摘要:
The present invention provides a microfluidic device. The microfluidic device comprises a first fluidic compartment(10) and a second fluidic compartment (11). The microfluidic device furthermore comprises at least one micromechanical actuator element (14) for, when in use, forcing a sample fluid to flow from the first fluidic compartment (10) into the second fluidic compartment (11).
摘要:
L'invention concerne un dispositif microfluidique comprenant au moins une première plaque (112) formant le substrat et présentant au moins une perforation (113) et, de chaque côté de cette première plaque (112), en au moins plusieurs emplacements, un matériau apte à délimiter des portions de canaux, ledit matériau étant formé, en au moins un de ces emplacements, d'un matériau activable (114, 116) pouvant faire varier son volume par activation, ledit matériau étant agencé auxdits emplacements selon une disposition qui permet, lors d'une première phase et par activation d'au moins un emplacement constitué dudit matériau activable, la transformation depuis une première configuration vers une deuxième configuration, ce par quoi est modifié un réseau tridimensionnel qui correspond, dans la deuxième configuration et selon le choix du ou des emplacements qui sont activés dans ladite première phase, à différents parcours de liquide présentant plusieurs portions de canaux (117, 119) parallèles au plan de la première plaque (112), situées dans des plans décalés, au moins de chaque côté de cette première plaque (11), et entre lesquelles se situe au moins une desdites perforations (113).
摘要:
A microfluidic device (10) has a fluid channel (20) and a blocker (22), removable by heating, occluding the fluid channel (20). The device (10) may have a substrate (14) and a cover (12) covering the substrate. The cover (12) may have a groove, formed by heating the cover (12) with a die biased against the cover (12), forming the fluid channel (20). A section of the cover (12) may be heated and deformed to block the channel (20). A heating element (30) may be formed on the substrate (14) for heating the blocker (22) or the section of the cover (12) to be deformed. The device may have interconnected fluid channels (20) and gates or valves, which may include such a blocker (22) removable by heating, for directing fluid flow through the fluid channels.
摘要:
The invention relates to a testing system comprising a fluid container (10) and an optical system (30) for the investigation of fluid samples. The fluid container (10) is provided with microchannels (13, 14) that contain and guide sample fluid. Active elements (1), particularly consisting of a hydrogel mixed with a light absorbing dye, are disposed in said microchannels. The active elements can be transferred from a non-activated state to an activated state with a different shape by a laser beam (35). This can be used to design micro valves and/or pumps. The laser beam (35) is preferably generated by an optical system (30) that is derived from the reading/writing unit of a Compact Disc player.
摘要:
A system and method for dispensing pico-liter amounts of fluid through a mechanical nozzle using a magnetostrictive device that changes dimensions under an applied magnetic field. This device, with the possible help of a bias magnet, can be used to open and close the end of a fluid dispensing nozzle. An X-Y positioner can position a slide beneath the nozzle to produce a micro-array of fluid spots. The magnetostrictive nozzle can dispense fluid quantities as low as 50 pico-liters and operate at a rate of up to 10 kHz.
摘要:
Methods and devices for thermal processing of multiple samples at the same time are disclosed. The assemblies include carriers and sample processing devices with process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas. The carriers may be used to apply selective compression to the sample processing devices.
摘要:
Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.
摘要:
Provided herein are methods and devices for controlled metering of a volume of fluid into a bioreactor chamber by use of a thermally-activated actuator that provides simultaneous temperature control and fluidic valve capability. The device may be an elastomeric valve assembly comprising: a thermally-activated actuator, a microfluidic cartridge and an elastomeric membrane operably connected to the thermally-activated actuator. Upon thermal activation of the thermally-activated actuator the elastomeric contact surface is forced into a lumen of the conduit of the microfluidic cartridge to fluidically seal the conduit, while the thermally-activated actuator is in thermal contact with a bioreactor chamber.
摘要:
Die Vorrichtung dient zum Steuern von Fluidströmen in Lab-on-a-Chip-Systemen. Sie weist ein Array von Ventilen auf, welche in n Spalten S n und m Zeilen Z m angeordnet sind und jeweils ausgelegt sind, einen Fluidstrom in einem zugehörigen Durchflusskanal (4) zu steuern. Das Array umfasst mindestens zwei Ventile, wobei jede Spalte S n höchstens ein Ventil und jede Zeile Z m zwischen Null und n Ventilen aufweist. Eine Einrichtung (13) zum Betätigen der Ventile ist vorgesehen. Die Ventile werden über eine Druckkraft betätigt. Zum Herstellen der Vorrichtung werden die Durchflusskanäle (4) entsprechend der Anordnung der Ventile angeordnet.