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177 条记录 (耗时 0.045 秒)

    Magnetic fluid cleaning station
    92.
    发明授权
    Magnetic fluid cleaning station 失效
    磁性液体清洗站

    公开(公告)号：US4684242A

    公开(公告)日：1987-08-04

    申请号：US822375

    申请日：1986-01-27

    申请人： Peter G. Schultz

    发明人： Peter G. Schultz

    IPC分类号： G03G21/00

    CPC分类号： G03G21/0005 ,  G03G21/0047 ,  G03G2221/0005

    摘要： An electrographic copier has a moveable dielectric member, a developing station for applying toner to selected areas of the dielectric member, and cleaning apparatus for removing residual toner from the dielectric member. The cleaning apparatus includes wall structure defining a cavity open to the dielectric member, and having close-clearance gap regions between the wall structure and the dielectric member magnetically permeable cleaning fluid fills the cavity. Magnetic field producing structure magnetically coupled through the cleaning fluid in the gap regions forms a magnetic seal in the gap regions, thereby inhibiting leakage of the cleaning fluid from the cavity through the gap regions.

    摘要翻译： 电摄影复印机具有可移动电介质构件，用于将调色剂施加到电介质构件的选定区域的显影站以及用于从电介质构件去除残留调色剂的清洁装置。 清洁装置包括限定通向电介质构件的空腔的壁结构，并且在壁结构和电介质构件之间具有密隙间隙区域，磁性可渗透的清洁流体填充空腔。 通过间隙区域中的清洁流体磁耦合的磁场产生结构在间隙区域中形成磁性密封，从而防止清洁流体从空腔通过间隙区域泄漏。

    Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
    96.
    发明授权
    Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine 有权
    含有非天然氨基酸苯基硒代半胱氨酸的蛋白质的遗传程序表达

    公开(公告)号：US08394605B2

    公开(公告)日：2013-03-12

    申请号：US13492240

    申请日：2012-06-08

    申请人： Jiangyun Wang ,  Peter G. Schultz

    发明人： Jiangyun Wang ,  Peter G. Schultz

    IPC分类号： C12P21/00 ,  C12N9/00 ,  C12N1/00 ,  C07K14/00

    CPC分类号： C12N9/104 ,  C12N9/93 ,  C12N15/67 ,  C12P21/02

    摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel sythetases molecules, methods for identifying and making the novel synthetases, methods for producing containing the unnatural amino acid phenylselenocysteine and translation systems. The invention further provides methods for producing modified proteins (e.g., lapidated proteins) through targeted modification of the phenylselenocysteine residue in a protein.

    摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸苯硒代半胱氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交氨基-tRNA合成酶，编码新型sythetases分子的多核苷酸，用于鉴定和制备新合成酶的方法，含有非天然氨基酸苯基硒代半胱氨酸的生产方法和翻译系统。 本发明进一步提供通过蛋白质中的苯基硒代半胱氨酸残基的靶向修饰产生修饰的蛋白质（例如，研磨蛋白质）的方法。

    Compositions and methods for inducing cell dedifferentiation
    97.
    发明授权
    Compositions and methods for inducing cell dedifferentiation 有权
    用于诱导细胞去分化的组合物和方法

    公开(公告)号：US08309555B2

    公开(公告)日：2012-11-13

    申请号：US12563802

    申请日：2009-09-21

    申请人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    发明人： Shuibing Chen ,  Sheng Ding ,  Peter G. Schultz

    IPC分类号： C07D473/16 ,  C07D473/24 ,  A61K31/52 ,  A61P19/08 ,  A61P19/10

    CPC分类号： C12N5/0696 ,  C07D473/16 ,  C07D473/24

    摘要： The present invention provides 2,6-disubstituted purine compounds, compositions and methods for dedifferentiating lineage committed mammalian cells into stem cells. The present invention also provides methods of inducing dedifferentiation of lineage committed mammalian cells into stem cells, which can be further differentiated into various lineage committed cells. Methods of identifying additional 2,6-disubstituted purine compounds useful for inducing dedifferentiation of lineage committed cells into stem cells are also provided.

    摘要翻译： 本发明提供2,6-二取代的嘌呤化合物，用于将分裂的哺乳动物细胞分化为干细胞的组合物和方法。 本发明还提供了诱导分泌哺乳动物细胞去干细胞到干细胞中的方法，其可进一步分化成各种谱系确定的细胞。 还提供了用于鉴定用于诱导分化为干细胞的遗传分化细胞的另外的2,6-二取代的嘌呤化合物的方法。

    Genetically encoded fluorescent coumarin amino acids
    99.
    发明授权
    Genetically encoded fluorescent coumarin amino acids 失效
    遗传编码荧光香豆素氨基酸

    公开(公告)号：US08192952B2

    公开(公告)日：2012-06-05

    申请号：US12227383

    申请日：2007-05-21

    申请人： Jiangyun Wang ,  Jianming Xie ,  Peter G. Schultz

    发明人： Jiangyun Wang ,  Jianming Xie ,  Peter G. Schultz

    IPC分类号： C12P21/00 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C12P21/02 ,  C12N9/93 ,  C12N15/10 ,  C12N15/67

    摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.

    摘要翻译： 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将香豆素非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸掺入到在细菌宿主细胞如大肠杆菌中产生的蛋白质中。 本发明提供了例如但不限于新型正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸L-（7-羟基香豆素-4-基）乙基甘氨酸的蛋白质的方法和相关翻译系统。

    Production of Carrier-Peptide Conjugates Using Chemically Reactive Unnatural Amino Acids
    100.
    发明申请
    Production of Carrier-Peptide Conjugates Using Chemically Reactive Unnatural Amino Acids 有权
    使用化学活性非天然氨基酸生产载体肽结合物

    公开(公告)号：US20110312027A1

    公开(公告)日：2011-12-22

    申请号：US13133629

    申请日：2009-12-09

    申请人： Travis Young ,  Peter G. Schultz

    发明人： Travis Young ,  Peter G. Schultz

    IPC分类号： C12P21/00 ,  C12N1/19 ,  C12N9/96 ,  C07K19/00 ,  C07K1/107

    CPC分类号： C07K16/18 ,  C07K14/765 ,  C07K14/78 ,  C07K19/00 ,  C12N15/62 ,  C12N15/815 ,  C12P21/02

    摘要： Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal translation systems in methylotrophic yeast and methods of using these systems to produce carrier and target polypeptide variants comprising unnatural amino acids are provided.

    摘要翻译： 提供了制备载体多肽的方法，其包括将第一非天然氨基酸掺入载体多肽变体中，将第二非天然氨基酸掺入靶多肽变体中，并使第一和第二非天然氨基酸反应以产生缀合物。 还提供了使用提供的方法生产的缀合物。 此外，提供了甲基营养酵母中的正交翻译系统以及使用这些系统产生包含非天然氨基酸的载体和靶多肽变体的方法。