公开(公告)号：US20160370343A1

公开(公告)日：2016-12-22

申请号：US15004712

申请日：2016-01-22

Applicant: University of Southern California ,  Doheny Eye Institute

Inventor： Mark Humayun ,  Anhish Ahuja ,  Charles Le Pere

IPC: G01N33/483 ,  A61F9/00 ,  G01N21/64 ,  A61B3/12 ,  G06T7/00 ,  G01N21/59

CPC classification number: G01N33/4833 ,  A61B3/12 ,  A61F9/00 ,  A61F9/0017 ,  A61K49/0017 ,  A61L27/38 ,  A61L27/3834 ,  G01N21/59 ,  G01N21/6486 ,  G01N2201/12 ,  G06T7/0012 ,  G06T2207/10004 ,  G06T2207/30024

Abstract: Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy.

公开(公告)号：US20160367992A1

公开(公告)日：2016-12-22

申请号：US15251061

申请日：2016-08-30

Applicant: Faxitron Bioptics, LLC

Inventor： Ciaran Purdy ,  Donogh O'Driscoll

IPC: B01L9/00 ,  G01N33/483

CPC classification number: B01L9/52 ,  A61B10/0096 ,  B01L2300/0609 ,  B01L2300/0809 ,  B01L2300/123 ,  G01N33/4833 ,  G01N2223/307 ,  G01N2223/6126

Abstract: A specimen holding and positioning apparatus operable to substantially non-movably maintain a specimen (e.g., an excised tissue specimen) in a fixed or stable orientation with respect to the apparatus during imaging operations (e.g., x-ray imaging), transport (e.g., from a surgery room to a pathologist's laboratory), and the like for use in facilitating accurate detection and diagnosis of cancers and/or other abnormalities of the specimen.

Abstract translation: 一种样本保持和定位装置，其可操作以在成像操作（例如，x射线成像）期间，相对于装置（例如，x射线成像），运输（例如，X射线成像），基本上不可移动地将样本（例如，切除的组织标本） 从手术室到病理学家的实验室）等用于促进癌症的准确检测和诊断和/或样本的其他异常。

公开(公告)号：US20160349231A1

公开(公告)日：2016-12-01

申请号：US14724365

申请日：2015-05-28

Applicant: AxoGen, Inc.

Inventor： Curt DEISTER

IPC: G01N33/483 ,  G06T7/60 ,  G06T7/00

CPC classification number: G01N33/4833 ,  G01N33/5026 ,  G01N33/56966 ,  G01R33/5608 ,  G01R33/56341

Abstract: Techniques and systems are disclosed for a bioassay that is an in vitro mimic of peripheral nerve generation using the sensory neurons that innervate the peripheral nervous system. In some embodiments, the techniques may assist in detecting the bioactivity or potency of nerve grafts (e.g., processed, acellular human allografts) for fostering or supporting peripheral nerve regeneration. In various embodiments, techniques comprise affixing a harvested sensory neuron (e.g., a DRG) to a nerve graft segment to form a test construct; culturing the test construct in a medium; analyzing the test construct to indicate the amount of outgrowing peripheral nerve structure; and determining the potency of the nerve graft from a metric derived from the analysis. In some embodiments, techniques and materials may be used to test the effect of a varied test condition on peripheral nerve growth.

Abstract translation: 公开了用于生物测定的技术和系统，其是使用支配周围神经系统的感觉神经元的体外模拟周围神经生成。 在一些实施方案中，该技术可以有助于检测神经移植物（例如，加工的，无细胞的人类同种异体移植物）的生物活性或效力，以促进或支持周围神经再生。 在各种实施方案中，技术包括将收获的感觉神经元（例如，DRG）附着到神经移植物片段以形成测试构建体; 在培养基中培养测试构建体; 分析测试结构以表明周围神经结构的量; 并从分析得出的度量确定神经移植物的效力。 在一些实施方案中，可以使用技术和材料来测试不同的测试条件对周围神经生长的影响。

公开(公告)号：US09506907B2

公开(公告)日：2016-11-29

申请号：US13771007

申请日：2013-02-19

Applicant: The Research Foundation of State University of New York

Inventor： Magnus Bergkvist ,  Sara Brenner ,  Ioannis Danias ,  Susan Sharfstein ,  Yubing Xie ,  Alison Gracias ,  Karen Y. Torrejon

IPC: C12Q1/02 ,  G01N33/483 ,  C12N5/079 ,  A61F9/007

CPC classification number: G01N33/4833 ,  A61F9/00781 ,  C12N5/0621 ,  C12N2503/02 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2533/32 ,  C12N2533/54

Abstract: The present invention relates to methods of manufacture and utility of an artificial trabecular meshwork [TM] that utilizes micro- and nanofabricated materials bioengineered to mimic the structure and function of native outflow system of the eye.

Abstract translation: 本发明涉及人造小梁网的制造和应用的方法[TM]，其利用生物工程化的微米和纳米制品材料来模仿眼睛的天然流出系统的结构和功能。

公开(公告)号：US20160343539A1

公开(公告)日：2016-11-24

申请号：US15114978

申请日：2015-01-28

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Takahiko HARIYAMA ,  Yasuharu TAKAKU ,  Hiroshi SUZUKI ,  Satoshi HIRAKAWA ,  Hideaki KAWASAKI ,  Masatsugu SHIMOMURA ,  Daisuke ISHII ,  Isao OHTA ,  Yoshinori MURANAKA

IPC: H01J37/20 ,  G01N33/50 ,  H01J37/22 ,  G01N33/483

CPC classification number: H01J37/20 ,  G01N33/4833 ,  G01N33/5011 ,  G01N2223/612 ,  G01N2800/7028 ,  H01J37/22 ,  H01J2237/2002 ,  H01J2237/2007

Abstract: Provided are a protective agent for electron microscopic observation in a vacuum which can protect a biological sample in a water-containing state, such as a mammal, a plant tissue or a cultured cell, and a single cell in the living state without deforming it even in a vacuum, a kit using the same, methods for observation, diagnosis, evaluation, and quantification of a sample by an electron microscope, and a sample stage to be used for the observation. The protective agent for electron microscopic observation of the present invention contains a a component to impart the survival environment, a saccharide, and an electrolyte.

Abstract translation: 提供一种用于真空中电子显微镜观察的保护剂，其可以保护生物状态中的含水状态的生物样品例如哺乳动物，植物组织或培养细胞，以及单一细胞，而不使其变形甚至 在真空中，使用其的试剂盒，通过电子显微镜观察，诊断，评价和定量样品的方法以及用于观察的样品台。 本发明的电子显微镜观察用保护剂含有赋予生存环境的成分，糖类和电解质。

公开(公告)号：US20160341678A1

公开(公告)日：2016-11-24

申请号：US15227292

申请日：2016-08-03

Applicant: ICAGEN, INC.

Inventor： Lori J. Peterson ,  Cameron A. Mortillaro ,  Benjamin P. Warner ,  Nathan H. Zahler ,  Pratima Bharti ,  Chang-Tai Hsieh ,  Emilia A. Solomon

IPC: G01N23/223 ,  G01N33/487 ,  A61B6/00 ,  G01N33/483

CPC classification number: G01N23/223 ,  A61B6/485 ,  G01N33/4833 ,  G01N33/487 ,  G01N2223/076 ,  G01N2223/0766 ,  G01N2223/612 ,  G01N2223/6126

Abstract: The present invention is a method to quantify biomarkers. The method uses an X-ray fluorescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.

Abstract translation: 本发明是一种量化生物标志物的方法。 该方法使用X射线荧光光谱仪对样品进行X射线荧光分析，以获得源自生物标志物的光谱特征; 并量化生物标志物的X射线荧光信号。

公开(公告)号：US09500586B2

公开(公告)日：2016-11-22

申请号：US14842330

申请日：2015-09-01

Applicant: NXGEN PARTNERS IP, LLC

Inventor： Solyman Ashrafi ,  Roger Linquist

IPC: G01N21/59 ,  G01N24/00 ,  G01R33/36 ,  G01N21/17

CPC classification number: G01N21/59 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/17 ,  G01N21/21 ,  G01N24/00 ,  G01N24/08 ,  G01N33/483 ,  G01N33/4833 ,  G01N33/487 ,  G01N2021/1765 ,  G01R33/3657 ,  G01R33/3692

Abstract: An apparatus that detects a material within a sample includes signal generation circuitry that generates a first signal having at least one orbital angular momentum applied thereto and applies the first signal to the sample. A detector receives the first signal after the first signal passes through the sample and detects the material responsive to a detection of a predetermined profile of orbital angular momentum states within the first signal received from the sample.

Abstract translation: 检测样本内的材料的装置包括信号产生电路，其产生具有施加到其上的至少一个轨道角动量的第一信号，并将第一信号施加到样本。 检测器在第一信号通过样本之后接收第一信号，并且响应于在从样本接收的第一信号内的轨道角动量状态的预定轮廓的检测来检测材料。

公开(公告)号：US20160327536A1

公开(公告)日：2016-11-10

申请号：US15107893

申请日：2014-12-23

Applicant: SATURAS LTD

Inventor： Moshe Meron

IPC: G01N33/00 ,  A01G25/16 ,  B01D61/02 ,  B01D61/00 ,  G01N33/483 ,  G01N13/04

CPC classification number: G01N33/0098 ,  A01G25/167 ,  B01D61/005 ,  G01N7/10 ,  G01N13/04 ,  G01N33/4833 ,  G01N2333/415

Abstract: A device and a system are for measuring fluid potential in a plant tissue by measuring pressure changes caused due to osmosis of the plant fluid. The measuring device includes a compartment having a ridged body configured for containing an osmoticum. The compartment has at least one opening; at least two selective barrier layers, such as a membrane positioned at least over the openings of the compartment; and at least one pressure sensor configured for detecting changes in pressure of fluid in the compartment. The selective barrier is located for selectively allowing water transfer between the plant fluid and the osmoticum in the compartment. The compartment is configured such that there is a direct contact between the plant fluid and the osmoticum therein via the selective barrier.

Abstract translation: 装置和系统用于通过测量由于植物液体的渗透引起的压力变化来测量植物组织中的液体潜力。 测量装置包括具有构造成容纳渗透压的脊状体的隔室。 隔间至少有一个开口; 至少两个选择性阻隔层，例如至少位于隔室开口上方的膜; 以及至少一个压力传感器，构造成用于检测隔室中的流体的压力变化。 选择性屏障位于选择性地允许植物液体和隔室中的渗透液之间的水分转移。 隔室被构造成使得植物液体和其中的渗透物经由选择性屏障直接接触。

公开(公告)号：US09490113B2

公开(公告)日：2016-11-08

申请号：US12755769

申请日：2010-04-07

Applicant: Akos Vertes ,  Bennett N. Walker ,  Jessica A. Stolee ,  Scott T. Retterer

Inventor： Akos Vertes ,  Bennett N. Walker ,  Jessica A. Stolee ,  Scott T. Retterer

IPC: H01J49/04 ,  G01N33/68

CPC classification number: G01N33/6851 ,  G01N33/4833 ,  G01N33/6848 ,  H01J49/0031 ,  H01J49/0418 ,  Y02E10/52

Abstract: The production and use of semiconducting nanopost arrays made by nanofabrication is described herein. These nanopost arrays (NAPA) provide improved laser ionization yields and controllable fragmentation with switching or modulation capabilities for mass spectrometric detection and identification of samples deposited on them.

Abstract translation: 本文描述了通过纳米制造制造的半导体纳米柱阵列的生产和使用。 这些纳米阵列（NAPA）提供改进的激光离子化产率和可控的碎片化，具有开关或调制能力，用于质谱检测和识别沉积在其上的样品。

公开(公告)号：US09488621B2

公开(公告)日：2016-11-08

申请号：US13571662

申请日：2012-08-10

Applicant: Gregory Kaduchak ,  Michael D Ward

Inventor： Gregory Kaduchak ,  Michael D Ward

IPC: G01N1/20 ,  G01N15/10 ,  G01N37/00 ,  G01N29/14 ,  G01N15/14 ,  G01N33/483 ,  B01L3/00 ,  G01N1/10 ,  B01D15/08 ,  G01N1/40

CPC classification number: G01N29/14 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2400/0439 ,  B01L2400/0487 ,  G01N15/1404 ,  G01N15/1459 ,  G01N15/1463 ,  G01N33/4833 ,  G01N2001/4094 ,  G01N2015/1081 ,  G01N2015/1415 ,  G01N2015/142 ,  G01N2015/149

Abstract: The present invention is a method and apparatus for acoustically manipulating one or more particles.