公开(公告)号：US09409009B2

公开(公告)日：2016-08-09

申请号：US14073117

申请日：2013-11-06

申请人： THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES

发明人： Anil K. Thota ,  Ranu Jung ,  Sathyakumar S. Kuntaegowdanahalli

IPC分类号： A61N1/05 ,  A61B5/00 ,  A61B5/04

CPC分类号： A61N1/0558 ,  A61B5/04001 ,  A61B5/0488 ,  A61B5/04888 ,  A61B5/4029 ,  A61B5/4076 ,  A61B5/6839 ,  A61B5/6877 ,  A61B2562/0209 ,  A61B2562/125 ,  A61B2562/18 ,  A61B2562/245 ,  A61N1/05 ,  A61N1/0507 ,  Y10T29/49208

摘要： A multi-lead multi-electrode system and method of manufacturing the multi-lead multi-electrode system includes a multi-electrode lead that may be used to deploy multiple separable electrodes to different spaced apart contact sites, such as nerve or muscle tissues, for example, that are spatially distributed over a large area.

摘要翻译： 多引线多电极系统和多引线多电极系统的制造方法包括多电极引线，其可用于将多个可分离电极部署到不同间隔的接触部位，例如神经或肌肉组织，用于 例如，空间分布在大面积上。

公开(公告)号：US09332918B1

公开(公告)日：2016-05-10

申请号：US13887660

申请日：2013-05-06

申请人： Jill Buckley ,  Jay L. Shils

发明人： Jill Buckley ,  Jay L. Shils

IPC分类号： A61B5/05 ,  A61B5/04 ,  A61B5/00 ,  A61N1/05 ,  A61N1/04

CPC分类号： A61B5/04001 ,  A61B5/4029 ,  A61B5/4041 ,  A61B5/459 ,  A61B5/4821 ,  A61B5/6824 ,  A61B5/6831 ,  A61B5/7425 ,  A61B5/746 ,  A61B2560/0475 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/046 ,  A61B2562/14 ,  A61B2562/164 ,  A61B2562/222 ,  A61N1/0456 ,  A61N1/0484 ,  A61N1/0551

摘要： In one embodiment, the invention relates to systems, methods, and apparatus relating to the detection of a neuropathy such as a periopertive neuropathy. In one embodiment, a wristband comprising a plurality of anodes and cathodes is used. The wristband can be a component in a electrode array that includes a plurality of reference or recording electrodes. The electrode array can be configured to stimulate and collect responsive signals from an ulnar, a median, radial and posterior tibial nerve. The simulation and signal collection can be performed on a continuous basis for time periods of interest such as a given perioperative time period using a monitoring device.

摘要翻译： 在一个实施方案中，本发明涉及与神经病的检测有关的系统，方法和装置，例如围手术期神经病变。 在一个实施例中，使用包括多个阳极和阴极的腕带。 腕带可以是包括多个参考电极或记录电极的电极阵列中的部件。 电极阵列可以被配置为刺激并收集来自尺骨，中间，径向和后胫神经的响应信号。 模拟和信号收集可以在使用监视装置的给定的围手术期的持续时间期间进行。

公开(公告)号：US09326719B2

公开(公告)日：2016-05-03

申请号：US13720563

申请日：2012-12-19

申请人： Board of Regents, The University of Texas System

发明人： Taner Akkin ,  Thomas E. Milner ,  Digant P. Dave ,  H. Grady Rylander, III

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61N1/00 ,  A61N5/06 ,  A61N1/36

CPC分类号： A61B5/4041 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0082 ,  A61B5/40 ,  A61B5/4029 ,  A61B5/6821 ,  A61B5/7225 ,  A61B5/7282 ,  A61N1/00 ,  A61N1/3605 ,  A61N5/0622

摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.

公开(公告)号：US09164107B2

公开(公告)日：2015-10-20

申请号：US14270623

申请日：2014-05-06

申请人： INSTITUT PASTEUR

发明人： Marie-Lise Gougeon ,  Beatrice Poirier-Beaudoin ,  Valerie Seffer ,  Hela Saidi

IPC分类号： G01N33/68 ,  G01N33/569

CPC分类号： G01N33/6896 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/15 ,  A61B5/4029 ,  A61B5/4064 ,  A61B5/407 ,  A61B5/4082 ,  A61B5/4088 ,  A61B2010/0077 ,  G01N33/56988 ,  G01N33/6854 ,  G01N2333/16 ,  G01N2333/52 ,  G01N2333/522 ,  G01N2333/523 ,  G01N2800/28 ,  G01N2800/56

摘要： The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a patient, and the use of this method in the prognostic and/or diagnosis of neurological disorders. These methods are in particular applicable to the monitoring of the human immunodeficiency virus (HIV) infection of a subject who is known to be infected with HIV and in the prognostic and/or diagnostic of the state of progression of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS, in particular the state of progression or the state of progression toward neurological disorders associated with AIDS. Finally, the invention is also about method to determine the immune deficiency or level of immune activation of a patient, in particular a HIV-infected patient.

摘要翻译： 本发明涉及用于定量样品中特异性的高迁移率组盒I（HMGB1）的特异性抗体的体外方法，特别是从患者获得的血清样品或脑脊液样品中的使用，以及该方法在预后中的用途 和/或神经系统疾病的诊断。 这些方法特别适用于监测已知感染艾滋病毒的受试者的人体免疫缺陷病毒（HIV）感染以及获得性免疫缺陷综合征（AIDS）进展状态的预后和/或诊断。 或艾滋病的进展状态，特别是与AIDS相关的神经障碍的进展状态或进展状态。 最后，本发明还涉及确定患者，特别是HIV感染患者的免疫缺陷或免疫激活水平的方法。

公开(公告)号：US09072886B2

公开(公告)日：2015-07-07

申请号：US14180972

申请日：2014-02-14

申请人： Rehabtronics, Inc.

发明人： Robert Andrew Gaunt ,  Arthur Prochazka

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61B5/00 ,  A61N1/04

CPC分类号： A61N1/05 ,  A61B5/0028 ,  A61B5/4029 ,  A61B5/4082 ,  A61N1/0472 ,  A61N1/0504 ,  A61N1/0556 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/36071

摘要： The invention provides an implant, system and method for electrically stimulating a target tissue to either activate or block neural impulses. The implant provides a conductive pathway for a portion of electrical current flowing between surface electrodes positioned on the skin and transmits that current to the target tissue. The implant has a passive electrical conductor of sufficient length to extend from subcutaneous tissue located below a surface cathodic electrode to the target tissue. The conductor has a pick-up end which forms an electrical termination having a sufficient surface area to allow a sufficient portion of the electrical current to flow through the conductor, in preference to flowing through body tissue between the surface electrodes, such that the target tissue is stimulated to either activate or block neural impulses. The conductor also has a stimulating end which forms an electrical termination for delivering the current to the target body tissue.

公开(公告)号：US08996112B2

公开(公告)日：2015-03-31

申请号：US14157571

申请日：2014-01-17

申请人： Cardiac Pacemakers, Inc.

发明人： M. Jason Brooke

IPC分类号： A61N1/18 ,  A61N1/37 ,  A61B5/00 ,  A61N1/36 ,  A61N1/365 ,  A61B5/04 ,  A61B5/042 ,  A61B5/0488 ,  A61B5/11 ,  A61N1/368 ,  A61N1/372

CPC分类号： A61N1/371 ,  A61B5/04001 ,  A61B5/042 ,  A61B5/0488 ,  A61B5/1107 ,  A61B5/4029 ,  A61B5/4848 ,  A61B2562/0219 ,  A61N1/3601 ,  A61N1/36585 ,  A61N1/3684 ,  A61N1/3706 ,  A61N1/3712 ,  A61N1/372

摘要： Approaches for characterizing a phrenic stimulation threshold, a cardiac capture threshold, a maximum device parameter, and a minimum device parameter are described. A plurality of cardiac pacing pulses can be delivered by using a cardiac pacing device, a pacing parameter of the plurality of cardiac pacing pulses being changed between delivery of at least some of the pulses. One or more sensor signals can be evaluated to detect stimulation of the phrenic nerve by one or more of the plurality of cardiac pacing pluses. The evaluation of the one or more sensor signals and the pacing parameter can be compared to determine if a phrenic stimulation threshold is at least one of higher than a maximum device parameter and lower than a minimum device parameter.

摘要翻译： 描述了表征膈刺激阈值，心脏捕获阈值，最大装置参数和最小装置参数的方法。 可以通过使用心脏起搏装置递送多个心脏起搏脉冲，在递送至少一些脉冲之间改变多个心脏起搏脉冲的起搏参数。 可以评估一个或多个传感器信号以通过多个心脏起搏器中的一个或多个来检测膈神经的刺激。 可以比较一个或多个传感器信号和起搏参数的评估，以确定膈刺激阈值是否高于最大设备参数并低于最小设备参数中的至少一个。

公开(公告)号：US08942797B2

公开(公告)日：2015-01-27

申请号：US12818319

申请日：2010-06-18

申请人： Stephen Bartol ,  Christopher Wybo

发明人： Stephen Bartol ,  Christopher Wybo

IPC分类号： A61B5/05 ,  A61N1/00 ,  A61B5/0488 ,  A61B5/11 ,  A61B5/00

CPC分类号： A61B5/0488 ,  A61B5/1106 ,  A61B5/1107 ,  A61B5/4029 ,  A61B5/4893 ,  A61B5/6828 ,  A61B5/7217 ,  A61B2505/05 ,  A61B2560/0412

摘要： A system for detecting the presence of a nerve within a subject includes a stimulator configured to provide a stimulus to a portion of the subject, a sensing device configured to be placed in communication with a muscle of the subject and to generate an output signal corresponding to a monitored parameter of the muscle, the sensing device including a mechanical sensor configured to monitor a mechanical parameter of the muscle, and a receiver configured to receive the output signal from the sensing device and to determine if the output signal corresponds to the stimulus provided by the stimulator.

摘要翻译： 用于检测受试者内的神经的存在的系统包括被配置为向受试者的一部分提供刺激的刺激器，被配置为被放置成与受试者的肌肉连通并且产生对应于 肌肉的监测参数，感测装置包括被配置为监测肌肉的机械参数的机械传感器，以及被配置为从感测装置接收输出信号并且确定输出信号是否对应于由 刺激者。

公开(公告)号：US20140329707A1

公开(公告)日：2014-11-06

申请号：US14269986

申请日：2014-05-05

申请人： The Trustees of Boston College

发明人： Michael J. Naughton ,  Thomas C. Chiles ,  Michael J. Burns ,  John P. Christianson ,  Jeffrey R. Naughton ,  Binod Rizal

IPC分类号： G01N33/94 ,  A61B5/04 ,  A61N5/06 ,  G01N33/487

CPC分类号： A61N5/0622 ,  A61B5/0082 ,  A61B5/04001 ,  A61B5/4029 ,  A61B5/4058 ,  A61B5/4076 ,  A61B5/6877 ,  A61B2562/0285 ,  A61B2562/046 ,  A61N2005/0652 ,  H01B1/02

摘要： The invention provides novel devices and methods that enable ultrahigh spatial and temporal resolution interfaces that allow access and intervention to local (intra- and proximate extra-neuronal) neuroelectronic and neurotransmitter molecular signatures associated with aberrant cell function and cell death leading to neurodegenerative diseases. Scalable devices based on a unique nanocoaxial electrode array of the invention offer neural recording and control at unprecedented levels of precisions.

摘要翻译： 本发明提供了新颖的装置和方法，其能够实现超高空间和时间分辨率界面，其允许接近和干预与导致神经变性疾病的异常细胞功能和细胞死亡相关的局部（内和近神经外）神经电子和神经递质分子特征。 基于本发明的独特的纳米轴向电极阵列的可扩展装置以前所未有的精度提供神经记录和控制。

公开(公告)号：US08795190B2

公开(公告)日：2014-08-05

申请号：US14168819

申请日：2014-01-30

申请人： Todd O'Brien

发明人： Todd O'Brien

IPC分类号： A61B5/00

CPC分类号： A61B5/0051 ,  A61B5/4029 ,  A61B5/4827

摘要： A digital tuning fork device for administering a vibratory sensation test to a human subject comprising an integrated vibratory mechanism and timer, with the vibratory mechanism generating vibrations having a known frequency and amplitude, with the amplitude of the vibrations degrading over time to replicate in a controlled manner the natural degradation of vibrations generated by a mechanical tuning fork, and a method of use thereof. Alternatively, the amplitude of the vibrations may be initially very small and then increase over time in a controlled manner to test first perception of feeling.

摘要翻译： 一种数字音叉装置，用于向包括综合振动机构和定时器的人体受试者施加振动感测试，振动机构产生具有已知频率和振幅的振动，随着时间的推移，振动的振幅随着时间的推移而复制， 方式由机械音叉产生的振动的自然降解及其使用方法。 或者，振动的振幅可以最初非常小，然后以受控的方式随时间增加以测试第一感觉感觉。

公开(公告)号：US20140163411A1

公开(公告)日：2014-06-12

申请号：US14098419

申请日：2013-12-05

申请人： NEUROVISION MEDICAL PRODUCTS, INC.

发明人： James Lee Rea

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B5/0488

CPC分类号： A61B5/04001 ,  A61B5/0488 ,  A61B5/4029 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/746

摘要： A method of monitoring relative nerve health and the presence of neuropraxia is described. The methods utilize the integration of a waveform function of an elicited or monitored nerve response to provide an indication of the strength of a detected signal from a nerve and thus the relative health and integrity of the nerve. In some embodiments motor nerve stimulation innervates muscle and an EMG waveform is obtained in response thereto. The integration under the waveform is expressed and an indexed value indicating a percentage of a certain threshold value. Methods set forth provide a more reliable status of a nerve in real-time and allow action to be taken to reduce neuropraxia or prevent permanent nerve damage.

摘要翻译： 描述了监测相对神经健康和神经缺损的存在的方法。 所述方法利用引发或监测的神经反应的波形函数的积分来提供来自神经的检测信号的强度的指示，从而提供神经的相对健康和完整性。 在一些实施例中，运动神经刺激支配肌肉并且响应于此获得EMG波形。 表示波形下的积分，并指示指示某一阈值的百分比的索引值。 所提出的方法实时提供神经的更可靠的状态，并且可以采取行动来减少神经缺损或预防永久性神经损伤。