摘要:
The disclosure relates to a method of producing induced beta cells from urine-derived cells, the method comprising providing urine-derived cells; inducing the urine-derived cells by culturing said urine-derived cells in a primary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a first period of time to obtain induced endoderm cells; inducing the induced endoderm cells by culturing said induced endoderm cells in a secondary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a second period of time to obtain induced pancreatic precursor cells; and inducing the induced pancreatic precursor cells by culturing said pancreatic precursor cells in a tertiary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a third period of time to obtain induced beta cells.
摘要:
The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosure further relates to the use of such compounds as research tools, use in therapy, to compositions and agents comprising said compounds, and to methods of treatment using said compounds.
摘要:
The present disclosure relates to methods and products for labelling, binding and/or detection of lipids. Certain embodiments provide a method of labelling a lipid. The method comprises exposing the lipid to a complex comprising a transition metal carbonyl compound, a conjugated bidentate ligand and a tetrazolato compound, and thereby labelling the lipid by binding the complex to the lipid.
摘要:
The present disclosure relates to modulators of 14-3-3 functionality and their use in methods and compositions for preventing and/or treating various diseases, conditions and states, such as cancer and healing of wounds. Certain embodiments of the present disclosure provide a method of preventing and/or treating a disease, condition or state in a subject associated with altered 14-3-3 protein functionality and/or which would benefit from altering 14-3-3 functionality, the method comprising administering to the subject an effective amount of an agent which inhibits dimerization of the 14-3-3 protein, thereby preventing and/or treating the disease, condition or state in the subject.
摘要:
Methods and systems are described which provide solutions for determining how to allocate terminals to slots in order to maximize communication system performance in the case where there is no feedback channel between a multiuser satellite receiver and terminals within the field of view. Terminals operate independently of each other and choose transmission slots based upon the geographic position of the terminal. Terminals can be programmed with a slot selector to choose slots according to some deterministic or non deterministic function of the current position. A slot plan database may be used to assist in efficient slot selection. Regular and irregular grid based allocation methods are described, that reduce the likelihood that too many terminals transmit using the same slot within the field of view. Satellite induced Doppler effects can be utilized be further increase slot re-use and to improve allocation of slots so that the receiver sees an approximately uniform distribution of frequencies over the frequency band to improve system throughput. The approaches described herein greatly reduce or eliminate the probability of failure at the receiver, which has numerous implementation advantages such as reduced cost, complexity, and power consumption.
摘要:
A weed seed devitalization arrangement for use with a. combine harvester, attached to the combine harvester, towed behind, or standalone. The weed seed devitalization arrangement receives weed seeds entrained in a. portion of the air and material previously discharged from a combine harvester or other crop/lawn cutung apparatus. The weed seed devitalization arrangement includes a roton'stator arrangement including but not necessarily excluding other elements, one or more stationary substantially circular array of weed seed impact members, the members being arranged so as to impact weed seeds being provided into the substantially circular array; and one or more rotatable substantially circular array of weed seed impact members, the rotatable array movable with respect to a stationary substantially circular array of weed seed impact members, the impact members of the rotatable substantially circular array arranged to impact weed seeds being directed through the rotatable substantially circular array. Another element may be a driven rotating clement at or near the central portion of the rotor/stator arrangement for receiving the portion of air and material discharged from the combine harvester entrained with weed seeds and for providing a flow of air and entrained material including weed seed into the arrays of the arrangement.
摘要:
A multiple access slotted wireless communication system comprising a plurality of terminals and a multi-access receiver is described. The multi-access receiver can decode multiple transmissions in each slot of a frame from terminals in its field of view. Each terminal has an active state for transmitting and an inactive state. After receiving acknowledgement of a successful transmission by the terminal, the terminal enters the inactive state for at least a transmission delay time. This may be the remaining time that the terminal is in the field of view of the multi-access receiver. This may be achieved by the terminal using a probability of transmission to determine whether or not to transmit in the next frame. The terminal may also be configured to select the slot in a frame, and this may be based upon information such as which slots were acknowledged. The receiver may use compression to transmit acknowledgement messages.
摘要:
The present disclosure provides methods for detecting biological print(s) or biological fluid(s) or target low molecular weight analyte(s) therein comprising contacting the suspected print(s) or fluid(s) with porous semiconductor substrates or microparticles (MPs) under conditions to allow said semiconductor substrates or microparticles to adhere to the print(s) or fluid(s) or analyte(s) therein, and analysing the adhered porous semiconductor substrates or MPs to detect the print(s), fluid(s) or analytes when present. The disclosure also includes method for making porous semiconductor substrates.
摘要:
Disclosed herein is a composition of matter comprising metal nanoparticles dispersed in a protein matrix comprising an elastic protein or homolog or fragment thereof. The metal may be an electrocatalyst metal. Also disclosed are electrodes, electrochemical half-cells and fuel cells comprising the composition of matter.