公开(公告)号：US20180110973A1

公开(公告)日：2018-04-26

申请号：US15794333

申请日：2017-10-26

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Matthew D. Johnson ,  Edgar Peña ,  Simeng Zhang ,  Steven Deyo ,  YiZi Xiao

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/372

CPC classification number: A61N1/0534 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4836 ,  A61N1/36082 ,  A61N1/36128 ,  A61N1/37247

Abstract: Systems and methods for programming multi-electrode neuromodulation systems, with applications for at least deep brain stimulation (DBS) therapy. One or more configurations can be generated and presented to a user for selection. The selected configurations can be settings for programming a pulse generator. The one or more configurations can be Pareto optimal in terms of one or more objective values and can be generated using a particle swarm optimization. The generated configurations can be visualized on a Pareto front for user selection. Objective values can include minimizing power use, maximizing activation of neural pathways and/or regions of interest, minimizing activation of neural pathways and or regions of avoidance, and maximizing or minimizing the distance to sources of sensed functional data.

公开(公告)号：US20180110473A1

公开(公告)日：2018-04-26

申请号：US15564778

申请日：2016-04-07

Applicant: Korea University Research and Business Foundation

Inventor： Dong-Joo Kim

IPC: A61B5/00 ,  A61B5/021

CPC classification number: A61B5/7278 ,  A61B5/021 ,  A61B5/02116 ,  A61B5/4064 ,  A61B5/4842 ,  A61B5/7225 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/742

Abstract: The present invention relates to a device and a method for detecting a feature of an arterial blood pressure (ABP) waveform. The feature detecting method of an ABP waveform according to an exemplary embodiment of the present invention includes: searching a peak and a trough; detecting a systolic peak based on a time interval between a peak and a neighboring peak and an average pressure value; detecting a pulse onset with respect to a trough directly before the systolic peak; extracting a candidate of a dicrotic notch based on a magnitude of the systolic peak and a measurement time; detecting a point having a lowest pressure value among candidates of the dicrotic notch as a dicrotic notch and detecting a dicrotic peak based on the dicrotic notch; and classifying the detected dicrotic notches into a normal notch and a transient notch.

公开(公告)号：US09940712B2

公开(公告)日：2018-04-10

申请号：US15304206

申请日：2015-04-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Roland Henry ,  Stephen Hauser ,  Alyssa Zhu ,  Esha Datta

IPC: A61B5/00 ,  G06T7/00 ,  A61B5/055

CPC classification number: G06T7/0012 ,  A61B5/0022 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4041 ,  A61B5/4064 ,  A61B5/407 ,  A61B5/4848 ,  A61B5/4893 ,  G06F19/00 ,  G06T2207/30012 ,  G06T2207/30016

Abstract: Methods and systems are provided for the automated detection and analysis of structural tissue alterations related to myelin and axons/neurons in one or more biological structures of a patient's nervous system obtained from data from a medical imaging system, or the initial sensing or data collection processes such as, those that could be used to generate an image. In some embodiments, the method comprises, at a system having a memory and one or more processor for processing and displaying images of the biological structure, computationally processing at least a T1 weighted magnetic resonance image of the structure and a T2 weighted magnetic resonance image of the structure in order to analyze at least a portion of the structure of the nervous system using a plurality of stored tissue classifier elements to determine if the portion of the structure correlates with the presence of myelin. Such methods are useful for the detection of diseases associated with demyelination.

公开(公告)号：US20180092588A1

公开(公告)日：2018-04-05

申请号：US15832871

申请日：2017-12-06

Applicant: Facense Ltd.

Inventor： Arie Tzvieli ,  Gil Thieberger ,  Ari M. Frank

IPC: A61B5/16 ,  A61B5/01 ,  A61B5/00

CPC classification number: A61B5/165 ,  A61B5/0075 ,  A61B5/0077 ,  A61B5/015 ,  A61B5/163 ,  A61B5/168 ,  A61B5/4064 ,  A61B5/486 ,  A61B5/4884 ,  A61B5/6803 ,  A61B5/6814 ,  A61B2562/0271 ,  G01J5/0025 ,  G02B27/0172 ,  G02B27/0176 ,  G02B2027/0138 ,  G02B2027/014 ,  G02B2027/0141 ,  H04N5/2257 ,  H04N5/23219 ,  H04N5/33

Abstract: Brain activity, and in particular which hemisphere is relatively more effective, is correlated with the dominant nostril (i.e., the nostril through which most of the air is exhaled when breathing through the nose). Since each side of the brain plays a different role in different types of activities, it may be better to conduct certain activities when a certain nostril is dominant. Described herein are systems and methods for suggesting activities according to the dominant nostril. In one embodiment, a system includes a sensor and a computer. The sensor takes measurements of a user that are indicative of the user's dominant nostril. The computer predicts, based on the measurements, which of the user's nostrils will be the dominant nostril at a future time and may suggest having a suitable activity accordingly.

公开(公告)号：US20180092575A1

公开(公告)日：2018-04-05

申请号：US15680401

申请日：2017-08-18

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Kevin E. Bennet ,  Kendall H. Lee

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61B5/1473 ,  A61B5/14546 ,  A61B5/4064 ,  A61B5/4836 ,  A61B5/6868 ,  A61N1/0534 ,  A61N1/36121 ,  G01N27/308 ,  G01N33/4833 ,  G01N33/50

Abstract: This document provides methods and materials involved in assessing concentrations of analytes in an environment using a diamond-containing carbon electrode. For example, methods and materials for using FSCV or paired pulse voltammetry to discriminate analytes based on their adsorption characteristics to a diamond-containing carbon electrode are described herein.

公开(公告)号：US20180078734A1

公开(公告)日：2018-03-22

申请号：US15565252

申请日：2016-04-14

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Stefan PFUNDTNER ,  Gary Nelson GARCIA MOLINA ,  Tsvetomira Kirova TSONEVA

IPC: A61M21/02 ,  A61B5/048 ,  A61B5/00

CPC classification number: A61M21/02 ,  A61B5/0476 ,  A61B5/048 ,  A61B5/0484 ,  A61B5/4064 ,  A61B5/4812 ,  A61B5/6803 ,  A61M2021/0005 ,  A61M2021/0016 ,  A61M2021/0022 ,  A61M2021/0027 ,  A61M2021/0044 ,  A61M2021/0055 ,  A61M2205/3303 ,  A61M2230/10

Abstract: The present disclosure pertains to a system configured to provide sensory stimulation to a subject (12) during a sleep session. The system includes one or more sensory stimulators (16) configured to provide sensory stimulation to the subject; one or more sensors (18) configured to generate output signals conveying information related to brain activity of the subject; and one or more processors (20) configured to detect individual slow waves in the subject; control the one or more sensory stimulators to provide sensory stimulation to the subject based on the detected individual slow waves; predict a timing for occurrence of a predicted slow wave based on the previously detected individual slow waves; and responsive to not detecting the predicted slow wave at the predicted timing control the one or more sensory stimulators to provide sensory stimulation at the predicted timing for occurrence of the predicted slow wave.

公开(公告)号：US09901650B2

公开(公告)日：2018-02-27

申请号：US14769396

申请日：2014-02-21

Applicant: University of Rochester ,  The Research Foundation for The State University of New York

Inventor： Maiken Nedergaard ,  Jeffrey J. Iliff ,  Helene Benveniste ,  Rashid Deane

IPC: A61K51/04 ,  A61K49/00 ,  A61K31/41 ,  A61K38/10 ,  A61B5/055 ,  A61B5/00 ,  G01N33/68 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/55 ,  A61K31/551 ,  A61K49/06 ,  A61M27/00 ,  A61B6/03

CPC classification number: A61K51/0491 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4082 ,  A61B6/037 ,  A61B2576/026 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/437 ,  A61K31/55 ,  A61K31/551 ,  A61K38/10 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/06 ,  A61M27/00 ,  G01N33/6896 ,  G01N2800/2814 ,  G01N2800/50

Abstract: Methods are provided for measuring glio-vascular pathway (“glymphatic system”) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange in the brain. The methods can be used to track the exchange between CSF and ISF compartments. An imaging agent is optionally administered intrathecally. The imaging agent can be a negative or positive (paramagnetic) contrast agent and dynamic or contrast-enhanced magnetic resonance imaging (MRI) of the brain can be performed. The imaging agent can be a positron-emitting radionuclide tracer and positron emission tomography (PET) can be performed. Methods for treating diseases or disorders of the mammalian brain are also provided, in which the methods increase or decrease glymphatic clearance.

公开(公告)号：US20180049690A1

公开(公告)日：2018-02-22

申请号：US15681277

申请日：2017-08-18

Applicant: Matthew Walker

Inventor： Matthew Walker

IPC: A61B5/00 ,  A61B5/11

CPC classification number: A61B5/4812 ,  A61B5/024 ,  A61B5/0476 ,  A61B5/1114 ,  A61B5/1118 ,  A61B5/4064 ,  A61B5/4519 ,  A61B5/4815 ,  A61B5/6803 ,  A61B5/6814 ,  A61B5/6817 ,  A61B2562/0219 ,  A61B2562/0247

Abstract: Provided are mechanisms and processes for tracking sleep. Devices may include an accelerometer configured to measure macro and micro sensitivity movement of head, movement of throb of vessels close to the ear, monitor changes in heart rate and pulse rate and blood pressure. Devices may also include a sensor configured to measure changes in middle inner ear muscle, wherein the sensor is a pressure sensor configured to measure ear drum pressure differentiation as a measure of middle ear muscle activity. Devices may further include an electrical sensor configured to measure voltage of electrical activity from brain and identify and measure brain wave patterns.

公开(公告)号：US09883825B2

公开(公告)日：2018-02-06

申请号：US14382514

申请日：2013-03-26

Applicant: HITACHI MEDICAL CORPORATION

Inventor： Hirokazu Asaka ,  Takashi Ishizuka

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/02 ,  A61B5/026 ,  A61B5/0295 ,  A61B5/06 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/024

CPC classification number: A61B5/14552 ,  A61B5/0042 ,  A61B5/0073 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/02416 ,  A61B5/0261 ,  A61B5/0295 ,  A61B5/062 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14553 ,  A61B5/4064 ,  A61B5/6803 ,  A61B5/6814 ,  A61B5/6844 ,  A61B2560/0418 ,  A61B2562/0233 ,  A61B2562/223 ,  A61B2562/228

Abstract: A living body optical measurement apparatus of the present invention includes: a light irradiation/measurement unit for irradiating light to an object and measuring the light passed through the object, a signal processing unit for processing measurement data of the light irradiation/measurement unit and creating a living body optical measurement image, and a position measurement unit for measuring positions where light is irradiated to an object and where the passing light is extracted from the object, the light irradiation/measurement unit includes plural optical fibers. The light irradiation/measurement unit includes plural optical fibers, plural optical fiber plugs attached to the plural optical fibers respectively, and a holder fixed detachably at a measurement site of an object and holds the plural optical fiber plugs. The position measurement unit includes a mobile position sensor and an engaging member having a shape detachably engaged with the plural optical fiber plugs attached to the mobile position sensor and held in the holder.

公开(公告)号：US20180028098A1

公开(公告)日：2018-02-01

申请号：US15551102

申请日：2016-02-10

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Toru YAMADA ,  Shinji UMEYAMA

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/4064 ,  A61B5/6814 ,  A61B5/7203 ,  A61B10/00

Abstract: Provided is a multi-channel brain-functional near infrared spectroscopy device capable of easily levelling detector noise. The following control is performed: setting transmittances of all of optical attenuators to 1, setting intensities of all of light sources to a maximum light intensity within a safe irradiation range; determining the effective illumination intensity of each light source probe i as well as a minimum effective illumination intensity and a maximum effective illumination intensity thereof; changing the transmittance ai of each optical attenuator i on the light source probe side to [the minimum effective illumination intensity/effective illumination intensity of each light source probe i], thereby levelling the effective illumination intensity; and increasing the intensities of all of the light sources by W=[the maximum effective illumination intensity/the minimum effective incident efficiency] times, and determining the effective detection rate of each detector probe j as well as the minimum effective detection rate thereof; and performing control so as to level the effective detection rate by changing the transmittance aj of each optical attenuator j on the detector probe side to [the minimum effective detection rate/effective detection rate of each detector probe j], thereby equalizing detector noise among all the channels k.