利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

44 条记录 (耗时 0.022 秒)

    Fabrication of tunneling junction for nanopore DNA sequencing
    2.
    发明授权
    Fabrication of tunneling junction for nanopore DNA sequencing 有权
    纳米孔DNA测序隧道结的制备

    公开(公告)号：US09222930B2

    公开(公告)日：2015-12-29

    申请号：US13971532

    申请日：2013-08-20

    申请人： International Business Machines Corporation

    发明人： Hongbo Peng ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC分类号： H01B13/00 ,  G01N33/487 ,  C12Q1/68 ,  C25D7/12 ,  C23C18/16 ,  C25D5/02 ,  C25D7/00 ,  C25D3/50 ,  C25D21/12 ,  C23C18/42

    CPC分类号： G01N33/48721 ,  C12Q1/6869 ,  C23C18/161 ,  C23C18/1644 ,  C23C18/1675 ,  C23C18/42 ,  C25D3/50 ,  C25D5/02 ,  C25D7/00 ,  C25D7/12 ,  C25D21/12

    摘要： A mechanism is provided for forming a nanodevice. A reservoir is filled with a conductive fluid, and a membrane is formed to separate the reservoir in the nanodevice. The membrane includes an electrode layer having a tunneling junction formed therein. The membrane is formed to have a nanopore formed through one or more other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. The tunneling junction of the electrode layer is narrowed to a narrowed size by electroplating or electroless deposition. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a current signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base.

    摘要翻译： 提供了用于形成纳米器件的机构。 储存器填充有导电流体，并且形成膜以分离纳米装置中的储存器。 膜包括其中形成有隧道结的电极层。 膜形成为具有通过膜的一个或多个其它层形成的纳米孔，使得纳米孔与电极层的隧道结对准。 电极层的隧道结通过电镀或无电沉积而变窄到窄的尺寸。 当向电极层施加电压时，通过在要测量的隧道结中的基底产生隧道电流作为区分基底的当前签名。 当在隧道结的内表面上形成有机涂层时，在电极层和基底之间形成瞬态结合。

    Integrated nanowire/nanosheet nanogap and nanopore for DNA and RNA sequencing
    3.
    发明授权
    Integrated nanowire/nanosheet nanogap and nanopore for DNA and RNA sequencing 有权
    用于DNA和RNA测序的纳米纳米片和纳米孔纳米孔

    公开(公告)号：US08975095B2

    公开(公告)日：2015-03-10

    申请号：US13904403

    申请日：2013-05-29

    申请人： International Business Machines Corporation

    发明人： Shu-Jen Han ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC分类号： H01L21/66 ,  C12Q1/68 ,  G01N27/414 ,  G01N27/447

    CPC分类号： C12Q1/6869 ,  G01N27/4145 ,  G01N27/4146 ,  G01N33/48721 ,  Y10S977/924 ,  C12Q2563/116 ,  C12Q2563/157 ,  C12Q2565/631

    摘要： A technique is provided for base recognition in an integrated device is provided. A target molecule is driven into a nanopore of the integrated device. The integrated device includes a nanowire separated into a left nanowire part and a right nanowire part to form a nanogap in between, a source pad connected to the right nanowire part, a drain pad connected to the left nanowire part, and the nanopore. The source pad, the drain pad, the right nanowire part, the left nanowire part, and the nanogap together form a transistor. The nanogap is part of the nanopore. A transistor current is measured while a single base of the target molecule is in the nanogap of the nanopore, and the single base affects the transistor current. An identity of the single base is determined according to a change in the transistor current.

    摘要翻译： 提供了一种用于集成设备中的基础识别的技术。 靶分子被驱动到集成器件的纳米孔中。 集成器件包括分离成左纳米线部分的纳米线和右纳米线部分，以在其间形成纳米间隙，连接到右纳米线部分的源极焊盘，连接到左纳米线部分的漏极焊盘和纳米孔。 源极焊盘，漏极焊盘，右侧的纳米线部分，左侧的纳米线部分和纳米光栅一起形成晶体管。 纳米孔是纳米孔的一部分。 测量晶体管电流，同时目标分子的单个碱基位于纳米孔的纳米隙中，单个碱基影响晶体管电流。 根据晶体管电流的变化确定单个基极的身份。

    INTEGRATED NANOWIRE/NANOSHEET NANOGAP AND NANOPORE FOR DNA AND RNA SEQUENCING
    5.
    发明申请
    INTEGRATED NANOWIRE/NANOSHEET NANOGAP AND NANOPORE FOR DNA AND RNA SEQUENCING 有权
    综合纳米/纳米NAPNA和纳米级DNA和RNA序列

    公开(公告)号：US20140326604A1

    公开(公告)日：2014-11-06

    申请号：US13904403

    申请日：2013-05-29

    申请人： International Business Machines Corporation

    发明人： Shu-Jen Han ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC分类号： C12Q1/68 ,  G01N27/447

    CPC分类号： C12Q1/6869 ,  G01N27/4145 ,  G01N27/4146 ,  G01N33/48721 ,  Y10S977/924 ,  C12Q2563/116 ,  C12Q2563/157 ,  C12Q2565/631

    摘要： A technique is provided for base recognition in an integrated device is provided. A target molecule is driven into a nanopore of the integrated device. The integrated device includes a nanowire separated into a left nanowire part and a right nanowire part to form a nanogap in between, a source pad connected to the right nanowire part, a drain pad connected to the left nanowire part, and the nanopore. The source pad, the drain pad, the right nanowire part, the left nanowire part, and the nanogap together form a transistor. The nanogap is part of the nanopore. A transistor current is measured while a single base of the target molecule is in the nanogap of the nanopore, and the single base affects the transistor current. An identity of the single base is determined according to a change in the transistor current.

    摘要翻译： 提供了一种用于集成设备中的基础识别的技术。 靶分子被驱动到集成器件的纳米孔中。 集成器件包括分离成左纳米线部分的纳米线和右纳米线部分，以在其间形成纳米间隙，连接到右纳米线部分的源极焊盘，连接到左纳米线部分的漏极焊盘和纳米孔。 源极焊盘，漏极焊盘，右侧的纳米线部分，左侧的纳米线部分和纳米光栅一起形成晶体管。 纳米孔是纳米孔的一部分。 测量晶体管电流，同时目标分子的单个碱基位于纳米孔的纳米隙中，单个碱基影响晶体管电流。 根据晶体管电流的变化确定单个基极的身份。

    Increasing the Capture Zone by Nanostructure Patterns
    8.
    发明申请
    Increasing the Capture Zone by Nanostructure Patterns 审中-公开

    公开(公告)号：US20170234833A1

    公开(公告)日：2017-08-17

    申请号：US15583501

    申请日：2017-05-01

    申请人： International Business Machines Corporation

    发明人： Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

    IPC分类号： G01N27/447 ,  C12Q1/68 ,  G01N33/487

    CPC分类号： G01N27/44791 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N27/403 ,  G01N33/48721

    摘要： Techniques for increasing the capture zone in nano and microchannel-based polymer testing structures using concentric arrangements of nanostructures, such as nanopillars are provided. In one aspect, a testing structure for testing polymers is provided that includes a first fluid reservoir and a second fluid reservoir formed in an electrically insulating substrate; at least one channel formed in the insulating substrate that interconnects the first fluid reservoir and the second fluid reservoir; and an arrangement of nanostructures within either the first fluid reservoir or the second fluid reservoir wherein the nanostructures are arranged so as to form multiple concentric circles inside either the first fluid reservoir or the second fluid reservoir with each of the concentric circles being centered at an entry point of the channel. A method of analyzing a polymer using the testing structure is also provided.

    Integrated nanopore and paul trap mechanism for DNA capture and motion control
    10.
    发明授权
    Integrated nanopore and paul trap mechanism for DNA capture and motion control 有权
    用于DNA捕获和运动控制的集成纳米孔和保留阱机制

    公开(公告)号：US09201057B2

    公开(公告)日：2015-12-01

    申请号：US13738315

    申请日：2013-01-10

    申请人： International Business Machines Corporation

    发明人： Hongbo Peng ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC分类号： G01N33/487 ,  C12Q1/68 ,  B82Y30/00

    CPC分类号： G01N33/48721 ,  B82Y30/00 ,  C12Q1/6869 ,  C12Q2565/631

    摘要： A mechanism is provided for capturing a molecule via an integrated system. An alternating voltage is applied to a Paul trap device in an electrically conductive solution to generate electric fields. The Paul trap device is integrated with a nanopore device to form the integrated system. Forces from the electric fields of the Paul trap device position the molecule to a nanopore in the nanopore device. A first voltage is applied to the nanopore device to capture the molecule in the nanopore of the nanopore device.

    摘要翻译： 提供了用于通过集成系统捕获分子的机制。 将交流电压施加到导电溶液中的保持阱陷阱装置以产生电场。 保存陷阱装置与纳米孔装置集成以形成集成系统。 来自保护陷阱装置的电场的力将分子定位在纳米孔装置中的纳米孔。 将第一电压施加到纳米孔装置以捕获纳米孔装置的纳米孔中的分子。