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公开(公告)号：US12195754B2
公开(公告)日：2025-01-14
申请号：US17235910
申请日：2021-04-20
Inventor： Ruei-Yue Liang , Kai-Ling Zhang , Ming-Hsi Chuang , Po-Cheng Lin , Chun-Hung Chen , Pei-Syuan Chao
Abstract: The present invention relates to a cell differentiation medium composition, a high secretion insulin-producing cells and a preparation method thereof. The high secretion insulin-producing cells obtained by using the cell differentiation medium composition to induce stem cell differentiated under specific conditions can secrete a large amount of insulin in a short time, and when the high-secreting insulin-producing cells are transplanted into the human body, they are not easy to be swallowed by macrophages, which can improve the survival rate of the insulin-producing cells and prolong the time of insulin secretion thereby.
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2.发明公开公开(公告)号：US20230201266A1
公开(公告)日：2023-06-29
申请号：US17470487
申请日：2021-09-09
Inventor： Feng-Huei Lin , Che-Yung Kuan , Yu-Ying Lin , Ching-Yun Chen , Zhi-Yu Chen , I-Hsuan Yang , Ming-Hsi Chuang , Po-Cheng Lin , Chia-Hsin Lee , Kai-Ling Zhang , Pei-Syuan Chao , Wan-Sin Syu , Chun-Hung Chen , Ting-Ju Wang
IPC: A61K35/28 , A61P19/02 , C12N5/0775 , C12N5/00
CPC classification number: A61K35/28 , A61P19/02 , C12N5/0062 , C12N5/0667 , C12N2513/00 , C12N2533/30
Abstract: The present disclosure provides a method for treating arthritis by using a stem cell preparation. The stem cell preparation of the present disclosure can effectively delay cartilage degeneration caused by arthritis, and it is confirmed by whole blood analysis and blood biochemical analysis that the stem cell preparation in the form of three-dimensional stem cell spheres provides a safe treatment for arthritis. The present disclosure also provides a method for preparing the stem cell preparation.
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公开(公告)号：US20230193198A1
公开(公告)日：2023-06-22
申请号：US18066999
申请日：2022-12-15
Inventor： Ming-Hsi Chuang , Po-Cheng Lin , Chia-Hsin Lee , Mao-Hsuan Huang
IPC: C12N5/074
CPC classification number: C12N5/0607 , C12N2533/74 , C12N2500/98 , C12N2500/12 , C12N2500/32 , C12N2523/00
Abstract: A method for stably amplifying a pluripotent stem cell comprises the following steps: (a) a cell implantation step: implanting pluripotent stem cells directly into a porous scaffold such that the porous scaffold contains 1×104 or more of the pluripotent stem cells; and (b) a cell amplification step: immersing the porous scaffold in a specific culture medium which is xeno-free (XF) and performing amplification culture at an ambient temperature of 35.5-39.5° C. and a CO2 concentration of 5% to obtain the amplified pluripotent stem cells, wherein the amplified pluripotent stem cells aggregate to present an embryoid body state. The amplification method of the present disclosure can easily obtain an excellent effect of increasing an amplification multiple of the pluripotent stem cells to about 3 times or more.
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公开(公告)号：US20150274923A1
公开(公告)日：2015-10-01
申请号：US14632730
申请日：2015-02-26
Inventor： Jui-Yang Lai , Kao-Yuan Chang , Zih-Han Hong , Po-Cheng Lin , Ming-Hsi Chuang
CPC classification number: C08J9/36 , A61K9/5031 , A61K35/28 , A61K35/35 , A61L27/16 , A61L27/18 , A61L27/22 , A61L27/50 , A61L27/56 , A61L27/58 , A61L2300/222 , A61L2300/236 , A61L2300/25 , A61L2300/252 , A61L2300/64 , A61L2430/28 , C08J2207/10 , C08J2367/04 , C08J2405/08 , C08L67/04 , C08L29/04
Abstract: A method for manufacturing a hollow particle is provided. The method comprises the steps of (a) providing a hollow particulate; (b) soaking the hollow particulate in an amine solution to form amine groups on the surface of the hollow particulate; (c) adding a polypeptide, and the polypeptide is linked to the amine groups on the surface of the hollow particulate; and (d) adding a target molecule, and the target molecule is bound to the amine group which are still not bound.
Abstract translation: 提供一种制造中空颗粒的方法。 该方法包括以下步骤：（a）提供中空颗粒; （b）将中空颗粒浸泡在胺溶液中以在中空颗粒的表面上形成胺基; （c）加入多肽，并且多肽与中空颗粒表面上的胺基连接; 和（d）添加目标分子，并且靶分子与尚未结合的胺基结合。
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公开(公告)号：US20150238534A1
公开(公告)日：2015-08-27
申请号：US14632760
申请日：2015-02-26
Inventor： Jui-Yang Lai , Li-Jyuan Luo , Zih-Han Hong , Kao-Yuan Chang , Po-Cheng Lin , Ming-Hsi Chuang
CPC classification number: C08J9/36 , A61K9/5031 , A61K35/28 , A61K35/35 , A61L27/16 , A61L27/18 , A61L27/22 , A61L27/50 , A61L27/56 , A61L27/58 , A61L2300/222 , A61L2300/236 , A61L2300/25 , A61L2300/252 , A61L2300/64 , A61L2430/28 , C08J2207/10 , C08J2367/04 , C08J2405/08 , C08L67/04 , C08L29/04
Abstract: A hollow particle is provided. The hollow particle of the invention comprises (a) a hollow microparticle, (b) a plural of linking molecules binding the surface of the microparticle, (c) a polypeptide binding the linking molecule, and (d) a target molecule binding the linking molecule. The hollow microparticle of the invention can deliver more cells and provides a higher rate of cell transplantation by the hollow structures, polypeptides and target molecules. The present invention also provides a manufacture of the hollow microparticle and a cell carrier.
Abstract translation: 提供中空颗粒。 本发明的中空颗粒包含（a）中空微粒，（b）多个结合微粒表面的连接分子，（c）与结合分子结合的多肽，和（d）结合连接分子的靶分子 。 本发明的中空微粒可以递送更多的细胞并通过中空结构，多肽和靶分子提供更高的细胞移植速率。 本发明还提供了中空微粒和电池载体的制造。
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Patent Agency Ranking
公开(公告)号：US20150231052A1
公开(公告)日：2015-08-20
申请号：US14321954
申请日：2014-07-02
Inventor： Shinn-Zong LING , Horng-Jyh Harn , Tzyy-Wen Chiou , Po-Cheng Lin
CPC classification number: A61K8/64 , A61F7/02 , A61F2007/0003 , A61F2007/0062 , A61F2007/0088 , A61K8/981 , A61K2800/805 , A61K2800/86 , A61K2800/88 , A61N5/0625 , A61Q7/00 , A61Q19/08
Abstract: A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.
Abstract translation: 提供间充质干细胞提取物及其用途，其中间充质干细胞提取物包括营养因子，如骨形态发生蛋白-7（BMP-7），基质细胞衍生因子-1（SDF-1） ，血管内皮生长因子（VEGF），CXC趋化因子受体4型（CXCR4），脑源性神经营养因子（BDNF）和/或白细胞介素-17（IL-17），其中提取物特别适用于修复皮肤 老化。
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公开(公告)号：US20250092356A1
公开(公告)日：2025-03-20
申请号：US18964649
申请日：2024-12-01
Inventor： Ruei-Yue Liang , Kai-Ling Zhang , Ming-Hsi Chuang , Po-Cheng Lin , Chun-Hung Chen , Pei-Syuan Chao
Abstract: The present invention relates to a cell differentiation medium composition, a high secretion insulin-producing cells and a preparation method thereof. The high secretion insulin-producing cells obtained by using the cell differentiation medium composition to induce stem cell differentiated under specific conditions can secrete a large amount of insulin in a short time, and when the high-secreting insulin-producing cells are transplanted into the human body, they are not easy to be swallowed by macrophages, which can improve the survival rate of the insulin-producing cells and prolong the time of insulin secretion thereby.
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公开(公告)号：US20240117316A1
公开(公告)日：2024-04-11
申请号：US18376566
申请日：2023-10-04
Inventor： Yu-Chen Tsai , Ming-Hsi Chuang , Po-Cheng Lin
IPC: C12N5/0775 , A61K35/28
CPC classification number: C12N5/0665 , A61K35/28
Abstract: The present disclosure provides a method for preparing mesenchymal stem cell-derived extracellular vesicle, the mesenchymal stem cell-derived extracellular vesicle prepared by the method, and use of the mesenchymal stem cell-derived extracellular vesicle for reducing adipogenesis and treating osteoarthritis. The mesenchymal stem cell-derived extracellular vesicle of the present disclosure achieves the effect of reducing adipogenesis and treating osteoarthritis through various efficacy experiments.
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公开(公告)号：US20230233613A1
公开(公告)日：2023-07-27
申请号：US17963219
申请日：2022-10-11
Inventor： Po-Cheng Lin , Pi-Chun Huang , Chia-Hsin Lee , Ming-Hsi Chuang , Chun-Hung Chen , Chao-Liang Chang , Kai-Ling Zhang , Yi-Chun Lin , Yu-Chen Tsai , Peggy Leh Jiunn Wong , Ruei-Yue Liang
IPC: A61K35/28 , A61K9/00 , C12N5/0789
CPC classification number: A61K35/28 , A61K9/0085 , A61K9/0019 , C12N5/0647 , C12N2501/10 , C12N2502/1382 , C12N2501/2304 , C12N2501/2313
Abstract: The present invention provides a pharmaceutical composition for treating chronic stroke, involving injection via brain into the cranium of a patient having chronic stroke for six months or more; the pharmaceutical composition is a suspension at least comprising TS stem cells, an active synergistic component and a growth factor, wherein the expression level of CD34 and CD45 of the TS stem cells is 10% or less, and the expression level of CD90 and CD105 is 90% or more; the active synergistic component is an extracellular vesicle; the growth factor is at least one selected from the group consisting of HGF, G-CSF, Fractalkine, IP-10, EGF, IL-1α, IL-1β, IL-4, IL-5, IL-13, IFNγ, TGFα and sCD40L. The present invention overcomes the limitations of previous cell therapy and provides a cell-based preparation that is clinically safe and therapeutically effective for chronic cerebral stroke.
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公开(公告)号：US20180250216A1
公开(公告)日：2018-09-06
申请号：US15980184
申请日：2018-05-15
Inventor： Shinn-Zong Lin , Horng-Jyh Harn , Tzyy-Wen Chiou , Po-Cheng Lin
CPC classification number: A61K8/64 , A61F7/02 , A61F2007/0003 , A61F2007/0062 , A61F2007/0088 , A61K8/981 , A61K2800/805 , A61K2800/86 , A61K2800/88 , A61N5/0625 , A61Q7/00 , A61Q19/08
Abstract: A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.
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