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    Process for the biological production of L-pipecolic acid
    3.
    发明授权
    Process for the biological production of L-pipecolic acid 有权
    生产L-哌啶酸的方法

    公开(公告)号：US07022502B2

    公开(公告)日：2006-04-04

    申请号：US10169257

    申请日：2000-12-22

    申请人： Tadashi Fujii ,  Yasuhide Aritoku ,  Manabu Mukaihara ,  Takao Narita ,  Hitosi Agematu ,  Kunio Isshiki

    发明人： Tadashi Fujii ,  Yasuhide Aritoku ,  Manabu Mukaihara ,  Takao Narita ,  Hitosi Agematu ,  Kunio Isshiki

    IPC分类号： C12P17/00

    CPC分类号： C12Y105/01002 ,  C12N9/0026 ,  C12N9/0028 ,  C12P17/12

    摘要： A process for the production of L-pipecolic acid which comprises the step of reducing delta-1-piperideine-6-carboxylic acid by the use of pyrroline-5-carboxylate reductase. The delta-1-piperideine-6-carboxylic acid is obtained by the step of converting L-lysine by the use of lysine 6-aminotransferase encoded by a gene of Flavobacterium lutescens. The steps of reducing delta-1-piperideine-6-carboxylic acid and the converting of L-lysine into L-pipecolic acid by the use of lysine 6-aminotransferase are carried out by using a bacterium transformed with a gene encoding lysine 6-aminotransferase wherein such bacterium comprises pyrroline-5-carboxylate reductase encoded by a gene of Escherichia coli or a coryneform bacterium. A recombinant bacterium which can be used in this production process is also provided. Thus, the present invention can provide an efficient biological process for the production of L-pipecolic acid (or 2-piperidinecarboxylic acid).

    摘要翻译： 一种生产L-哌啶酸的方法，其包括通过使用吡咯啉-5-羧酸酯还原酶还原δ-1-哌啶-6-羧酸的步骤。 通过使用由黄杆菌（Flavobacterium lutescens）基因编码的赖氨酸6-氨基转移酶转化L-赖氨酸的步骤获得δ-1-哌啶-6-羧酸。 通过使用赖氨酸6-氨基转移酶减少δ-1-哌啶-6-羧酸和L-赖氨酸转化成L-哌啶酸的步骤是通过使用转染有编码赖氨酸6-氨基转移酶的基因的细菌 其中这种细菌包括由大肠杆菌或棒杆菌型细菌的基因编码的吡咯啉-5-羧酸还原酶。 还提供了可用于该生产方法的重组细菌。 因此，本发明可以提供生产L-哌啶酸（或2-哌啶羧酸）的有效的生物学方法。

    Chrysomycin derivative compounds and use as antitumor agents
    4.
    发明授权
    Chrysomycin derivative compounds and use as antitumor agents 失效
    赤霉素衍生物，用作抗肿瘤剂

    公开(公告)号：US6030951A

    公开(公告)日：2000-02-29

    申请号：US308710

    申请日：1999-07-08

    申请人： Takashi Nakashima ,  Tadashi Fujii ,  Kazuya Sakai ,  Tomohiro Sameshima ,  Hiroyuki Kumagai ,  Takeo Yoshioka

    发明人： Takashi Nakashima ,  Tadashi Fujii ,  Kazuya Sakai ,  Tomohiro Sameshima ,  Hiroyuki Kumagai ,  Takeo Yoshioka

    IPC分类号： C07D311/78 ,  C07D407/04 ,  C12P17/06 ,  A61K31/70 ,  C07H7/04

    CPC分类号： C07D407/04 ,  C07D311/78 ,  C12P17/06

    摘要： Disclosed are the novel C-glycoside compounds Mer-1020dA, Mer-1020dB, Mer-1020dC and Mer-1020dD which have a chromophore group in common with well-known chrysomycins A and B, but can be distinguished from the chrysomycins and the like in that the novel C-glycoside compounds have a sugar residue having a higher degree of oxidation, as well as the compound Mer-1020dE comprising only the chromophore thereof. Among these compounds, the C-glycoside compounds are antibiotics which have low toxicity and can strongly inhibit the growth of solid cancer cells in particular.

    摘要翻译： PCT No.PCT / JP97 / 04007 Sec。 371日期：1999年7月8日 102（e）1999年7月8日PCT PCT 1997年11月4日PCT公布。 公开号WO98 / 22612 PCT 日期1998年5月28日公开了具有发色团组的新颖的C-糖苷化合物Mer-1020dA，Mer-1020dB，Mer-1020dC和Mer-1020dD，与着名的科莫昔霉素A和B相同，但可以区别于科莫昔霉素 因为新型C-糖苷化合物具有较高氧化度的糖残基以及仅包含其发色团的化合物Mer-1020dE。 在这些化合物中，C-糖苷化合物是具有低毒性并特别强烈地抑制固体癌细胞生长的抗生素。

    Nuclear reactor
    8.
    发明授权
    Nuclear reactor 失效
    核反应堆

    公开(公告)号：US06718001B2

    公开(公告)日：2004-04-06

    申请号：US09942945

    申请日：2001-08-31

    申请人： Masataka Hidaka ,  Tadashi Fujii ,  Masaya Ohtsuka ,  Naoyuki Yamada ,  Junichi Yamashita

    发明人： Masataka Hidaka ,  Tadashi Fujii ,  Masaya Ohtsuka ,  Naoyuki Yamada ,  Junichi Yamashita

    IPC分类号： G21C900

    CPC分类号： G21C15/18 ,  G21Y2002/301 ,  G21Y2002/50 ,  G21Y2004/30 ,  Y02E30/40

    摘要： In an indirect cycle nuclear reactor, a size of the reactor containment vessel is decreased by removing decay heat inside the reactor pressure vessel without using any active component to improve the economic feasibility. A main steam pipe communicating with a heat exchanger of the indirect cycle nuclear reactor is branched in a position upstream of a main steam isolation valve to connect the branched pipe to a heat exchanger in a pressure suppression pool through an isolation valve. A feed water pipe is also branched in a position upstream of an isolation valve to connect the branched pipe to the heat exchanger through the isolation valve. Decay heat is dissipated from the heat exchanger into the pressure suppression pool, and condensed water condensed by heat dissipation is returned to the heat exchanger to cool the inside of the pressure vessel. Heat in the pressure suppression pool is transferred from a condensing type heat exchanger to a heat dissipater outside a containment vessel to be dissipated to the outside of the containment vessel.

    摘要翻译： 在间接循环核反应堆中，通过在反应器压力容器内除去腐蚀热而不使用任何活性组分来改善反应堆容纳容器的尺寸以改善经济可行性。 与间接循环核反应堆的热交换器连通的主蒸汽管在主蒸汽隔离阀的上游位置分支，以通过隔离阀将分支管连接到压力抑制池中的热交换器。 给水管也在隔离阀的上游位置分支，以通过隔离阀将分支管连接到热交换器。 衰变热从热交换器消散到压力抑制池中，通过散热冷凝的冷凝水返回到热交换器以冷却压力容器的内部。 压力抑制池中的热量从冷凝式热交换器传送到安全壳外部的散热器，以散发到安全壳的外部。

    Fluid plant and its operating method
    9.
    发明授权
    Fluid plant and its operating method 失效
    流体工厂及其操作方法

    公开(公告)号：US5566709A

    公开(公告)日：1996-10-22

    申请号：US77063

    申请日：1993-06-16

    申请人： Tadashi Fujii ,  Yoshiyuki Kataoka ,  Shoichiro Kinoshita

    发明人： Tadashi Fujii ,  Yoshiyuki Kataoka ,  Shoichiro Kinoshita

    IPC分类号： G21D3/00 ,  F04B49/03 ,  F04B49/06 ,  F04B49/10 ,  G05D7/06 ,  G21D3/04 ,  G21D3/08 ,  F04B41/06

    CPC分类号： G05D7/0682 ,  F04B49/03 ,  F04B49/065 ,  F04B49/106 ,  G21D3/08 ,  Y02E30/40 ,  Y10T137/7761 ,  Y10T137/86027 ,  Y10T137/86163

    摘要： In a plant equipment comprising apparatus of a plurality of systems and control means for switching the systems and changing capacities of the apparatus, an apparatus of each system bas a rated capacity which is 1/N of a capacity of the whole equipment, and the plant equipment is constituted of (N+1) systems. In conditions of normal operation, all the (N+1) systems are operated at capacities less than the rated capacity through the control means. During normal operation, when one system is inspected, or when an abnormality occurs in one system, this system is stopped by the control means. Capacities of apparatus in N of the systems which are operated are increased to the rated 1/N capacity through the control means, and operation is continued with a structure of 1/N capacity.times.N systems. When the maintenance of apparatus in the stopped system is finished, the stopped system is restarted, so as to operate all of the (N+1) systems at capacities less than the rated capacity again.

    摘要翻译： 在包括多个系统的设备和用于切换系统和改变设备的容量的控制装置的设备设备中，每个系统的设备的额定容量为整个设备的容量的1 / N，并且该设备 设备由（N + 1）系统构成。 在正常运行的情况下，所有（N + 1）系统通过控制装置运行在小于额定容量的容量下。 在正常操作期间，当一个系统被检查时，或者在一个系统中发生异常时，该系统被控制装置停止。 通过控制装置将运行的系统中的N个装置的容量增加到额定的1 / N容量，并且以1 / N capacity×N系统的结构继续运行。 当停止的系统中的设备的维护完成时，重新启动停止的系统，以便再次以小于额定容量的容量操作所有的（N + 1）系统。

    Sheet supply apparatus
    10.
    发明授权
    Sheet supply apparatus 失效
    供纸装置

    公开(公告)号：US5174560A

    公开(公告)日：1992-12-29

    申请号：US886193

    申请日：1992-05-21

    申请人： Tadashi Fujii

    发明人： Tadashi Fujii

    IPC分类号： B65H3/08 ,  B65H3/56 ,  B65H9/00 ,  B65H9/06 ,  B65H9/10

    CPC分类号： B65H3/0833

    摘要： A sheet supply apparatus supplies a sheet such as an X-ray sheet film from a cassette to a recording device. The sheet supply apparatus has at least a pair of rollers for gripping and feeding a sheet, a feeding mechanism for feeding a sheet from a storage cassette and supplying the sheet along a feed path to the pair of rollers, a tilt correcting mechanism having for correcting the sheet out of a tilted condition with respect to a direction transverse to the feed path, and a position correcting mechanism for displacing the pair of rollers in the direction while the pair of rollers is gripping the sheet, to correct the sheet positionally with respect to the direction. The feeding mechanism has suction devices movable into the feed path for attracting the sheet under vacuum, and the tilt correcting mechanism has at least a pair of stoppers movable into the feed path for engaging a leading end of the sheet to correct the sheet out of the tilted condition. The sheet supply apparatus also has a drive mechanism for displacing the suction devices and the stoppers between the feed path and respective positions outside of the feed path.

    摘要翻译： 片材供应装置将诸如X射线片材的片材从盒子提供到记录装置。 片材供给装置具有至少一对用于夹持和供给片材的辊子，用于从存储盒进给片材并将片材沿着进给路径供给到该对辊子的进给机构，用于校正 所述片材相对于与所述进给路径横向的方向处于倾斜状态;以及位置校正机构，用于在所述一对辊子夹持所述片材的同时使所述一对辊沿所述方向移位，以相对于所述片材的位置校正所述片材 方向。 进给机构具有能够进入进给路径的抽吸装置，用于在真空下吸引片材，并且倾斜校正机构具有至少一对可移动到进给路径中的止动件，用于接合片材的前端以将片材从 倾斜状态。 供纸装置还具有驱动机构，用于使进给路径和进给路径外侧的相应位置之间的抽吸装置和止动件移位。