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1.发明申请Plastic microfabricated structure for biochip, microfabricated thermal device, microfabricated reactor, microfabricated reactor array, and micro array using the same 有权用于生物芯片，微制造热装置，微制造反应堆，微制造反应堆阵列和使用其的微阵列的塑料微制造结构公开(公告)号：US20050139993A1
公开(公告)日：2005-06-30
申请号：US10899177
申请日：2004-07-27
IPC分类号： H01L23/02 , B01J19/00 , B01L3/00 , C40B60/14 , H01L23/10 , H01L27/14 , H01L29/06 , H01L29/82 , H01L29/84
CPC分类号： B01J19/0093 , B01J2219/00495 , B01J2219/00605 , B01J2219/0061 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00783 , B01J2219/00804 , B01J2219/00833 , B01J2219/00853 , B01J2219/00858 , B01J2219/00873 , B01J2219/00961 , B01L3/502707 , B01L3/50851 , B01L2200/12 , B01L2200/147 , B01L2300/0819 , B01L2300/12 , B01L2300/1827 , B33Y80/00 , C40B60/14 , G01N27/128
摘要： Provided are a plastic microfabricated structure, and a microfabricated thermal device, a microfabricated reactor, a microfabricated reactor array and a micro array using the same, which may be applied to a bio chip, and the present invention may fabricate the plastic microfabricated structure for providing a heating region by means of insulating plastic, which has a thin thickness, flatness enough to allow a photolithography process to be performed, thermal isolation in its some or total area, and a small thermal mass, and on top of the heating region of the plastic microfabricated structure, a heater, a temperature sensor for sensing a temperature, an electrode, and an electrode pad are formed to thereby fabricate the microfabricated heating device, whereby element may be readily fabricated at a low cost, and the heating region is formed of a plastic thin layer, so that uniform temperature control is possible even with a low power, and various samples may be thermally treated at a fast speed to obtain their reaction and analysis.
摘要翻译： 本发明提供一种塑料微制造结构，微制造热装置，微制造反应器，微制造反应器阵列和使用其的微阵列，其可以应用于生物芯片，并且本发明可以制造塑料微制造结构以提供 通过绝缘塑料的加热区域，其具有薄的厚度，足够的平坦度，以允许执行光刻工艺，其一些或总面积的热隔离和小的热质量，以及在 形成塑料微加工结构，加热器，用于感测温度的温度传感器，电极和电极焊盘，从而制造微制造加热装置，从而可以以低成本容易地制造元件，并且加热区域由 塑料薄层，使得即使在低功率下也能进行均匀的温度控制，并且各种样品可以在fa处进行热处理 速度获得反应和分析。
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公开(公告)号：US20050142036A1
公开(公告)日：2005-06-30
申请号：US10899143
申请日：2004-07-27
CPC分类号： B01L3/502707 , B01J2219/00286 , B01J2219/00389 , B01J2219/00495 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00869 , B01J2219/00873 , B01L7/00 , B01L2300/1827 , C40B60/14 , H05B3/26 , H05B2203/003 , H05B2203/013 , H05B2203/017
摘要： Provided is a micro-fluidic heating system, which comprises a micro-fluidic control element for providing a chamber, a flow path and a valve, and a main body for heating the inside of the chamber in contact with the micro-fluidic control element, wherein the micro-fluidic control element consists of an upper substrate for providing the chamber, the flow path and the valve, and a lower substrate as a thin film bonded to the upper substrate, and the main body consists of a membrane in which heating means and suction holes are formed, and support member for supporting the membrane, and the heating means is partially in contact with the lower substrate of the chamber to heat the inside of the chamber, so that thermal transfer efficiency becomes maximized and temperature of each chamber may be independently controlled in the case of configuration having chambers arranged in array.
摘要翻译： 提供了一种微流体加热系统，其包括用于提供腔室，流路和阀门的微流控制元件和用于加热与微流控制元件接触的腔室内部的主体， 其特征在于，所述微流体控制元件由用于提供所述室，所述流路和所述阀的上基板以及与所述上基板接合的薄膜的下基板构成，所述主体由膜构成，加热单元 并且形成吸入孔，并且用于支撑膜的支撑构件，并且加热装置部分地与室的下基板接触以加热室的内部，使得热传递效率变得最大，并且每个室的温度可以 在配置有排列成阵列的腔室的情况下，可独立控制。
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公开(公告)号：US20050133101A1
公开(公告)日：2005-06-23
申请号：US10898964
申请日：2004-07-27
CPC分类号： B01F13/0086 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0622 , B01L2400/0688 , B33Y70/00 , B33Y80/00 , Y10T137/2082 , Y10T137/2224
摘要： Provided is a microfluidic control device and method for controlling the microfluid, and a fine amount of fluid is controlled even with natural fluid flow and solution injection, wherein a pressure barrier of a capillary is removed by a surface tension change resulted from the solution injection to thereby obtain transport, interflow, mixing, and time delay of the microfluid, and to detail this, solution is injected to meet the boundary surface of the stopped fluid when the fluid is stopped by the stop valve, so that a function of the stop valve is removed to obtain the transport, interflow, and mixing of the fluid, and the method for controlling the microfluid may be applied to the microfluidic control device for biochemical reaction, and it uses only the capillary force change resulted from solution injection to thereby have its structure simplified.
摘要翻译： 提供了一种用于控制微流体的微流控制装置和方法，并且即使使用天然流体流动和溶液注入也能控制微量的流体，其中毛细管的压力屏障由于溶液注入导致的表面张力变化而被去除 从而获得微流体的运输，流动，混合和时间延迟，并且为了详细说明，当流体被截止阀停止时，溶液被注入以满足停止的流体的边界表面，使得截止阀 被移除以获得流体的输送，流动和混合，并且用于控制微流体的方法可以应用于用于生物化学反应的微流控制装置，并且其仅使用由溶液注入引起的毛细管力变化，从而使其 结构简化。
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公开(公告)号：US20070275394A1
公开(公告)日：2007-11-29
申请号：US11634437
申请日：2006-12-06
申请人： Dong Shin , Moon Jung , Se Park , Hyeon Pyo , Chang Choi
发明人： Dong Shin , Moon Jung , Se Park , Hyeon Pyo , Chang Choi
CPC分类号： C12Q1/6825 , B82B1/001 , C12Q2565/133 , C12Q2563/137
摘要： Provided are a nucleic acid nanostructure including: a substrate; a nucleic acid quadruplex immobilized on the substrate to be vertical with respect to the substrate; a metal ion present in a unit lattice of the nucleic acid quadruplex, the unit lattice being made up of eight nucleobases; and a nanoparticle bound to an end of the nucleic acid quadruplex, and a method of manufacturing the same. According to the method, a nucleic acid nanostructure having an array of nanoparticles can be manufactured. The nucleic acid nanostructure can be applied as a sensor nanostructure for sensors such as gas sensors, chemical sensors, and biosensors. In particular, a nucleic acid nanostructure in which metal nanoparticles, e.g., gold or silver, are introduced can be useful as a device having local surface plasmon characteristics.
摘要翻译： 提供的核酸纳米结构包括：底物; 固定在所述基板上的相对于所述基板垂直的核酸四重链; 存在于核酸四联体的单位晶格中的金属离子，单位晶格由八个核碱基组成; 和结合到核酸四链体末端的纳米颗粒及其制造方法。 根据该方法，可以制造具有纳米颗粒阵列的核酸纳米结构。 核酸纳米结构可用作传感器的传感器纳米结构，如气体传感器，化学传感器和生物传感器。 特别地，其中引入金属纳米颗粒例如金或银的核酸纳米结构可用作具有局部表面等离子体特征的器件。
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公开(公告)号：US20050142872A1
公开(公告)日：2005-06-30
申请号：US11026572
申请日：2004-12-30
申请人： Se Park
发明人： Se Park
IPC分类号： H01L21/027 , H01L21/44 , H01L21/768
CPC分类号： H01L21/76802
摘要： An object of the present invention is to provide a method that is capable of forming easily a fine pattern corresponding to a high integration density device, without using a new exposure apparatus. The object of the present invention as noted above is accomplished by etching a second insulating layer to expose a portion of an underlying first insulating layer; forming a third insulating layer on the entire surface of the substrate; etching the third insulating layer and the first insulating layer using the second insulating layer as an etch barrier, to define a pattern region; forming a material layer on the entire surface of the substrate so as to fill the pattern region; and planarizing the material layer and/or substrate so as to expose the first insulating layer, to form a pattern.
摘要翻译： 本发明的目的是提供一种能够容易地形成与高集成度密度装置相对应的精细图案的方法，而不使用新的曝光装置。 如上所述的本发明的目的是通过蚀刻第二绝缘层以暴露下面的第一绝缘层的一部分来实现; 在所述基板的整个表面上形成第三绝缘层; 使用第二绝缘层作为蚀刻阻挡层蚀刻第三绝缘层和第一绝缘层，以限定图案区域; 在基板的整个表面上形成材料层以填充图案区域; 并且平坦化材料层和/或衬底以露出第一绝缘层，以形成图案。
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6.发明申请Biomolecule detection device, mobile phone for biomolecule detection, and biomolecule detection method 失效生物分子检测装置，生物分子检测手机和生物分子检测方法公开(公告)号：US20070131552A1
公开(公告)日：2007-06-14
申请号：US11634710
申请日：2006-12-06
CPC分类号： G01N27/44704 , A61B5/0002 , G01N33/5438 , G01N33/544 , G01N33/548
摘要： Provided are a biomolecule detection device, a mobile phone for biomolecule detection, and a biomolecule detection method. The biomolecule detection device includes an electrophoresis unit comprising an electrophoretic gel filtering erythrocytes and leukocytes in blood and transferring proteins and DNAs in the blood, and at least one type of a probe biomolecule, immobilized in the electrophoretic gel, reacting with a target biomolecule; a conversion unit converting a result of a reaction between the target biomolecule and the probe biomolecule to an electrical signal; and a lead-out unit receiving, converting, and transmitting the electrical signal.
摘要翻译： 提供了生物分子检测装置，用于生物分子检测的移动电话和生物分子检测方法。 生物分子检测装置包括电泳单元，其包含在血液中过滤红细胞和白细胞并在血液中转移蛋白质和DNA的电泳凝胶，以及固定在电泳凝胶中的至少一种类型的探针生物分子，与目标生物分子反应; 转换单元，将目标生物分子与探针生物分子之间的反应结果转换为电信号; 以及接收，转换和发送电信号的引出单元。
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7.发明申请Plasma apparatus and apparatus for fabricating optical fiber preform by using the same 审中-公开用于制造光纤预制棒的等离子体装置和装置公开(公告)号：US20060196230A1
公开(公告)日：2006-09-07
申请号：US11244664
申请日：2005-10-06
申请人： Se Park , Jin-Haing Kim , Jin-Han Kim , Mun-Hyun Do
发明人： Se Park , Jin-Haing Kim , Jin-Han Kim , Mun-Hyun Do
IPC分类号： C03B37/018
CPC分类号： H01J37/32541 , C03B37/01426 , H05H1/46
摘要： A plasma apparatus is disclosed. The plasma apparatus includes an internal electrode having a hollow section for receiving precursor gas and oxygen gas therein, an external electrode accommodating the internal electrode therein while forming a gap therebetween in such a manner that inert gas and oxygen gas are introduced into the gap. The plasma apparatus also includes a power source for applying a DC voltage or a radio frequency (RF) AC voltage to the internal and external electrodes in order to generate plasma between the internal and external electrodes.
摘要翻译： 公开了一种等离子体装置。 等离子体装置包括内部电极，其具有用于接收前体气体和氧气的中空部分，外部电极容纳内部电极，同时在惰性气体和氧气引入到间隙中形成间隙。 等离子体装置还包括用于向内部和外部电极施加直流电压或射频（RF）AC电压以在内部和外部电极之间产生等离子体的电源。
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8.发明申请Programmable mask and method of fabricating biomolecule array using the same 失效可编程掩模和使用其制造生物分子阵列的方法公开(公告)号：US20060030030A1
公开(公告)日：2006-02-09
申请号：US11100544
申请日：2005-04-07
CPC分类号： G03F7/70291 , G02F1/1393 , G03F7/70566
摘要： The present invention relates to a programmable mask used in a photolithography process for fabricating a biomolecule array and a method of fabricating a biomolecule array using the same and, more particularly, to a programmable mask which can increase a contrast ratio of transmittance versus shielding of light incident to a liquid crystal which constitutes each pixel by irradiating parallel ultraviolet (“UV”) light generated from an external parallel light exposure device to a certain cell and using a vertically aligned liquid crystal panel or an LC panel having no spacer, and a method of fabricating a biomolecule array using the same.
摘要翻译： 本发明涉及用于制造生物分子阵列的光刻工艺中使用的可编程掩模，以及使用该可编程掩模制造生物分子阵列的方法，更具体地说，涉及一种可增加透射率对光屏蔽对比度的可编程掩模 通过将从外部平行曝光装置产生的平行紫外线（“UV”）光照射到某个单元并使用垂直取向的液晶面板或不具有间隔物的LC面板，对构成每个像素的液晶进行入射;以及方法 制造使用其的生物分子阵列。
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公开(公告)号：US20060014937A1
公开(公告)日：2006-01-19
申请号：US11100553
申请日：2005-04-07
申请人： Heui Kang , Byung Lee , Se Park , Moo Song , Tae Yoo , Jae Lee , Chang Kim , Sang Park , Kang Na
发明人： Heui Kang , Byung Lee , Se Park , Moo Song , Tae Yoo , Jae Lee , Chang Kim , Sang Park , Kang Na
CPC分类号： C07K16/082 , C07K2317/24
摘要： A humanized antibody of the present invention shows similar antigen-binding affinity to a mouse monoclonal antibody and significantly low immunogenecity. Therefore, the humanized antibody of the present invention can be effectively used for treating chronic hepatitis B and preventing HBV infection of a patient received liver transplantation and vertical transmission from a mother infected with HBV to a fetus.
摘要翻译： 本发明的人源化抗体对小鼠单克隆抗体显示出类似的抗原结合亲和力，并且显着低的免疫原性。 因此，本发明的人源化抗体可以有效地用于治疗慢性乙型肝炎并预防接受肝移植的患者和从感染HBV的母亲到胎儿的垂直传播的HBV感染。
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10.发明申请Method for fabricating a multimode optical fiber preform having longitudinal uniformity 审中-公开制造具有纵向均匀性的多模光纤预制件的方法公开(公告)号：US20060185398A1
公开(公告)日：2006-08-24
申请号：US11348390
申请日：2006-02-06
申请人： Jin-Haing Kim , Se Park , Mun-Hyun Do
发明人： Jin-Haing Kim , Se Park , Mun-Hyun Do
IPC分类号： C03B37/07 , C03B37/018
CPC分类号： C03B37/01807 , C03B2201/31 , C03B2203/26 , C03B2207/70
摘要： A method for fabricating a multimode optical fiber preform having a longitudinal uniformity is provided. The method of fabricating includes performing a plurality of radial deposition passes using a thermal source while inserting raw materials into a glass tube. A reference chemical core shape index is set to determine a refractive index profile of a preform section. A core shape index distribution of each longitudinal deposition pass varying in a longitudinal direction of the glass tube is set such that an error of a reference chemical core shape index distribution in the longitudinal direction of the preform defined by the reference chemical core shape index is compensated for and such that a uniform chemical core shape index is obtained in the longitudinal direction. Deposition is performed while an amount of raw materials corresponding to a preset chemical core shape index is inserted in each longitudinal deposition pass of each radial deposition pass.
摘要翻译： 提供了一种制造具有纵向均匀性的多模光纤预制件的方法。 制造方法包括在将原材料插入玻璃管中时使用热源进行多个径向沉积通道。 设定参考化学品核心形状指数以确定预制件部分的折射率分布。 设定在玻璃管的长度方向上变化的各纵向沉积通路的芯形指数分布，使得由参考化学核心形状指数所限定的预成型件在长度方向上的基准化学品核心形状指数分布的误差被补偿 并且使得在纵向方向上获得均匀的化学核心形状指数。 在每个径向沉积通道的每个纵向沉积通道中插入对应于预设化学核心形状指数的原料的量的沉积。
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