公开(公告)号：US20200155821A1

公开(公告)日：2020-05-21

申请号：US16684638

申请日：2019-11-15

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital,Inc.

Inventor： Robert S. Langer ,  Carlo Giovanni Traverso ,  Sahab Babaee ,  Simo Pajovic ,  Jiuyun Shi

IPC: A61M31/00 ,  A61L31/16 ,  A61M5/142

Abstract: Residence devices for long term delivery of therapeutic compounds and/or for sensing one or more relevant parameters in vivo are disclosed. In one embodiment, a residence device may include a plurality of links interconnected by a corresponding plurality of flexible hinges to permit the residence device to be deformed into a contracted configuration and subsequently permitted to return to an expanded configuration once positioned in a desired location, such as the stomach, of a subject. In some instances, at least a portion of the interconnected links may include a first link segment, a second link segment, and a coupling that selectively connects the first link segment to the second link segment. The coupling may be configured to weaken or decouple a connection between the first link segment and the second link segment when exposed to a temperature greater than a threshold temperature to selectively weaken and/or disassemble the residence device.

公开(公告)号：US20190070108A1

公开(公告)日：2019-03-07

申请号：US16177687

申请日：2018-11-01

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, JR. ,  Philip A. Eckhoff

IPC: A61K9/00 ,  C08L33/14 ,  A61K47/69 ,  A61K47/58 ,  C08L33/08 ,  C08L33/02 ,  C08G83/00 ,  C08G63/08 ,  C08G18/73 ,  C08G18/42 ,  A61M31/00 ,  A61K47/42 ,  A61K47/40 ,  A61K47/34 ,  A61K47/32 ,  A61K47/10 ,  A61K31/7048 ,  A61K31/65 ,  A61K31/357 ,  A61K9/48

Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

公开(公告)号：US10149635B2

公开(公告)日：2018-12-11

申请号：US15237405

申请日：2016-08-15

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Albert Joseph Swiston ,  Robert S. Langer ,  Tadd Bernard Hughes ,  Kerry Johnson ,  Carlo Giovanni Traverso

IPC: A61B5/00 ,  A61B5/07 ,  A61B5/0205 ,  A61B5/11 ,  A61B7/02 ,  A61B5/02 ,  A61B5/08 ,  A61B8/02

Abstract: Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, the approach disclosed here enables vital sign monitoring internally from the gastrointestinal tract. The large animal (porcine) experiments and a robust processing disclosed herein demonstrate the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage.

公开(公告)号：US20140228715A1

公开(公告)日：2014-08-14

申请号：US14116628

申请日：2012-05-14

Applicant: The General Hospital Corporation ,  Massachusetts Institute of Technology

Inventor： Avraham D. Schroeder ,  Carlo Giovanni Traverso ,  Baris E. Polat ,  Kathryn A. Whitehead ,  Daniel G. Anderson ,  Robert S. Langer, Jr. ,  Carl Magnus Schoellhammer ,  Daniel Blankschtein

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/01 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4839 ,  A61M31/002 ,  A61M37/0092

Abstract: A method of delivering a substance includes providing a substance at a location in a gastrointestinal (GI) tract, excluding a buccal membrane, of a biological body; and applying ultrasonic waves, having a frequency between about 20 kHz and about 10 MHz, at the location. The method can include storing the substance in at least one reservoir and exposing a medium within or of the GI tract to the substance. The method can further include delivering a device into the GI tract, the device including at least one ultrasound transducer and circuitry; powering the at least one ultrasound transducer and circuitry from within the device; and driving the at least one ultrasound transducer, using the circuitry, in a manner causing the at least one ultrasound transducer to emit ultrasonic waves to a medium within or of the GI tract.

Abstract translation: 递送物质的方法包括在生物体的胃肠（GI）道（不包括颊膜）的位置处提供物质; 并且在该位置施加具有约20kHz至约10MHz之间的频率的超声波。 该方法可以包括将物质储存在至少一个储存器中并将GI道内或介质中的介质暴露于物质。 该方法还可以包括将装置递送到胃肠道，该装置包括至少一个超声换能器和电路; 为设备内的至少一个超声换能器和电路供电; 以及使得所述至少一个超声换能器以使得所述至少一个超声换能器向胃肠道内或胃肠道内的介质发射超声波的方式来驱动所述至少一个超声换能器。

公开(公告)号：US12036324B2

公开(公告)日：2024-07-16

申请号：US17826799

申请日：2022-05-27

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

Inventor： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer ,  Jorrit Jeroen Water ,  Morten Revsgaard Frederiksen ,  Bo Uldall Kristiansen ,  Mikkel Oliver Jespersen ,  Mette Poulsen ,  Peter Herskind ,  Brian Jensen

IPC: A61K9/48 ,  A61B5/145 ,  A61B10/02 ,  A61J3/07 ,  A61K9/00 ,  A61K38/28 ,  A61M5/142 ,  A61M5/145 ,  A61M5/158 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61B10/06 ,  A61N1/05

CPC classification number: A61K9/4808 ,  A61B5/14503 ,  A61B5/14539 ,  A61B10/02 ,  A61J3/07 ,  A61K9/0002 ,  A61K9/0012 ,  A61K9/0021 ,  A61K9/0065 ,  A61K9/0092 ,  A61K9/4866 ,  A61K38/28 ,  A61M5/14276 ,  A61M5/1454 ,  A61M5/158 ,  A61M5/2033 ,  A61M5/329 ,  A61M5/3295 ,  A61M31/002 ,  A61M37/0015 ,  A61M37/0069 ,  A61N1/325 ,  A61N1/36007 ,  A61B2010/0208 ,  A61B10/0233 ,  A61B10/06 ,  A61M2005/14284 ,  A61M2005/1581 ,  A61M2005/1585 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2205/0238 ,  A61M2205/21 ,  A61M2210/1053 ,  A61M2210/106 ,  A61N1/0509

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

公开(公告)号：US20240024250A1

公开(公告)日：2024-01-25

申请号：US18204882

申请日：2023-06-01

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

IPC: A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61B5/145 ,  A61B10/02 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61K38/28 ,  A61M5/158 ,  A61M5/145

CPC classification number: A61K9/4808 ,  A61J3/07 ,  A61K9/0002 ,  A61K9/0012 ,  A61K9/4866 ,  A61B5/14503 ,  A61B5/14539 ,  A61B10/02 ,  A61M5/14276 ,  A61M37/0015 ,  A61N1/325 ,  A61N1/36007 ,  A61K9/0065 ,  A61K9/0092 ,  A61M5/2033 ,  A61M5/329 ,  A61M5/3295 ,  A61M31/002 ,  A61K9/0021 ,  A61K38/28 ,  A61M5/158 ,  A61M5/1454 ,  A61M37/0069 ,  A61B2010/0208 ,  A61M2005/14284 ,  A61M2037/0023 ,  A61M2205/0238 ,  A61M2205/21 ,  A61M2210/106 ,  A61M2037/0053 ,  A61B10/0233 ,  A61M2005/1585 ,  A61N1/0509

Abstract: Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression).

公开(公告)号：US20230380768A1

公开(公告)日：2023-11-30

申请号：US18316954

申请日：2023-05-12

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Robert S. Langer ,  Carlo Giovanni Traverso ,  Yong Lin Kong

IPC: A61B5/00 ,  A61B5/07 ,  A61M31/00

CPC classification number: A61B5/6885 ,  A61B5/073 ,  A61B5/6871 ,  A61B5/0031 ,  A61B5/4238 ,  A61B5/6861 ,  A61M31/002 ,  A61B2560/0443 ,  A61B2562/0285 ,  A61B2562/162 ,  A61M2205/0216 ,  A61M2205/0272 ,  A61M2205/3523 ,  A61M2210/1053

Abstract: Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

公开(公告)号：US11771829B2

公开(公告)日：2023-10-03

申请号：US16778152

申请日：2020-01-31

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

Inventor： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  Morten Revsgaard Frederiksen ,  Mikkel Oliver Jespersen ,  Brian Mouridsen ,  Jesper Windum ,  Mette Poulsen ,  Brian Jensen ,  Jorrit Jeroen Water ,  Mikkel Wennemoes Hvitfeld Ley ,  Xiaoya Lu ,  Andreas Vegge

IPC: A61M5/20 ,  A61K9/00 ,  A61M5/30

CPC classification number: A61M5/2033 ,  A61K9/0024 ,  A61M5/30 ,  A61M2005/202 ,  A61M2202/0007 ,  A61M2202/30 ,  A61M2210/1042

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

公开(公告)号：US20230101687A1

公开(公告)日：2023-03-30

申请号：US17784598

申请日：2020-12-10

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Carlo Giovanni Traverso ,  Ameya R. Kirtane ,  Junwei Li ,  Thomas Wang ,  James Byrne ,  Alexis Jones

IPC: A61L24/04 ,  A61L27/18 ,  A61L24/08 ,  A61L24/06 ,  A61L27/16 ,  A61L27/20

Abstract: The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide abroad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

公开(公告)号：US11607390B2

公开(公告)日：2023-03-21

申请号：US16691579

申请日：2019-11-21

Applicant: Massachusetts Institute of Technology ,  Novo Nordisk A/S ,  The Brigham and Women's Hospital, Inc.

Inventor： Alex G. Abramson ,  Morten Revsgaard Frederiksen ,  Brian Jensen ,  Mikkel Oliver Jespersen ,  Carlo Giovanni Traverso

IPC: A61K9/48 ,  A61K9/00 ,  A61M5/142 ,  A61M37/00 ,  A61N1/36 ,  A61M31/00 ,  A61M5/158 ,  A61J3/07 ,  A61B5/145 ,  A61B10/02 ,  A61N1/32 ,  A61M5/20 ,  A61M5/32 ,  A61K38/28 ,  A61N1/05

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.