公开(公告)号：US20240294952A1

公开(公告)日：2024-09-05

申请号：US18411156

申请日：2024-01-12

申请人： KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION ,  KONAN GAKUEN ,  NIPPON SUISAN KAISHA, LTD.

发明人： Yuji Okita ,  Makoto Ito ,  Rie Hamaguchi ,  Hatsumi Goda ,  Seiya Mochinaga ,  Daisuke Honda

IPC分类号： C12P7/6432 ,  C10G3/00 ,  C12N1/00 ,  C12N1/12 ,  C12N15/09 ,  C12N15/52 ,  C12N15/79 ,  C12P1/00 ,  C12P7/64 ,  C12P7/6427 ,  C12P7/6472 ,  C12P19/34 ,  C12R1/00 ,  C12R1/89

CPC分类号： C12P7/6432 ,  C12N15/09 ,  C12N15/79 ,  C12P1/00 ,  C12P7/64 ,  C12P7/6427 ,  C12P7/6472 ,  C12P19/34 ,  C10G3/00 ,  C12N1/00 ,  C12N1/125 ,  C12N15/52 ,  C12R2001/00 ,  C12R2001/89

摘要： A method for producing a microbial oil includes genetically modifying a labyrinthulid which belongs to the genus Parietichytrium or the genus Schizochytrium by disrupting and/or silencing a Δ4 desaturase gene, a C20 elongase gene, and/or a C18 elongase gene, or by being transformed with an ω3 desaturase gene; culturing the labyrinthulid; and collecting the microbial oil from the labyrinthulid. The labyrinthulid has an activity of synthesizing DHA via a PUFA-PKS pathway in an amount of not more than 1/100 of a total amount of DHA synthesized in the labyrinthulid or no activity of producing PUFAs via the PUFA-PKS pathway, and the labyrinthulid has an activity of producing PUFAs via an endogenous elongase-desaturase pathway.

公开(公告)号：US11952581B2

公开(公告)日：2024-04-09

申请号：US17532634

申请日：2021-11-22

申请人： BASF PLANT SCIENCE GMBH

发明人： Thorsten Zank ,  Jörg Bauer ,  Petra Cirpus ,  Amine Abbadi ,  Ernst Heinz ,  Xiao Qiu ,  Patricia Vrinten ,  Petra Sperling ,  Frederic Domergue ,  Astrid Schmidt ,  Helene Kirsch

IPC分类号： A01H1/00 ,  A23D9/00 ,  A23D9/02 ,  A23L33/115 ,  C11B1/00 ,  C12N9/02 ,  C12N9/10 ,  C12N15/82 ,  C12P7/64 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472

CPC分类号： C12N15/8247 ,  A01H1/00 ,  A23D9/00 ,  A23D9/02 ,  A23L33/115 ,  C11B1/00 ,  C12N9/0071 ,  C12N9/0083 ,  C12N9/0093 ,  C12N9/1029 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472 ,  C12Y114/19 ,  C12Y114/19003 ,  C12Y203/01199 ,  A23V2002/00 ,  Y02P20/52

摘要： The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with Δ5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode Δ6-desaturases, Δ5-desaturases, Δ4-desaturases and/or Δ6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained. The invention also relates to the nucleic acids, and constructs, vectors and transgenic organisms comprising the same, as well as oils, lipids and/or fatty acids produced by the process according to the invention and to their use.

公开(公告)号：US20240043880A1

公开(公告)日：2024-02-08

申请号：US17767808

申请日：2020-09-22

申请人： BioPhero ApS

发明人： Bettina Lorántfy ,  Irina Borodina

IPC分类号： C12P7/04 ,  C12P7/24 ,  C12P7/64 ,  C12N9/10 ,  C12N9/02 ,  C12N1/16

CPC分类号： C12P7/04 ,  C12P7/24 ,  C12P7/64 ,  C12N9/1029 ,  C12N9/001 ,  C12N1/165 ,  C12Y203/01086 ,  C12Y103/03006

摘要： The present invention relates to improved methods for producing a hydrophobic compound, in particular a hydrophobic compound which is a pheromone such as an insect pheromone, in a fermentation process involving cultivation of a microorganism such as a yeast, said microorganism producing said hydrophobic compound, wherein the methods facilitate recovery of the hydrophobic compound from the fermentation broth, increase the titer of the hydrophobic compound and/or increase secretion of the hydrophobic compound from the microorganism.

公开(公告)号：US20230383229A1

公开(公告)日：2023-11-30

申请号：US18447387

申请日：2023-08-10

申请人： LOCUS SOLUTIONS IPCO, LLC

发明人： SEAN FARMER ,  PAUL S. ZORNER ,  KEN ALIBEK ,  KENT ADAMS ,  TYLER DIXON

IPC分类号： C12M1/34 ,  C12M3/00 ,  C12M1/00 ,  C12P19/44 ,  C12N1/14 ,  C12N1/16 ,  C12N1/20 ,  C12P7/64

CPC分类号： C12M41/26 ,  C12M23/44 ,  C12M23/52 ,  C12M23/58 ,  C12M41/12 ,  C12P19/44 ,  C12N1/14 ,  C12N1/16 ,  C12N1/20 ,  C12P7/64 ,  Y02A40/10

摘要： The invention relates to systems and methods for effective production and use of microorganisms and/or the fermentation broth in which they are produced. Advantageously, the system is cost-effective, scalable, quick, versatile, efficacious, and helpful in reducing resistance to chemical compounds and residue that concerns consumers.

公开(公告)号：US20230357728A1

公开(公告)日：2023-11-09

申请号：US18146661

申请日：2022-12-27

申请人： GINKGO BIOWORKS, INC.

发明人： Vasiliki TSAKRAKLIDES ,  Annapurna KAMINENI

IPC分类号： C12N9/02 ,  C12P7/64 ,  C12N15/81

CPC分类号： C12N9/0071 ,  C12Y114/19001 ,  C12Y114/19006 ,  C12P7/64 ,  C12N15/81

摘要： The current methods and compositions provide for nucleotide sequences of promoters from Yarrowia lipolytica which may be used to drive gene expression in a cell. In some aspects, the promoters are useful for modulating lipid production in oleaginous organisms such as yeast.

公开(公告)号：US11802298B2

公开(公告)日：2023-10-31

申请号：US17082124

申请日：2020-10-28

申请人： Cathay Biotech Inc. ,  CIBT America Inc.

发明人： Min Xu ,  Yingli Hao ,  Chen Yang ,  Naiqiang Li ,  Xiucai Liu

IPC分类号： C12P7/64 ,  C12P7/6409 ,  C08G69/26 ,  C12P7/44 ,  C08G63/16 ,  C07C55/20

CPC分类号： C12P7/6409 ,  C07C55/20 ,  C08G63/16 ,  C08G69/26 ,  C12P7/44

摘要： The present invention provides a decanedioic acid produced by microbial fermentation process, in which the content of C10 aliphatic acid and C10 hydroxy aliphatic acid is maintained at a very low level. The present invention also provides a preparation method of the decanedioic acid and a polymer prepared by using the decanedioic acid as monomer. The decanedioic acid provided by the present invention is prepared by microbial fermentation process. The decanedioic acid product which is produced through the processes of microbial fermentation and separation has a higher purity, a higher thermal stability, and a lower impurity content. The decanedioic acid provided by the present invention could satisfy the requirements of high grade product of polyamide or polyester to produce polymer with excellent qualities. The preparation method of the decanedioic acid provided by the present invention which has many advantages of mild reaction conditions, environmental friendliness, high yield, and good product quality, may replace the chemical method to be used in industrial scale production of the decanedioic acid.

公开(公告)号：US11773417B2

公开(公告)日：2023-10-03

申请号：US16971713

申请日：2019-06-26

申请人： CJ CHEILJEDANG CORPORATION

发明人： Ji Young Kim ,  Myung Geun Park ,  Hye Min Park ,  Jung Woon Choi ,  Sang Min Park ,  Sang Young Bae ,  Jin Sook Chang

IPC分类号： C12P7/64 ,  C12N1/12 ,  C12R1/89

CPC分类号： C12P7/64 ,  C12N1/12 ,  C12N1/125 ,  C12R2001/89

摘要： The present disclosure relates to strains of Thraustochytrium genus, including a high content of polyunsaturated fatty acids, and a method of producing a biomass using the same. According to the novel CJM01 microalgae of Thraustochytrium genus of the present disclosure, the content of lipids in the biomass and the content of unsaturated fatty acid such as docosahexaenoic acid in the biomass are high, so that the microalgae itself, a biomass produced by the culturing and fermentation of microalgae, a condensate of the biomass, and a dried product of the biomass are very useful as a feed composition.

公开(公告)号：US11760969B2

公开(公告)日：2023-09-19

申请号：US16331438

申请日：2017-09-08

申请人： Locus Solutions IPCo, LLC

发明人： Sean Farmer ,  Paul S. Zorner ,  Ken Alibek ,  Kent Adams ,  Tyler Dixon

IPC分类号： C12N1/14 ,  C12N1/16 ,  C12N1/20 ,  C12P7/64 ,  C12M1/34 ,  C12M3/00 ,  C12M1/00 ,  C12P19/44

CPC分类号： C12M41/26 ,  C12M23/44 ,  C12M23/52 ,  C12M23/58 ,  C12M41/12 ,  C12N1/14 ,  C12N1/16 ,  C12N1/20 ,  C12P7/64 ,  C12P19/44 ,  Y02A40/10

摘要： The invention relates to systems and methods for effective production and use of microorganisms and/or the fermentation broth in which they are produced. Advantageously, the system is cost-effective, scalable, quick, versatile, efficacious, and helpful in reducing resistance to chemical compounds and residue that concerns consumers.

公开(公告)号：US11725290B2

公开(公告)日：2023-08-15

申请号：US16086572

申请日：2017-03-18

申请人： Kiverdi, Inc.

发明人： John S. Reed ,  Jil Geller ,  Sonali Hande

IPC分类号： C25B1/04 ,  C12N1/20 ,  C12P1/04 ,  C12P5/00 ,  C12P7/64 ,  C12P13/04 ,  C12P21/02 ,  C12P7/6409 ,  C12P17/16 ,  C12P13/00 ,  C12P25/00

CPC分类号： C25B1/04 ,  C12N1/20 ,  C12P1/04 ,  C12P5/00 ,  C12P7/64 ,  C12P7/6409 ,  C12P13/001 ,  C12P13/04 ,  C12P17/167 ,  C12P21/02 ,  C12P25/00

摘要： Microorganisms and bioprocesses are provided that convert gaseous C1 containing substrates, such as syngas, producer gas, and renewable H2 combined with CO2, into nutritional and other useful bioproducts.

公开(公告)号：US20230250413A1

公开(公告)日：2023-08-10

申请号：US18012979

申请日：2021-10-05

申请人： FUJI OIL HOLDINGS INC.

发明人： Shigeki MIZUSHIMA

IPC分类号： C12N11/02 ,  C12P7/64 ,  C12N9/20 ,  A23D9/007 ,  A23D9/04 ,  A23L29/00

CPC分类号： C12N11/02 ,  A23D9/04 ,  A23D9/007 ,  A23L29/06 ,  C12N9/20 ,  C12P7/64

摘要： The present invention addresses the objective of providing a novel, reproducible plant-based enzyme-immobilization carrier that is biodegradable and imposes a low environmental load and is also harmless for the human body. The technical concept of the present invention was achieved with the discovery, in response to the objective, that a prescribed porous body based on plant protein, e.g., from soy, functions as an enzyme-immobilization carrier.