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公开(公告)号:US20180215777A1
公开(公告)日:2018-08-02
申请号:US15748336
申请日:2016-07-29
Applicant: UNIVERSITY OF SOUTH AUSTRALIA , CURTIN UNIVERSITY
Inventor: Doug Brooks , Sally Plush , Massimiliano Massi , Stefano Stagni
IPC: C07H23/00 , G01N33/58 , A61K49/00 , G01N33/574
CPC classification number: C07H23/00 , A61K33/24 , A61K49/0019 , A61K49/0052 , C07F13/00 , G01N33/57434 , G01N33/582
Abstract: The present disclosure relates to complexes for intracellular imaging and also to methods and kits for intracellular imaging or cell labelling. Certain embodiments of the present disclosure provide a complex comprising a transition metal carbonyl compound, a conjugated bidentate ligand and a tetrazolato compound comprising a saccharide group.
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公开(公告)号:US09923624B2
公开(公告)日:2018-03-20
申请号:US14430096
申请日:2013-09-20
Applicant: UNIVERSITY OF SOUTH AUSTRALIA
Inventor: David Victor Lawrie Haley , John Lawrence Buetefuer , Alexander James Grant , William George Cowley , Gottfried Lechner , Ingmar Rudiger Land , Robert George McKilliam , Andre Pollok , Linda Mary Davis , Ricky Rocco Luppino , Sorin Adrian Barbulescu
CPC classification number: H04B7/18513 , H04B7/185 , H04B7/212 , H04W40/20 , Y02D70/00 , Y02D70/164 , Y02D70/38 , Y02D70/446
Abstract: A communication system is disclosed. In an embodiment, the communication system includes a user node for receiving data from a remote application program, the data including message data for communication to a central application program operatively associated with the remote application program; plurality of geographically distributed gateway nodes; one or more access nodes for receiving the message data from the user node via a first communications interface, and communicating the message data via a second communications interface to one or more of the plurality of geographically distributed gateway nodes; and a hub for communicating with the one or more of the plurality of geographically distributed gateway nodes to receive the message data for communication to the central application.
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公开(公告)号:US20180016556A1
公开(公告)日:2018-01-18
申请号:US15538465
申请日:2015-12-22
Applicant: University of South Australia
Inventor: Yanchuang HAN , Xin-Fu ZHOU , WooKyung KIM , JunYong YANG , JiHee KIM
Abstract: The disclosure relates to a method of producing induced beta cells from urine-derived cells, the method comprising providing urine-derived cells; inducing the urine-derived cells by culturing said urine-derived cells in a primary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a first period of time to obtain induced endoderm cells; inducing the induced endoderm cells by culturing said induced endoderm cells in a secondary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a second period of time to obtain induced pancreatic precursor cells; and inducing the induced pancreatic precursor cells by culturing said pancreatic precursor cells in a tertiary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a third period of time to obtain induced beta cells.
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公开(公告)号:US09828351B2
公开(公告)日:2017-11-28
申请号:US15321693
申请日:2015-06-26
Applicant: MONASH UNIVERSITY , UNIVERSITY OF SOUTH AUSTRALIA , CENTRAL ADELAIDE LOCAL HEALTH NETWORK INCORPORATED
Inventor: Bernard Luke Flynn , Luigi Aurelio , Carmen Vittoria Scullino , Bing Hui Wang , Stuart Maxwell Pitson , Melissa Rose Pitman
IPC: C07D271/113 , C07D285/08 , C07D419/12 , C07D285/135 , C07D271/07 , C07D277/56 , C07D271/10 , C07D413/12 , C07D413/10 , C07D271/107
CPC classification number: C07D285/08 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/107 , C07D271/113 , C07D277/56 , C07D285/135 , C07D413/10 , C07D413/12 , C07D419/12
Abstract: The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosure further relates to the use of such compounds as research tools, use in therapy, to compositions and agents comprising said compounds, and to methods of treatment using said compounds.
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公开(公告)号:US20170328922A1
公开(公告)日:2017-11-16
申请号:US15528166
申请日:2015-03-19
Inventor: Doug Brooks , Sally Plush , Massimiliano Massi
IPC: G01N33/92 , C07D471/04 , G01N33/50 , G01N33/58 , C07D257/04 , G01N33/574 , C07F13/00
CPC classification number: G01N33/92 , C07D257/04 , C07D401/04 , C07D471/04 , C07F13/00 , G01N33/5005 , G01N33/574 , G01N33/586 , G01N2405/02 , G01N2405/06 , G01N2405/10
Abstract: The present disclosure relates to methods and products for labelling, binding and/or detection of lipids. Certain embodiments provide a method of labelling a lipid. The method comprises exposing the lipid to a complex comprising a transition metal carbonyl compound, a conjugated bidentate ligand and a tetrazolato compound, and thereby labelling the lipid by binding the complex to the lipid.
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公开(公告)号:US20170312249A1
公开(公告)日:2017-11-02
申请号:US15517755
申请日:2015-10-08
Inventor: Joanna Woodcock , Angel Lopez , Stuart Maxwell Pitson , Michael Susithiran Samuel , Carl Coolen
IPC: A61K31/395 , A61K45/06 , A61K31/452 , A61K31/40 , A61K9/06 , A61K47/10 , A61K9/00
Abstract: The present disclosure relates to modulators of 14-3-3 functionality and their use in methods and compositions for preventing and/or treating various diseases, conditions and states, such as cancer and healing of wounds. Certain embodiments of the present disclosure provide a method of preventing and/or treating a disease, condition or state in a subject associated with altered 14-3-3 protein functionality and/or which would benefit from altering 14-3-3 functionality, the method comprising administering to the subject an effective amount of an agent which inhibits dimerization of the 14-3-3 protein, thereby preventing and/or treating the disease, condition or state in the subject.
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公开(公告)号:US09763253B2
公开(公告)日:2017-09-12
申请号:US14421526
申请日:2013-08-14
Applicant: University of South Australia
Inventor: Alexander James Grant , David Victor Lawrie Haley , Robert George McKilliam , William George Cowley , Linda Mary Davis
CPC classification number: H04W72/048 , H04B7/18539 , H04B7/2121 , H04W48/04 , H04W64/00 , H04W72/04 , H04W72/0446 , H04W84/18
Abstract: Methods and systems are described which provide solutions for determining how to allocate terminals to slots in order to maximize communication system performance in the case where there is no feedback channel between a multiuser satellite receiver and terminals within the field of view. Terminals operate independently of each other and choose transmission slots based upon the geographic position of the terminal. Terminals can be programmed with a slot selector to choose slots according to some deterministic or non deterministic function of the current position. A slot plan database may be used to assist in efficient slot selection. Regular and irregular grid based allocation methods are described, that reduce the likelihood that too many terminals transmit using the same slot within the field of view. Satellite induced Doppler effects can be utilized be further increase slot re-use and to improve allocation of slots so that the receiver sees an approximately uniform distribution of frequencies over the frequency band to improve system throughput. The approaches described herein greatly reduce or eliminate the probability of failure at the receiver, which has numerous implementation advantages such as reduced cost, complexity, and power consumption.
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公开(公告)号:US09723790B2
公开(公告)日:2017-08-08
申请号:US14768159
申请日:2014-02-19
Inventor: Nicholas Kane Berry , Chris Saunders
CPC classification number: A01F12/00 , A01D41/12 , A01D41/1243 , A01F12/40
Abstract: A weed seed devitalization arrangement for use with a. combine harvester, attached to the combine harvester, towed behind, or standalone. The weed seed devitalization arrangement receives weed seeds entrained in a. portion of the air and material previously discharged from a combine harvester or other crop/lawn cutung apparatus. The weed seed devitalization arrangement includes a roton'stator arrangement including but not necessarily excluding other elements, one or more stationary substantially circular array of weed seed impact members, the members being arranged so as to impact weed seeds being provided into the substantially circular array; and one or more rotatable substantially circular array of weed seed impact members, the rotatable array movable with respect to a stationary substantially circular array of weed seed impact members, the impact members of the rotatable substantially circular array arranged to impact weed seeds being directed through the rotatable substantially circular array. Another element may be a driven rotating clement at or near the central portion of the rotor/stator arrangement for receiving the portion of air and material discharged from the combine harvester entrained with weed seeds and for providing a flow of air and entrained material including weed seed into the arrays of the arrangement.
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公开(公告)号:US09668210B2
公开(公告)日:2017-05-30
申请号:US14430100
申请日:2013-09-20
Applicant: UNIVERSITY OF SOUTH AUSTRALIA
Inventor: Alexander James Grant , David Victor Lawrie Haley , Robert George McKilliam , William George Cowley , Ho Leung Chan
CPC classification number: H04W52/0216 , H04B7/212 , H04J11/0036 , H04L5/0055 , H04W52/0229 , H04W52/0241 , H04W52/028 , H04W72/0446 , Y02D70/164 , Y02D70/446
Abstract: A multiple access slotted wireless communication system comprising a plurality of terminals and a multi-access receiver is described. The multi-access receiver can decode multiple transmissions in each slot of a frame from terminals in its field of view. Each terminal has an active state for transmitting and an inactive state. After receiving acknowledgement of a successful transmission by the terminal, the terminal enters the inactive state for at least a transmission delay time. This may be the remaining time that the terminal is in the field of view of the multi-access receiver. This may be achieved by the terminal using a probability of transmission to determine whether or not to transmit in the next frame. The terminal may also be configured to select the slot in a frame, and this may be based upon information such as which slots were acknowledged. The receiver may use compression to transmit acknowledgement messages.
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公开(公告)号:US09656601B2
公开(公告)日:2017-05-23
申请号:US14936024
申请日:2015-11-09
Applicant: University of South Australia , SMR Patents S.A.R.L.
Inventor: Drew Raymond Evans , Kamil Zuber , Colin James Hall , Simon David Field , David Derry Chamberlain , Andrew Brian Little , Simon Belcher , Eugene Schmirin , Mark Delaine , James Nicholas Dickson
CPC classification number: B60Q1/2665 , B60Q1/38 , C22C28/00 , C23C14/0015 , C23C14/024 , C23C14/20 , C23C14/205 , C23C14/228 , C23C14/35 , C23C28/00 , C23C30/00 , F21S43/26 , G02B27/142 , G02B27/144 , Y10T428/12 , Y10T428/12569 , Y10T428/12847 , Y10T428/265
Abstract: The present invention relates to a polymeric substrate being coated with a reflective coating, particularly a chromium-based reflective coating.
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