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    1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
    92.
    发明授权
    1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof 有权
    1-芳基-5-烷基吡唑衍生物化合物，其制备方法及其使用方法

    公开(公告)号：US09339033B2

    公开(公告)日：2016-05-17

    申请号：US14325761

    申请日：2014-07-08

    Applicant: MERIAL, INC.

    Inventor： Loic Patrick Le Hir de Fallois ,  Hyoung Ik Lee ,  Philip Reid Timmons ,  William Glenn Cawthorne, Jr. ,  Adalberto Perez de Leon

    IPC: A01N43/56 ,  C07D401/04 ,  C07D231/18 ,  A01N47/02 ,  A61K31/415 ,  A61K31/4439 ,  A61K45/06 ,  A01N25/02

    CPC classification number: A01N43/56 ,  A01N25/02 ,  A01N47/02 ,  A61K31/415 ,  A61K31/4439 ,  A61K45/06 ,  C07D231/18 ,  C07D401/04

    Abstract: Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: R1 is hydrogen, cyano, halogen, R8, formyl, —C(O)R8, —C(O)OR8, —C(O)NR9R10, or —C(S)NH2; R2 is R8 or —S(O)mR11; R3 is methyl, ethyl or C1-C4 haloalkyl; R4, R5 and R7 are independently hydrogen, halogen, alkyl, haloalkyl, cyano or nitro; R6 is halogen, alkyl, haloalkyl, alkoxy, haloalkyloxy, cyano, nitro, —C(O)R12, —S(O)nR12 or SF5; Z is a nitrogen atom or C—R13; R8 is alkyl, haloalkyl, cycloalkyl or halocycloalkyl; R9 is hydrogen, alkyl, haloalkyl or alkoxy; R10 is hydrogen, alkyl, haloalkyl or alkoxy; R11 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or cycloalkyl; R12 is alkyl or haloalkyl; R13 is hydrogen, halogen, cyano, nitro, alkyl, haloalkyl, alkoxy or haloalkoxy; m is 0, 1 or 2; and n is 0, 1 or 2; or a salt thereof, the method of making compounds of formula (I) and the use of these compounds against ectoparasites, endoparasites and pests.

    Abstract translation: 提供式（I）的1-芳基-5-烷基吡唑化合物：其中：R 1是氢，氰基，卤素，R 8，甲酰基，-C（O）R 8，-C（O）OR 8，-C ）NR 9 R 10或-C（S）NH 2; R2是R8或-S（O）mR11; R3是甲基，乙基或C1-C4卤代烷基; R4，R5和R7独立地是氢，卤素，烷基，卤代烷基，氰基或硝基; R 6是卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，氰基，硝基，-C（O）R 12，-S（O）n R 12或SF 5; Z是氮原子或C-R13; R8是烷基，卤代烷基，环烷基或卤代环烷基; R9是氢，烷基，卤代烷基或烷氧基; R 10是氢，烷基，卤代烷基或烷氧基; R11是烷基，卤代烷基，烯基，卤代烯基，炔基，卤代炔基或环烷基; R12是烷基或卤代烷基; R 13是氢，卤素，氰基，硝基，烷基，卤代烷基，烷氧基或卤代烷氧基; m为0,1或2; 且n为0,1或2; 或其盐，制备式（I）化合物的方法以及这些化合物对外寄生虫，内寄生虫和害虫的用途。

    PET CARE CLEANSING COMPOSITION
    98.
    发明申请
    PET CARE CLEANSING COMPOSITION 审中-公开

    公开(公告)号：US20190091133A1

    公开(公告)日：2019-03-28

    申请号：US15774534

    申请日：2016-11-09

    Applicant: MERIAL INC.

    Inventor： Eric Anthony Hansen

    IPC: A61K8/892 ,  A61Q5/02 ,  A61K8/34 ,  A61K8/33 ,  A61K8/49 ,  A61K8/9794 ,  A61K8/9789 ,  A61K8/67

    Abstract: A method of treating the skin or hair on a dog containing an effective amount of an ectoparasiticide previously applied to the skin or hair, comprising applying a quantity of a cleansing composition directly to the skin or hair, wherein the treatment does not result in reducing the efficacy of the ectoparasiticide against adult fleas (C. felis) or adult ticks (R. sanguineus) below 90% efficacy for at least a month after application of the ectoparasiticide; wherein the cleansing composition comprises about 1-3% glycerin; about 2-4% silicone copolyol esters, water and is essentially free of surfactant.

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