公开(公告)号：WO2007059113A3

公开(公告)日：2007-05-24

申请号：PCT/US2006/044154

申请日：2006-11-14

Applicant: CYTOKINETICS, INC. ,  COLLIBEE, Scott ,  BERGNES, Gustave ,  HAMILTON, Matthew, Richard ,  MORGAN, Bradley, P. ,  MORGANS, David J., Jr.

Inventor： COLLIBEE, Scott ,  BERGNES, Gustave ,  HAMILTON, Matthew, Richard ,  MORGAN, Bradley, P. ,  MORGANS, David J., Jr.

IPC: A01N35/00 ,  A61K31/12

Abstract: Compounds useful for treating cellular proliferative diseases are disclosed.

公开(公告)号：WO2007025892A1

公开(公告)日：2007-03-08

申请号：PCT/EP2006/065498

申请日：2006-08-21

Applicant: F. HOFFMANN-LA ROCHE AG ,  BANNER, Bruce Lester ,  BILOTTA, Joseph Anthony ,  FOTOUHI, Nader ,  GILLESPIE, Paul ,  GOODNOW JR., Robert Alan ,  HAMILTON, Matthew Michael ,  HAYNES, Nancy-Ellen ,  KOWALCZYK, Agnieszka ,  MAYWEG, Alexander V. ,  MYERS, Michael Paul ,  PIETRANICO-COLE, Sherrie Lynn ,  SCOTT, Nathan Robert ,  THAKKAR, Kshitij Chhabilbhai ,  TILLEY, Jefferson Wright

Inventor： BANNER, Bruce Lester ,  BILOTTA, Joseph Anthony ,  FOTOUHI, Nader ,  GILLESPIE, Paul ,  GOODNOW JR., Robert Alan ,  HAMILTON, Matthew Michael ,  HAYNES, Nancy-Ellen ,  KOWALCZYK, Agnieszka ,  MAYWEG, Alexander V. ,  MYERS, Michael Paul ,  PIETRANICO-COLE, Sherrie Lynn ,  SCOTT, Nathan Robert ,  THAKKAR, Kshitij Chhabilbhai ,  TILLEY, Jefferson Wright

IPC: C07D231/54 ,  A61P3/00 ,  A61K31/4184

CPC classification number: C07D231/54

Abstract: Provided herein are compounds of the formula (I); as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供了式（I）的化合物; 以及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。

公开(公告)号：WO2005075435A1

公开(公告)日：2005-08-18

申请号：PCT/US2005/002644

申请日：2005-01-31

Applicant: VERTEX PHARMACEUTICALS INCORPORATED ,  HADIDA RUAH, Sarah, S. ,  GROOTENHUIS, Peter, D., J. ,  MILLER, Mark, T. ,  HAMILTON, Matthew?

Inventor： HADIDA RUAH, Sarah, S. ,  GROOTENHUIS, Peter, D., J. ,  MILLER, Mark, T. ,  HAMILTON, Matthew?

IPC: C07D231/40

CPC classification number: C07D231/40 ,  C07D233/46 ,  C07D233/88 ,  C07D263/48 ,  C07D271/10 ,  C07D271/113 ,  C07D277/40 ,  C07D277/46 ,  C07D277/54 ,  C07D277/82 ,  C07D285/135 ,  C07D317/60 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D493/10

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators (I) or a pharmaceutically acceptable salt thereof, wherein: Ht is a 5-membered heteroaromatic ring containing 1-4 heteroatoms selected from O, S, N or NH, wherein said ring is optionally fused to a 6-membered monocyclic or 10-membered bicyclic carbocyclic or heterocyclic, aromatic or non-aromatic ring, wherein Ht is optionally substituted with w occurrences of -WR w , wherein w is 0-5; ring A is 3-7 membered monocyclic ring having 0-3 heteroatoms selected from O, S, N, or NH, wherein ring A is optionally substituted with q occurrences of QR Q ; ring B is optionally fused to 5-6 membered carbocyclic or heterocyclic, aromatic or non-aromatic ring .

Abstract translation: 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂（I）或其药学上可接受的盐治疗ABC转运蛋白介导的疾病的方法，其中：Ht是含有1-4个选自O，S，N或NH的杂原子的5元杂芳环 其中所述环任选地与6元单环或10元双环碳环或杂环，芳族或非芳族环稠合，其中Ht任选被-WR w的w出现取代，其中w为0-5 ; 环A是具有0-3个选自O，S，N或NH的杂原子的3-7元单环，其中环A任选地被Q Q发生的Q Q取代; 环B任选地与5-6元碳环或杂环，芳族或非芳族环稠合。

公开(公告)号：WO2005035514A3

公开(公告)日：2005-04-21

申请号：PCT/US2004/033367

申请日：2004-10-08

Applicant: VERTEX PHARMACEUTICALS INCORPORATED? ,  HADIDA RUAH, Sara S.? ,  SINGH, Ashvani K.? ,  MILLER, Mark T.? ,  HAMILTON, Matthew? ,  GROOTENHUIS, Peter D.J.?

Inventor： HADIDA RUAH, Sara S.? ,  SINGH, Ashvani K.? ,  MILLER, Mark T.? ,  HAMILTON, Matthew? ,  GROOTENHUIS, Peter D.J.?

IPC: C07D307/87

Abstract: The present invention provides compounds of Formula (I) useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein R B , n, B, R C , R D , R E , A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula (I), useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.

公开(公告)号：WO2019036794A1

公开(公告)日：2019-02-28

申请号：PCT/CA2018/050268

申请日：2018-03-07

Applicant: HAMILTON, Matthew

Inventor： HAMILTON, Matthew ,  RUMBOLT, Chuck ,  BENOIT, Donovan ,  TROKE, Matthew ,  LOCKYER, Robert

IPC: G06T9/00 ,  G06F3/14 ,  G06T1/00 ,  G06T15/00

Abstract: A system and methods for a CODEC driving a real-time light field display for multi-dimensional video streaming, interactive gaming and other light field display applications is provided applying a layered scene decomposition strategy. Multi-dimensional scene data is divided into a plurality of data layers of increasing depths as the distance between a given layer and the plane of the display increases. Data layers are sampled using a plenoptic sampling scheme and rendered using hybrid rendering, such as perspective and oblique rendering, to encode light fields corresponding to each data layer. The resulting compressed, (layered) core representation of the multi-dimensional scene data is produced at predictable rates, reconstructed and merged at the light field display in real-time by applying view synthesis protocols, including edge adaptive interpolation, to reconstruct pixel arrays in stages (e.g. columns then rows) from reference elemental images.

公开(公告)号：WO2013181365A1

公开(公告)日：2013-12-05

申请号：PCT/US2013/043321

申请日：2013-05-30

Applicant: EXACTECH, INC. ,  ROCHE, Christopher ,  HAMILTON, Matthew

Inventor： ROCHE, Christopher ,  HAMILTON, Matthew ,  DIEP, Phong

IPC: A61F2/30 ,  A61F2/40 ,  A61B17/58

CPC classification number: A61F2/40 ,  A61F2/4014 ,  A61F2002/30331 ,  A61F2002/30367 ,  A61F2002/30433 ,  A61F2002/305 ,  A61F2002/30553 ,  A61F2002/30616 ,  A61F2002/4022 ,  F04C2270/041

Abstract: A reverse shoulder prosthesis includes a humeral adapter tray (300) configured to sit near a resected surface of a humerus, the humeral adapter tray (300) comprising: a cavity (302); a central bore; and a distal face (304) including a boss (310), the boss (310): (i) configured as an extension of the distal face, (ii) posteriorly offset from the central bore by at least 10 mm, and (iii) configured to engage a humeral stem; and a humeral liner (250) comprising: a distal rim (252) configured to sit within the cavity (302) of the humeral adapter tray (300); and a concave articulating surface configured to mate with a convex articulating surface of a glenosphere. Offsetting the reverse shoulder humeral adapter tray shifts the humerus in the posterior direction so as to result in better deltoid wrapping, more anatomic muscle tensioning, and larger muscle moment arms during both abduction and internal/external rotation.

Abstract translation: 肱骨适配器托盘（300）包括：空腔（302）;肱骨适配器托盘（300），其构造成位于肱骨的切除表面附近。 中心孔 以及包括凸起（310）的远侧面（304），所述凸台（310）：（i）构造成所述远侧面的延伸部，（ii）从所述中心孔向后偏移至少10mm，和（iii ）配置为接合肱骨柄; 和肱骨衬垫（250），包括：构造成位于肱骨适配器托盘（300）的空腔（302）内的远侧边缘（252）; 以及构造成与微球的凸形铰接表面配合的凹形铰接表面。 抵消反向肱骨适配器托盘将肱骨向后移动，以便在外展和内部/外部旋转期间导致更好的三角肌包裹，更多的解剖肌张力和更大的肌肉力量臂。

公开(公告)号：WO2011067174A1

公开(公告)日：2011-06-09

申请号：PCT/EP2010/068279

申请日：2010-11-26

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David, Robert ,  HAMILTON, Matthew, Michael

Inventor： BOLIN, David, Robert ,  HAMILTON, Matthew, Michael

IPC: A61P3/10 ,  C07C233/25 ,  C07C233/47 ,  C07C233/60 ,  A61K31/095 ,  A61K31/194 ,  A61K31/195 ,  A61K31/401 ,  C07C311/08 ,  C07C311/09 ,  C07D207/08 ,  C07D207/16

CPC classification number: C07C233/25 ,  A61K31/095 ,  A61K31/194 ,  A61K31/195 ,  A61K31/401 ,  C07C233/47 ,  C07C233/60 ,  C07C311/08 ,  C07C311/09 ,  C07C2601/08 ,  C07D207/08 ,  C07D207/16

Abstract: Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。

公开(公告)号：WO2009037222A1

公开(公告)日：2009-03-26

申请号：PCT/EP2008/062234

申请日：2008-09-15

Applicant: F. HOFFMANN-LA ROCHE AG ,  BOLIN, David Robert ,  CAI, Jianping ,  CHEUNG, Adrian Wai-Hing ,  GOODNOW JR., Robert Alan ,  HAMILTON, Matthew Michael ,  LI, Shiming ,  MCDERMOTT, Lee Apostle ,  YUN, Weiya

Inventor： BOLIN, David Robert ,  CAI, Jianping ,  CHEUNG, Adrian Wai-Hing ,  GOODNOW JR., Robert Alan ,  HAMILTON, Matthew Michael ,  LI, Shiming ,  MCDERMOTT, Lee Apostle ,  YUN, Weiya

IPC: C07D401/14 ,  C07D403/12 ,  C07D407/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/437 ,  A61K31/416 ,  A61K31/404 ,  A61P3/00

CPC classification number: C07D413/12 ,  C07D401/14 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Provided herein are compounds of the formula (I), as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.

Abstract translation: 本文提供式（I）化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症，II型糖尿病和代谢综合征。

公开(公告)号：WO2007059113A2

公开(公告)日：2007-05-24

申请号：PCT/US2006044154

申请日：2006-11-14

Applicant: CYTOKINETICS INC ,  COLLIBEE SCOTT ,  BERGNES GUSTAVE ,  HAMILTON MATTHEW RICHARD ,  MORGAN BRADLEY P ,  MORGANS DAVID J JR

Inventor： COLLIBEE SCOTT ,  BERGNES GUSTAVE ,  HAMILTON MATTHEW RICHARD ,  MORGAN BRADLEY P ,  MORGANS DAVID J JR

IPC: A61K31/4245

CPC classification number: C07D211/82

Abstract: Compounds useful for treating cellular proliferative diseases are disclosed.

Abstract translation: 公开了用于治疗细胞增殖性疾病的化合物。

公开(公告)号：WO2005035514A2

公开(公告)日：2005-04-21

申请号：PCT/US2004033367

申请日：2004-10-08

Applicant: VERTEX PHARMA ,  HADIDA RUAH SARA S ,  SINGH ASHVANI K ,  MILLER MARK T ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

Inventor： HADIDA RUAH SARA S ,  SINGH ASHVANI K ,  MILLER MARK T ,  HAMILTON MATTHEW ,  GROOTENHUIS PETER D J

IPC: A61K31/00 ,  A61K31/335 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/495 ,  A61K45/06 ,  C07C233/11 ,  C07C233/22 ,  C07C233/60 ,  C07C233/65 ,  C07C233/73 ,  C07C235/34 ,  C07C235/46 ,  C07C235/48 ,  C07C307/00 ,  C07C311/16 ,  C07C311/17 ,  C07C323/60 ,  C07D209/42 ,  C07D213/82 ,  C07D215/54 ,  C07D215/56 ,  C07D217/26 ,  C07D231/14 ,  C07D231/56 ,  C07D237/28 ,  C07D261/20 ,  C07D307/68 ,  C07D307/85 ,  C07D307/87 ,  C07D333/32 ,  C07D333/70 ,  C07D407/12 ,  C07D307/00

CPC classification number: C07D307/87 ,  A61K31/00 ,  A61K31/335 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61K31/495 ,  A61K45/06 ,  C07C233/22 ,  C07C233/60 ,  C07C233/65 ,  C07C233/73 ,  C07C235/34 ,  C07C235/46 ,  C07C235/48 ,  C07C311/16 ,  C07C311/17 ,  C07C323/60 ,  C07C2601/08 ,  C07D209/42 ,  C07D213/82 ,  C07D215/54 ,  C07D217/26 ,  C07D231/14 ,  C07D231/56 ,  C07D237/28 ,  C07D261/20 ,  C07D307/68 ,  C07D307/85 ,  C07D333/32 ,  C07D333/70 ,  C07D407/12

Abstract: The present invention provides compounds of Formula (I) useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein R , n, B, R , R , R , A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula (I), useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.

Abstract translation: 本发明提供可用作ABC转运蛋白活性调节剂的式（I）化合物或其药学上可接受的盐，其中R b，n，B，R c，R d，R e， A和Z一般在下面的类和子类中进行描述。 本发明还提供与式（I）相关的药物组合物，方法和试剂盒，其可用作调节剂，以及用于治疗与ABC转运蛋白相关的疾病和疾病状况。