公开(公告)号：US12065624B2

公开(公告)日：2024-08-20

申请号：US17289431

申请日：2019-10-29

申请人： Green Lizard Technologies Ltd.

发明人： Peter Goodrich ,  Eoghain O'Hara ,  Martin Atkins

IPC分类号： C11B3/06 ,  A23L5/20 ,  C07C215/08

CPC分类号： C11B3/06 ,  A23L5/27 ,  C07C215/08

摘要： The invention relates to processes for the refining of oils. In particular, the invention relates to processes for the refining of oils of biological origin such as vegetable oils.

公开(公告)号：US20240246898A1

公开(公告)日：2024-07-25

申请号：US18489240

申请日：2023-10-18

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Dan PEER ,  Srinivas RAMISHETTI

IPC分类号： C07C211/22 ,  A61K47/18 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  C07C59/01 ,  C07C215/08 ,  C07C219/04 ,  C07C229/02 ,  C07C229/10 ,  C07C229/12 ,  C07C233/00 ,  C07C243/00 ,  C07C243/10 ,  C07C243/14 ,  C07C243/16 ,  C07C243/26 ,  C07C243/28 ,  C07C279/04 ,  C07C333/10 ,  C07D233/64 ,  C07D295/13 ,  C07D295/15 ,  C12N15/113

CPC分类号： C07C211/22 ,  A61K47/18 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  C07C59/01 ,  C07C215/08 ,  C07C219/04 ,  C07C229/02 ,  C07C229/10 ,  C07C229/12 ,  C07C233/00 ,  C07C243/00 ,  C07C243/10 ,  C07C243/14 ,  C07C243/16 ,  C07C243/26 ,  C07C243/28 ,  C07C279/04 ,  C07C333/10 ,  C07D233/64 ,  C07D295/13 ,  C07D295/15 ,  C12N15/113 ,  C12N2310/14

摘要： The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.

公开(公告)号：US20240166595A1

公开(公告)日：2024-05-23

申请号：US18519529

申请日：2023-11-27

申请人： Genentech, Inc.

发明人： Rémy Angelaud ,  Tobias Bruetsch ,  Francis Gosselin ,  Chong Han ,  Alfred Stutz

IPC分类号： C07C313/06 ,  B01J23/72 ,  C07C215/08 ,  C07D263/20 ,  C07D498/04 ,  C07F7/18

CPC分类号： C07C313/06 ,  B01J23/72 ,  C07C215/08 ,  C07D263/20 ,  C07D498/04 ,  C07F7/1892

摘要： Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound (10-2) and compound 18:

公开(公告)号：US11912950B2

公开(公告)日：2024-02-27

申请号：US17444440

申请日：2021-08-04

申请人： BASF SE

发明人： Markus Hansch ,  Harald Boehnke ,  Wolfgang Grabarse ,  Ludwig Voelkel ,  Maxim Peretolchin

IPC分类号： C10L1/222 ,  C10L1/2383 ,  C10M133/54 ,  C10M133/56 ,  C10M141/06 ,  C10M133/14 ,  C10L1/188 ,  C07C213/08 ,  C07C215/08 ,  C10M133/08 ,  C10N30/06 ,  C10N40/25

CPC分类号： C10L1/2222 ,  C07C213/08 ,  C07C215/08 ,  C10L1/1883 ,  C10L1/222 ,  C10L1/2225 ,  C10L1/2383 ,  C10M133/08 ,  C10M133/14 ,  C10M133/54 ,  C10M133/56 ,  C10M141/06 ,  C10L2200/0259 ,  C10L2200/043 ,  C10L2200/0423 ,  C10L2200/0446 ,  C10L2270/023 ,  C10L2270/026 ,  C10L2290/24 ,  C10M2207/127 ,  C10M2215/042 ,  C10M2215/26 ,  C10M2215/28 ,  C10N2030/06 ,  C10N2040/253 ,  C10N2040/255

摘要： The invention relates to the use of quaternized nitrogen compounds as a fuel and lubricant additive or kerosene additive, such as in particular as a detergent additive, for decreasing or preventing deposits in the injection systems of direct-injection diesel engines, in particular in common rail injection systems, for decreasing the fuel consumption of direct-injection diesel engines, in particular of diesel engines having common rail injection systems, and for minimizing the power loss in direct-injection diesel engines, in particular in diesel engines having common rail injection systems; the invention further relates to the use as an additive for petrol, in particular for operation of DISI engines.

公开(公告)号：US20220056367A1

公开(公告)日：2022-02-24

申请号：US17289431

申请日：2019-10-29

申请人： Green Lizard Technologies Ltd. ,  FGV Applied Technologies SDN. BHD.

发明人： Peter Goodrich ,  Eoghain O'Hara ,  Martin Atkins

IPC分类号： C11B3/06 ,  C07C215/08 ,  A23L5/20

摘要： The invention relates to processes for the refining of oils. In particular, the invention relates to processes for the refining of oils of biological origin such as vegetable oils.

公开(公告)号：US11242327B2

公开(公告)日：2022-02-08

申请号：US16613397

申请日：2018-05-11

申请人： RECURIUM IP HOLDINGS, LLC

发明人： Chad Daniel Hopkins ,  Joseph Robert Pinchman ,  Kevin Duane Bunker ,  Deborah Helen Slee ,  Brant Clayton Boren ,  Mehmet Kahraman

IPC分类号： C07D277/28 ,  C07D213/38 ,  C07D235/14 ,  C07D239/26 ,  C07D263/56 ,  C07D277/64 ,  A61P29/00 ,  A61P25/04 ,  C07C211/38 ,  C07C211/40 ,  C07C215/08 ,  C07C217/52 ,  C07C229/14 ,  C07C235/14 ,  C07C237/04 ,  C07C271/24

摘要： Disclosed herein are compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.

公开(公告)号：US20220024885A1

公开(公告)日：2022-01-27

申请号：US17393834

申请日：2021-08-04

申请人： Supernus Pharmaceuticals, Inc.

发明人： Likan LIANG ,  Padmanabh P. BHATT ,  David DAIN ,  Jean-Philippe TAQUET ,  Aleksandr PECHENOV ,  Alexei TCHESNOKOV ,  Reynold MARIAUX

IPC分类号： C07D265/30 ,  C07C217/34 ,  C07D265/32 ,  C07C215/08

摘要： Provided here are methods of manufacture of viloxazine and its various salts, as well as viloxazine-related compounds, such as novel intermediate reaction products and polymorphs thereof. In particular, the methods provide a substantially pure API of viloxazine HCl while avoiding undesirable impurities. The methods further provide for separating, identifying, and characterizing novel polymorphs of viloxazine. Further provided are methods for synthesis and identification and characterization of novel intermediates of viloxazine, as well as for some important metabolites and precursors of metabolites of viloxazine.

公开(公告)号：US11111239B2

公开(公告)日：2021-09-07

申请号：US16675097

申请日：2019-11-05

申请人： GB006, INC.

发明人： Antonio J. Barbosa

IPC分类号： C07D417/06 ,  A61P35/00 ,  C07C215/08

摘要： The present invention provides new salts and crystalline forms of leukadherin LA1 [(Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid] according to Formula I. Methods for preparation of the salts and crystalline forms are also described, as well as methods for treating β2 integrin-mediated diseases and conditions using the salts and crystalline forms.

公开(公告)号：US20210171437A1

公开(公告)日：2021-06-10

申请号：US17181041

申请日：2021-02-22

申请人： VERA THERAPEUTICS, INC.

发明人： James M. Coull ,  Brian D. Gildea

IPC分类号： C07C229/08 ,  C07D239/54 ,  C07C271/20 ,  C07D239/47 ,  C07C269/06 ,  C07D473/34 ,  C07C229/26 ,  C07C221/00 ,  C07D473/06 ,  C07D473/18 ,  C07C309/30 ,  C07C225/06 ,  C07C227/18 ,  C07C215/08 ,  C07C213/08

摘要： The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester Acid Salts, as described below) that can be used to prepare PNA monomers wherein said PNA monomers can be used to prepare said PNA oligomers. In some embodiments, the disclosure features sulfonic acid salts of Backbone Ester compounds, which sulfonic acid salts generally tend to be crystalline and can be obtained in reasonably good yield, often without requiring any chromatographic purification of the reaction product of the Backbone Ester synthesis reaction. This disclosure also pertains to novel methods for the synthesis of said Backbone Ester compounds and novel methods for the formation of the related sulfonic acid salts. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethy-(TCE), 2,2,2-tribromoethyl-(TBE), 2-iodoethyl-groups (2-IE) and 2-bromoethyl-(2-BrE) as the ester group. These particular ester groups can be removed under conditions where both Boc and Fmoc protected amine groups are stable.

公开(公告)号：US10821430B2

公开(公告)日：2020-11-03

申请号：US16328033

申请日：2017-08-30

申请人： Dow Technology Investments LLC

发明人： Mohmed A. Syed ,  Apoorva Kulkarni ,  Vera P. Santos Castro ,  Victor J. Sussman ,  John C. McKeen ,  Cathy L. Tway ,  Clifford S. Todd

IPC分类号： B01J37/02 ,  B01J23/50 ,  B01J37/00 ,  C07C213/04 ,  C07D301/10 ,  C07D317/36 ,  C07C215/08 ,  C07D317/04 ,  B01J21/04 ,  B01J35/10 ,  B01J37/08 ,  C07C29/00 ,  C07C41/02 ,  C07C68/00 ,  C07C213/00 ,  C07D301/03

摘要： A process for preparing a silver-containing catalyst for the selective oxidation of ethylene to ethylene oxide including the steps of: (a) providing a multimodal support, (b) preparing an impregnation solution comprising a silver component, (c) impregnating, at least once, the multimodal support of step (a) with the silver-containing impregnation solution of step (b) to form an impregnated support; (d) subjecting the impregnated multimodal support from step (c) to a removal means, such as a centrifuge, at least once, for a time sufficient to remove impregnated silver impregnation solution from the multimodal support and to control the amount of silver in the pores of the multimodal support by selectively removing impregnated silver impregnation solution from a set of larger pores in the multimodal support; (e) roasting, at least once, the multimodal support after the step (d); (f) optionally, repeating the impregnation step (c), (g) optionally, repeating the centrifugation step (d), and (h) optionally, repeating the calcination step (e).