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159 条记录 (耗时 0.026 秒)

    Tissue implant
    93.
    发明申请
    Tissue implant 审中-公开
    组织植入

    公开(公告)号：US20010016772A1

    公开(公告)日：2001-08-23

    申请号：US09770620

    申请日：2001-01-29

    发明人： David A. Lee ,  Daniel L. Bader ,  Myra D. Stephens

    IPC分类号： A61F002/38 ,  A61F002/44

    CPC分类号： A61L27/3856 ,  A61L27/3804 ,  A61L27/3843 ,  A61L27/3852 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/06 ,  A61F2/30 ,  C08L89/06 ,  C08L5/08 ,  C12N5/00

    摘要： A biochemical implant is described which comprises at least two matrix components. The first matrix component is composed of collagen with a porous macrostructure with the ability to withstand tensile or shear forces. The second matrix component is a hydrated alginate gel which substantially fills the porous macrostructure of the first component and exerts a swelling pressure. The implant additionally comprises a population of cells comprising chondrocytes, fibrochondrocytes, fibroblasts or osteoblasts, or precursors thereof.

    摘要翻译： 描述了包括至少两个矩阵分量的生化植入物。 第一个基质组分由具有能承受拉伸或剪切力的多孔宏观结构的胶原组成。 第二基质组分是水合藻酸盐凝胶，其基本上填充第一组分的多孔宏观结构并发挥溶胀压力。 植入物还包含包含软骨细胞，纤维软骨细胞，成纤维细胞或成骨细胞或其前体的细胞群。

    Intervertebral fusion device
    95.
    发明授权
    Intervertebral fusion device 有权

    公开(公告)号：US11883560B2

    公开(公告)日：2024-01-30

    申请号：US17384824

    申请日：2021-07-26

    申请人： National Taiwan University

    发明人： Wei-Hsing Tuan

    IPC分类号： A61F2/44 ,  A61L27/38 ,  A61L27/06 ,  A61L27/40 ,  A61L27/56 ,  A61L27/10

    CPC分类号： A61L27/3856 ,  A61L27/06 ,  A61L27/105 ,  A61L27/40 ,  A61L27/56 ,  A61L2430/38

    摘要： An intervertebral fusion device includes a structural ceramic body. The structural ceramic body has a bottom surface, a top surface, a peripheral surface connected between the bottom surface and the top surface, and at least one pore channel penetrating the bottom surface and the top surface. The inner surface of the pore channel is either a convex curved surface or a funnel-shaped surface. For the pore channel having the convex curved surface, the pore diameter of the pore channel gradually expands from the center of the pore channel to the top surface and the bottom surface. The pore diameter can also gradually expand from the bottom surface to the top surface. The peripheral surface of the structural ceramic body is wavy or zigzag.

    INTERVERTEBRAL DISC IMPLANT
    97.
    发明申请
    INTERVERTEBRAL DISC IMPLANT 审中-公开

    公开(公告)号：US20160143745A1

    公开(公告)日：2016-05-26

    申请号：US14903622

    申请日：2014-07-11

    申请人： MOUNT SINAI HOSPITAL

    发明人： Rita Kandel ,  J. Paul Santerre ,  Shu Qiu Li

    IPC分类号： A61F2/44 ,  C12N5/00 ,  A61L27/18 ,  A61L27/38 ,  A61L27/12

    CPC分类号： A61F2/442 ,  A61F2002/4435 ,  A61F2002/4445 ,  A61F2002/4495 ,  A61L27/12 ,  A61L27/18 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3817 ,  A61L27/3856 ,  A61L27/3895 ,  A61L2430/38 ,  C12N5/0068 ,  C08L75/04

    摘要： The disclosure relates to an intervertebral disc implant comprising a first construct comprising a continuous layer of nucleus pulposus (NP) tissue directly or indirectly on and integrated with a substrate, and a second construct surrounding the first construct comprising one or more continuous layers of annulus fibrosus (AF) tissue on and adherent to a scaffold, wherein the AF tissue, which is composed of single or multiple adherent layers, is integrated with the NP tissue. The disclosure also relates to methods of preparing the multi-tissue intervertebral disc and using the intervertebral disc as an implant.

    摘要翻译： 本公开涉及一种椎间盘植入物，其包括第一构建体，其包含直接或间接地在基底上并与其一体化的髓核（NP）组织的连续层，以及围绕第一构建体的第二构建体，其包含一个或多个连续的纤维环层 （AF）组织并附着于支架，其中由单个或多个粘附层组成的AF组织与NP组织结合。 本公开还涉及制备多组织椎间盘并使用椎间盘作为植入物的方法。