METHOD OF INDUCING BETA CELLS FROM URINE-DERIVED CELLS USING SMALL MOLECULES

    公开(公告)号:US20180016556A1

    公开(公告)日:2018-01-18

    申请号:US15538465

    申请日:2015-12-22

    IPC分类号: C12N5/071 C12N5/074

    摘要: The disclosure relates to a method of producing induced beta cells from urine-derived cells, the method comprising providing urine-derived cells; inducing the urine-derived cells by culturing said urine-derived cells in a primary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a first period of time to obtain induced endoderm cells; inducing the induced endoderm cells by culturing said induced endoderm cells in a secondary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a second period of time to obtain induced pancreatic precursor cells; and inducing the induced pancreatic precursor cells by culturing said pancreatic precursor cells in a tertiary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a third period of time to obtain induced beta cells.

    Channel allocation in a communication system

    公开(公告)号:US09763253B2

    公开(公告)日:2017-09-12

    申请号:US14421526

    申请日:2013-08-14

    摘要: Methods and systems are described which provide solutions for determining how to allocate terminals to slots in order to maximize communication system performance in the case where there is no feedback channel between a multiuser satellite receiver and terminals within the field of view. Terminals operate independently of each other and choose transmission slots based upon the geographic position of the terminal. Terminals can be programmed with a slot selector to choose slots according to some deterministic or non deterministic function of the current position. A slot plan database may be used to assist in efficient slot selection. Regular and irregular grid based allocation methods are described, that reduce the likelihood that too many terminals transmit using the same slot within the field of view. Satellite induced Doppler effects can be utilized be further increase slot re-use and to improve allocation of slots so that the receiver sees an approximately uniform distribution of frequencies over the frequency band to improve system throughput. The approaches described herein greatly reduce or eliminate the probability of failure at the receiver, which has numerous implementation advantages such as reduced cost, complexity, and power consumption.

    Weed seed devitalization arrangement

    公开(公告)号:US09723790B2

    公开(公告)日:2017-08-08

    申请号:US14768159

    申请日:2014-02-19

    IPC分类号: A01F12/40 A01D41/12 A01F12/00

    摘要: A weed seed devitalization arrangement for use with a. combine harvester, attached to the combine harvester, towed behind, or standalone. The weed seed devitalization arrangement receives weed seeds entrained in a. portion of the air and material previously discharged from a combine harvester or other crop/lawn cutung apparatus. The weed seed devitalization arrangement includes a roton'stator arrangement including but not necessarily excluding other elements, one or more stationary substantially circular array of weed seed impact members, the members being arranged so as to impact weed seeds being provided into the substantially circular array; and one or more rotatable substantially circular array of weed seed impact members, the rotatable array movable with respect to a stationary substantially circular array of weed seed impact members, the impact members of the rotatable substantially circular array arranged to impact weed seeds being directed through the rotatable substantially circular array. Another element may be a driven rotating clement at or near the central portion of the rotor/stator arrangement for receiving the portion of air and material discharged from the combine harvester entrained with weed seeds and for providing a flow of air and entrained material including weed seed into the arrays of the arrangement.