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公开(公告)号：US09566723B2
公开(公告)日：2017-02-14
申请号：US14139740
申请日：2013-12-23
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma , Fuh-Wei Tang , Ni Ding
CPC classification number: B29C71/02 , A61F2/82 , A61F2/915 , A61F2002/91558 , A61F2002/91583 , A61F2210/0004 , A61F2240/001 , A61L2/007 , A61L2/08 , A61L2/087 , A61L31/06 , A61L31/148 , A61L2202/21 , A61L2202/24 , A61L2400/18 , B29C35/02 , B29C2035/0877 , B29C2071/022 , B29L2031/753 , C08J7/08 , C08J7/123 , C08J2367/04 , C08L67/04
Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.
Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。
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公开(公告)号：US09248218B2
公开(公告)日：2016-02-02
申请号：US14530595
申请日：2014-10-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xiao Ma
IPC: A61L31/14 , A61L31/06 , C08G63/08 , C08G63/90 , A61F2/89 , C08L67/04 , C09J167/04 , A61K9/20 , C09D167/04 , A61K9/16
CPC classification number: A61L31/148 , A61F2/82 , A61F2/89 , A61F2/958 , A61F2002/30062 , A61F2210/0004 , A61K9/1647 , A61K9/204 , A61L31/06 , B29C47/0066 , B29K2067/046 , B29L2031/7534 , C08G63/08 , C08G63/90 , C08J2367/04 , C08L67/04 , C09D167/04 , C09J167/04
Abstract: Methods of making a biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal. Methods include making a poly(L-lactide) material for a stent with uniformly distributed L-lactide monomer through control of polymerization conditions during PLLA synthesis, control of post-processing conditions, or both.
Abstract translation: 公开了由聚（L-丙交酯）和低浓度的L-丙交酯单体制备可生物降解的聚合物支架的方法。 调节L-丙交酯的浓度以提供适合于包括冠状动脉，外周和鼻部在内的不同治疗应用的降解行为。 方法包括通过控制PLLA合成期间的聚合条件，后处理条件的控制或两者来制备具有均匀分布的L-丙交酯单体的支架的聚（L-丙交酯）材料。
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103.发明申请SHEATHS REDUCING RECOIL AND LOSS OF RETENTION FOR POLYMER SCAFFOLDS CRIMPED TO BALLOONS 审中-公开减少对气球造成破坏的聚合物破坏物的恢复和损失公开(公告)号：US20150328028A1
公开(公告)日：2015-11-19
申请号：US14716715
申请日：2015-05-19
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Jhoan Bayogo
IPC: A61F2/958
CPC classification number: A61F2/0095 , A61F2/958 , A61F2/962 , A61F2/97 , A61F2002/011 , A61F2002/9522 , A61F2002/9583 , A61F2240/001 , A61F2250/0059 , B23P11/005 , Y10T29/49826 , Y10T29/49838 , Y10T29/49909 , Y10T29/49915
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A single piece sheath is placed over the scaffold immediately following crimping of the scaffold to the balloon. The single piece sheath is replaced by a two-piece sheath, which is removed prior to performing a medical procedure using the medical device.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 在将支架压合到气囊之后立即将单件护套放置在支架上方。 单件护套由两件式护套代替，其在使用医疗装置执行医疗程序之前被移除。
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104.发明授权Controlling moisture in and plasticization of bioresorbable polymer for melt processing 有权控制生物可吸收聚合物的水分和塑化，用于熔体加工公开(公告)号：US09168677B2
公开(公告)日：2015-10-27
申请号：US14311175
申请日：2014-06-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/1018 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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105.发明授权Methods for crimping a polymeric scaffold to a delivery balloon and achieving stable mechanical properties in the scaffold after crimping 有权将聚合物支架卷曲到输送球囊并在压接之后在支架中实现稳定的机械性能的方法公开(公告)号：US09155870B2
公开(公告)日：2015-10-13
申请号：US14263961
申请日：2014-04-28
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang
CPC classification number: A61F2/958 , A61F2002/9522 , A61F2240/001 , A61L31/06 , A61L31/16 , A61M25/1034 , B23P11/025 , B29D23/00 , B29K2067/043 , B29K2067/046 , B29K2995/0082 , Y10T29/49865 , Y10T29/49913 , Y10T29/49925 , Y10T29/49927 , Y10T29/49929 , C08L67/04
Abstract: A medical device-includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes inflating the delivery balloon during a diameter reduction to improve scaffold retention. A crimping temperature is maintained at about the onset of glass transition of the polymer material to facilitate more rapid stabilization of mechanical properties in the scaffold following crimping.
Abstract translation: 一种医疗装置 - 包括卷曲到具有膨胀气囊的导管的聚合物支架。 支架通过包括在直径减小期间使输送气囊膨胀以改善支架保持力的方法卷曲到气囊。 卷曲温度保持在大约聚合物材料的玻璃化转变开始处，以便在压接之后在支架中更快速地稳定机械性能。
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Patent Agency Ranking
公开(公告)号：US20150238332A1
公开(公告)日：2015-08-27
申请号：US14700028
申请日：2015-04-29
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Luis Sucy Vazquez , Hung T. Nguyen , Scott H. Mueller , Kathleen Yan
CPC classification number: A61F2/82 , A61F2/95 , A61F2/958 , A61F2002/91566 , A61F2002/9522 , A61F2250/0067 , B29C53/30 , B29C67/0014 , B29D23/00 , B29D23/001 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , Y10T29/4994 , Y10T29/49945 , Y10T29/53996
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the catheter by a multi-step process for increasing scaffold-catheter yield following a crimping sequence. Damage reduction during a crimping sequence includes modifying blades of a crimper, adopting a multi-step crimping sequence, and inflating a supporting balloon to support the scaffold during crimping.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 通过多步骤方法将支架卷曲到导管，以在压接顺序之后增加支架导管产量。 在压接顺序期间的损伤减少包括修改卷边机的叶片，采用多步压接顺序，以及在压接期间使支撑气囊膨胀以支撑支架。
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107.发明申请METHOD OF INCREASING STENT RETENTION OF BIOABSORBABLE SCAFFOLDING WITH A SHEATH 审中-公开增加生物可降解性的保护性的方法公开(公告)号：US20150224707A1
公开(公告)日：2015-08-13
申请号：US14692615
申请日：2015-04-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Xioa Ma , Rommel C. Lumauig
IPC: B29C65/56
CPC classification number: B29C65/567 , A61F2/915 , A61F2/958 , A61F2002/9522 , Y10T29/49925
Abstract: A medical device includes a polymer stent crimped to a catheter having an expansion balloon. The stent is crimped to the balloon by a process that includes heating the stent to a temperature below the polymer's glass transition temperature to improve stent retention without adversely affecting the mechanical characteristics of the stent when later deployed to support a body lumen. A variable diameter sheath with a central portion that prevents expansion of the stent when the balloon is pressurized and larger diameter ends is disposed over the crimped stent-balloon assembly. The balloon is pressurized and the larger diameter ends of the sheath allow the balloon beyond the ends of the stent to expand. The balloon is then depressurized.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物支架。 将支架通过包括将支架加热到低于聚合物玻璃化转变温度的温度的方法来卷曲到气囊，以改善支架保持，而不会在稍后部署以支撑体腔时对支架的机械特性产生不利影响。 具有中心部分的可变直径护套设置在卷曲的支架 - 球囊组件上方，该中心部分防止当球囊被加压并且较大直径末端时支架膨胀。 气囊被加压，并且护套的较大直径的端部允许超出支架的端部的气囊膨胀。 然后将气球减压。
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108.发明申请TUBE EXPANSION PROCESSES FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS 有权用于半结晶聚合物的管扩展方法以最大限度地减少破裂韧性公开(公告)号：US20140374963A1
公开(公告)日：2014-12-25
申请号：US14480484
申请日：2014-09-08
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , James P. Oberhauser , Thierry Glauser , David Wrolstad , Yunbing Wang
CPC classification number: B29C61/04 , B29C35/045 , B29C35/0805 , B29C71/0063 , B29C71/02 , B29C2035/0822 , B29C2071/022 , B29K2067/046 , B29K2105/258 , B29K2995/004 , B29K2995/006 , B29K2995/0089 , B29L2031/7534
Abstract: Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold.
Abstract translation: 公开了制造具有改进的断裂韧性的聚合物支架的方法，包括聚合物管的径向膨胀和从膨胀管制造支架。 聚合物管设置在模具内并且可以用辐射加热。 加热管在模具内径向扩张。
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109.发明申请POLYESTER IMPLANTABLE MEDICAL DEVICE WITH CONTROLLED IN VIVO BIODEGRADABILITY 审中-公开具有生物可降解性控制的聚酯可植入医疗器械公开(公告)号：US20140364575A1
公开(公告)日：2014-12-11
申请号：US14456739
申请日：2014-08-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang
CPC classification number: A61L31/041 , A61K9/0024 , A61K9/1647 , A61L27/26 , A61L31/148 , C08L67/04
Abstract: This invention relates to blends of high, optionally medium, and low molecular weight polyesters where at least the low molecular weight polyester is substituted with an acidic moiety, the biodegradation of the blends being controllable by selection of the mean molecular weigh of each fraction, the quantity of each fraction in the blend and the amount and pKa of the acidic moiety(ies).
Abstract translation: 本发明涉及高，任选中等和低分子量聚酯的共混物，其中至少低分子量聚酯被酸性部分取代，共混物的生物降解可通过选择各部分的平均分子量来控制， 共混物中每个级分的量和酸性部分的量和pKa。
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110.发明授权Tube expansion processes for semicrystalline polymers to maximize fracture toughness 有权用于半结晶聚合物的管膨胀过程以使断裂韧性最大化公开(公告)号：US08828305B2
公开(公告)日：2014-09-09
申请号：US13631061
申请日：2012-09-28
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , James P. Oberhauser , Thierry Glauser , David K. Wrolstad , Yunbing Wang
IPC: B29C49/64
CPC classification number: B29C61/04 , B29C35/045 , B29C35/0805 , B29C71/0063 , B29C71/02 , B29C2035/0822 , B29C2071/022 , B29K2067/046 , B29K2105/258 , B29K2995/004 , B29K2995/006 , B29K2995/0089 , B29L2031/7534
Abstract: Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold.
Abstract translation: 公开了制造具有改进的断裂韧性的聚合物支架的方法，包括聚合物管的径向膨胀和从膨胀管制造支架。 聚合物管设置在模具内并且可以用辐射加热。 加热管在模具内径向扩张。
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