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1.发明授权公开(公告)号：US08052956B2
公开(公告)日：2011-11-08
申请号：US11579775
申请日：2005-04-28
申请人： Sven Albrecht , Armin Olbrich , Michael Reiss , Frank Schrumpf , Juliane Meese-Marktscheffel , Uwe Kutzler
发明人： Sven Albrecht , Armin Olbrich , Michael Reiss , Frank Schrumpf , Juliane Meese-Marktscheffel , Uwe Kutzler
CPC分类号： C01G41/02 , C01G41/00 , C01P2004/32 , C01P2004/61 , C01P2006/10 , C22B34/36 , Y10T428/2982
摘要： Process for the production of a powdered spherical tungstic acid by acidification of an aqueous alkaline tungstate solution with mineral acid at elevated temperature, preferably in a continuous stirred tank or a cascade of at least 2 continuous stirred tanks, and tungstic acid obtainable in this way, which is characterized by a high bulk density and spherical morphology.
摘要翻译： 通过酸性碱性钨酸盐水溶液与无机酸在升高的温度下酸化，优选在连续搅拌槽或至少2个连续搅拌槽的级联中制备粉状球状钨酸的方法和以这种方式可得到的钨酸， 其特征在于高堆积密度和球形形态。
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2.发明申请Methods for measuring transforming growth factor beta (TGF-beta) receptor signaling activity and uses thereof 审中-公开用于测量转化生长因子β（TGF-β）受体信号传导活性的方法及其用途公开(公告)号：US20090074790A1
公开(公告)日：2009-03-19
申请号：US11489287
申请日：2006-07-19
申请人： Michael Reiss , Judy Kleinstein
发明人： Michael Reiss , Judy Kleinstein
IPC分类号： A61K39/395 , G01N33/53 , C12Q1/68 , C40B30/00 , C40B40/06
CPC分类号： C07K16/18 , G01N2333/495
摘要： Methods are disclosed for determining the optimal biologic dose of a TGFβ receptor kinase inhibitor for administration to patients in need of such therapy and for monitoring the effectiveness of therapy with a TGFβ receptor kinase inhibitor in patients receiving such therapy. Kits comprising antibodies and reagents useful in such methods are also disclosed.
摘要翻译： 公开了用于确定用于施用于需要这种治疗的患者的TGFbeta受体激酶抑制剂的最佳生物剂量的方法，并且用于监测接受这种治疗的患者中用TGFbeta受体激酶抑制剂治疗的有效性。 还公开了包含在这些方法中有用的抗体和试剂的试剂盒。
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公开(公告)号：US06863992B2
公开(公告)日：2005-03-08
申请号：US10761440
申请日：2004-01-21
申请人： Timothy P. Weihs , Omar Knio , Michael Reiss , David van Heerden
发明人： Timothy P. Weihs , Omar Knio , Michael Reiss , David van Heerden
IPC分类号： B21C37/00 , B23K1/00 , B23K20/00 , B23K20/06 , B23K20/08 , B23K28/00 , B23K35/02 , B23K35/34 , B32B15/01 , B32B18/00 , B32B37/00 , C04B37/02 , C06B21/00 , C06B33/00 , C06B45/14 , C06C7/00 , C06C7/02 , C23C14/14 , F24V30/00 , H05K3/34 , B32B15/00
CPC分类号： B23K35/0238 , B23K1/0006 , B23K20/00 , B23K20/06 , B23K20/08 , B23K20/165 , B23K28/00 , B23K35/0233 , B23K35/34 , B32B15/01 , B32B15/017 , B32B18/00 , B32B2311/24 , C04B37/006 , C04B37/026 , C04B2235/6562 , C04B2235/6565 , C04B2237/121 , C04B2237/122 , C04B2237/123 , C04B2237/124 , C04B2237/368 , C04B2237/40 , C04B2237/402 , C04B2237/60 , C04B2237/68 , C04B2237/708 , C04B2237/72 , C04B2237/78 , C06B21/0083 , C06B45/14 , C21D2211/008 , C23C14/14 , F24V30/00 , H05K3/3463 , H05K3/3494 , H05K2203/0405 , H05K2203/1163 , Y10S72/70 , Y10S228/902 , Y10S428/924 , Y10S428/926 , Y10S428/94 , Y10S428/941 , Y10T29/302 , Y10T29/308 , Y10T29/49925 , Y10T29/49929 , Y10T156/1002 , Y10T428/12028 , Y10T428/12063 , Y10T428/12069 , Y10T428/12076 , Y10T428/1209 , Y10T428/12229 , Y10T428/12361 , Y10T428/12431 , Y10T428/12438 , Y10T428/12451 , Y10T428/12493 , Y10T428/1259 , Y10T428/12632 , Y10T428/12736 , Y10T428/1275 , Y10T428/12778 , Y10T428/12819 , Y10T428/12903 , Y10T428/12944 , Y10T428/24942 , Y10T428/25 , Y10T428/265 , Y10T428/2993 , Y10T428/31678
摘要： Reactive foils and their uses are provided as localized heat sources useful, for example, in ignition, joining and propulsion. An improved reactive foil is preferably a freestanding multilayered foil structure made up of alternating layers selected from materials that will react with one another in an exothermic and self-propagating reaction. Upon reacting, this foil supplies highly localized heat energy that may be applied, for example, to joining layers, or directly to bulk materials that are to be joined. This foil heat-source allows rapid bonding to occur at room temperature in virtually any environment (e.g., air, vacuum, water, etc.). If a joining material is used, the foil reaction will supply enough heat to melt the joining materials, which upon cooling will form a strong bond, joining two or more bulk materials.
摘要翻译： 活性箔及其用途被提供为例如在点燃，接合和推进中有用的局部热源。 改进的活性箔优选是独立的多层箔结构，其由选自在放热和自蔓延反应中将彼此反应的材料的交替层组成。 当箔反应时，该箔片提供高度局部化的热能，其可以被应用于例如接合层，或者直接地应用于待接合的散装材料。 这种箔片热源允许在几乎任何环境（例如空气，真空，水等）中在室温下快速结合。 如果使用接合材料，箔反应将提供足够的热量以熔化接合材料，其在冷却时将形成强结合，连接两种或更多种散装材料。
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公开(公告)号：US20050003228A1
公开(公告)日：2005-01-06
申请号：US10761444
申请日：2004-01-21
申请人： Timothy Weihs , Todd Hufnagel , Omar Knio , Michael Reiss , David Heerden , Howard Feldmesser
发明人： Timothy Weihs , Todd Hufnagel , Omar Knio , Michael Reiss , David Heerden , Howard Feldmesser
IPC分类号： B21C37/00 , B23K1/00 , B23K20/00 , B23K20/06 , B23K20/08 , B23K28/00 , B23K35/02 , B23K35/34 , B32B15/01 , B32B18/00 , B32B37/00 , C04B37/02 , C06B21/00 , C06B33/00 , C06B45/14 , C06C7/00 , C06C7/02 , C23C14/14 , F24V30/00 , H05K3/34 , B32B1/00
CPC分类号： B23K35/0238 , B23K1/0006 , B23K20/00 , B23K20/06 , B23K20/08 , B23K20/165 , B23K28/00 , B23K35/0233 , B23K35/34 , B32B15/01 , B32B15/017 , B32B18/00 , B32B2311/24 , C04B37/006 , C04B37/026 , C04B2235/6562 , C04B2235/6565 , C04B2237/121 , C04B2237/122 , C04B2237/123 , C04B2237/124 , C04B2237/368 , C04B2237/40 , C04B2237/402 , C04B2237/60 , C04B2237/68 , C04B2237/708 , C04B2237/72 , C04B2237/78 , C06B21/0083 , C06B45/14 , C21D2211/008 , C23C14/14 , F24V30/00 , H05K3/3463 , H05K3/3494 , H05K2203/0405 , H05K2203/1163 , Y10S72/70 , Y10S228/902 , Y10S428/924 , Y10S428/926 , Y10S428/94 , Y10S428/941 , Y10T29/302 , Y10T29/308 , Y10T29/49925 , Y10T29/49929 , Y10T156/1002 , Y10T428/12028 , Y10T428/12063 , Y10T428/12069 , Y10T428/12076 , Y10T428/1209 , Y10T428/12229 , Y10T428/12361 , Y10T428/12431 , Y10T428/12438 , Y10T428/12451 , Y10T428/12493 , Y10T428/1259 , Y10T428/12632 , Y10T428/12736 , Y10T428/1275 , Y10T428/12778 , Y10T428/12819 , Y10T428/12903 , Y10T428/12944 , Y10T428/24942 , Y10T428/25 , Y10T428/265 , Y10T428/2993 , Y10T428/31678
摘要： Reactive foils and their uses are provided as localized heat sources useful, for example, in ignition, joining and propulsion. An improved reactive foil is preferably a freestanding multilayered foil structure made up of alternating layers selected from materials that will react with one another in an exothermic and self-propagating reaction. Upon reacting, this foil supplies highly localized heat energy that may be applied, for example, to joining layers, or directly to bulk materials that are to be joined. This foil heat-source allows rapid bonding to occur at room temperature in virtually any environment (e.g., air, vacuum, water, etc.). If a joining material is used, the foil reaction will supply enough heat to melt the joining materials, which upon cooling will form a strong bond, joining two or more bulk materials.
摘要翻译： 活性箔及其用途被提供为例如在点燃，接合和推进中有用的局部热源。 改进的活性箔优选是独立的多层箔结构，其由选自在放热和自蔓延反应中将彼此反应的材料的交替层组成。 当箔反应时，该箔片提供高度局部化的热能，其可以被应用于例如接合层，或者直接地应用于待接合的散装材料。 这种箔片热源允许在几乎任何环境（例如空气，真空，水等）中在室温下快速结合。 如果使用接合材料，箔反应将提供足够的热量以熔化接合材料，其在冷却时将形成强结合，连接两种或更多种散装材料。
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5.发明授权公开(公告)号：US06991855B2
公开(公告)日：2006-01-31
申请号：US10761439
申请日：2004-01-21
申请人： Timothy P. Weihs , Omar Knio , Michael Reiss , David van Heerden
发明人： Timothy P. Weihs , Omar Knio , Michael Reiss , David van Heerden
IPC分类号： B32B7/00
CPC分类号： B23K35/0238 , B23K1/0006 , B23K20/00 , B23K20/06 , B23K20/08 , B23K20/165 , B23K28/00 , B23K35/0233 , B23K35/34 , B32B15/01 , B32B15/017 , B32B18/00 , B32B2311/24 , C04B37/006 , C04B37/026 , C04B2235/6562 , C04B2235/6565 , C04B2237/121 , C04B2237/122 , C04B2237/123 , C04B2237/124 , C04B2237/368 , C04B2237/40 , C04B2237/402 , C04B2237/60 , C04B2237/68 , C04B2237/708 , C04B2237/72 , C04B2237/78 , C06B21/0083 , C06B45/14 , C21D2211/008 , C23C14/14 , F24V30/00 , H05K3/3463 , H05K3/3494 , H05K2203/0405 , H05K2203/1163 , Y10S72/70 , Y10S228/902 , Y10S428/924 , Y10S428/926 , Y10S428/94 , Y10S428/941 , Y10T29/302 , Y10T29/308 , Y10T29/49925 , Y10T29/49929 , Y10T156/1002 , Y10T428/12028 , Y10T428/12063 , Y10T428/12069 , Y10T428/12076 , Y10T428/1209 , Y10T428/12229 , Y10T428/12361 , Y10T428/12431 , Y10T428/12438 , Y10T428/12451 , Y10T428/12493 , Y10T428/1259 , Y10T428/12632 , Y10T428/12736 , Y10T428/1275 , Y10T428/12778 , Y10T428/12819 , Y10T428/12903 , Y10T428/12944 , Y10T428/24942 , Y10T428/25 , Y10T428/265 , Y10T428/2993 , Y10T428/31678
摘要： Reactive foils and their uses are provided as localized heat sources useful, for example, in ignition, joining and propulsion. An improved reactive foil is preferably a freestanding multilayered foil structure made up of alternating layers selected from materials that will react with one another in an exothermic and self-propagating reaction. Upon reacting, this foil supplies highly localized heat energy that may be applied, for example, to joining layers, or directly to bulk materials that are to be joined. This foil heat-source allows rapid bonding to occur at room temperature in virtually any environment (e.g., air, vacuum, water, etc.). If a joining material is used, the foil reaction will supply enough heat to melt the joining materials, which upon cooling will form a strong bond, joining two or more bulk materials.
摘要翻译： 活性箔及其用途被提供为例如在点燃，接合和推进中有用的局部热源。 改进的活性箔优选是独立的多层箔结构，其由选自在放热和自蔓延反应中将彼此反应的材料的交替层组成。 当箔反应时，该箔片提供高度局部化的热能，其可以被应用于例如接合层，或者直接地应用于待接合的散装材料。 这种箔片热源允许在几乎任何环境（例如空气，真空，水等）中在室温下快速结合。 如果使用接合材料，箔反应将提供足够的热量以熔化接合材料，其在冷却时将形成强结合，连接两种或更多种散装材料。
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公开(公告)号：US06534194B2
公开(公告)日：2003-03-18
申请号：US09846447
申请日：2001-05-01
申请人： Timothy P. Weihs , Michael Reiss
发明人： Timothy P. Weihs , Michael Reiss
IPC分类号： B32B1500
CPC分类号： B32B18/00 , B23K1/0006 , B23K20/00 , B23K20/06 , B23K20/08 , B23K20/165 , B23K28/00 , B23K35/0233 , B23K35/0238 , B23K35/34 , B32B15/01 , B32B15/017 , B32B2311/24 , C04B37/006 , C04B37/026 , C04B2235/6562 , C04B2235/6565 , C04B2237/121 , C04B2237/122 , C04B2237/123 , C04B2237/124 , C04B2237/368 , C04B2237/40 , C04B2237/402 , C04B2237/60 , C04B2237/68 , C04B2237/708 , C04B2237/72 , C04B2237/78 , C06B21/0083 , C06B45/14 , C21D2211/008 , C23C14/14 , F24V30/00 , H05K3/3463 , H05K3/3494 , H05K2203/0405 , H05K2203/1163 , Y10S72/70 , Y10S228/902 , Y10S428/94 , Y10T29/49925 , Y10T29/49929 , Y10T428/12028 , Y10T428/12063 , Y10T428/12069 , Y10T428/12076 , Y10T428/1209 , Y10T428/12229 , Y10T428/12361 , Y10T428/12438 , Y10T428/12451 , Y10T428/12493 , Y10T428/1259 , Y10T428/12632 , Y10T428/1275 , Y10T428/12819 , Y10T428/12903 , Y10T428/12944 , Y10T428/25 , Y10T428/265 , Y10T428/2993
摘要： In accordance with the invention a reactive multilayer foil is fabricated by providing an assembly (stack or multilayer) of reactive layers, inserting the assembly into a jacket, deforming the jacketed assembly to reduce its cross sectional area, flattening the jacketed assembly into a sheet, and then removing the jacket. Advantageously, the assembly is wound into a cylinder before insertion into the jacket, and the jacketed assembly is cooled to a temperature below 100° C. during deforming. The resulting multilayer foil is advantageous as a freestanding reactive foil for use in bonding, ignition or propulsion.
摘要翻译： 根据本发明，通过提供反应层的组件（堆叠或多层），将组件插入夹套中，使夹套组件变形以减小其横截面面积，将夹套组件压扁成片，制成反应性多层箔， 然后取下外套。 有利的是，在插入夹套之前将组件缠绕到圆筒中，并且将夹套的组件在变形期间冷却到低于100℃的温度。 所得的多层箔作为用于粘合，点燃或推进的独立的活性箔是有利的。
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公开(公告)号：US06991856B2
公开(公告)日：2006-01-31
申请号：US10247998
申请日：2002-09-20
申请人： Timothy P. Weihs , Michael Reiss , Omar Knio , Albert Joseph Swiston, Jr. , David van Heerden , Todd Hufnagel
发明人： Timothy P. Weihs , Michael Reiss , Omar Knio , Albert Joseph Swiston, Jr. , David van Heerden , Todd Hufnagel
CPC分类号： C06B21/0083 , B23K1/0006 , B23K20/00 , B23K20/06 , B23K20/08 , B23K20/165 , B23K28/00 , B23K35/0233 , B23K35/0238 , B23K35/34 , B32B15/01 , B32B15/017 , C06B45/14 , C21D2211/008 , C23C14/14 , F24V30/00 , H05K3/3463 , H05K3/3494 , H05K2203/0405 , H05K2203/1163 , Y10S228/902 , Y10S428/94 , Y10T29/301 , Y10T29/302 , Y10T29/308 , Y10T29/49826 , Y10T428/12028 , Y10T428/12063 , Y10T428/12069 , Y10T428/12076 , Y10T428/1209 , Y10T428/12229 , Y10T428/12361 , Y10T428/12438 , Y10T428/12451 , Y10T428/12493 , Y10T428/1259 , Y10T428/12632 , Y10T428/1275 , Y10T428/12819 , Y10T428/12903 , Y10T428/12944
摘要： Reactive foils and their uses are provided as localized heat sources useful, for example, in ignition, joining and propulsion. An improved reactive foil is preferably a freestanding multilayered foil structure made up of alternating layers selected from materials that will react with one another in an exothermic and self-propagating reaction. Upon reacting, this foil supplies highly localized heat energy that may be applied, for example, to joining layers, or directly to bulk materials that are to be joined. This foil heat-source allows rapid bonding to occur at room temperature in virtually any environment (e.g., air, vacuum, water, etc.). If a joining material is used, the foil reaction will supply enough heat to melt or soften the joining material, which upon cooling will form a strong bond, joining two or more bulk materials. If no joining material is used, the foil reaction supplies heat directly to at least two bulk materials, melting or softening a portion of each bulk, which upon cooling, form a strong bond. Additionally, the foil may be designed with openings that allow extrusion of the joining (or bulk) material through the foil to enhance bonding.
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公开(公告)号：US06736942B2
公开(公告)日：2004-05-18
申请号：US09846486
申请日：2001-05-01
申请人： Timothy P. Weihs , Todd Hufnagel , Omar Knio , Michael Reiss , David van Heerden , Howard Feldmesser
发明人： Timothy P. Weihs , Todd Hufnagel , Omar Knio , Michael Reiss , David van Heerden , Howard Feldmesser
IPC分类号： C23C1434
CPC分类号： B23K35/0238 , B23K1/0006 , B23K20/00 , B23K20/06 , B23K20/08 , B23K20/165 , B23K28/00 , B23K35/0233 , B23K35/34 , B32B15/01 , B32B15/017 , B32B18/00 , B32B2311/24 , C04B37/006 , C04B37/026 , C04B2235/6562 , C04B2235/6565 , C04B2237/121 , C04B2237/122 , C04B2237/123 , C04B2237/124 , C04B2237/368 , C04B2237/40 , C04B2237/402 , C04B2237/60 , C04B2237/68 , C04B2237/708 , C04B2237/72 , C04B2237/78 , C06B21/0083 , C06B45/14 , C21D2211/008 , C23C14/14 , F24V30/00 , H05K3/3463 , H05K3/3494 , H05K2203/0405 , H05K2203/1163 , Y10S72/70 , Y10S228/902 , Y10S428/924 , Y10S428/926 , Y10S428/94 , Y10S428/941 , Y10T29/302 , Y10T29/308 , Y10T29/49925 , Y10T29/49929 , Y10T156/1002 , Y10T428/12028 , Y10T428/12063 , Y10T428/12069 , Y10T428/12076 , Y10T428/1209 , Y10T428/12229 , Y10T428/12361 , Y10T428/12431 , Y10T428/12438 , Y10T428/12451 , Y10T428/12493 , Y10T428/1259 , Y10T428/12632 , Y10T428/12736 , Y10T428/1275 , Y10T428/12778 , Y10T428/12819 , Y10T428/12903 , Y10T428/12944 , Y10T428/24942 , Y10T428/25 , Y10T428/265 , Y10T428/2993 , Y10T428/31678
摘要： Reactive foils and their uses are provided as localized heat sources useful, for example, in ignition, joining and propulsion. An improved reactive foil is preferably a freestanding multilayered foil structure made up of alternating layers selected from materials that will react with one another in an exothermic and self-propagating reaction. Upon reacting, this foil supplies highly localized heat energy that may be applied, for example, to joining layers, or directly to bulk materials that are to be joined. This foil heat-source allows rapid bonding to occur at room temperature in virtually any environment (e.g., air, vacuum, water, etc.). If a joining material is used, the foil reaction will supply enough heat to melt the joining materials, which upon cooling will form a strong bond, joining two or more bulk materials.
摘要翻译： 活性箔及其用途被提供为例如在点燃，接合和推进中有用的局部热源。 改进的活性箔优选是独立的多层箔结构，其由选自在放热和自蔓延反应中将彼此反应的材料的交替层组成。 当箔反应时，该箔片提供高度局部化的热能，其可以被应用于例如接合层，或者直接地应用于待接合的散装材料。 这种箔片热源允许在几乎任何环境（例如空气，真空，水等）中在室温下快速结合。 如果使用接合材料，箔反应将提供足够的热量以熔化接合材料，其在冷却时将形成强结合，连接两种或更多种散装材料。
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公开(公告)号：US20090035542A1
公开(公告)日：2009-02-05
申请号：US11874727
申请日：2007-10-18
申请人： Timothy P. Weihs , Omar Knio , Michael Reiss , David van Heerden , Todd Hufnagel , Howard Feldmesser
发明人： Timothy P. Weihs , Omar Knio , Michael Reiss , David van Heerden , Todd Hufnagel , Howard Feldmesser
CPC分类号： B23K35/0238 , B23K1/0006 , B23K20/00 , B23K20/06 , B23K20/08 , B23K20/165 , B23K28/00 , B23K35/0233 , B23K35/34 , B32B15/01 , B32B15/017 , B32B18/00 , B32B2311/24 , C04B37/006 , C04B37/026 , C04B2235/6562 , C04B2235/6565 , C04B2237/121 , C04B2237/122 , C04B2237/123 , C04B2237/124 , C04B2237/368 , C04B2237/40 , C04B2237/402 , C04B2237/60 , C04B2237/68 , C04B2237/708 , C04B2237/72 , C04B2237/78 , C06B21/0083 , C06B45/14 , C21D2211/008 , C23C14/14 , F24V30/00 , H05K3/3463 , H05K3/3494 , H05K2203/0405 , H05K2203/1163 , Y10S72/70 , Y10S228/902 , Y10S428/924 , Y10S428/926 , Y10S428/94 , Y10S428/941 , Y10T29/302 , Y10T29/308 , Y10T29/49925 , Y10T29/49929 , Y10T156/1002 , Y10T428/12028 , Y10T428/12063 , Y10T428/12069 , Y10T428/12076 , Y10T428/1209 , Y10T428/12229 , Y10T428/12361 , Y10T428/12431 , Y10T428/12438 , Y10T428/12451 , Y10T428/12493 , Y10T428/1259 , Y10T428/12632 , Y10T428/12736 , Y10T428/1275 , Y10T428/12778 , Y10T428/12819 , Y10T428/12903 , Y10T428/12944 , Y10T428/24942 , Y10T428/25 , Y10T428/265 , Y10T428/2993 , Y10T428/31678
摘要： Reactive foils and their uses are provided as localized heat sources useful, for example, in ignition, joining and propulsion. An improved reactive foil is preferably a freestanding multilayered foil structure made up of alternating layers selected from materials that will react with one another in an exothermic and self-propagating reaction. Upon reacting, this foil supplies highly localized heat energy that may be applied, for example, to joining lawyers, or directly to bulk materials that are to be joined. This foil heat-source allows rapid bonding to occur at room temperature in virtually any environment (e.g. air, vacuum, water, etc.). If a joining material is used, the foil reaction will supply enough heat to melt the joining materials, which upon cooling will form a strong bond, joining two or more bulk materials.
摘要翻译： 活性箔及其用途被提供为例如在点燃，接合和推进中有用的局部热源。 改进的活性箔优选是独立的多层箔结构，其由选自在放热和自蔓延反应中将彼此反应的材料的交替层组成。 一旦发生反应，该箔片提供高度局部化的热能，例如可以应用于加入律师，或者直接加入待连接的散装材料。 这种箔片热源允许在几乎任何环境（例如空气，真空，水等）中在室温下快速粘合发生。 如果使用接合材料，箔反应将提供足够的热量以熔化接合材料，其在冷却时将形成强结合，连接两种或更多种散装材料。
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