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    BLOOD VISCOSITY MEASURING METHOD AND SYSTEM
    91.
    发明申请
    BLOOD VISCOSITY MEASURING METHOD AND SYSTEM 审中-公开
    血液粘度测量方法与系统

    公开(公告)号：US20150099988A1

    公开(公告)日：2015-04-09

    申请号：US14047792

    申请日：2013-10-07

    申请人： Andre Cernasov ,  Nathalie Cernasov

    发明人： Andre Cernasov ,  Nathalie Cernasov

    IPC分类号： A61B5/02 ,  A61B7/04 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/107

    CPC分类号： A61B5/02035 ,  A61B5/0002 ,  A61B5/0205 ,  A61B5/02444 ,  A61B5/0285 ,  A61B5/1072 ,  A61B5/681 ,  A61B5/686 ,  A61B5/6876 ,  A61B7/04

    摘要： According to an example, a blood viscosity value of blood flowing through a blood vessel may be calculated by detecting a deformation of a blood vessel due to a pulsatile wave of blood flowing through the blood vessel, determining a pulsatile wave velocity of the pulsatile wave based upon the detected deformation, and calculating the blood viscosity value of the blood flowing through the blood vessel based on a predetermined relationship between blood viscosity and the determined pulsatile wave velocity.

    摘要翻译： 根据一个例子，流经血管的血液的血液粘度值可以通过检测由于血液中流动的血液的脉动波而导致的血管变形来确定脉搏波的脉动波速度 根据检测出的变形，根据血液粘度与所确定的脉动波速度之间的预定关系计算流过血管的血液的血液粘度值。

    Method for assessing stenosis severity through stenosis mapping
    92.
    发明授权
    Method for assessing stenosis severity through stenosis mapping 有权
    通过狭窄测绘评估狭窄程度的方法

    公开(公告)号：US08977339B1

    公开(公告)日：2015-03-10

    申请号：US14098125

    申请日：2013-12-05

    申请人： Zhongle Wu ,  James P. Jacobs

    发明人： Zhongle Wu ,  James P. Jacobs

    IPC分类号： A61B5/05 ,  A61B5/02 ,  A61B6/00 ,  A61B5/021 ,  A61B5/107 ,  A61B6/03 ,  A61B8/08 ,  A61B5/00 ,  A61B5/026

    CPC分类号： A61B6/5217 ,  A61B5/0044 ,  A61B5/02007 ,  A61B5/02035 ,  A61B5/021 ,  A61B5/0263 ,  A61B5/1075 ,  A61B5/7282 ,  A61B6/032 ,  A61B6/504 ,  A61B6/5205 ,  A61B8/0891 ,  G06F19/00

    摘要： A method of assessing stenosis severity for a patient includes obtaining patient information relevant to assessing severity of a stenosis, including anatomical imaging data of the patient. Based on the anatomical imaging data, the existence of any lesions of concerns may be identified. A three dimensional image can be generated of any irregular shaped lesion of concern and a surrounding area from the patient anatomical imaging data. A plurality of comparative two dimensional lesion specific models may be created that have conditions that correspond to the three dimensional model. The comparative two dimensional models may represent vessels having regular shaped lesions with each of the comparative two dimensional models represents a different stenosis severity. The three dimensional model can then be mapped to one of the plurality of comparative two dimensional models. After this mapping, a diagnosis of whether the patient has coronary artery disease may be made.

    摘要翻译： 评估患者狭窄严重程度的方法包括获得与评估狭窄程度相关的患者信息，包括患者的解剖成像数据。 基于解剖成像数据，可以确定任何病症的存在。 可以从患者的解剖学成像数据中产生所关注的任何不规则形状的病变和周围区域的三维图像。 可以创建具有对应于三维模型的条件的多个对比二维损伤特定模型。 比较二维模型可以代表具有规则形状损伤的血管，每个比较二维模型代表不同的狭窄严重程度。 然后可以将三维模型映射到多个比较二维模型中的一个。 在该映射之后，可以对患者是否患有冠状动脉疾病进行诊断。

    Blood vessel function inspecting apparatus
    93.
    发明授权
    Blood vessel function inspecting apparatus 有权
    血管功能检查仪

    公开(公告)号：US08845542B2

    公开(公告)日：2014-09-30

    申请号：US13394496

    申请日：2009-09-09

    申请人： Hiroshi Masuda ,  Chikao Harada ,  Hidenori Suzuki

    发明人： Hiroshi Masuda ,  Chikao Harada ,  Hidenori Suzuki

    IPC分类号： A61B5/02 ,  A61B5/0225 ,  A61B8/08 ,  A61B8/00 ,  A61B8/06 ,  G01S15/89

    CPC分类号： A61B8/485 ,  A61B5/02035 ,  A61B5/02225 ,  A61B5/0225 ,  A61B8/06 ,  A61B8/0858 ,  A61B8/0891 ,  A61B8/4218 ,  A61B8/488 ,  A61B8/5223 ,  G01S15/899

    摘要： It is provided a blood vessel function inspecting apparatus including: a blood vessel diameter measuring portion configured to measure a diameter of a blood vessel; a blood vessel wall thickness measuring portion configured to measure a wall thickness of the blood vessel; and a blood vessel function index value calculating portion configured to calculate a function index value for diagnosing the blood vessel of its function, after releasing of the blood vessel from blood flow obstruction, by dividing an amount of dilatation of said diameter of the blood vessel continuously measured by said blood vessel diameter measuring portion, by the wall thickness measured by said blood vessel wall thickness measuring portion.

    摘要翻译： 本发明提供一种血管功能检查装置，包括：血管直径测量部，被配置为测量血管的直径; 构造成测量血管壁厚的血管壁厚测量部; 以及血管功能指标值计算部，其被配置为通过将所述血管直径的扩张量连续地除以从血流阻塞释放血液之后，计算用于诊断其功能的血管的功能指标值 由所述血管直径测量部分测量由所述血管壁厚度测量部分测量的壁厚。

    SYSTEMS AND METHODS FOR ESTIMATING BLOOD FLOW CHARACTERISTICS FROM VESSEL GEOMETRY AND PHYSIOLOGY
    95.
    发明申请
    SYSTEMS AND METHODS FOR ESTIMATING BLOOD FLOW CHARACTERISTICS FROM VESSEL GEOMETRY AND PHYSIOLOGY 审中-公开
    用于从血管几何和生理学估计血液流量特征的系统和方法

    公开(公告)号：US20140073977A1

    公开(公告)日：2014-03-13

    申请号：US13895893

    申请日：2013-05-16

    申请人： Leo GRADY ,  Gilwoo CHOI ,  Michael SINGER

    发明人： Leo GRADY ,  Gilwoo CHOI ,  Michael SINGER

    IPC分类号： A61B5/00 ,  A61B5/02 ,  A61B5/145 ,  A61B5/026 ,  A61B5/021

    CPC分类号： A61B5/7267 ,  A61B5/0022 ,  A61B5/02035 ,  A61B5/021 ,  A61B5/026 ,  A61B5/14535 ,  A61B5/742 ,  G16H50/20 ,  G16H50/50 ,  G16H50/70

    摘要： Systems and methods are disclosed for estimating patient-specific blood flow characteristics. One method includes acquiring, for each of a plurality of individuals, a geometric model and estimated blood flow characteristics of at least part of the individual's vascular system; executing a machine learning algorithm on the geometric model and estimated blood flow characteristics for each of the plurality of individuals; identifying, using the machine learning algorithm, features predictive of blood flow characteristics corresponding to a plurality of points in the geometric models; acquiring, for a patient, a geometric model of at least part of the patient's vascular system; and using the identified features to produce estimates of the patient's blood flow characteristic for each of a plurality of points in the patient's geometric model.

    摘要翻译： 公开了用于估计患者特异性血流特征的系统和方法。 一种方法包括为多个个体中的每一个获取个体血管系统的至少一部分的几何模型和估计的血流特性; 对所述多个个体中的每一个执行对所述几何模型的机器学习算法和估计的血流特性; 使用机器学习算法识别预测与几何模型中的多个点相对应的血流特性的特征; 为患者获取至少部分患者血管系统的几何模型; 以及使用所识别的特征来产生对患者几何模型中的多个点中的每一个点的患者血流特性的估计。

    Blood vessel function inspecting apparatus
    96.
    发明授权
    Blood vessel function inspecting apparatus 有权
    血管功能检查仪

    公开(公告)号：US08657748B2

    公开(公告)日：2014-02-25

    申请号：US13377329

    申请日：2009-06-09

    申请人： Naotaka Nitta ,  Hiroshi Masuda

    发明人： Naotaka Nitta ,  Hiroshi Masuda

    IPC分类号： A61B8/00 ,  A61B5/02

    CPC分类号： A61B5/145 ,  A61B5/02007 ,  A61B5/02035 ,  A61B5/14535 ,  A61B8/06 ,  A61B8/4218 ,  A61B8/5223 ,  G01N11/00

    摘要： A blood vessel function inspecting apparatus including a first blood state index value calculating portion that obtains estimated hematocrit values at a plurality of points predetermined within a blood vessel, on the basis of values of a blood viscosity and values of a shear rate at said plurality of points, which are respectively extracted from a viscosity distribution and a shear rate distribution, and according to reference relationships between a hematocrit value and the blood viscosity, which reference relationships respectively correspond predetermined different values of the shear rate; and a second blood state index value calculating portion that calculates, as said blood state index value, a value relating to an amount of difference of the estimated hematocrit values at said plurality of points with respect to each other, which amount is minimized by transforming said reference relationships at the same ratio for all of the values of the shear rate.

    摘要翻译： 一种血管功能检查装置，其包括：第一血液指标值计算部，其根据血液粘度的值和所述多个血压指数值的剪切速度值，求出在血管内预定的多个点处的估计的血细胞比容值 分别从粘度分布和剪切速度分布提取，并且根据血细胞比容值和血液粘度之间的参考关系，该参考关系分别对应于剪切速率的预定不同值; 以及第二血液指标值计算部，其计算与所述血液状态指标值相关的与所述多个点相对于彼此的所估计的血细胞比容值的差值相关的值，所述量通过变换所述 对于剪切速率的所有值，参考关系以相同的比例。

    In vivo sensor and method of making same
    97.
    发明授权
    In vivo sensor and method of making same 有权
    体内传感器及其制作方法

    公开(公告)号：US08372139B2

    公开(公告)日：2013-02-12

    申请号：US09783633

    申请日：2001-02-14

    申请人： Steven R. Bailey ,  Christopher T. Boyle ,  Denes Marton ,  Christopher E. Banas

    发明人： Steven R. Bailey ,  Christopher T. Boyle ,  Denes Marton ,  Christopher E. Banas

    IPC分类号： A61F2/82

    CPC分类号： A61B5/02035 ,  A61B5/01 ,  A61B5/02 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/076 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/4842 ,  A61B5/6862 ,  A61B5/6876 ,  A61B6/12 ,  A61B8/0841 ,  A61B2562/0247 ,  A61B2562/0276 ,  A61B2562/12 ,  A61B2562/164 ,  A61F2/82 ,  A61F2/91 ,  A61F2/958 ,  A61F2250/0096 ,  A61F2310/00023 ,  A61L27/04 ,  A61L31/022 ,  B23K1/19

    摘要： Implantable in vivo sensors used to monitor physical, chemical or electrical parameters within a body. The in vivo sensors are integral with an implantable medical device and are responsive to externally or internally applied energy. Upon application of energy, the sensors undergo a phase change in at least part of the material of the device which is then detected external to the body by conventional techniques such as radiography, ultrasound imaging, magnetic resonance imaging, radio frequency imaging or the like. The in vivo sensors of the present invention may be employed to provide volumetric measurements, flow rate measurements, pressure measurements, electrical measurements, biochemical measurements, temperature, measurements, or measure the degree and type of deposits within the lumen of an endoluminal implant, such as a stent or other type of endoluminal conduit. The in vivo sensors may also be used therapeutically to modulate mechanical and/or physical properties of the endoluminal implant in response to the sensed or monitored parameter.

    摘要翻译： 用于监测体内物理，化学或电学参数的植入式体内传感器。 体内传感器与可植入医疗设备是一体的，并且响应外部或内部施加的能量。 在施加能量时，传感器在装置的材料的至少一部分中经历相变，然后通过诸如放射照相术，超声成像，磁共振成像，射频成像等的常规技术在身体外部检测。 本发明的体内传感器可用于提供体积测量，流速测量，压力测量，电测量，生化测量，温度，测量或测量腔内植入物内腔内沉积物的程度和类型，例如 作为支架或其他类型的腔内导管。 体内传感器还可以用于治疗地响应于感测或监测的参数来调节腔内植入物的机械和/或物理性质。

    Supported molecular biofluid viscosity sensors for in vitro and in vivo use
    99.
    发明授权
    Supported molecular biofluid viscosity sensors for in vitro and in vivo use 失效
    支持用于体外和体内使用的分子生物流体粘度传感器

    公开(公告)号：US07943390B2

    公开(公告)日：2011-05-17

    申请号：US12426653

    申请日：2009-04-20

    申请人： Mark A. Haidekker ,  Sheila Grant ,  Emmanuel Theodorakis ,  Marcos Intaglietta ,  John A. Frangos

    发明人： Mark A. Haidekker ,  Sheila Grant ,  Emmanuel Theodorakis ,  Marcos Intaglietta ,  John A. Frangos

    IPC分类号： G01N33/00

    CPC分类号： G01N11/14 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/02035 ,  G01N2011/008

    摘要： A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.

    摘要翻译： 一种用于测量粘度的装置和方法，包括将分子转子连接到固体表面，将固体表面暴露于具有待测量粘度的流体，并进行光学测量以确定粘度。 固体表面优选为石英，聚苯乙烯或硅酸盐玻璃，例如光纤探针或玻璃比色皿。 分子转子是包括通过单键连接的电子给体基团和电子受体基团的类型，使得基团可以相对于彼此旋转，并且当旋转受阻时表现出荧光发射。