公开(公告)号：US20050090733A1

公开(公告)日：2005-04-28

申请号：US10921896

申请日：2004-08-20

申请人： Wilco Van Der Lugt ,  Jeroen Schuurman ,  Johan Henning ,  Stefan Kwa ,  Johann Kindlein

发明人： Wilco Van Der Lugt ,  Jeroen Schuurman ,  Johan Henning ,  Stefan Kwa ,  Johann Kindlein

IPC分类号： G01R33/28 ,  A61B5/055 ,  A61B5/06 ,  A61B6/06 ,  A61B8/12 ,  A61B17/00 ,  A61B19/00 ,  A61N5/10 ,  A61B5/05

CPC分类号： A61B5/055 ,  A61B6/06 ,  A61B8/12 ,  A61B8/4461 ,  A61B8/483 ,  A61B90/36 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61N5/1027 ,  A61N5/1049 ,  A61N2005/1011 ,  G06T11/008 ,  G06T2211/428

摘要： The invention relates to a method for determining the position of a surgical tool relative to a target volume inside an animal body according to a pre-plan comprising the steps of i) obtaining a plurality of two-dimensional images of said target volume using imaging means, each 2D-image being represented by an image data slice I(x,y,z); ii) reconstructing from said plurality of image data slices I(x,y,z) a three-dimensional image of said target volume using transformation means, said 3D-image being represented by a volumetric image data array V(x,y,z); iii) displaying said three-dimensional image of said target volume to an user using displaying means.

摘要翻译： 本发明涉及一种用于根据预先计划确定外科手术工具相对于动物体内的目标体积的位置的方法，包括以下步骤：i）使用成像装置获得所述目标体积的多个二维图像 每个2D图像由图像数据切片I（x，y，z）表示; ii）使用变换装置从所述多个图像数据切片I（x，y，z）重建所述目标体积的三维图像，所述3D图像由体积图像数据阵列V（x，y，z）表示 ）; iii）使用显示装置将所述目标体积的所述三维图像显示给用户。

公开(公告)号：US20050085681A1

公开(公告)日：2005-04-21

申请号：US10897382

申请日：2004-07-22

申请人： James Stubbs ,  Rance Winkler

发明人： James Stubbs ,  Rance Winkler

IPC分类号： A61B17/00 ,  A61B19/00 ,  A61N5/10 ,  A61M36/04

CPC分类号： A61N5/1027 ,  A61B90/04 ,  A61B2017/00867 ,  A61B2090/0427 ,  A61M37/0069 ,  A61N2005/1094

摘要： A brachytherapy device including a spacing member is disclosed herein. The spacing member is useful in that the instrument is effective to limit the amount of radiation that comes into contact with the sensitive tissue, and thereby protect sensitive tissue from overheating or hotspots, and/or protect against radiation exposure outside of the patient's body which may affect healthcare providers or others who might come close to the patient. In particular, the spacing apparatus is effective to control the proximity of a brachytherapy device to the outer surface of the sensitive tissue proximate to a surgical excision site.

摘要翻译： 本文公开了包括间隔构件的近距离放射治疗装置。 间隔构件是有用的，因为该仪器有效地限制与敏感组织接触的辐射量，从而保护敏感组织免于过热或热点，和/或防止辐射暴露在患者体外，可能 影响医疗保健提供者或其他可能接近病人的人。 特别地，间隔装置有效地控制近距离放射治疗装置邻近手术切除部位的敏感组织的外表面。

公开(公告)号：US20050038312A1

公开(公告)日：2005-02-17

申请号：US10921784

申请日：2004-08-18

申请人： Thomas Green ,  Ryan Boucher ,  Yuri Belman

发明人： Thomas Green ,  Ryan Boucher ,  Yuri Belman

IPC分类号： A61M5/32 ,  A61M36/04 ,  A61M36/12 ,  A61N5/10

CPC分类号： A61M37/0069 ,  A61M5/329 ,  A61M2210/166 ,  A61N5/1007 ,  A61N5/1027 ,  A61N2005/1009 ,  A61N2005/101 ,  A61N2005/1011

摘要： Methods and apparatus are provided for loading therapeutic materials into brachytherapy needles. The apparatus comprises an apparatus with chambers, and radioactive seed and spacer cartridges received therein. The apparatus may be used in conjunction with a standard brachytherapy needle coupled to the distal end of the apparatus. The plunger dislodges seeds and spacers from the cartridge chambers to load the needle with a predetermined packing arrangement.

摘要翻译： 提供了将治疗材料装入近距离放射治疗针的方法和装置。 该装置包括具有室的装置，以及容纳在其中的放射性种子和间隔柱。 该装置可以与联接到装置的远端的标准近距离放射治疗针结合使用。 柱塞从盒室移除种子和间隔物，以预定的包装装置装载针头。

公开(公告)号：US20040267081A1

公开(公告)日：2004-12-30

申请号：US10804856

申请日：2004-03-19

申请人： NeoSeed Technology LLC.

发明人： Thomas C. Green ,  Michael Hogendijk ,  Keith Seiler ,  Larry DeSoto ,  Edo Ziring

IPC分类号： A61M036/12

CPC分类号： A61N5/1007 ,  A61N5/1027 ,  A61N2005/1011

摘要： Apparatus and methods for depositing radioactive seeds into a patient's prostate are provided that include impedance measuring circuitry for detecting whether the distal end of an elongated needle extends into a patient's bladder. The elongated needle includes two conductive traces and a lumen adapted to receive a column of radioactive seeds and spacers. The impedance measuring circuitry is coupled to the conductive traces of the elongated needle and provides a display indicative of the monitored impedance.

摘要翻译： 提供了用于将放射性种子沉积到患者前列腺中的装置和方法，其包括用于检测细长针的远端是否延伸到患者膀胱内的阻抗测量电路。 细长的针包括两个导电迹线和适于接收一列放射性种子和间隔物的内腔。 阻抗测量电路耦合到细长针的导电迹线，并提供指示所监视的阻抗的显示。

公开(公告)号：US20040230087A1

公开(公告)日：2004-11-18

申请号：US10619928

申请日：2003-07-15

发明人： Richard A. Terwilliger ,  Gary A. Lamoureux

IPC分类号： A61M036/12

CPC分类号： A61M37/0069 ,  A61B17/3468 ,  A61B2017/3407 ,  A61B2017/3411 ,  A61N5/1027 ,  A61N2005/1012 ,  A61N2005/1023

摘要： A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated strand made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the strand. The delivery system and method further customize the strand based on a prescription. The strands can have custom end spacings, which allow the optimal placing of seeds within the treatment tissue by implanting a plurality of strands to the same depth. A plurality of these strands can be implanted at the same time by the use of a guiding device.

摘要翻译： 一种用于间质放射治疗的递送系统和方法，其包括在生物体组织中可生物吸收的基本上轴向刚性且纵向柔性的由细长的材料构成的细长股线，以及分散在股线内预定阵列中的多个放射性种子。 递送系统和方法基于处方进一步定制链。 股线可以具有定制的端部间隔，其允许通过将多个股线植入同一深度来最佳地将种子放置在处理组织内。 可以通过使用引导装置同时植入多个这些股线。

公开(公告)号：US20040220577A1

公开(公告)日：2004-11-04

申请号：US10853476

申请日：2004-05-25

发明人： Andrew H. Cragg ,  Jonathan Kagan

IPC分类号： A61B017/16

CPC分类号： A61B17/320758 ,  A61B17/1617 ,  A61B17/1671 ,  A61B17/1757 ,  A61B17/32002 ,  A61B17/320725 ,  A61B17/66 ,  A61B17/70 ,  A61B17/7055 ,  A61B17/8805 ,  A61B2017/00261 ,  A61B2017/00734 ,  A61B2017/00867 ,  A61B2017/2905 ,  A61B2017/320733 ,  A61F2/441 ,  A61F2/442 ,  A61F2/4455 ,  A61F2/4465 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2002/2821 ,  A61F2002/2835 ,  A61F2002/30092 ,  A61F2002/30291 ,  A61F2002/3055 ,  A61F2002/30563 ,  A61F2002/30566 ,  A61F2002/30677 ,  A61F2002/30774 ,  A61F2002/30841 ,  A61F2002/3085 ,  A61F2002/30879 ,  A61F2002/30884 ,  A61F2002/30892 ,  A61F2002/30925 ,  A61F2002/3097 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2210/0014 ,  A61F2230/0091 ,  A61F2310/00353 ,  A61N5/1027 ,  Y10S606/914

摘要： One or more shaped axial bore extending from an accessed posterior or anterior target point are formed in the cephalad direction through vertebral bodies and intervening discs, if present, in general alignment with a visualized, trans-sacral axial instrumentation/fusion (TASIF) line in a minimally invasive, low trauma, manner. An anterior axial instrumentation/fusion line (AAIFL) or a posterior axial instrumentation/fusion line (PAIFL) that extends from the anterior or posterior target point, respectively, in the cephalad direction following the spinal curvature through one or more vertebral body is visualized by radiographic or fluoroscopic equipment. Preferably, curved anterior or posterior TASIF axial bores are formed in axial or parallel or diverging alignment with the visualized AAIFL or PAIFL, respectively, employing bore forming tools that can be manipulated from proximal portions thereof that are located outside the patient's body to adjust the curvature of the anterior or posterior TASIF axial bores as they are formed in the cephalad direction. Further bore enlarging tools are employed to enlarge one or more selected section of the anterior or posterior TASIF axial bore(s), e.g., the cephalad bore end or a disc space, so as to provide a recess therein that can be employed for various purposes, e.g., to provide anchoring surfaces for spinal implants inserted into the anterior or posterior TASIF axial bore(s).

公开(公告)号：US20040192998A1

公开(公告)日：2004-09-30

申请号：US10818207

申请日：2004-04-05

发明人： Richard A. Brauckman ,  Jack C. White ,  Glenn A. Dill ,  Michael R. Moody

IPC分类号： A61N005/00 ,  A61N001/30 ,  A61M029/00

CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1025

摘要： Radiation delivery devices useful in brachytherapy which employ radioactive palladium-103 as the radiation source material are disclosed. Certain embodiments of the disclosed radiation delivery devices have the advantages that they can be fabricated with the desired specific activity, that the self-shielding effects of the devices are minimized, that the radioactive source material is bonded to a substrate in a manner which substantially prevents it from becoming detached, and that a variety of customizable radiation delivery devices can be made using the concepts of the invention. Also disclosed are processes for bonding radiation source material to various substrates using electroless plating, chemical vapor deposition and polymer matrices. These processes have the advantage that they can be applied to bond the radiation source material to a wide variety of substrates including different substrate materials and differently shaped substrates, thereby providing the ability to tailor the radiation delivery devices to the specific requirements of a particular brachytherapy treatment.

公开(公告)号：US20040167372A1

公开(公告)日：2004-08-26

申请号：US10784083

申请日：2004-02-20

发明人： Rance A. Winkler ,  Timothy J. Patrick ,  Carribeth B. Ramey

IPC分类号： A61N005/00 ,  A61F002/44 ,  A61M029/00

CPC分类号： A61F2/446 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/30858 ,  A61F2002/4475 ,  A61M25/10 ,  A61M29/02 ,  A61M2210/1003 ,  A61N5/1027 ,  A61N2005/1005 ,  A61N2005/1021

摘要： A radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue surrounding an interstitial space is provided. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases. In general, the system includes a catheter member having a proximal end, a distal end, and an inner lumen extending therethrough, and a structural support adapted to fit within an interstitial space in load bearing portion of a patient's body and having an internal space for removably receiving the distal end of the catheter member. At least one anchoring element can be disposed proximate to the distal end of the catheter. The anchoring element is preferably adapted to fit within the internal space in the structural support so as to anchor the distal end of the catheter therein. The system further includes a radiation source disposable within the internal space of the structural support through the lumen in the catheter for delivering radiation to tissue surrounding the interstitial space.

摘要翻译： 提供了放射治疗系统，优选近距离放射治疗系统，用于将辐射递送到间质空间周围的组织。 尽管该系统可用于各种目的，但该系统优选用于治疗脊柱转移。 通常，该系统包括具有近端，远端和延伸穿过其中的内腔的导管构件，以及适于装配在患者身体的承载部分中的间隙空间内的结构支撑件，并具有用于 可移除地接收导管构件的远端。 至少一个锚定元件可以布置成靠近导管的远端。 锚固元件优选地适于装配在结构支撑件内的内部空间中，以便将导管的远端固定在其中。 该系统还包括通过导管中的内腔在结构支撑件的内部空间内一次性放射的辐射源，用于将辐射传送到围绕间隙空间的组织。

公开(公告)号：US20040147811A1

公开(公告)日：2004-07-29

申请号：US10756588

申请日：2004-01-12

发明人： Chris J. Diederich ,  Dana L. Deardorff

IPC分类号： A61M029/00

CPC分类号： A61M29/02 ,  A61B2017/00092 ,  A61B2017/00274 ,  A61B2017/00557 ,  A61B2018/005 ,  A61B2018/00547 ,  A61B2090/0436 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/0037 ,  A61M2025/1013 ,  A61N5/1027 ,  A61N2005/1094

摘要： An apparatus and method for shielding non-target tissues and organs during thermotherapy, brachytherapy or other treatment of a diseased target tissue. The apparatus includes a catheter shaft having input and output lumens and at least one inflatable balloon. A plurality of input lumens within the catheter shaft allows the passage of liquid or gas through an input port and into the interior of the balloon thereby inflating the balloon. The gas or liquid can then be cycled through the inflated balloon through an output port and output lumen and out of the catheter shaft. Temperature sensors or other sensors may be attached to the balloon or catheter to monitor temperature or other conditions at the treatment site. The catheter is positioned between the target tissue or organ and sensitive non-target tissues in proximity to the target tissue and inflated causing a physical separation of tissues as well as a physical shield.

公开(公告)号：US06761680B2

公开(公告)日：2004-07-13

申请号：US10162548

申请日：2002-06-04

申请人： Richard A. Terwilliger ,  Gary A. Lamoureux

发明人： Richard A. Terwilliger ,  Gary A. Lamoureux

IPC分类号： A61N500

CPC分类号： A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024 ,  B29C47/0023 ,  B29C47/021 ,  B29C47/028 ,  G21G4/08

摘要： A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and radially flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands is also provided. The delivery system and method further customize the member based on a prescription.

摘要翻译： 一种用于间质放射治疗的递送系统和方法，包括由活体组织中生物可吸收的材料制成的基本上轴向刚性和径向柔性的细长构件，以及以预定阵列分散在细长构件内的多个放射性种子。 放射性种子可以分散在由相同材料制成的组装的半壳内。 用于辐射种子的外壳也可以由挤压材料制成。 还提供了用于制造自动制作种子股的间质放射线种子股的系统。 递送系统和方法基于处方进一步定制成员。