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280 条记录 (耗时 0.039 秒)

    Low profile package for an implantable device
    92.
    发明授权
    Low profile package for an implantable device 有权
    用于植入式装置的薄型包装

    公开(公告)号：US08090448B2

    公开(公告)日：2012-01-03

    申请号：US12205659

    申请日：2008-09-05

    申请人： Robert J. Greenberg ,  Joseph H. Schulman

    发明人： Robert J. Greenberg ,  Joseph H. Schulman

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0543 ,  A61N1/36046 ,  A61N1/37247 ,  A61N1/375 ,  H01L2224/16225 ,  Y10T29/49165

    摘要： The present invention is a low profile hermetic package for an implantable medical device. The package includes a non-conductive substrate including a plurality of straight conductive vias through the non-conductive substrate. A conductive cover hermetically enclosing an electronics circuit is bonded to the non-conductive substrate. The device is low profile. The width of the non-conductive substrate is grater than the height of the cover.

    摘要翻译： 本发明是用于可植入医疗装置的薄型密封包装。 该封装包括非导电衬底，其包括穿过非导电衬底的多个直的导电通孔。 气密地封装电子电路的导电盖被粘合到非导电基底上。 该设备薄型。 非导电性基板的宽度比盖的高度大。

    Pixel re-mapping for visual prosthesis
    95.
    发明授权
    Pixel re-mapping for visual prosthesis 有权
    视觉假体的像素重新映射

    公开(公告)号：US07962221B2

    公开(公告)日：2011-06-14

    申请号：US11493471

    申请日：2006-07-25

    申请人： Robert J. Greenberg ,  Richard Williamson

    发明人： Robert J. Greenberg ,  Richard Williamson

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36046

    摘要： A method and apparatus for adjusting a visual image provided to a patient. In one embodiment, an image may be presented to the patient to obtain the patient's subjective perception of the image, and the patient may either manipulate the image to obtain a desired adjustment, or guide a clinician performing the adjustment. In another embodiment, the clinician may make objective observations of, for example, the position of an electrode array on the patient's retina, and make adjustments accordingly. The adjustment may be a spatial adjustment comprising a re-mapping performed to decreases image distortion resulting from differences in the patient's perception of stimulation of different areas of the retina. Such distortion may result from differences between the patient's perception of stimulation falling within the macula, and stimulation falling within the periphery surrounding the macula. The adjustment may also compensate for translations or rotations of the electrode array on the retina.

    摘要翻译： 一种用于调整提供给患者的视觉图像的方法和装置。 在一个实施例中，可以向患者呈现图像以获得患者对图像的主观感知，并且患者可以操纵图像以获得期望的调整，或指导进行调整的临床医师。 在另一个实施例中，临床医生可以对例如患者视网膜上的电极阵列的位置进行客观观察，并进行相应的调整。 调整可以是空间调整，其包括执行的重新映射，以减少由于患者对视网膜的不同区域的刺激的感知的差异而导致的图像失真。 这种变形可能由患者对黄斑内的刺激感知以及落在黄斑周围周边的刺激之间的差异引起。 该调整还可以补偿视网膜上的电极阵列的平移或旋转。

    Electrode with increased stability and method of manufacturing the same
    96.
    发明授权
    Electrode with increased stability and method of manufacturing the same 有权
    增加稳定性的电极及其制造方法

    公开(公告)号：US07937153B2

    公开(公告)日：2011-05-03

    申请号：US11820744

    申请日：2007-06-19

    申请人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

    发明人： Dao Min Zhou ,  Jerry Ok ,  Neil Hamilton Talbot ,  Brian V. Mech ,  James Singleton Little ,  Robert J. Greenberg

    IPC分类号： A61N1/00

    CPC分类号： A61N1/0543 ,  A61N1/36046

    摘要： An implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. An implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.

    摘要翻译： 具有增加的稳定性的可植入电极具有聚集结构，其中电极的表面被包括充满棒或柱的开口的材料覆盖。 具有增加的稳定性的可植入电极，其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。 一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。 一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层。

    Video processing methods for improving visual acuity and/or perceived image resolution
    97.
    发明授权
    Video processing methods for improving visual acuity and/or perceived image resolution 有权
    用于改善视力和/或感知图像分辨率的视频处理方法

    公开(公告)号：US07925354B2

    公开(公告)日：2011-04-12

    申请号：US11879982

    申请日：2007-07-19

    申请人： Robert J. Greenberg ,  Richard P. Williamson ,  Joseph H. Schulman ,  Reza P. Rassool ,  Lee J. Mandell ,  Abraham N. Seidman

    发明人： Robert J. Greenberg ,  Richard P. Williamson ,  Joseph H. Schulman ,  Reza P. Rassool ,  Lee J. Mandell ,  Abraham N. Seidman

    IPC分类号： A61N1/08

    CPC分类号： A61N1/36046

    摘要： A method and apparatus for improving visual acuity when providing a visual image from a “high” resolution input device to a “low” resolution output device. The described invention is of particular use when the output device is an array of electrodes as part of a retinal prosthesis used to restore vision to a visually-impaired patient. In that various limitations may, within the foreseeable future, limit the density of such an electrode array (and thus the resolution of the output image), the present invention teaches techniques to assign processed pixel subsets of a higher resolution image to a single electrode. By varying the pixel subsets, e.g., by jittering, and/or altering the processing criteria, the perceived visual acuity may be further improved. Alternatively and additionally, such processing may be further extended to drive neighboring electrodes in combination to thus stimulate virtual electrode sites and thus further enhance visual acuity.

    摘要翻译： 当从“高”分辨率输入装置向“低”分辨率输出装置提供视觉图像时，用于提高视力的方法和装置。 当输出设备是用作将视力恢复到视觉障碍患者的视网膜假体的一部分的电极阵列时，所描述的本发明是特别有用的。 因此，在可预见的将来可能会限制这种电极阵列的密度（因此输出图像的分辨率）的各种限制，本发明教导了将更高分辨率图像的经处理的像素子集分配给单个电极的技术。 通过例如通过抖动和/或改变处理标准来改变像素子集，可以进一步改善感知的视敏度。 另外地和另外地，这样的处理可以进一步延伸以组合驱动相邻电极，从而刺激虚拟电极位置，从而进一步提高视敏度。

    Electrode array for visual stimulation
    99.
    发明授权
    Electrode array for visual stimulation 有权
    用于视觉刺激的电极阵列

    公开(公告)号：US07835798B2

    公开(公告)日：2010-11-16

    申请号：US11926047

    申请日：2007-10-28

    申请人： Robert J. Greenberg ,  Joseph H. Schulman

    发明人： Robert J. Greenberg ,  Joseph H. Schulman

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0543 ,  A61N1/36046 ,  A61N1/37247 ,  A61N1/375 ,  H01L2224/16225 ,  Y10T29/49165

    摘要： An electrode array adapted for stimulating the retina to create the perception of vision in blind patients. The electrode array may be embodied as a combination of a subretinal electrode array and an epiretinal electrode array, with an electronics unit external to the eye. The subretinal and epiretinal arrays are in electrical communication with each other and are suitable to pass an electrical signal through retinal tissue.

    摘要翻译： 适用于刺激视网膜以产生盲患者视力感知的电极阵列。 电极阵列可以被实施为视网膜下电极阵列和视网膜电极阵列的组合，其中眼睛外部具有电子单元。 视网膜下和视网膜阵列彼此电连通并且适合于通过视网膜组织传递电信号。

    Sub-threshold stimulation to precondition neurons for supra-threshold stimulation
    100.
    发明授权
    Sub-threshold stimulation to precondition neurons for supra-threshold stimulation 有权
    用于超临界刺激的预处理神经元的亚阈值刺激

    公开(公告)号：US07765009B2

    公开(公告)日：2010-07-27

    申请号：US11924313

    申请日：2007-10-25

    申请人： Robert J. Greenberg ,  Matthew J. McMahon

    发明人： Robert J. Greenberg ,  Matthew J. McMahon

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36046 ,  A61N1/0543

    摘要： In order to generate the smallest phosphenes possible, it is advantageous to selectively stimulate smaller cells. By hyperpolarizing the somas of the large cells selectively with sub-threshold anodic ‘pre-pulse’ stimuli (making them more difficult to stimulate) and then selectively depolarize the smaller cells one can selectively stimulate smaller cells. Alternatively, one can hyperpolarize the dendrites of the cells with larger dendritic fields by applying sub-threshold anodic currents on surrounding electrodes and then depolarizing the smaller cells in the center. Further, one can manipulate the phases of an individual biphasic wave to affect selective stimulation resulting in more focal responses. It is possible to increase resolution with the ‘pre-pulse’ described above. One can also effect resolution by modifying the pulse order of the cathodic and anodic phases. Further, one can isolate the effect of the phases by separating them in time (long inter-phase interval) or by making one of the phases long and low amplitude—always keeping equal total charge for the two phases. As an example, one can preferentially stimulate smaller ganglion cells by providing a longer sub-threshold anodic pulse balanced with a shorter supra-threshold cathodic pulse. Preferentially stimulating the smaller ganglion cells will allow stimulation of different brightness levels while maintaining high spatial resolution.

    摘要翻译： 为了产生可能的最小磷光体，有利的是选择性地刺激较小的细胞。 通过使用亚阈值阳极“预脉冲”刺激（使它们更难刺激）选择性地超极化大细胞的体细胞，然后选择性去极化较小的细胞，可以选择性地刺激较小的细胞。 或者，可以通过在周围电极上施加亚阈值阳极电流然后使中心的较小细胞去极化来超极化具有较大树枝状场的细胞的树突。 此外，人们可以操纵单个双相波的相位以影响选择性刺激，导致更多的局部反应。 可以用上述'预脉冲'来提高分辨率。 也可以通过改变阴极和阳极相的脉冲顺序来影响分辨率。 此外，可以通过在时间上（长的相间间隔）将它们分离，或者通过使相位中的一个长和低振幅 - 总是保持两相的总电荷来隔离相的影响。 作为示例，可以通过提供用较短的超阈值阴极脉冲平衡的较长的亚阈值阳极脉冲来优先地刺激较小的神经节细胞。 优先刺激较小的神经节细胞将允许刺激不同的亮度水平，同时保持高的空间分辨率。