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公开(公告)号：US08597590B2
公开(公告)日：2013-12-03
申请号：US12789363
申请日：2010-05-27
Applicant: Min Yue , David M. Liu , Joy Roy , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John R. Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Maryam Shariati , Umberto Ulmanella
Inventor： Min Yue , David M. Liu , Joy Roy , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John R. Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Maryam Shariati , Umberto Ulmanella
IPC: G01N21/75
CPC classification number: C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统，其中所述基底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测相容和测定相容的材料构成。
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公开(公告)号：US20110020179A1
公开(公告)日：2011-01-27
申请号：US12789363
申请日：2010-05-27
Applicant: Min Yue , David M. Liu , Yuh-Min Chiang , Joon-Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
Inventor： Min Yue , David M. Liu , Yuh-Min Chiang , Joon-Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
IPC: G01N33/00
CPC classification number: C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统，其中所述基底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测相容和测定相容的材料构成。
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3.发明申请公开(公告)号：US20090136849A1
公开(公告)日：2009-05-28
申请号：US11921205
申请日：2006-03-29
Applicant: Min Yue , Wanhong Zhang
Inventor： Min Yue , Wanhong Zhang
CPC classification number: H01M4/587 , H01M4/1393 , H01M10/0525 , Y02E60/122
Abstract: A composite carbon material of negative electrode in lithium ion, which is made of composite graphite, includes a spherical graphite and a cover layer, wherein the cover layer is pyrolytic carbon of organic substance. Inserted transition metal elements are contained between layers of graphite crystal. Preparation of the negative electrode includes the steps of: crushing graphite, shaping to form a spherical shape, purifying treatment, washing, dewatering and drying, dipped in salt solution doped by transition metal in multivalence, mixed with organic matter, covering treatment, and carbonizing treatment or graphitization treatment. The negative electrode provides advantages of reversible specific capacity larger than 350 mAh/g, coulomb efficiency higher than 94% at first cycle, conservation rate for capacity larger than 8-% in 500 times of circulation.
Abstract translation: 由复合石墨制成的锂离子负极复合碳材料包括球形石墨和覆盖层，其中覆盖层是有机物质的热解碳。 嵌入的过渡金属元素包含在石墨晶体层之间。 负极的制备包括以下步骤：粉碎石墨，成形为球形，净化处理，洗涤，脱水和干燥，浸渍在多价掺杂过渡金属的盐溶液中，与有机物混合，覆盖处理和碳化 治疗或石墨化治疗。 负极提供可逆比容量大于350 mAh / g的优点，库仑效率在第一次循环时高于94％，在循环500次时容量大于8％的保存率。
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公开(公告)号：US20080278731A1
公开(公告)日：2008-11-13
申请号：US12044321
申请日：2008-03-07
Applicant: Arun Majumdar , Srinath Satyanarayana , Min Yue
Inventor： Arun Majumdar , Srinath Satyanarayana , Min Yue
CPC classification number: G01N33/54373 , Y10T428/31681 , Y10T428/31692 , Y10T428/31721 , Y10T428/31855
Abstract: A sensor may include a membrane to deflect in response to a change in surface stress, where a layer on the membrane is to couple one or more probe molecules with the membrane. The membrane may deflect when a target molecule reacts with one or more probe molecules.
Abstract translation: 传感器可以包括响应于表面应力变化而偏转的膜，其中膜上的层将一个或多个探针分子与膜耦合。 当靶分子与一个或多个探针分子反应时，膜可能会偏转。
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公开(公告)号：US07029570B2
公开(公告)日：2006-04-18
申请号：US10699232
申请日：2003-10-31
Applicant: Thomas G. Mason , Min Yue Lin
Inventor： Thomas G. Mason , Min Yue Lin
IPC: C10G31/00
CPC classification number: G01N23/20 , Y10T436/21 , Y10T436/24
Abstract: The thermal decomposition of Athabasca asphaltene at relatively low ( 350° C.) temperatures are attained.
Abstract translation: 据信，相对低（<350℃）的Athabasca沥青质的热分解是通过消除位于沥青质的外围位置上的基团进行的。 在达到升高（> 350℃）温度之前，不会发生更严重的沥青质结构降解。
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Patent Agency Ranking
公开(公告)号：US20110052446A1
公开(公告)日：2011-03-03
申请号：US12872997
申请日：2010-08-31
Applicant: Kirk HIRANO , Mark ANDERSEN , Jian GONG , Sam WOO , David COX , Joon Mo YANG , Min YUE , Maryam SHARIATI , John BRIDGHAM , David LIU
Inventor： Kirk HIRANO , Mark ANDERSEN , Jian GONG , Sam WOO , David COX , Joon Mo YANG , Min YUE , Maryam SHARIATI , John BRIDGHAM , David LIU
CPC classification number: C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
Abstract: Various flowcell configurations and systems are provided as are methods of making and using same. The flowcells, systems, and methods of use can be useful in carrying out sequencing reactions and next generation sequencing methods.
Abstract translation: 提供了各种流通池配置和系统，其制造和使用方法也是如此。 流动池，系统和使用方法可用于进行测序反应和下一代测序方法。
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7.发明授权公开(公告)号：US08993170B2
公开(公告)日：2015-03-31
申请号：US11921205
申请日：2006-03-29
Applicant: Min Yue , Wanhong Zhang
Inventor： Min Yue , Wanhong Zhang
IPC: H01M4/133 , H01M4/1393 , H01M4/583 , H01M10/0525 , B05D3/02 , B05D5/12 , C01B31/04 , C09C1/46 , H01M4/587
CPC classification number: H01M4/587 , H01M4/1393 , H01M10/0525 , Y02E60/122
Abstract: A composite carbon material of negative electrode in lithium ion, which is made of composite graphite, includes a spherical graphite and a cover layer, wherein the cover layer is pyrolytic carbon of organic substance. Inserted transition metal elements are contained between layers of graphite crystal. Preparation of the negative electrode includes the steps of: crushing graphite, shaping to form a spherical shape, purifying treatment, washing, dewatering and drying, dipped in salt solution doped by transition metal in multivalence, mixed with organic matter, covering treatment, and carbonizing treatment or graphitization treatment. The negative electrode provides advantages of reversible specific capacity larger than 350 mAh/g, coulomb efficiency higher than 94% at first cycle, conservation rate for capacity larger than 8-% in 500 times of circulation.
Abstract translation: 由复合石墨制成的锂离子负极复合碳材料包括球形石墨和覆盖层，其中覆盖层是有机物质的热解碳。 嵌入的过渡金属元素包含在石墨晶体层之间。 负极的制备包括以下步骤：粉碎石墨，成形为球形，净化处理，洗涤，脱水和干燥，浸渍在多价掺杂过渡金属的盐溶液中，与有机物混合，覆盖处理和碳化 治疗或石墨化治疗。 负极提供可逆比容量大于350 mAh / g的优点，库仑效率在第一次循环时高于94％，在循环500次时容量大于8％的保存率。
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公开(公告)号：US07344678B2
公开(公告)日：2008-03-18
申请号：US10420661
申请日：2003-04-21
Applicant: Arun Majumdar , Srinath Satyanarayana , Min Yue
Inventor： Arun Majumdar , Srinath Satyanarayana , Min Yue
IPC: B32B5/02
CPC classification number: G01N33/54373 , Y10T428/31681 , Y10T428/31692 , Y10T428/31721 , Y10T428/31855
Abstract: A sensor may include a membrane to deflect in response to a change in surface stress, where a layer on the membrane is to couple one or more probe molecules with the membrane. The membrane may deflect when a target molecule reacts with one or more probe molecules.
Abstract translation: 传感器可以包括响应于表面应力变化而偏转的膜，其中膜上的层将一个或多个探针分子与膜耦合。 当靶分子与一个或多个探针分子反应时，膜可能会偏转。
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9.发明申请Devices and Methods for Controlling Bubble Formation in Microfluidic Devices 审中-公开用于控制微流控装置中气泡形成的装置和方法公开(公告)号：US20070280856A1
公开(公告)日：2007-12-06
申请号：US11422057
申请日：2006-06-02
Applicant: Umberto Ulmanella , Eric S. Nordman , Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Min Yue , Carol Schembri , David Liu
Inventor： Umberto Ulmanella , Eric S. Nordman , Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Min Yue , Carol Schembri , David Liu
IPC: B01L3/02
CPC classification number: B01L3/502746 , B01L3/502723 , B01L3/502784 , B01L2200/0642 , B01L2200/0673 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B01L2400/086
Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers. At least some of the sample chambers may include a dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.
Abstract translation: 微流体装置可以包括样品分配网络，其包括多个样品室，其被配置为装载用于生物样品的生物样品的生物样品，而在样品室中，生物样品具有在加载期间在样品室内移动的弯液面。 样品分配网络还可以包括多个入口通道，每个入口通道与生物样品流动连通并配置成将生物样品流动到相应的样品室，以及多个出口通道，每个出口通道流动连通并且被配置为 从相应的样品室流动生物样品。 至少一些样品室可以包括物理修改，其被配置为控制弯液面的运动，以便控制至少一些样品室内的气泡形成。 至少一些样品室可以包括位于与至少一些样品室流动连通的入口通道附近的至少一些样品室内的干燥试剂。
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公开(公告)号：US20070014695A1
公开(公告)日：2007-01-18
申请号：US11380327
申请日：2006-04-26
Applicant: Min Yue , David Liu , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles Vann , Nigel Beard , Ian Harding , John Van Camp , Alexander Dromaretsky , Sergey Ermakov , Mark Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
Inventor： Min Yue , David Liu , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles Vann , Nigel Beard , Ian Harding , John Van Camp , Alexander Dromaretsky , Sergey Ermakov , Mark Oldham , Joy Roy , Maryam Shariati , Umberto Ulmanella
IPC: B01L3/00
CPC classification number: C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统，其中所述基底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品从每个样品室流出。 底物可以由检测相容和测定相容的材料构成。
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