公开(公告)号：US09707342B2

公开(公告)日：2017-07-18

申请号：US14844355

申请日：2015-09-03

申请人： BAYER MEDICAL CARE INC.

发明人： Arthur E. Uber, III ,  Barry L. Tucker ,  Mark Trocki ,  Raymond C. Hoffman ,  Marc A. Mabie

IPC分类号： A61N5/00 ,  A61M5/178 ,  G21F5/018 ,  G21F5/06 ,  A61M5/00 ,  A61N5/10 ,  A61M5/31

CPC分类号： A61M5/1785 ,  A61M5/007 ,  A61M5/31 ,  A61M2005/3104 ,  A61M2205/0211 ,  A61M2205/0238 ,  A61N5/1002 ,  A61N5/1007 ,  A61N2005/1021 ,  A61N2005/1094 ,  G21F5/018 ,  G21F5/06

摘要： A syringe shield useful for containing a syringe loaded with radioactive and/or light sensitive drugs is disclosed. The syringe shield may reduce a healthcare provider's exposure to radiation and/or may reduce or eliminate ambient light contamination to optically sensitive components in the syringe.

公开(公告)号：US09694201B2

公开(公告)日：2017-07-04

申请号：US14261285

申请日：2014-04-24

申请人： Covidien LP

发明人： Brian M. Strauss ,  Jeffrey J. Valko

IPC分类号： A61N5/10 ,  A61B17/12 ,  A61B17/00

CPC分类号： A61N5/1002 ,  A61B17/00491 ,  A61B17/12109 ,  A61B17/12172 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B18/00 ,  A61B2017/00898 ,  A61B2017/00942 ,  A61B2018/00577 ,  A61N5/1007 ,  A61N2005/1021 ,  A61N2005/1098

摘要： A method of radio-ablation in conjunction with embolic implants used for pre-embolization of branch arteries in radio-ablation of the liver or other diseased tissue.

公开(公告)号：US09597053B2

公开(公告)日：2017-03-21

申请号：US12137364

申请日：2008-06-11

申请人： Stephen E. Hidem ,  Aaron M. Fontaine ,  Janet L. Gelbach ,  Patrick M. McDonald ,  Kathryn M. Hunter

发明人： Stephen E. Hidem ,  Aaron M. Fontaine ,  Janet L. Gelbach ,  Patrick M. McDonald ,  Kathryn M. Hunter

IPC分类号： A61B6/03 ,  A61M5/14 ,  A61N5/10 ,  A61B6/00 ,  G06F19/00 ,  G21G4/08 ,  A61M5/142 ,  A61M5/00 ,  A61B6/10 ,  A61K51/00

CPC分类号： A61B6/582 ,  A61B6/037 ,  A61B6/107 ,  A61B6/481 ,  A61B2090/392 ,  A61K51/00 ,  A61M5/007 ,  A61M5/14 ,  A61M5/1407 ,  A61M5/142 ,  A61M2205/50 ,  A61M2209/08 ,  A61N5/1001 ,  A61N5/1007 ,  A61N2005/1021 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/40 ,  G21G4/08

摘要： Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer includes pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system parameters for quality control, and/or to perform purges of the system.

公开(公告)号：US09572788B2

公开(公告)日：2017-02-21

申请号：US14276994

申请日：2014-05-13

申请人： President and Fellows of Harvard College

发明人： Randall King ,  Xing Zeng ,  Katharine L. Sackton

IPC分类号： A61K31/27 ,  A61K31/506 ,  A61P35/00 ,  A61N5/10 ,  A61K45/06 ,  A61K31/436 ,  A61K31/138 ,  A61K31/337 ,  A61K31/4196 ,  A61K31/496 ,  A61K31/555 ,  A61K47/48

CPC分类号： A61K31/27 ,  A61K31/138 ,  A61K31/337 ,  A61K31/4196 ,  A61K31/436 ,  A61K31/496 ,  A61K31/506 ,  A61K31/555 ,  A61K45/06 ,  A61K47/48038 ,  A61K47/542 ,  A61N5/1001 ,  A61N2005/1021 ,  A61N2005/109 ,  A61K2300/00

摘要： The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting complex (APC) by a synergistic mechanism.

摘要翻译： 本公开提供了用于治疗细胞周期障碍的组合物和方法。 本公开的组合物包括proTAME，TAME和apcin的前药类似物，其组合通过协同机制抑制后期促进复合物（APC）的活性或功能。

公开(公告)号：US20160303397A1

公开(公告)日：2016-10-20

申请号：US15142000

申请日：2016-04-29

申请人： BAYER HEALTHCARE LLC

发明人： ALAN D. HIRSCHMAN ,  ARTHUR E. UBER, III ,  DAVID M. REILLY ,  JOHN F. KALAFUT ,  FREDERICK W. TROMBLEY, III ,  STEVEN J. REMIS ,  SCOTT GRIFFITH ,  DOUGLAS DESCALZI ,  RICHARD DEWIT ,  DAVID M. GRIFFITHS ,  MARC A. MABIE ,  MARK TROCKI

IPC分类号： A61N5/10 ,  A61M5/168 ,  G21G4/08 ,  A61B6/03 ,  G06F19/00 ,  A61M5/172 ,  A61B5/055

CPC分类号： A61N5/1001 ,  A61B5/0205 ,  A61B5/055 ,  A61B5/7289 ,  A61B6/032 ,  A61B6/037 ,  A61B6/0478 ,  A61B6/107 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4423 ,  A61B6/507 ,  A61B6/508 ,  A61B6/5288 ,  A61B6/548 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1456 ,  A61M5/16827 ,  A61M5/16881 ,  A61M5/1723 ,  A61M5/1785 ,  A61M2205/3576 ,  A61N5/1071 ,  A61N2005/1021 ,  A61N2005/1094 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G21F5/015 ,  G21G4/08

摘要： An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.

摘要翻译： 公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与 患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。 在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。 进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

公开(公告)号：US20160287900A1

公开(公告)日：2016-10-06

申请号：US15152525

申请日：2016-05-11

申请人： Bracco Diagnostics Inc.

发明人： Charles R. Quirico ,  Ernest Balestracci ,  Rolf E. Swenson ,  Daniel D. Darst ,  Eric J. Krause ,  Vishal N. Lokhande ,  Jacob S. Childs

IPC分类号： A61N5/10 ,  A61M5/00 ,  A61K51/00 ,  G21G4/08 ,  G21F3/00 ,  A61M5/168 ,  A61M5/142

CPC分类号： A61M5/007 ,  A61B6/037 ,  A61B6/107 ,  A61B6/481 ,  A61B6/507 ,  A61B50/13 ,  A61B90/39 ,  A61B2050/105 ,  A61B2090/392 ,  A61K51/00 ,  A61M5/14 ,  A61M5/1409 ,  A61M5/142 ,  A61M5/1452 ,  A61M5/158 ,  A61M5/16854 ,  A61M5/16881 ,  A61M5/365 ,  A61M2005/1403 ,  A61M2205/18 ,  A61M2205/276 ,  A61M2205/3375 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/584 ,  A61M2205/587 ,  A61M2205/6009 ,  A61M2205/6054 ,  A61M2205/6072 ,  A61M2205/70 ,  A61M2205/75 ,  A61M2209/084 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/1075 ,  A61N2005/1021 ,  A61N2005/1022 ,  A61N2005/1074 ,  A61N2005/1094 ,  B62B3/005 ,  G06F19/00 ,  G06F19/3468 ,  G06F21/31 ,  G16H20/17 ,  G21F3/00 ,  G21F7/00 ,  G21G1/0005 ,  G21G1/001 ,  G21G4/08 ,  G21G2001/0031

摘要： Infusion system configurations and assemblies facilitate routing of infusion circuit tubing lines. Tubing lines are routed into and out from compartments of a shielding assembly for the infusion system, at locations which prevent kinking and/or crushing of the lines, and/or provide for ease in assembling the circuit. A plurality of the lines may be held together by a support frame to form a disposable infusion circuit subassembly, that can further facilitate routing of the lines.

公开(公告)号：US20160250502A1

公开(公告)日：2016-09-01

申请号：US15082504

申请日：2016-03-28

申请人： UNIVERSITY OF ZURICH

发明人： ALFRED BUCK ,  BRUNO WEBER

IPC分类号： A61N5/10

CPC分类号： A61N5/1075 ,  A61K51/00 ,  A61M5/007 ,  A61M5/1407 ,  A61M5/16813 ,  A61M5/16827 ,  A61M39/28 ,  A61M2005/1403 ,  A61M2205/051 ,  A61M2205/3379 ,  A61M2210/065 ,  A61N5/1001 ,  A61N2005/1021 ,  G06F19/00

摘要： A method of delivering a radioactive liquid includes, performing an initialization, including; extracting at least a first amount of a radioactive liquid from a source of radioactive liquid, measuring a radioactivity level for the first amount of radioactive liquid, and performing a calibration phase. The calibration phase includes, extracting a second amount of radioactive liquid from the source of radioactive liquid wherein the second amount is calculated based on the radioactivity level of the first amount to provide a total dose of radioactive liquid having a predetermined radioactivity level, and delivering the total dose and performing at least one more calibration and delivery phases.

公开(公告)号：US20160120752A1

公开(公告)日：2016-05-05

申请号：US14992320

申请日：2016-01-11

申请人： BAYER HEALTHCARE LLC

发明人： Jason L. Bazala ,  Ryan C. Kaintz

IPC分类号： A61J1/20 ,  A61M5/00 ,  A61J1/14 ,  A61N5/10

CPC分类号： A61J1/2065 ,  A61J1/1412 ,  A61J1/16 ,  A61J1/20 ,  A61J1/201 ,  A61J1/2096 ,  A61M5/007 ,  A61N5/1002 ,  A61N2005/1021 ,  A61N2005/1094

摘要： A pharmaceutical transport container includes a first body portion adapted to receive at least a portion of a pharmaceutical vial, a second body portion removably engaged with the first body portion to fully enclose the vial, and, optionally, a ratcheting mechanism to permit rotation of the cap member relative to the second body portion upon application of rotational force of a predetermined amount. A pharmaceutical transport container may also include, for example, a guide tab extending from an exterior surface of the second body portion to engage a guide slot defined in a fluid injection system docking station, whereby the transport container translates axially and rotationally into the docking station to establish a fluid connection between the vial and a fluid connector mechanism or element disposed within the docking station.

公开(公告)号：US20160008497A1

公开(公告)日：2016-01-14

申请号：US14793603

申请日：2015-07-07

申请人： Sirtex Medical Limited

发明人： Jens Ricke ,  Holger Amthauer ,  Oliver Grober

IPC分类号： A61K51/12 ,  A61N5/10 ,  A61K45/06

CPC分类号： A61K51/1251 ,  A61K45/06 ,  A61N5/1001 ,  A61N2005/1021

摘要： Accordingly, the present invention provides a method of treating lung neoplasia in a subject in need of treatment, by subjecting the patient to SIRT.

摘要翻译： 因此，本发明提供了通过对患者进行SIRT治疗需要治疗的受试者的肺瘤形成的方法。

公开(公告)号：US20150367003A1

公开(公告)日：2015-12-24

申请号：US14841125

申请日：2015-08-31

申请人： MO-SCI CORPORATION

发明人： Delbert E. Day ,  Yiyong He

IPC分类号： A61K51/02 ,  A61B6/00 ,  A61B6/03 ,  A61K51/12 ,  A61N5/10

CPC分类号： A61K51/1255 ,  A61B6/037 ,  A61B6/4057 ,  A61K9/0019 ,  A61K51/025 ,  A61K51/1244 ,  A61N5/1001 ,  A61N2005/1021

摘要： This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging.

摘要翻译： 本发明涉及用于放射治疗和/或放射成像的低密度放射性硅铝酸镁（MAS）微粒。