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公开(公告)号:US11634455B2
公开(公告)日:2023-04-25
申请号:US16195145
申请日:2018-11-19
IPC分类号: C07K14/505 , C07K1/107 , C07K14/575 , C07K14/62 , C07K14/635 , C07K14/695 , C07K1/04 , C07K14/605 , A61K47/54 , C07C269/04 , C07C269/06 , C07C271/02 , C07C323/60 , C07K14/00 , C07K14/47 , A61K38/00
摘要: The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula 1 in the synthesis of peptide derivatives.
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公开(公告)号:US11576981B2
公开(公告)日:2023-02-14
申请号:US16770273
申请日:2018-12-06
发明人: Rima Al-awar , Andrew Zhang , Ahmed Mamai
IPC分类号: A61K47/68 , A61K45/06 , A61P35/00 , C07C323/60 , C07D207/46
摘要: The present application is directed to compounds of Formula (I)-(VIII): compositions comprising these compounds and their uses, for example as medicaments and/or diagnostics.
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公开(公告)号:US20220202777A1
公开(公告)日:2022-06-30
申请号:US17229347
申请日:2021-04-13
申请人: Allergan, Inc.
IPC分类号: A61K31/417 , C07K5/062 , C07K5/078 , C07K5/072 , C07C275/30 , C07C317/42 , C07C323/44 , C07D209/20 , C07D233/64 , C07C317/50 , C07C323/60 , A61K31/17 , A61K31/197 , A61K31/216 , A61K31/4045 , A61K31/198
摘要: The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
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公开(公告)号:US20210395194A1
公开(公告)日:2021-12-23
申请号:US17216285
申请日:2021-03-29
发明人: Michael Neary , James Nieman , Steven Tanis , Daniel Lawton , Garry Smith
IPC分类号: C07C327/34 , C07D327/04 , C07D241/08 , C07C323/57 , C07C323/60 , C07C323/58 , C07C323/59 , C07C327/32 , C07C329/06 , C07D277/14 , C07C327/26 , C07D277/08
摘要: Novel substituted N-acetyl-L-cysteine (NAC) derivatives and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.
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公开(公告)号:US11124498B2
公开(公告)日:2021-09-21
申请号:US16462460
申请日:2017-11-15
申请人: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人: Michael A. Fischbach , Chun-Jun Guo , Christopher A. Voigt , Fang-Yuan Chang , Jon Clardy , Thomas Wyche
IPC分类号: C07D403/14 , C07C237/20 , C07D403/12 , C07C323/60 , C07D241/18 , C07D241/12 , C07D403/06
摘要: Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.
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公开(公告)号:US11103583B2
公开(公告)日:2021-08-31
申请号:US16460812
申请日:2019-07-02
发明人: Joseph E. Payne , John A. Gaudette , Zheng Hou , Mohammad Ahmadian , Lei Yu , Victor Knopov , Violetta Akopian , Priya Karmali , Richard P. Witte , Neda Safarzadeh , Wenbin Ying , Jun Zhang
IPC分类号: A61K47/20 , C07C323/60 , C07D333/38 , C07C271/16 , C07D333/40 , C07C317/44 , C07C333/04 , C07C235/08 , C07C237/08 , C07D207/16 , A61K47/14 , A61K9/127 , A61K47/18 , A61K47/22 , C07C237/16
摘要: The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
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公开(公告)号:US20210238130A1
公开(公告)日:2021-08-05
申请号:US17269338
申请日:2019-08-29
发明人: Julien MICHEL , Alessio DE SIMONE , Charalampos IOANNIDIS , Jordi JUAREZ-JIMENEZ , Charis GEORGIOU , Arun GUPTA , Alison HULME , Malcolm WALKINSHAW , Dahlia DOUGHTY SHENTON
IPC分类号: C07C275/24 , C07D257/04 , C07C323/60 , C07D491/08 , C07D207/16 , C07D403/12
摘要: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof useful as inhibitors of Cyclophilins and modulators of cyclophilin-like proteins. The invention also relates to uses of said compounds in the treatment of various disorders. Formula (I), wherein: R1 and R2 are each independently is selected from the group consisting of —R, -haloalkyl, -hydroxyalkyl, —OR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, and —N(R)2; wherein R2 could also be a sulphide; each R is independently hydrogen, C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, sulphur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms selected from nitrogen, oxygen, or sulphur; R3 is Formula (Ia) selected from the group consisting of —OEt, and wherein R5 and R6 are independently selected from the group consisting of H, halide, methoxy, thiomethyl, morpholine and trifluoromethyl; R4 is selected from the group consisting of C1-6-alkyl-, and R4.1—CH2— wherein, R4.1 is C3-6-cycloalkyl-, a 5-6 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, sulphur; optionally substituted with one R4.1.1 wherein, R4.1.1 is selected from —H, C1-4-alkyl, optionally substituted with one substituent selected from H2N(O)C— or EtO(O)C—; X is carbon or nitrogen; A is selected from the group consisting of 6 membered unsaturated ring, with 1-3 nitrogen atoms, which is optionally substituted by —NH2, and Formula (Ib), wherein ring B is a fused 5-10 membered saturated or partially unsaturated heterocyclic mono-bicyclic ring having 1-3 heteroatoms selected from nitrogen, oxygen or sulphur, which is optionally substituted by —OH; and m is 1 or 2; and n is 1 or 2.
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公开(公告)号:US20210230217A1
公开(公告)日:2021-07-29
申请号:US16768341
申请日:2018-12-21
发明人: David Jackson , Ian Holmes , Weiguang Zeng , Christophe Demaison
IPC分类号: C07K5/062 , C07C317/48 , C07C323/60 , A61K47/54 , A61K47/60 , A61P11/00
摘要: The present invention relates to TLR2 agonist compounds and their compositions, and the use of such compounds and compositions in the prevention and/or treatment of respiratory infections, or diseases or conditions associated with viral or bacterial infections.
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公开(公告)号:US11046726B2
公开(公告)日:2021-06-29
申请号:US15928533
申请日:2018-03-22
申请人: QIAGEN SCIENCES, LLC
发明人: Mong Sano Marma , Jerzy Olejnik , Ilia Korboukh
IPC分类号: C07H19/10 , C07H19/14 , C07F7/18 , C07C323/12 , C09B11/24 , C09B23/08 , C09B1/00 , C09B5/24 , C09B23/16 , C12Q1/6869 , C12Q1/6876 , C07C323/60 , C07D207/46 , C12Q1/6811
摘要: The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.
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公开(公告)号:US11046644B2
公开(公告)日:2021-06-29
申请号:US16410885
申请日:2019-05-13
申请人: ALLERGAN, INC.
发明人: Haiqing Yuan , Richard L. Beard , Xiaoxia Liu , John E. Donello , Veena Viswanath , Michael E. Garst
IPC分类号: C07C311/21 , C07D307/82 , C07C323/49 , C07C317/34 , C07D307/64 , C07C311/44 , A61K31/18 , A61K31/10 , A61P27/02 , C07F9/59 , C07C317/44 , C07C323/52 , C07C323/56 , C07C323/60 , C07D295/13 , C07D295/185 , C07D295/24 , C07F9/30 , C07F9/32 , C07F9/40 , C07F9/53 , C07F9/6533 , C07D233/64 , C07D405/12 , C07D413/12 , C07D417/12 , C07C317/36 , C07D213/52 , C07D333/34 , C07D277/40 , C07C317/42 , C07C317/50 , C07C323/67 , C07D213/32 , C07C321/30 , C07D207/09 , C07D207/46
摘要: The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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