摘要:
The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要:
The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and condition associated with abnormal deposition of A-beta protein.
摘要:
Disclosed are compounds of the formula: (I) where variables Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
摘要:
Disclosed.are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (I) wherein the variables R 1 , R 2 , R 3 , R 4 , R 5 , X 1 , and X 2 are defined herein.
摘要:
The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a colletion of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要:
The invention relates to a combination of a decoder and a portable object with a chip (30'). The decoder comprises: a. a functional block with a printed circuit (56) on which integrated circuits (51) are fixed, an element (53), forming a guide cavity (50) into which a first key can be introduced, which then comes into contact with read/write contact pads (54), projecting on one face of the printed circuit (56), b. two half shells, for the housing (55, 55'), which combine to house said functional block, one of the half shells comprising two transverse protective screens (52, 52'), facing the guide cavity (50). The portable object with a chip is in the form of a second key (30'), used as a replacement for the first key and which can be obtained by detaching a pre-cut formed in an ISO format chipcard, called ID-1, said second key (30') being wider and thinner than the first key. Contact strips (22) on said second key (30') contact with the read/write contact pads (54) by guiding the second key using the two protective screens (52; 52') in one of said half shells (55') and the upper edges of said cavity, without which said second key (30') would enter said cavity (50).
摘要:
Disclosed are compounds of the formula (I) and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, R N , and R C are defined herein. These compounds interact with and inhibit the activity of the enzyme beta- secretase. These compounds are therefore useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions and methods of treatment of these diseases are also disclosed.
摘要翻译:公开了式(I)化合物及其药学上可接受的盐,其中变量G,L,A,W,E,R2,R3,R4,R5,Rb,N, > C sb>在此定义。 这些化合物相互作用并抑制β-分泌酶的活性。 因此,这些化合物可用于治疗阿尔茨海默病和其他类似疾病。 还公开了治疗这些疾病的药物组合物和方法。
摘要:
A method and apparatus relating to a receiver/decoder (2000) in a digital television environment, including logical devices (6000, 6002) (including logical demultiplexer devices) for representing physical (6012) and other devices in the receiver/decoder. The method includes the instantiation (6016, 6018) of devices by the receiver/decoder as required to support functionality thereof. The method further includes the use of multiple demultiplexers/remultiplexers, for example in the recording of more than one service simultaneously; and a control word device for the management of control word operations; the use of two or more tuners. Various elements of a digital television system (such as a receiver/decoder and a set top box) are also disclosed.
摘要:
The invention relates to novel aminoalkanol derivatives and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要:
A method for securing a portable security module for use with a decoding element, the portable security module and the decoding element allowing to descramble scrambled audiovisual information. The method comprises analyzing at the portable security module a sequence of command messages, the command messages of the sequence being received at the portable security module at distinct times.