公开(公告)号：US11857949B2

公开(公告)日：2024-01-02

申请号：US18026978

申请日：2022-06-03

申请人： Resonac Corporation

发明人： Naoki Uchiyama ,  Yuzuru Kokido

IPC分类号： B01J20/28 ,  B01J20/285 ,  G01N30/52 ,  G01N30/02

CPC分类号： B01J20/285 ,  G01N30/52 ,  B01J2220/54 ,  G01N2030/022 ,  G01N2030/525

摘要： A packing material, wherein to a porous organic polymer carrier including 60 to 95 mol % of a repeating unit derived from glycidyl methacrylate and 5 to 40 mol % of a repeating unit derived from a polyfunctional monomer, one end of at least one alkylene group selected from a linear alkylene group, a cycloalkylene group, and a linear alkylcycloalkylene group, having 4 to 9 carbon atoms is bonded by a glycidyl group derived from glycidyl methacrylate, and an other end of the alkylene group is bonded to any one end of a polyol via an ether bond.

公开(公告)号：US20230366860A1

公开(公告)日：2023-11-16

申请号：US18196575

申请日：2023-05-12

申请人： Waters Technologies Corporation

发明人： Szabolcs Fekete ,  Matthew A. Lauber

IPC分类号： G01N30/52 ,  G01N30/56 ,  B01D15/38 ,  B01D15/16

CPC分类号： G01N30/52 ,  G01N30/56 ,  B01D15/3847 ,  B01D15/166 ,  G01N2030/562 ,  G01N2030/027

摘要： The present disclosure is directed to liquid chromatography columns and methods utilizing a stationary phase sorbent having two or more gradient factors. Each of the two or more gradient factors varies in a progressive manner along a length of the stationary phase sorbent in a direction from an inlet to an outlet of the column (i.e., along a length of the column). As a result of including these new continuous stationary phase gradients, new selectivities allowing for separation and analysis of complex samples including large biomolecules is achievable.

公开(公告)号：US11782033B2

公开(公告)日：2023-10-10

申请号：US16252081

申请日：2019-01-18

申请人： The Regents of The University of Michigan

发明人： Edward T. Zellers ,  Changhua Zhan ,  Robert W. Hower ,  Joseph A. Potkay

IPC分类号： G01N1/40 ,  G01N30/60 ,  G01N30/08 ,  G01N30/16 ,  G01N30/52 ,  G01N25/00 ,  G01N30/00 ,  F16L53/00

CPC分类号： G01N30/6095 ,  G01N1/405 ,  G01N30/08 ,  G01N30/16 ,  F16L53/00 ,  G01N25/00 ,  G01N30/52 ,  G01N2030/0095

摘要： A microscale collector and injector device comprises a microscale passive pre-concentrator (μPP) and a microscale progressively-heated injector (μPHI). The μPP devices comprises first and second substrate portions, a first collection material, a μPP heater, and an outlet. The first substrate portion defines an array of microscale diffusion channels. The first and second substrate portions cooperate to define a first compartment in fluid communication with the diffusion channels. The first collection material is disposed within the first compartment, at least partially surrounding the outlet. The μPP heater is disposed in thermal communication with the second substrate portion. The μPHI device comprises third and fourth substrate portions, a second collection material, and a plurality of μPHI heaters. The third and fourth substrate portions cooperate to define a second compartment. The second collection material is disposed within the second compartment. The μPHI heaters are disposed in thermal communication with the second compartment.

公开(公告)号：US11709156B2

公开(公告)日：2023-07-25

申请号：US16746031

申请日：2020-01-17

申请人： Waters Technologies Corporation

发明人： Xiaoxiao Liu ,  Anna Boardman ,  Mathew H. DeLano ,  Matthew A. Lauber

IPC分类号： G01N30/56 ,  G01N30/52 ,  B05D1/00 ,  G01N30/60 ,  G01N33/74 ,  G01N33/68 ,  G01N33/92

CPC分类号： G01N30/56 ,  B05D1/60 ,  G01N30/52 ,  G01N30/6052 ,  B05D2202/00 ,  B05D2203/35 ,  B05D2518/10 ,  G01N33/6803 ,  G01N33/74 ,  G01N33/92 ,  G01N2030/567

摘要： A device for processing samples is disclosed. Interior surfaces of the device, which come in contact with fluids, define wetted surfaces. A portion of the wetted surfaces are coated with an alkylsilyl coating having the Formula I:




R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20—.

公开(公告)号：US11491465B2

公开(公告)日：2022-11-08

申请号：US15522897

申请日：2015-11-05

申请人： GEOSERVICES EQUIPEMENTS ,  LA SOCIETE DES AMIS DE L'ECOLE SUPERIEURE DE PHYSIQUE ET CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Jerome Breviere ,  Joachim Pragash Fleury ,  Jerome Vial ,  Didier Thiébaut ,  Anouar Essoussi ,  Imadeddine Azzouz ,  Kamran Danaie

IPC分类号： B01J20/286 ,  B01J20/10 ,  B01J20/28 ,  B01J20/30 ,  G01N30/52

摘要： A silica-based stationary phase for chromatography columns and the methods of preparing such. More particularly, but not by way of limitation, a silica-based stationary phase that is substantially free of polyethers (e.g., polymer glycols). Also, a chromatography column comprising a silica-based stationary phase substantially free of polyethers (e.g., polymer glycols) within its channels as either a thin-film coating and/or a monolith and/or a monolithic coating. More particularly, a micro-electro-mechanical system (MEMS) chromatograph comprising a silica-based monolith substantially free of polyethers (e.g., polymer glycols) as the stationary phase within the micro-channels of the column.

公开(公告)号：US11305271B2

公开(公告)日：2022-04-19

申请号：US15677526

申请日：2017-08-15

申请人： EMD Millipore Corporation

发明人： David Yavorsky ,  John Amara ,  Joaquin Umana ,  William Cataldo ,  Mikhail Kozlov ,  Matthew Stone

IPC分类号： B01D15/36 ,  B01J20/28 ,  B01J47/12 ,  B01J39/26 ,  C12N7/02 ,  B01J47/014 ,  B01J47/127 ,  B01D15/38 ,  C07K1/18 ,  B01J41/20 ,  B01D15/32 ,  B01J20/285 ,  B01J20/287 ,  B01J20/32 ,  C07K16/00 ,  C12N7/00 ,  G01N30/52

摘要： Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).

公开(公告)号：US10981147B2

公开(公告)日：2021-04-20

申请号：US15986756

申请日：2018-05-22

申请人： Francois Parmentier

发明人： Francois Parmentier

IPC分类号： B01J20/30 ,  B01D15/18 ,  B01J20/08 ,  B01J20/12 ,  B01J20/18 ,  B01J20/28 ,  B01J20/283 ,  B01J20/284 ,  B01D53/04 ,  G01N30/60 ,  G01N30/52

摘要： The invention relates to a monolithic porous material based on amorphous silica or activated alumina or on one of their mixtures, the material comprising substantially rectilinear capillary ducts that lie parallel to one another, and being intended to be used as packing in a chromatography column, characterised in that: the ducts have, relative to one another, a substantially uniform cross section; the cross-section of each duct is uniform over its entire length; the ducts pass right through the material; the volume of micropores smaller than 0.3 nm is smaller than 50% of the total porous volume of the material.

公开(公告)号：US10948465B2

公开(公告)日：2021-03-16

申请号：US16019760

申请日：2018-06-27

申请人： RESTEK CORPORATION

发明人： Jaap De Zeeuw ,  William P. Bromps ,  Tracey Peters ,  Thomas E. Kane

IPC分类号： B01D53/02 ,  G01N30/60 ,  G01N30/56 ,  B01J20/28 ,  G01N30/02 ,  G01N30/52

摘要： A crescent PLOT column is disclosed, including a capillary column having an inlet, an outlet, a bore, and an inner surface surrounding the bore and extending between the inlet and the outlet. A layer of particles is localized on a radial portion of the inner surface. The layer of the particles includes a radial thickness decreasing from a center of the radial portion to a periphery of the radial portion, forming a crescent shape in a radial frame of reference. A method for preparing the crescent PLOT column is disclosed, including loading the capillary column with a fluid including a carrier and particles such that the fluid is contained within the capillary column. The capillary column and the fluid contained within the capillary column are subjected to a centrifugal force. The carrier is removed, and a layer of the particles is localized on the radial portion of the inner surface.

公开(公告)号：US10935525B2

公开(公告)日：2021-03-02

申请号：US16207125

申请日：2018-12-01

申请人： Kun Shan University

发明人： Hao-Lin Hsu ,  Chung-Yih Kuo ,  Jean-Hong Chen

IPC分类号： G01N30/00 ,  B01J20/281 ,  G01N30/54 ,  G01N30/72 ,  G01N30/02 ,  G01N30/52

摘要： A method for detecting a gas sample includes the following steps of: providing a carbon aerogel sleeve; introducing a gas sample to the carbon aerogel sleeve, and then sequentially extracting, concentrating, activating, and re-concentrating the gas sample adsorbed by the carbon aerogel and detecting a concentration of the re-concentrated gas sample by a gas chromatograph-mass spectrometer (GC-MS); and extracting the carbon aerogel for several hours with reflux in a dichloromethane solvent and a n-hexane solvent several times per hour to remove the residual gas sample, and then drying the extracted carbon aerogel for reuse, wherein the dichloromethane solvent and the n-hexane solvent are at a volume ratio of 0.001-1000.

公开(公告)号：US20210055271A1

公开(公告)日：2021-02-25

申请号：US16963784

申请日：2019-01-22

申请人： Marcellus Johannes Hubertus RAEDTS

发明人： Marcellus Johannes Hubertus RAEDTS

IPC分类号： G01N30/52 ,  B01D15/18 ,  G01N30/60

摘要： Disclosed is a continuous process in which a subset of a number of mutually identical columns, are connected in series. The process liquid, e.g. crude cell culture harvest, is supplied to the most upstream column of the subset. It flows successively through the in series connected columns and leaves the subset through the most downstream and flows into the downstream collection vessel. As soon as the packed bed of the most upstream column is become saturated with product, this column is disconnected from the subset. It is removed from the series connection. A replacement, identical, column is added such that it is connected in series downstream from the most downstream column of the subset. This process is repeated.