公开(公告)号：US20240342127A1

公开(公告)日：2024-10-17

申请号：US18685127

申请日：2022-09-06

Applicant: Alexion Pharmaceuticals, Inc.

Inventor： Eugene Scott Swenson ,  Wei-Jian Pan

IPC: A61K31/28 ,  G01N33/68 ,  G01N33/84

CPC classification number: A61K31/28 ,  G01N33/6893 ,  G01N33/84 ,  G01N2333/90287

Abstract: Disclosed are methods of treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old. Also disclosed are compositions comprising bis-choline tetrathiomolybdate for use in the treatment of a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old. Also disclosed are uses of a composition comprising bis-choline tetrathiomolybdate for the manufacture of a medicament for treating a copper metabolism-associated disease or disorder, such as Wilson disease (WD) in a subject, particularly in a subject who is from about 3 years old to less than about 18 years old.

公开(公告)号：US20240301476A1

公开(公告)日：2024-09-12

申请号：US18677250

申请日：2024-05-29

Applicant: DENSO CORPORATION

Inventor： Akira NUKAZUKA ,  Teppei SAKAI ,  Mana ASANO ,  Kei HAYAKAWA ,  Kazuhisa NAKAGAWA ,  Mai NIIMOTO

IPC: C12Q1/682 ,  C12N15/115 ,  C12Q1/6844 ,  C12Q1/6876 ,  G01N33/84

CPC classification number: C12Q1/682 ,  C12N15/115 ,  C12Q1/6844 ,  C12Q1/6876 ,  G01N33/84 ,  C12N2310/16

Abstract: An analysis method according to the present disclosure includes: mixing a binding substance and a sample including a target substance. The binding substance includes a nucleic acid region composed of a nucleic acid and having activity to bind to the target substance; removing the binding substance not bound to the target substance; amplifying the nucleic acid region; and detecting a phenomenon caused by the amplification of the nucleic acid region. For example, the analysis method includes: forming a complex of a template nucleic acid including a sequence complementary to a 3′ side sequence of the nucleic acid region; and amplifying the nucleic acid region by an action of a nucleic acid amplifying enzyme using the complex as a starting point.

公开(公告)号：US12078644B2

公开(公告)日：2024-09-03

申请号：US17253507

申请日：2019-04-18

Applicant: Panasonic Corporation

Inventor： Teppei Hosokawa ,  Norimitsu Tohnai

IPC: G01N33/84 ,  C07C63/28 ,  C07C211/07 ,  G01N21/64

CPC classification number: G01N33/84 ,  C07C63/28 ,  C07C211/07 ,  G01N21/6486

Abstract: An organic salt of the present disclosure contains terephthalic acid and at least one kind of primary alkylamine. An alkyl group constituting the primary alkylamine has 6 or more and 17 or less carbon atoms. The organic salt of the present disclosure can be used to detect a hydroxy radical contained in a gas, for example. The present disclosure provides: an organic salt that makes it possible to detect a hydroxy radical more easily as well as to detect a hydroxy radical generated in a living body; and a hydroxy-radical sensor adopting the organic salt.

公开(公告)号：US20240210400A1

公开(公告)日：2024-06-27

申请号：US18555933

申请日：2022-04-19

Applicant: Temple Therapeutics BV

Inventor： GHASSAN SAED

IPC: G01N33/573 ,  G01N33/574 ,  G01N33/84

CPC classification number: G01N33/573 ,  G01N33/57449 ,  G01N33/84 ,  G01N2333/908

Abstract: The current disclosure provides sensitive diagnostic methods that do not require invasive laparoscopic surgery. It was found that monomeric myeloperoxidase (MPO) was found in cells, tissues, and the sera of patients with endometriosis. This novel biomarker can be used to detect ovarian and endometrial hyperproliferative disorders. Accordingly, aspects of the disclosure relate to a method for evaluating a subject comprising detecting monomeric myeloperoxidase (MPO) in a biological sample from the subject. Also disclosed is a method for treating a subject with an endometrial or ovarian hyperproliferative disorder, the method comprising administering an treatment for the endometrial or ovarian hyperproliferative disorder to a subject that has had the level of monomeric MPO evaluated in a biological sample from the subject.

公开(公告)号：US11898195B2

公开(公告)日：2024-02-13

申请号：US17466474

申请日：2021-09-03

Applicant: The University of Chicago ,  National Centre for Biological Sciences

Inventor： Yamuna Krishnan ,  Saheli Halder

IPC: C12N15/11 ,  C12Q1/6825 ,  C12Q1/6816 ,  C12Q1/6876 ,  C12Q1/6809 ,  C12N15/113 ,  G01N33/84 ,  C12Q1/00 ,  C12Q1/02

CPC classification number: C12Q1/6809 ,  C12N15/111 ,  C12N15/113 ,  C12Q1/005 ,  C12Q1/025 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6876 ,  G01N33/84 ,  C12N2310/14 ,  C12N2310/3517 ,  C12Q1/6816 ,  C12Q2525/205 ,  C12Q2527/119 ,  C12Q1/6825 ,  C12Q2525/205 ,  C12Q2527/119 ,  C12Q2565/1015

Abstract: Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence CnXCnYCnZCn (SEQ ID NO. 6) wherein C is cytosine; X, Y and Z are each one or more of adenine, thymine, guanine, or combinations thereof; and n is greater than or equal to 2; and wherein at least 2 cytosine residues of the first single-stranded nucleic acid molecule are modified; and a second single-stranded nucleic acid molecule that is partially or fully complementary to the first single-stranded molecule, wherein a first label is conjugated to the first single-stranded nucleic acid molecule or the second single-stranded nucleic acid molecule; and wherein the first label is capable of producing a signal, wherein the intensity of the signal varies as a function of the conformation of the nucleic acid complex; and measuring the intensity of the signal and determining the pH from the measured signal.

公开(公告)号：US20240019450A1

公开(公告)日：2024-01-18

申请号：US18036797

申请日：2021-11-12

Applicant: THE UNIVERSITY OF SYDNEY

Inventor： Elizabeth NEW ,  Linda MITCHELL ,  Clara SHEN

IPC: G01N33/84 ,  G01N21/64 ,  C07D491/107

CPC classification number: G01N33/84 ,  G01N21/6428 ,  C07D491/107

Abstract: The present invention relates to a compound of formula (I): or a salt or solvate thereof, combinations comprising same, uses and methods thereof, and kits comprising same.

公开(公告)号：US11867698B2

公开(公告)日：2024-01-09

申请号：US17027391

申请日：2020-09-21

Applicant: Life Technologies Corporation

Inventor： Jeffrey Dzubay ,  Kyle Gee ,  Vladimir Martin ,  Aleksey Rukavishnikov ,  Daniel Beacham

IPC: G01N33/58 ,  G01N33/50 ,  G01N33/84 ,  C09B11/24 ,  C09B11/28 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07D209/14 ,  C09K11/06 ,  C07F5/02 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B57/00 ,  C09B69/00 ,  G01N31/22 ,  G01N33/80

CPC classification number: G01N33/582 ,  C07D209/14 ,  C07D311/82 ,  C07D311/90 ,  C07D405/12 ,  C07D413/04 ,  C07D491/22 ,  C07F5/02 ,  C07K1/13 ,  C09B7/00 ,  C09B11/12 ,  C09B11/24 ,  C09B11/28 ,  C09B57/00 ,  C09B69/00 ,  C09K11/06 ,  G01N31/22 ,  G01N33/5005 ,  G01N33/5058 ,  G01N33/5091 ,  G01N33/80 ,  G01N33/84 ,  G01N2333/245 ,  Y10T436/143333

Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I:






wherein the variables are described throughout the application.

公开(公告)号：US11852637B2

公开(公告)日：2023-12-26

申请号：US15776871

申请日：2016-11-19

Applicant: Duke University

Inventor： Homme W. Hellinga ,  Malin J. Allert

IPC: G01N33/58 ,  G01N33/68 ,  G01N21/64 ,  G01N33/542 ,  G01N33/84 ,  G01N33/06

CPC classification number: G01N33/84 ,  G01N33/06 ,  G01N33/582 ,  C07K2319/20 ,  G01N21/6428 ,  G01N33/542 ,  G01N2021/6439 ,  G01N2333/195

Abstract: The present subject matter provides biosensors for bicarbonate and calcium as well as compositions, devices, and methods comprising such biosensors.

公开(公告)号：US20230382928A1

公开(公告)日：2023-11-30

申请号：US18250916

申请日：2021-10-27

Applicant: CISBIO BIOASSAYS

Inventor： David PARKER ,  Jack FRADGLEY ,  Matthieu STARCK ,  Jurriaan ZWIER ,  Laurent LAMARQUE

IPC: C07F5/00 ,  G01N33/84

CPC classification number: C07F5/003 ,  G01N33/84 ,  G01N2458/40

Abstract: The invention relates to a compound of formula (I) wherein R1; R2, R3 and R4 are as defined in the description. The invention also relates to europium (III) complexes obtained from a compound of formula (I), or from a complexing agent including said compound, and to the use of such complexes to label organic or biological molecules.

公开(公告)号：US11782012B2

公开(公告)日：2023-10-10

申请号：US18061128

申请日：2022-12-02

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Wei Zhang ,  Brian Holman ,  Kevin Horan

IPC: G01N27/333 ,  G01N33/84 ,  C12Q1/25 ,  G01N27/416 ,  G01N33/50 ,  G01N33/49 ,  G01N27/30

CPC classification number: G01N27/333 ,  C12Q1/25 ,  G01N27/301 ,  G01N27/4163 ,  G01N33/4915 ,  G01N33/50 ,  G01N33/84

Abstract: A fluid analyzer for analyzing fluid samples comprising one or more analytes and a method of calibrating such. The fluid analyzer includes a control system to control at least one automated valve to pass at least three calibration reagents through a fluid channel to a secondary ion selective electrode, a primary ion selective electrode, and a reference electrode, and determine calibration information using calibration logic from signals generated by a meter, control the at least one automated valve to selectively pass different subsets of the at least three calibration reagents through the fluid channel to the secondary ion selective electrode, the primary ion selective electrode, and the reference electrode, and determine re-calibration information using the signals generated by the meter and at least one of the calibration information and re-calibration logic.