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公开(公告)号：US20190144957A1
公开(公告)日：2019-05-16
申请号：US16189692
申请日：2018-11-13
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick PURCELL , Suzanne LEE , Lixin DAI , Katherine Amy CONGDON , Stephen M. SPINELLA , Chi Man NG
Abstract: The invention herein provides biofabricated materials having zonal properties and methods of making biofabricated materials having zonal properties.
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公开(公告)号：US20230174955A1
公开(公告)日：2023-06-08
申请号：US17759881
申请日：2021-02-12
Applicant: Modern Meadow, Inc.
Inventor： Lixin DAI , Poonam SRIVASTAVA , Sumreet Singh JOHAR , Shashwat Mohan VAJPEYI , Mahadevan LAKSHMINARASIMHAN , James Egan WELCH
CPC classification number: C12N9/0071 , C07K14/78 , C12Y114/11002
Abstract: The disclosure herein provides a monomeric prolyl 4-hydroxylase. A microorganism including a monomeric prolyl 4-hydroxylase is provided. The disclosure provides a microorganism including a monomeric prolyl 4-hydroxylase; and another protein to be hydroxylated. A method for providing skincare benefits including applying the fusion protein of the present disclosure on skin is also taught.
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公开(公告)号：US20210308031A1
公开(公告)日：2021-10-07
申请号：US17269123
申请日：2019-08-16
Applicant: Modern Meadow, inc.
Inventor： Lixin DAI , Poonarn SRIVASTAVA
Abstract: The disclosure herein provides a fusion protein comprising prolyl 4-hydroxylase alpha subunit (P4HA) and a soluble protein partner. A fusion protein comprising prolyl 4-hydroxylase alpha subunit (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB) is provided. A microorganism including a fusion protein comprising prolyl 4-hydroxylase alpha subunit-1 (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB) is provided. The disclosure provides a microorganism including a fusion protein comprising prolyl 4-hydroxylase alpha subunit-1 (P4HA1) and prolyl 4-hydroxylase beta subunit (P4HB); and another protein to be hydroxylated. A method for providing skincare benefits including applying the fusion protein of the present disclosure on skin is also taught.
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公开(公告)号：US20170233944A1
公开(公告)日：2017-08-17
申请号：US15433566
申请日：2017-02-15
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick PURCELL , David Thomas WILLIAMSON , Lixin DAI , Darryl Miles CASSINGHAM , Stephen M. SPINELLA , Amy CONGDON
IPC: D06N3/00
CPC classification number: C08J3/24 , B32B1/08 , B32B3/266 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B7/12 , B32B9/025 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B2250/02 , B32B2250/03 , B32B2250/20 , B32B2250/40 , B32B2250/42 , B32B2255/02 , B32B2255/26 , B32B2262/0207 , B32B2262/0261 , B32B2262/0269 , B32B2262/0276 , B32B2262/0292 , B32B2262/04 , B32B2262/062 , B32B2262/065 , B32B2262/067 , B32B2262/08 , B32B2262/10 , B32B2262/101 , B32B2262/103 , B32B2262/106 , B32B2262/14 , B32B2264/105 , B32B2307/202 , B32B2307/208 , B32B2307/308 , B32B2307/4026 , B32B2307/422 , B32B2307/50 , B32B2307/51 , B32B2307/54 , B32B2307/5825 , B32B2307/708 , B32B2307/7265 , B32B2437/00 , B32B2437/02 , B32B2437/04 , B32B2439/46 , B32B2451/00 , B32B2457/00 , B32B2471/00 , B32B2479/00 , B32B2519/00 , B32B2571/00 , B32B2601/00 , B32B2605/003 , B32B2605/08 , B32B2605/12 , B32B2605/18 , C07K14/78 , C08J2389/06 , C14C9/00 , C14C9/02 , C14C13/00 , D01C3/00 , D01F4/00 , D04H1/00 , D04H1/4382 , D04H13/00 , D06M15/05 , D06M15/15 , D06M23/16 , D06M2101/06 , D06N3/00 , D06N3/0018 , D06N7/0097 , D06N2201/06 , D06N2203/02 , D06P3/32
Abstract: A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
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公开(公告)号：US20230033725A1
公开(公告)日：2023-02-02
申请号：US17819544
申请日：2022-08-12
Applicant: Modern Meadow, Inc.
Inventor： Samuel BROADBENT , Dale L. HANDLIN, JR. , Shaobo CAI , Zhe TAN , Casey CROWNHART , Nicholas YARAGHI , David WILLIAMSON , Alexander Iain NORMAN , Lixin DAI
Abstract: Protein polyurethane alloys including one or more proteins dissolved within one or more polyurethanes. The protein polyurethane alloy may have one or more mechanical properties that are superior to the polyurethane in the absence of protein. The protein polyurethane alloys may be incorporated into a layered material including one or more protein polyurethane alloy layers.
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Patent Agency Ranking
公开(公告)号：US20190092838A1
公开(公告)日：2019-03-28
申请号：US16125320
申请日：2018-09-07
Applicant: MODERN MEADOW, INC.
Inventor： Lixin DAI , Poonam SRIVASTAVA
Abstract: This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.
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公开(公告)号：US20170233838A1
公开(公告)日：2017-08-17
申请号：US15433777
申请日：2017-02-15
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick PURCELL , David Thomas WILLIAMSON , Lixin DAI , Darryl Miles CASSINGHAM , Stephen M. SPINELLA
CPC classification number: C08J3/24 , B32B1/08 , B32B3/266 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B7/12 , B32B9/025 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B2250/02 , B32B2250/03 , B32B2250/20 , B32B2250/40 , B32B2250/42 , B32B2255/02 , B32B2255/26 , B32B2262/0207 , B32B2262/0261 , B32B2262/0269 , B32B2262/0276 , B32B2262/0292 , B32B2262/04 , B32B2262/062 , B32B2262/065 , B32B2262/067 , B32B2262/08 , B32B2262/10 , B32B2262/101 , B32B2262/103 , B32B2262/106 , B32B2262/14 , B32B2264/105 , B32B2307/202 , B32B2307/208 , B32B2307/308 , B32B2307/4026 , B32B2307/422 , B32B2307/50 , B32B2307/51 , B32B2307/54 , B32B2307/5825 , B32B2307/708 , B32B2307/7265 , B32B2437/00 , B32B2437/02 , B32B2437/04 , B32B2439/46 , B32B2451/00 , B32B2457/00 , B32B2471/00 , B32B2479/00 , B32B2519/00 , B32B2571/00 , B32B2601/00 , B32B2605/003 , B32B2605/08 , B32B2605/12 , B32B2605/18 , C07K14/78 , C08J2389/06 , C14C9/00 , C14C9/02 , C14C13/00 , D01C3/00 , D01F4/00 , D04H1/00 , D04H1/4382 , D04H13/00 , D06M15/05 , D06M15/15 , D06M23/16 , D06M2101/06 , D06N3/00 , D06N3/0018 , D06N7/0097 , D06N2201/06 , D06N2203/02 , D06P3/32
Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
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公开(公告)号：US20250011392A1
公开(公告)日：2025-01-09
申请号：US18557244
申请日：2022-04-29
Applicant: Modern Meadow, Inc.
Inventor： Lixin DAI , Dale L HANDLIN, Jr. , Stanley LUE , Monique DE LEEUW , Dan DUEPPEN , Dave WILLIAMSON , Isabelle HANSENNE-CERVANTES , Brenna RAUW
Abstract: The present disclosure relates to a recombinant collagen, peptide fragments thereof, and sequence variants thereof. A novel Pichia pastoris strain for producing the recombinant collagen, fragments thereof, and sequence variants thereof, and methods of using the recombinant collagen, fragments, and sequence variants thereof are also provided. The present disclosure fulfills a need for environmentally friendly and safe alternatives for skincare.
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公开(公告)号：US20240099955A1
公开(公告)日：2024-03-28
申请号：US18263804
申请日：2022-02-04
Applicant: MODERN MEADOW, INC.
Inventor： Yelena ZOLOTARSKY , Lixin DAI , Dan DUEPPEN
Abstract: The present disclosure relates to a recombinant collagen fragment having a molecular weight of about 55 kDa, and compositions comprising the recombinant collagen fragment. Methods of producing the recombinant collagen fragment and methods of treatment using the recombinant collagen fragment are also provided.
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公开(公告)号：US20190203000A1
公开(公告)日：2019-07-04
申请号：US16358299
申请日：2019-03-19
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick PURCELL , David Thomas WILLIAMSON , Lixin DAI , Darryl Miles CASSINGHAM , Stephen M. SPINELLA
IPC: C08J3/24 , B32B3/26 , D06P3/32 , B32B29/02 , B32B27/12 , B32B23/10 , B32B15/14 , B32B15/02 , B32B9/02 , B32B7/12 , B32B5/02 , D01F4/00 , D04H1/00 , D06N3/00 , D04H1/4382 , C14C9/02 , C14C9/00 , C07K14/78 , D04H13/00 , C14C13/00 , D06N7/00 , D06M15/15 , B32B5/26 , D06M15/05 , D01C3/00 , B32B1/08
CPC classification number: C08J3/24 , B32B1/08 , B32B3/266 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B7/12 , B32B9/025 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B2250/02 , B32B2250/03 , B32B2250/20 , B32B2250/40 , B32B2250/42 , B32B2255/02 , B32B2255/26 , B32B2262/0207 , B32B2262/0261 , B32B2262/0269 , B32B2262/0276 , B32B2262/0292 , B32B2262/04 , B32B2262/062 , B32B2262/065 , B32B2262/067 , B32B2262/08 , B32B2262/10 , B32B2262/101 , B32B2262/103 , B32B2262/106 , B32B2262/14 , B32B2264/105 , B32B2307/202 , B32B2307/208 , B32B2307/308 , B32B2307/4026 , B32B2307/422 , B32B2307/50 , B32B2307/51 , B32B2307/54 , B32B2307/5825 , B32B2307/708 , B32B2307/7265 , B32B2437/00 , B32B2437/02 , B32B2437/04 , B32B2439/46 , B32B2451/00 , B32B2457/00 , B32B2471/00 , B32B2479/00 , B32B2519/00 , B32B2571/00 , B32B2601/00 , B32B2605/003 , B32B2605/08 , B32B2605/12 , B32B2605/18 , C07K14/78 , C08J2389/06 , C14C9/00 , C14C9/02 , C14C13/00 , D01C3/00 , D01F4/00 , D04H1/00 , D04H1/4382 , D04H13/00 , D06M15/05 , D06M15/15 , D06M23/16 , D06M2101/06 , D06N3/00 , D06N3/0018 , D06N7/0097 , D06N2201/06 , D06N2203/02 , D06P3/32
Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
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