公开(公告)号：US5443972A

公开(公告)日：1995-08-22

申请号：US239284

申请日：1994-05-06

申请人： Takafumi Kohama ,  Isao Kaneko ,  Takemichi Nakamura ,  Takeshi Kagasaki ,  Ryuzo Enokita ,  Keiichi Matsuda

发明人： Takafumi Kohama ,  Isao Kaneko ,  Takemichi Nakamura ,  Takeshi Kagasaki ,  Ryuzo Enokita ,  Keiichi Matsuda

IPC分类号： C07D309/38 ,  A61K31/655 ,  A61K31/665 ,  A61P7/00 ,  A61P31/10 ,  C07F9/117 ,  C07F9/655 ,  C12N1/14 ,  C12P9/00 ,  C12P17/06 ,  C12R1/465

CPC分类号： C07F9/6552 ,  C12P17/06 ,  Y10S435/903

摘要： New compounds, which we have named the "Leustroducsins" have the formula (I): ##STR1## in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, and salts thereof, and may be prepared by fermentation using a microorganism of the genus Streptomyces, especially a strain of the species Streptomyces platensis, such as strain SANK 60191 (FERM BP-3288). These compounds may be used for the treatment or prophylaxis of: adverse reactions resulting from cancer chemotherapy or radiotherapy; infections; cancer; cerebral dysfunction; and fungal infections.

摘要翻译： 我们命名为“雷诺霉素”的新化合物具有式（I）：其中R表示5-甲基己酰氧基，6-甲基辛酰氧基或7-甲基辛酰氧基的式（I）及其盐， 并且可以通过使用链霉菌属的微生物，特别是品种Streptomyces platensis的菌株如菌株SANK 60191（FERM BP-3288）的发酵来制备。 这些化合物可用于治疗或预防：由癌症化疗或放射治疗引起的不良反应; 感染; 癌症; 脑功能障碍; 和真菌感染。

公开(公告)号：US5334587A

公开(公告)日：1994-08-02

申请号：US857162

申请日：1992-03-25

申请人： Takafumi Kohama ,  Isao Kaneko ,  Takemichi Nakamura ,  Takeshi Kagasaki ,  Ryuzo Enokita ,  Keiichi Matsuda

发明人： Takafumi Kohama ,  Isao Kaneko ,  Takemichi Nakamura ,  Takeshi Kagasaki ,  Ryuzo Enokita ,  Keiichi Matsuda

IPC分类号： C07D309/38 ,  A61K31/655 ,  A61K31/665 ,  A61P7/00 ,  A61P31/10 ,  C07F9/117 ,  C07F9/655 ,  C12N1/14 ,  C12P9/00 ,  C12P17/06 ,  C12R1/465 ,  C07F9/06

CPC分类号： C07F9/6552 ,  C12P17/06 ,  Y10S435/903

摘要： New compounds, which we have named the "Leustroducsins" have the formula (I): ##STR1## in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, and salts thereof, and may be prepared by fermentation using a microorganism of the genus Streptomyces, especially a strain of the species Streptomyces platensis, such as strain SANK 60191 (FERM BP-3288). These compounds may be used for the treatment or prophylaxis of: adverse reactions resulting from cancer chemotherapy or radiotherapy; infections; cancer; cerebral dysfunction; and fungal infections.

摘要翻译： 我们命名为“雷诺霉素”的新化合物具有式（I）：其中R表示5-甲基己酰氧基，6-甲基辛酰氧基或7-甲基辛酰氧基的式（I）及其盐， 并且可以通过使用链霉菌属的微生物，特别是品种Streptomyces platensis的菌株如菌株SANK 60191（FERM BP-3288）的发酵来制备。 这些化合物可用于治疗或预防：由癌症化疗或放射治疗引起的不良反应; 感染; 癌症; 脑功能障碍; 和真菌感染。

公开(公告)号：US20060283421A1

公开(公告)日：2006-12-21

申请号：US11455672

申请日：2006-06-20

申请人： Isao Chiba ,  Ryuji Matsukado ,  Ryuta Matsui ,  Yoshinori Ishihara ,  Isao Kaneko

发明人： Isao Chiba ,  Ryuji Matsukado ,  Ryuta Matsui ,  Yoshinori Ishihara ,  Isao Kaneko

IPC分类号： F02D41/38

CPC分类号： F02D41/402 ,  F02D41/047 ,  Y02T10/44

摘要： A control system for an internal combustion engine that executes post injection, which is capable of accurately estimating the state of dilution of engine oil, thereby properly controlling the amount of oil dilution such that it does not become too large. In an internal combustion engine having an injector that injects fuel into a combustion chamber, post injection is executed in which fuel is injected from the injector during the expansion stroke or the exhaust stroke of the engine, based on a detected operating condition of the engine. The amount of dilution of engine oil diluted with fuel injected by post injection is calculated. The amount of fuel evaporated from the engine oil is calculated. A state of dilution of the engine oil is estimated based on the calculated engine dilution amount and the calculated fuel evaporation amount.

摘要翻译： 一种用于执行后喷射的内燃机的控制系统，其能够精确地估计发动机油的稀释状态，从而适当地控制油稀释量使其不会变得太大。 在具有将燃料喷射到燃烧室中的喷射器的内燃机中，基于检测到的发动机的运转状态，执行在发动机的膨胀冲程或排气冲程期间从喷射器喷射燃料的后喷射。 计算通过后喷射喷射的燃料稀释的发动机油的稀释量。 计算从发动机油中蒸发的燃料量。 基于所计算的发动机稀释量和计算出的燃料蒸发量来估计发动机油的稀释状态。

公开(公告)号：US6013374A

公开(公告)日：2000-01-11

申请号：US6381

申请日：1998-01-13

申请人： Akira Watanabe ,  Isao Kaneko ,  Atsushi Kasai ,  Kunio Bizen

发明人： Akira Watanabe ,  Isao Kaneko ,  Atsushi Kasai ,  Kunio Bizen

IPC分类号： B32B7/12 ,  C08J5/12 ,  C08J7/12 ,  H01M2/02 ,  H01M2/04 ,  H01M2/06 ,  H01M2/08 ,  H01M10/05 ,  B32B27/08 ,  B32B27/32 ,  B32B27/40 ,  B32B33/00

CPC分类号： C08J5/128 ,  B32B7/12 ,  C08J7/126 ,  H01M2/0277 ,  H01M2/04 ,  H01M2/0439 ,  H01M2/06 ,  H01M2/08 ,  C08J2323/00 ,  C08J2323/02 ,  H01M10/05 ,  Y10T428/1352 ,  Y10T428/1386 ,  Y10T428/31536 ,  Y10T428/3154 ,  Y10T428/31551 ,  Y10T428/31587 ,  Y10T428/31913 ,  Y10T428/31917 ,  Y10T428/31938

摘要： The present invention relates to battery parts comprising molded pieces made of polyolefin resin, whose surface to be bonded are treated so as to have at least one functional group selected from the group consisting of hydroxyl group, carboxyl group, carbonyl group, fluorosulfuryl group, sulfonic group and its metallic bases, said molded pieces being bonded together with reactive hot-melt adhesive.

摘要翻译： 本发明涉及包含由聚烯烃树脂制成的成型片的电池部件，其被接合表面被处理成具有至少一个选自羟基，羧基，羰基，氟代硫酰基，磺酸基的官能团 组和其金属基底，所述模制件通过反应性热熔粘合剂粘合在一起。

公开(公告)号：US5081206A

公开(公告)日：1992-01-14

申请号：US529433

申请日：1990-05-29

申请人： Kiyomi Yasuda ,  Terufumi Suzuki ,  Toshimasa Takata ,  Isao Kaneko

发明人： Kiyomi Yasuda ,  Terufumi Suzuki ,  Toshimasa Takata ,  Isao Kaneko

IPC分类号： C08G59/06 ,  C08G59/30 ,  C08G59/32 ,  C08G59/38 ,  C08L63/00

CPC分类号： C08L63/00 ,  C08G59/066 ,  C08G59/30 ,  C08G59/3218 ,  C08G59/38

摘要： A heat-resistant, flame-retardant epoxy resin composition is provided by combining or reating members selected from a polyfunctional epoxy resin, a bisphenol type epoxy resin, a highly halogenated bisphenol type epoxy resin, a low halogenated bisphenol type epoxy resin, and a halogenated bisphenol. The composition is suitable as a laminate useful for printed circuit boards.

公开(公告)号：US20090240057A1

公开(公告)日：2009-09-24

申请号：US12227397

申请日：2007-07-06

申请人： Toshihiro Nagata ,  Atsushi Kogure ,  Isao Kaneko ,  Norihisa Yonekura ,  Ryo Hanai

发明人： Toshihiro Nagata ,  Atsushi Kogure ,  Isao Kaneko ,  Norihisa Yonekura ,  Ryo Hanai

IPC分类号： C07D417/12 ,  C07D275/02

CPC分类号： C07D275/02 ,  A01N43/80 ,  A01N43/82 ,  C07D417/12

摘要： A 3,4-dihalogenoisothiazole derivative represented by the general formula [I] (wherein R1 is a halogen atom; A is an oxygen atom or a sulfur atom; and R is a C1-C6 alkyl group, a C2-C5 alkenyl group, a C2-C5 alkynyl group, a C3-C6 cycloalkyl group, a phenyl group or a 5- to 10-membered heterocyclic group containing at least one of oxygen atom, sulfur atom and nitrogen atom), or a salt thereof.

摘要翻译： 由通式[I]表示的3,4-二卤代异噻唑衍生物（其中R1是卤素原子; A是氧原子或硫原子; R是C1-C6烷基，C2-C5烯基， C 2 -C 5炔基，C 3 -C 6环烷基，苯基或含有氧原子，硫原子和氮原子中的至少一个的5元至10元杂环基）或其盐。

公开(公告)号：US07331171B2

公开(公告)日：2008-02-19

申请号：US11455672

申请日：2006-06-20

申请人： Isao Chiba ,  Ryuji Matsukado ,  Ryuta Matsui ,  Yoshinori Ishihara ,  Isao Kaneko

发明人： Isao Chiba ,  Ryuji Matsukado ,  Ryuta Matsui ,  Yoshinori Ishihara ,  Isao Kaneko

IPC分类号： F01N3/00 ,  F02D41/38

CPC分类号： F02D41/402 ,  F02D41/047 ,  Y02T10/44

摘要： A control system for an internal combustion engine that executes post injection, which is capable of accurately estimating the state of dilution of engine oil, thereby properly controlling the amount of oil dilution such that it does not become too large. In an internal combustion engine having an injector that injects fuel into a combustion chamber, post injection is executed in which fuel is injected from the injector during the expansion stroke or the exhaust stroke of the engine, based on a detected operating condition of the engine. The amount of dilution of engine oil diluted with fuel injected by post injection is calculated. The amount of fuel evaporated from the engine oil is calculated. A state of dilution of the engine oil is estimated based on the calculated engine dilution amount and the calculated fuel evaporation amount.

摘要翻译： 一种用于执行后喷射的内燃机的控制系统，其能够精确地估计发动机油的稀释状态，从而适当地控制油稀释量使其不会变得太大。 在具有将燃料喷射到燃烧室中的喷射器的内燃机中，基于检测到的发动机的运转状态，执行在发动机的膨胀冲程或排气冲程期间从喷射器喷射燃料的后喷射。 计算通过后喷射喷射的燃料稀释的发动机油的稀释量。 计算从发动机油蒸发的燃料量。 基于所计算的发动机稀释量和计算出的燃料蒸发量来估计发动机油的稀释状态。

公开(公告)号：US20050054732A1

公开(公告)日：2005-03-10

申请号：US10497183

申请日：2002-11-25

申请人： Masaki Meguro ,  Tomiichiro Oda ,  Yasuhiro Nakagami ,  Shinji Marumoto ,  Kazuo Koyama ,  Isao Kaneko

发明人： Masaki Meguro ,  Tomiichiro Oda ,  Yasuhiro Nakagami ,  Shinji Marumoto ,  Kazuo Koyama ,  Isao Kaneko

IPC分类号： A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  A61P25/28 ,  A61P43/00 ,  C07D237/20 ,  C07D237/22 ,  C07D239/48 ,  C07D239/50 ,  C07D241/20 ,  C07D251/18 ,  C07D251/48 ,  C07D251/52 ,  C07D251/70 ,  A61K31/137

CPC分类号： C07D239/48 ,  A61K31/50 ,  A61K31/505 ,  A61K31/53 ,  C07D237/20 ,  C07D237/22 ,  C07D239/50 ,  C07D241/20 ,  C07D251/18 ,  C07D251/48 ,  C07D251/52 ,  C07D251/70

摘要： The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors: (where, R1 and R2 are H or alkyl; Z1 and Z2 are H, alkyl, alkoxy, haloalkyl or halogeno; Z3 is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4 and Z5 are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).

摘要翻译： 本发明涉及阿尔茨海默病的预防药物或补救剂，或淀粉样蛋白原纤维形成抑制剂，其包括作为活性成分的下列通式（I）的化合物或其药理学允许的盐; 以及具有特定取代基的含氮杂芳基衍生物或其药学上允许的盐，其作为阿尔茨海默病的预防剂或治疗药物是有价值的，或作为淀粉样蛋白原纤维形成抑制剂：（其中，R 1和R 2， Z 1和Z 2是H，烷基，烷氧基，卤代烷基或卤代; Z 3是烷氧基，SH，烷硫基，NH 2，一或二烷基氨基，OH或卤素; Z 4和Z 5是H或卤素; A是4,6-嘧啶-1,3-二基，1,3,5-三嗪-2,6-二基等）。

公开(公告)号：US5871861A

公开(公告)日：1999-02-16

申请号：US727203

申请日：1996-10-08

申请人： Nobuyoshi Hirokou ,  Yuukichi Kobayashi ,  Isao Kaneko ,  Minoru Inoue ,  Tomikazu Koyama

发明人： Nobuyoshi Hirokou ,  Yuukichi Kobayashi ,  Isao Kaneko ,  Minoru Inoue ,  Tomikazu Koyama

IPC分类号： H01M2/20 ,  H01M2/26 ,  H01M2/30 ,  H01M4/04 ,  H01M10/04 ,  H01M10/052 ,  H01M10/058 ,  H01M10/38 ,  H01M10/60 ,  H01M10/613 ,  H01M10/625 ,  H01M10/627 ,  H01M10/647 ,  H01M10/651 ,  H01M10/6551 ,  H01M10/6553 ,  H01M10/6562 ,  H01M10/6563 ,  H01M10/6567

CPC分类号： H01M10/0525 ,  H01M10/613 ,  H01M10/654 ,  H01M10/6553 ,  H01M10/6563 ,  H01M10/6567 ,  H01M2/20 ,  H01M2/26 ,  H01M10/0413 ,  Y02P70/54

摘要： A lithium ion secondary cell comprises a plurality of single cells composed of a collector comprising positive electrodes composed of a metallic material coated with a positive electrode active substance; negative electrodes composed of a metallic material coated with a negative electrode active substance; separators interposed between the positive and negative electrodes; lugs of the metallic materials where the active substance is not coated; and conductors adapted to bunch and clamp the lugs of the positive and negative electrodes separately, the positive and negative electrodes being assembled in laminate alternatively, and the ends of the lugs of the positive and negative electrodes being welded to the respective conductors separately so that electric current can be taken out through the conductors.

摘要翻译： 锂离子二次电池包括由包含由涂覆有正极活性物质的金属材料构成的正极的集电体构成的多个单电池; 由涂覆有负极活性物质的金属材料构成的负极; 夹在正极和负极之间的隔板; 未涂覆活性物质的金属材料的凸耳; 以及分别对正极和负极的凸块进行束缚和夹紧的导体，正极和负极交替地组装成层压体，并且正极和负极的凸耳的端部分别焊接到相应的导体，使得电 电流可以通过导线取出。

公开(公告)号：US5783717A

公开(公告)日：1998-07-21

申请号：US517093

申请日：1995-08-21

申请人： Hiromi Ohsaki ,  Toshinobu Ishihara ,  Kazuyuki Asakura ,  Isao Kaneko ,  Kouhei Satou

发明人： Hiromi Ohsaki ,  Toshinobu Ishihara ,  Kazuyuki Asakura ,  Isao Kaneko ,  Kouhei Satou

IPC分类号： C07F3/06 ,  C07F5/00 ,  C07F5/06 ,  C07F3/00

CPC分类号： C07F5/063 ,  C07F3/06 ,  C07F5/00

摘要： A method for purifying an organometal compound by removing oxygen atom-containing compounds included in the organometal compound as impurities is herein disclosed. The method comprises the steps of mixing an organometal compound represented by the following formula: ##STR1## with a crude product including an oxygen atom-containing compound represented by the following formula: R.sub.3-n M.sup.1 (OR).sub.n or R.sub.2-m M.sup.2 (OR).sub.m and an alkylaluminum chloride represented by the formula: X.sub.6-q Al.sub.2 R and then distilling the resulting mixture. In the foregoing formulas, R's may be the same or different and each represents an alkyl group having 1 to 3 carbon atoms; M.sup.1 represents a trivalent metal element; M.sup.2 represents a divalent metal element; n is an integer of 1, 2 or 3; m is an integer of 1 or 2; q is an integer ranging from 1 to 5; and X represents a chlorine atom.

摘要翻译： 本文公开了通过除去作为杂质的有机金属化合物中包含的含氧原子的化合物来纯化有机金属化合物的方法。 该方法包括以下步骤：将由下式表示的有机金属化合物：＆lt; IMAGE＆gt;与由下式表示的含氧原子的化合物的粗产物：R3-n M1（OR）n或R2-m M2（ OR）m和由式X6-qAl2R表示的烷基氯化铝，然后蒸馏所得混合物。 在上述式中，R可以相同或不同，表示碳原子数1〜3的烷基。 M1表示三价金属元素; M2表示二价金属元素; n为1,2或3的整数; m为1或2的整数; q为1〜5的整数; X表示氯原子。