9

公开(公告)日：2024-07-11

申请号：US18494535

申请日：2023-10-25

申请人： Rani Therapeutics, LLC

发明人： Mir Imran ,  Sara Ansaloni ,  Radhika Korupolu ,  Joel M. Harris ,  Mir Hashim

IPC分类号： A61K9/00 ,  A61K38/37 ,  A61K38/48 ,  A61M5/142 ,  A61M5/148 ,  A61M5/172

CPC分类号： A61K9/0065 ,  A61K9/0024 ,  A61K38/37 ,  A61K38/4846 ,  A61M5/14276 ,  A61M5/148 ,  A61M5/1723 ,  A61B5/02035

摘要： Embodiments provide devices, preparations and methods for delivering therapeutic agents (TAs) such as clotting factors (CFs, e.g., Factor 8) within the GI tract. Many embodiments provide a swallowable device e.g., a capsule for delivering TAs into the intestinal wall (IW). Embodiments also provide TA preparations configured to be contained within the capsule, advanced from the capsule into the IW and/or surrounding tissue (ST) and degrade to release the TA into the bloodstream to produce a therapeutic effect (e.g., improved clotting). The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the IW or ST (e.g., the peritoneal cavity). Embodiments are particularly useful for delivery of CFs for treatment of clotting disorders (e.g., hemophilia) where such CFs are poorly absorbed and/or degraded within the GI tract.

公开(公告)号：US20240131258A1

公开(公告)日：2024-04-25

申请号：US18399007

申请日：2023-12-28

申请人： Magnolia Medical Technologies, Inc.

发明人： Gregory J. BULLINGTON ,  Richard G. PATTON ,  Shan E. GAW

IPC分类号： A61M5/168 ,  A61B5/15 ,  A61B5/154 ,  A61M5/148

CPC分类号： A61M5/16827 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150259 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150992 ,  A61B5/154 ,  A61M5/148

摘要： An apparatus includes a cannula assembly, a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing includes an inlet port removably coupled to the cannula assembly and defines an inner volume. The fluid reservoir is fluidically coupled to the housing and configured to receive and isolate a volume of bodily fluid from a patient. The flow control mechanism is at least partially disposed in the inner volume. The actuator is operably coupled to the flow control mechanism and is configured to move the flow control mechanism between a first configuration, in which bodily fluid can flow, via a fluid flow path defined by the flow control mechanism, from the cannula assembly, through the inlet port and into the fluid reservoir, to a second configuration, in which the fluid reservoir is fluidically isolated from the cannula assembly.

公开(公告)号：US20240115802A1

公开(公告)日：2024-04-11

申请号：US18390872

申请日：2023-12-20

申请人： Sanofi-Aventis Deutschland GMBH

发明人： Michael Schabbach ,  Meinolf Werner ,  Olaf Zeckai

IPC分类号： A61M5/148 ,  A61M5/142 ,  A61M5/152 ,  A61M5/158

CPC分类号： A61M5/1483 ,  A61M5/14228 ,  A61M5/14232 ,  A61M5/152 ,  A61M5/158 ,  A61M2205/12

摘要： A disposable cartridge for a drug delivery device includes a flexible bag to accommodate a liquid medicament and having an opening adjacent to a sidewall, a socket having a fluid channel in fluid communication with a cartridge fluid coupling, and a housing covering at least a portion of the flexible bag and having a receptacle to receive the socket with the flexible bag. The socket extends into the opening of the flexible bag. The flexible bag's sidewall is fixed between the socket and the receptacle.

公开(公告)号：US11904134B2

公开(公告)日：2024-02-20

申请号：US17027117

申请日：2020-09-21

申请人： DEKA Products Limited Partnership

发明人： Larry B. Gray

IPC分类号： A61M5/142 ,  F04B43/02 ,  A61M5/145 ,  A61M5/168 ,  G05D7/06 ,  F04B43/09 ,  F04B7/00 ,  A61M5/32 ,  B23P15/00 ,  A61B5/15 ,  A61B5/151 ,  A61M5/148 ,  G01F22/00 ,  A61M5/14 ,  F04B43/12 ,  A61M5/152 ,  A61M5/158 ,  A61M5/172 ,  G08C17/02 ,  H04B7/26 ,  G05B23/02 ,  A61B5/00 ,  A61M5/50 ,  A61M5/162 ,  A61M5/36 ,  A61B5/155 ,  A61J1/20

CPC分类号： A61M5/14248 ,  A61B5/150022 ,  A61B5/15117 ,  A61B5/150175 ,  A61B5/15186 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150503 ,  A61M5/142 ,  A61M5/148 ,  A61M5/1413 ,  A61M5/1452 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/14586 ,  A61M5/168 ,  A61M5/16804 ,  A61M5/16809 ,  A61M5/16831 ,  A61M5/3287 ,  B23P15/00 ,  F04B7/00 ,  F04B43/02 ,  F04B43/09 ,  G01F22/00 ,  G05D7/0676 ,  A61B5/0024 ,  A61B5/1427 ,  A61B5/15107 ,  A61B5/15119 ,  A61B5/15121 ,  A61B5/15123 ,  A61B5/15125 ,  A61B5/6833 ,  A61B2560/0412 ,  A61J1/20 ,  A61M5/141 ,  A61M5/14216 ,  A61M5/14224 ,  A61M5/14244 ,  A61M5/152 ,  A61M5/158 ,  A61M5/162 ,  A61M5/16813 ,  A61M5/16886 ,  A61M5/172 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/5086 ,  A61M2005/1402 ,  A61M2005/14208 ,  A61M2005/14252 ,  A61M2005/14268 ,  A61M2005/14506 ,  A61M2005/1581 ,  A61M2005/1583 ,  A61M2005/1585 ,  A61M2005/1586 ,  A61M2005/16863 ,  A61M2005/1726 ,  A61M2205/0266 ,  A61M2205/0294 ,  A61M2205/04 ,  A61M2205/16 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3341 ,  A61M2205/3368 ,  A61M2205/3375 ,  A61M2205/3379 ,  A61M2205/3389 ,  A61M2205/3523 ,  A61M2205/3546 ,  A61M2205/3569 ,  A61M2205/3576 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/8206 ,  A61M2205/8237 ,  A61M2206/22 ,  A61M2207/00 ,  A61M2209/045 ,  A61M2230/201 ,  F04B43/1253 ,  F04C2230/60 ,  G05B23/02 ,  G05D7/0647 ,  G08C17/02 ,  H04B7/2609 ,  Y10T29/494 ,  Y10T29/49236 ,  Y10T29/49412 ,  Y10T29/49826 ,  Y10T29/49828

摘要： A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

公开(公告)号：US11890452B2

公开(公告)日：2024-02-06

申请号：US16789034

申请日：2020-02-12

申请人： Magnolia Medical Technologies, Inc.

发明人： Gregory J. Bullington ,  Richard G. Patton ,  Shan E. Gaw

IPC分类号： A61M5/168 ,  A61M5/148 ,  A61B5/15 ,  A61B5/154

CPC分类号： A61M5/16827 ,  A61B5/15003 ,  A61B5/154 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150259 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150992 ,  A61M5/148

摘要： An apparatus includes a cannula assembly, a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing includes an inlet port removably coupled to the cannula assembly and defines an inner volume. The fluid reservoir is fluidically coupled to the housing and configured to receive and isolate a volume of bodily fluid from a patient. The flow control mechanism is at least partially disposed in the inner volume. The actuator is operably coupled to the flow control mechanism and is configured to move the flow control mechanism between a first configuration, in which bodily fluid can flow, via a fluid flow path defined by the flow control mechanism, from the cannula assembly, through the inlet port and into the fluid reservoir, to a second configuration, in which the fluid reservoir is fluidically isolated from the cannula assembly.

公开(公告)号：US20240036591A1

公开(公告)日：2024-02-01

申请号：US18275889

申请日：2022-02-04

申请人： PAVmed, Inc.

发明人： Lishan Aklog ,  Julian Fricks ,  Peter Aliski ,  Richard Yazbeck ,  Jessie Gifford

IPC分类号： G05D7/01 ,  A61M5/148

CPC分类号： G05D7/014 ,  A61M5/148

摘要： Systems and methods for managing flow along a pathway are provided herein. The system and method can include a pump for providing a fluid flow along the pathway, a flow regulator in fluid communication at its input end with the pump and designed to maintain flow therethrough at a substantially constant flow rate, and the pathway being in fluid communication with an output of the flow resistor for directing fluid flow to a destination at the substantially constant flow rate.

公开(公告)号：US11826544B2

公开(公告)日：2023-11-28

申请号：US16758587

申请日：2018-10-25

申请人： OSAA INNOVATION APS

发明人： Abdullah Ahmed Hessam

IPC分类号： A61M5/148 ,  A61M5/172 ,  A61M39/28 ,  A61M5/145

CPC分类号： A61M5/148 ,  A61M5/172 ,  A61M39/28 ,  A61M2005/14506 ,  A61M2205/36

摘要： The application discloses an assembly including a compressible bag and an apparatus for dispensing a liquid from a bag. The apparatus includes a housing with a dispensing end and an opposite rear end, a bottom part and top part and two side parts. A roller arrangement and a pair of steering tracks are mounted in a track length direction on the side parts, and the roller arrangement includes at least a front roller adapted to roll from the rear end towards the dispensing end. The surface of the roller is adapted for engagement with the compressible bag placed on the bottom part, and a gap is provided between the bottom part and the surface of the front roller, the gap being in the range of 2 to 10 mm where the surface of the front roller is closest to the bottom part.

公开(公告)号：US20230372606A1

公开(公告)日：2023-11-23

申请号：US18341032

申请日：2023-06-26

申请人： DEKA Products Limited Partnership

发明人： Dean Kamen ,  Larry B. Gray ,  Russell H. Beavis

IPC分类号： A61M5/142 ,  F04B43/02 ,  A61M5/145 ,  A61M5/168 ,  G05D7/06 ,  F04B43/09 ,  F04B7/00 ,  A61M5/32 ,  B23P15/00 ,  A61B5/15 ,  A61B5/151 ,  A61M5/148 ,  G01F22/00 ,  A61M5/14

CPC分类号： A61M5/14248 ,  F04B43/02 ,  A61M5/14586 ,  A61M5/16809 ,  G05D7/0676 ,  F04B43/09 ,  F04B7/00 ,  A61M5/3287 ,  B23P15/00 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15117 ,  A61B5/15186 ,  A61M5/14232 ,  A61M5/148 ,  A61M5/168 ,  A61M5/1452 ,  A61M5/142 ,  A61M5/16831 ,  A61M5/14212 ,  G01F22/00 ,  A61M5/1413 ,  A61M5/16804 ,  Y10T29/49236 ,  Y10T29/494 ,  Y10T29/49826 ,  Y10T29/49412 ,  Y10T29/49828 ,  A61M2005/14268 ,  A61M2205/0266 ,  A61M2205/0294 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3375 ,  A61M2205/3546 ,  A61M2205/3576 ,  A61M2205/8237 ,  A61M2206/22 ,  A61M2209/045 ,  G05D7/0647 ,  F04B43/1253

摘要： Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.

公开(公告)号：US11786654B2

公开(公告)日：2023-10-17

申请号：US17849059

申请日：2022-06-24

申请人： The Third Medical Center of the Chinese People's Liberation Army General Hospital

发明人： Bibo Peng ,  Shengnan Li ,  Jing Guo ,  Lina An

IPC分类号： A61M5/158 ,  A61M5/44 ,  A61M5/14 ,  A61M5/148 ,  A61M5/168

CPC分类号： A61M5/158 ,  A61M2005/1585 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/36 ,  A61M2205/3653 ,  A61M2205/505 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/587 ,  A61M2205/825 ,  A61M2205/8206 ,  A61M2205/8293 ,  A61M2210/02

摘要： The invention relates to the technical field of highland first aid, and particularly discloses a field first-aid infusion device for frigid highland zones. The device comprises a storage box, comprising a heat preservation and pressurization device, a marrow cavity puncture needle, a heat preservation infusion tube, a power-assisted puncture tool, a power supply and a power line, the heat preservation and pressurization device is electrically connected with the power supply through the power line, the heat preservation and pressurization device comprises a heating sleeve, magic tape is fixed to the surfaces of the two ends of the heating sleeve, a control box is fixed to the middle of the outer surface of the heating sleeve, and the power line is inserted into the control box.

公开(公告)号：US20230256170A1

公开(公告)日：2023-08-17

申请号：US18306528

申请日：2023-04-25

申请人： Sanofi-Aventis Deutschland GMBH

发明人： Michael Schabbach ,  Beate Franke ,  Giuliano Pradel ,  Ilario Melzi ,  Stefan Verlaak ,  Andrew Nelson

IPC分类号： A61M5/20 ,  A61M5/142 ,  A61M5/148 ,  A61M5/28 ,  A61M5/32

CPC分类号： A61M5/2033 ,  A61M5/14248 ,  A61M5/148 ,  A61M5/282 ,  A61M5/283 ,  A61M5/322 ,  A61M2005/2073 ,  A61M2005/31518

摘要： The present disclosure relates to a medicament delivery device comprising a housing, a reservoir for medicament disposed in the housing and a dispensing member. The dispensing member is moveable relative to the housing from a first position to a second position to dispense medicament from the reservoir when the reservoir contains medicament. The medicament delivery device further comprises first and second biasing members. The first biasing member is configured to urge the dispensing member from the first position to an intermediate position. The second biasing member is configured to urge the dispensing member from the intermediate position to the second position.