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公开(公告)号：US12024542B2
公开(公告)日：2024-07-02
申请号：US17687755
申请日：2022-03-07
申请人： Novo Nordisk A/S
发明人： Per Noergaard
IPC分类号： C07K14/395 , C07K14/605 , C12P21/02
CPC分类号： C07K14/395 , C07K14/605 , C12P21/02 , C07K2319/00
摘要： The present invention is related to Mating Factor α pro-peptide variants useful for the recombinant expression of polypeptides comprising a GLP-1 peptide in yeasts. The invention is also related to DNA sequences, vectors and host cells for use in expressing polypeptides in yeasts.
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公开(公告)号：US11926850B2
公开(公告)日：2024-03-12
申请号：US17204542
申请日：2021-03-17
发明人： Arlene M. Fosmer , Christopher K. Miller , Gregory Michael Poynter , Brian Jeffrey Rush , Jon Veldhouse
IPC分类号： C12N9/00 , C07K14/395 , C12N9/04 , C12N9/34 , C12P7/06
CPC分类号： C12N9/0006 , C07K14/395 , C12N9/2428 , C12P7/06 , C12Y101/02003 , C12Y101/02004 , C12Y302/01003
摘要： The present invention relates to genetically modified yeasts that can use lactate as a carbon source to produce a fermentation product. In one aspect, the yeasts can consume glucose and lactate simultaneously to produce ethanol. In one aspect, the genetically modified yeast is transformed to include a monocarboxylic/monocarboxylate transporter. In one aspect, the yeast can include one or more heterologous genes encoding lactate dehydrogenase (cytochrome) (EC 1.1.2.3 and/or 1.1.2.4).
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公开(公告)号：US11925193B2
公开(公告)日：2024-03-12
申请号：US17512368
申请日：2021-10-27
申请人： DSM IP ASSETS B.V.
IPC分类号： C12N1/16 , A23L2/60 , A23L27/30 , C07K14/39 , C07K14/395 , C07K14/40 , C12N9/24 , C12P15/00 , C12P19/56
CPC分类号： A23L27/36 , A23L2/60 , C07K14/39 , C07K14/395 , C07K14/40 , C12N1/16 , C12N9/2402 , C12P15/00 , C12P19/56
摘要： A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.
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公开(公告)号：US20240075152A1
公开(公告)日：2024-03-07
申请号：US18261264
申请日：2022-01-13
IPC分类号： A61K47/64 , A61K47/52 , C07K14/395
CPC分类号： A61K47/64 , A61K47/52 , C07K14/395 , C07K2299/00 , C07K2319/21 , C07K2319/73
摘要： Supramolecular assemblies, compositions thereof, and methods for preparing and use the same are provided. The supramolecular assemblies comprise a trimeric variant of a GCN4 peptide capable of self-assembly and incorporating one or more guest molecules in a functional 3D native structure.
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公开(公告)号：US11739338B2
公开(公告)日：2023-08-29
申请号：US16648625
申请日：2018-09-18
发明人： Brooks Henningsen , Sean Covalla , Rintze Zelle , Allan Froehlich
IPC分类号： C12N15/81 , C07K14/395 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/90 , C12N9/92 , C12N9/00 , C12P7/06
CPC分类号： C12N15/81 , C07K14/395 , C12N9/0006 , C12N9/1022 , C12N9/12 , C12N9/1205 , C12N9/90 , C12N9/92 , C12N9/93 , C12P7/06 , C12Y101/01001 , C12Y202/01002 , C12Y207/01017 , C12Y207/11001 , C12Y501/03001 , C12Y503/01006 , C12Y602/01001
摘要： Acetate is a potent microbial inhibitor which can affect the performance of yeast in ethanolic fermentation. The present disclosure provides a recombinant microbial host cell having (i) a first genetic modification for increasing the activity of one or more proteins that function in a first metabolic pathway to convert acetate into an alcohol in the microbial host cell; (ii) a second genetic modification for increasing the activity of one or more proteins that function in a second metabolic pathway to import glycerol in the recombinant microbial host cell (iii) a third genetic modification for increasing the activity of one or more proteins that function in a third metabolic pathway to convert a C5 carbohydrate into ethanol in the microbial host cell. The recombinant microbial host cell comprises and natively expresses native proteins that function in a fourth native metabolic pathway to produce glycerol in the microbial host cell.
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公开(公告)号：US11643443B2
公开(公告)日：2023-05-09
申请号：US15777070
申请日：2016-11-18
IPC分类号： C12N15/74 , C07K14/245 , C07K14/47 , C07K14/395 , C07K14/195 , C12N9/08 , C12N9/36
CPC分类号： C07K14/245 , C07K14/195 , C07K14/395 , C07K14/47 , C07K14/4711 , C07K14/4717 , C12N9/0065 , C12N9/2462 , C12Y111/01007 , C12Y302/01017 , C07K2319/00 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C07K2319/735
摘要： Methods of making engineered protein-based materials, nanofibers, and biofilms from bacterial amyloid-based structures that are capable of mediating long-range electron transport are provided.
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公开(公告)号：US20220194995A1
公开(公告)日：2022-06-23
申请号：US17687755
申请日：2022-03-07
申请人： Novo Nordisk A/S
发明人： Per Noergaard
IPC分类号： C07K14/395 , C07K14/605 , C12P21/02
摘要： The present invention is related to Mating Factor α pro-peptide variants useful for the recombinant expression of polypeptides comprising a GLP-1 peptide in yeasts. The invention is also related to DNA sequences, vectors and host cells for use in expressing polypeptides in yeasts.
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公开(公告)号：US11306304B2
公开(公告)日：2022-04-19
申请号：US16575350
申请日：2019-09-18
IPC分类号： C12N9/92 , C07K14/395 , C12P7/06
摘要： There is provided an engineered host cells comprising (a) one or more mutations in one or more endogenous genes encoding a protein associated with iron metabolism; and (b) at least one gene encoding a polypeptide having xylose isomerase activity, and methods of their use thereof.
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公开(公告)号：US11297862B2
公开(公告)日：2022-04-12
申请号：US15751674
申请日：2016-08-15
申请人： DSM IP ASSETS B.V.
IPC分类号： C07K14/39 , C12P19/56 , A23L27/30 , A23L2/60 , C12P15/00 , C07K14/395 , C07K14/40 , C12N1/16 , C12N9/24
摘要： A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.
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公开(公告)号：US20220090149A1
公开(公告)日：2022-03-24
申请号：US17416885
申请日：2019-12-23
发明人： Sudhanshu Vijay DOLE , Joel Stewart SCHMID , R. Rogers YOCUM , Theron HERMANN , Russell Lizardo UDANI , Sean Joseph REGAN , Mark Andrew SHEFF , Michelle SPENCER , Ryan SILLERS , Phatthanon PRASITCHOKE , Natthawut POOMSILA
IPC分类号： C12P7/56 , C12N9/12 , C07K14/395
摘要： The present invention discloses a genetically engineered Kluyveromyces sp. yeast strain that is capable of producing lactic acid from carbon source selected from glucose, fructose, sucrose or a mixture thereof wherein the genetically engineered yeast comprises at least one heterologous DNA cassette that confers production of a protein functioning as a fructose importer. The genetically engineered yeast strain according to this invention has an improvement of fructose utilization and use fructose as a faster rate than conventional strain, allowing for shorter fermentation times and improved economics.
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