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公开(公告)号：US20190048330A1
公开(公告)日：2019-02-14
申请号：US16108402
申请日：2018-08-22
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Asaph Aharoni , Samuel Bocobza , Tal Dahan , Avraham A. Levy
IPC: C12N9/22 , C12N15/62 , C12N15/113 , C07K14/08 , C12N15/82
Abstract: Disclosed herein are methods for gene targeting in a plant cell, as well as recombinant nucleic acid molecules used in these methods. Further disclosed are recombinant nucleic acid molecules comprising a target gene operably linked to a regulatory region of the UBQ10 gene.
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公开(公告)号：US20190031733A1
公开(公告)日：2019-01-31
申请号：US16055241
申请日：2018-08-06
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rachel Lea EISENBACH , Yosi GOZLAN , Esther TZEHOVAL
IPC: C07K14/705 , A61K35/17 , C12N15/10 , C07K14/725
Abstract: The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.
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公开(公告)号：US20190026502A1
公开(公告)日：2019-01-24
申请号：US16070679
申请日：2017-01-19
Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD , YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Gil SEGEV , Ido SHAHAF , Gilad ASHAROV , Moni NAOR
CPC classification number: G06F21/79 , G06F12/1408 , G06F16/00 , G06F16/245 , G06F21/602 , G06F21/6227 , G06F2212/1052 , H04L9/0861
Abstract: A method for searchable symmetric encryption. The method includes: accessing a computerized database that comprises keyword lists, each of the keyword lists comprising memory addresses of electronic documents that all contain a respective keyword; binning the memory addresses by performing balanced allocation of the memory addresses into ordered bins, such that at least some of the ordered bins each contains memory addresses of electronic documents that contain different keywords; encrypting each of the memory addresses with an encryption key that is derived from the keyword of the respective memory address; and storing the ordered bins at consecutive locations in a non-transient computer-readable memory, wherein the consecutive locations preserve the order of the ordered bins.
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公开(公告)号：US20190022152A1
公开(公告)日：2019-01-24
申请号：US16151455
申请日：2018-10-04
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Eran ELINAV , Eran SEGAL
IPC: A61K35/741 , C12Q1/6883 , C12Q1/04 , C12Q1/02
Abstract: A method of determining tolerance to an agent in a healthy subject is disclosed. The method comprises: (a) determining a signature of a microbiome in a sample of the healthy subject who has been subjected to the agent or condition; and (b) comparing the signature of the microbiome of the healthy subject to at least one reference signature of a pathological microbiome, wherein when the signature of the microbiome of the healthy subject is statistically significantly similar to the reference signature of the pathological microbiome, it is indicative that the healthy subject is intolerant to the agent.
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95.发明申请公开(公告)号：US20190015441A1
公开(公告)日：2019-01-17
申请号：US16068172
申请日：2017-01-05
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Idit SHACHAR , Hadas LEWINSKY , Lihi RADOMIR , Anna WIENER
IPC: A61K31/713 , A61K38/17 , A61P29/00 , A61P35/02 , A61P37/06
CPC classification number: A61K31/713 , A61K38/1774 , A61K2039/505 , A61P29/00 , A61P35/02 , A61P37/06 , C07K16/2896 , C07K2317/76
Abstract: A method of treating a malignant disease involving T cell exhaustion in a subject, with the proviso that said malignant disease is not a B cell malignancy, is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84, thereby treating the malignant disease involving the T cell exhaustion. Also disclosed is a method of treating an autoimmune or inflammatory disease in a subject, the method comprising administering to a subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of CD84. A method comprising administering to the subject a therapeutically effective amount of an agent capable of decreasing an activity or expression of SLAMF1, with the proviso that said agent is not an agent capable of decreasing an activity or expression of CD84, is also disclosed.
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Patent Agency Ranking
公开(公告)号：US10159724B2
公开(公告)日：2018-12-25
申请号：US15286327
申请日：2016-10-05
Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE , UNIVERSITAET DUISBURG-ESSEN
Inventor： Edward H. Schuchman , Erich Gulbins , Anthony Futerman , Yael Pewzner-Jung
Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
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公开(公告)号：US20180319849A1
公开(公告)日：2018-11-08
申请号：US16033240
申请日：2018-07-12
Applicant: Ariel-University Research and Development Company Ltd. , Yeda Research and Development Co. Ltd. , Indian Institute of Technology Bombay
Inventor： Mordechai Sheves , Irishi N. N. Namboothiri , Guy Patchornik
IPC: C07K14/215 , C12N1/20 , C12N1/06
CPC classification number: C07K14/215 , C12N1/06 , C12N1/20
Abstract: A method of precipitating cell membrane fragments from a cell lysate is disclosed. The method comprises contacting the cell lysate with a hydrophobic chelator and a metal ion under conditions that allow precipitation of the cell membrane fragments. Kits for precipitating cell membrane fragments are also disclosed.
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公开(公告)号：US10077437B2
公开(公告)日：2018-09-18
申请号：US15189021
申请日：2016-06-22
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Ron Milo , Arren Bar-Even , Elad Noor
IPC: C12N9/00 , C12N15/82 , C12N9/04 , C12N9/02 , C12N9/12 , C12N9/10 , C12N9/18 , C12N9/88 , C12N9/90 , C12P7/40 , C12N15/70 , C12P7/42 , C12P7/46 , C12P11/00 , G06F19/12
CPC classification number: C12N9/93 , C12N9/0006 , C12N9/0008 , C12N9/1018 , C12N9/1205 , C12N9/13 , C12N9/18 , C12N9/88 , C12N9/90 , C12N15/70 , C12N15/8245 , C12N15/8247 , C12N15/8269 , C12P7/40 , C12P7/42 , C12P7/46 , C12P11/00 , C12Y101/01059 , C12Y102/01018 , C12Y201/03001 , C12Y208/03001 , C12Y401/01031 , C12Y402/01017 , C12Y402/01054 , C12Y604/01001 , C12Y604/01002 , G16B5/00 , Y02P20/52
Abstract: A system for carbon fixation is provided. The system comprises enzymes which catalyze reactions of a carbon fixation pathway, wherein at least one of the reactions of the carbon fixation pathway is a carboxylation reaction, wherein products of the reactions of the carbon fixation pathway comprise oxaloacetate and malonyl-CoA, wherein an enzyme which performs the carboxylation reaction is selected from the group consisting of phophoenolpyruvate (PEP) carboxlase, pyruvate carboxylase and acetyl-CoA carboxylase and wherein an export product of the carbon fixation pathway is glyoxylate. Additional carbon fixation pathways are also provided and methods of generating same.
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公开(公告)号：US20180253517A1
公开(公告)日：2018-09-06
申请号：US15969904
申请日：2018-05-03
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Tali KIMCHI , Aharon WEISSBROD , Genadiy VASSERMAN
CPC classification number: G06F17/5009 , A01K1/031 , A01K29/005 , G01S3/14 , G01S3/7864 , G06K9/6282
Abstract: A method of identifying and classifying social complex behaviors among a group of model organisms, comprising implanting at least one RFID transponder in each model organism in said group of model organisms; enclosing said group of model organisms in a monitored space divided into RFID monitored segments; RFID tracking a position of each model organism by reading said at least one RFID transponder in each model organism over a period of time; capturing a sequence of images of each model organism over said period of time; and calculating at least one spatiotemporal model of each model organism based on time synchronization of said RFID tracked position of said model organism with said sequence of images.
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公开(公告)号：US10069094B2
公开(公告)日：2018-09-04
申请号：US15034186
申请日：2014-11-06
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Shahal Ilani , Sharon Pecker , Avishai Benyamini , Jonah Waissman , Assaf Hamo , Maayan Honig
IPC: H01L51/05 , H01L29/06 , H01L21/66 , H01L51/00 , H01L29/10 , H01L29/66 , H01L29/772 , H01L51/10 , C01B32/16
Abstract: A method for use in construction of an electronic device and a transistor structure are presented. The method comprising: providing one or more nanotubes grown on a surface of a first substrate; providing a desired electrode arrangement fabricated on a surface of a second substrate. The electrode arrangement comprises at least two elevated source and drain electrodes and one or more gate electrodes located in between said elevated source and drain electrodes. The method also comprises bringing the electrode arrangement on the second substrate to close proximity with the first substrate such that surfaces of the first and second substrates face each other; scanning said first substrate with said electrode arrangement and determining contact of electrodes of the electrode arrangement with a nanotube located on the first substrate; and detaching said nanotube from the first substrate to provide a transistor structure comprising an isolated nanotube between the source and drain electrodes.
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