Mitigation of photodamage in analytical reactions
    102.
    发明申请
    Mitigation of photodamage in analytical reactions 审中-公开
    减轻分析反应中的光损伤

    公开(公告)号:US20080176241A1

    公开(公告)日:2008-07-24

    申请号:US11981627

    申请日:2007-10-31

    IPC分类号: C12Q1/68 C12Q1/00 C12Q1/28

    摘要: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.

    摘要翻译: 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物,装置,系统和方法 这小于光损伤阈值期。

    Method of forming a tablet
    103.
    发明申请
    Method of forming a tablet 失效
    形成片剂的方法

    公开(公告)号:US20080131507A1

    公开(公告)日:2008-06-05

    申请号:US11906303

    申请日:2007-10-01

    IPC分类号: A61K9/20 A61K31/192

    摘要: A method of forming a tablet includes the steps of pre-blending an active pharmaceutical ingredient susceptible to tackiness and a blending additive with a first mixing effort to form a pre-blend mixture, wherein the first mixing effort and a second mixing effort, resulting from mixing at least one excipient with the pre-blend mixture, form a blend suitable for direct compression and compressing the blend to form the tablet. One way of achieving the first mixing effort is to pre-blend for an extended period of time. The method allows for directly compressing the blend without the need for a granulation step or roller compression. One such active pharmaceutical ingredient susceptible to tackiness is ibuprofen.

    摘要翻译: 形成片剂的方法包括以下步骤:将具有粘性的活性药物成分和混合添加剂预先混合以形成预混物混合物,其中第一混合力和第二混合力由 将至少一种赋形剂与预混物混合物混合,形成适于直接压缩和压缩混合物以形成片剂的共混物。 实现第一次混合努力的一种方式是预混合一段较长的时间。 该方法允许直接压缩共混物,而不需要造粒步骤或辊压缩。 易于粘性的一种这样的活性药物成分是布洛芬。

    SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS
    104.
    发明申请
    SUBSTRATES, SYSTEMS AND METHODS FOR ANALYZING MATERIALS 有权
    用于分析材料的基板,系统和方法

    公开(公告)号:US20080128627A1

    公开(公告)日:2008-06-05

    申请号:US11849157

    申请日:2007-08-31

    IPC分类号: G01T1/20 G02B6/12 G02B6/26

    摘要: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.

    摘要翻译: 用于分析材料的衬底,系统和方法,其包括设置在衬底上或衬底内的波导阵列,使得从波导发出的消逝场照射设置在衬底表面上或其附近的材料,从而允许分析这些材料。 底物,系统和方法用于各种分析操作,包括核酸分析,包括杂交和测序分析,细胞分析和其他分子分析。

    LENGTH-DEPENDENT RECOIL SEPARATION OF LONG MOLECULES
    105.
    发明申请
    LENGTH-DEPENDENT RECOIL SEPARATION OF LONG MOLECULES 有权
    长分子长寿命回收分离

    公开(公告)号:US20080060942A1

    公开(公告)日:2008-03-13

    申请号:US11938141

    申请日:2007-11-09

    IPC分类号: B01D57/02

    摘要: Separation of long molecules by length is obtained by forcing such molecules to traverse a boundary between a low free-energy region and a high free-energy region. In one embodiment, the high free-energy region is a dense pillar region or other structure formed on a semiconductor substrate. One or more membranes are used in further embodiments. The low free-energy region is a larger chamber formed adjacent the high free-energy region. A recoil phase allows longer molecules not fully driven into the high free-energy region to recoil into the low free-energy region. In a further variation, the high free-energy region is a membrane having nanoscale holes.

    摘要翻译: 通过强迫这样的分子穿过低自由能区域和高自由能区域之间的边界来获得长分子长度的分离。 在一个实施例中,高自由能区域是形成在半导体衬底上的致密柱状区域或其它结构。 在另外的实施方案中使用一种或多种膜。 低自由能区域是在高自由能区域附近形成的较大室。 反冲阶段允许更长的分子不完全驱动到高自由能区域以反冲到低自由能区域。 在另一变型中,高自由能区域是具有纳米孔的膜。

    MITIGATION OF PHOTODAMAGE IN ANALYTICAL REACTIONS
    109.
    发明申请
    MITIGATION OF PHOTODAMAGE IN ANALYTICAL REACTIONS 有权
    分析反应中光致变色的减缓

    公开(公告)号:US20070161017A1

    公开(公告)日:2007-07-12

    申请号:US11566153

    申请日:2006-12-01

    IPC分类号: C12Q1/68 C12Q1/26 C12M3/00

    摘要: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.

    摘要翻译: 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物,装置,系统和方法 这小于光损伤阈值期。

    Mitigation of photodamage in analytical reactions
    110.
    发明申请
    Mitigation of photodamage in analytical reactions 有权
    减轻分析反应中的光损伤

    公开(公告)号:US20070128133A1

    公开(公告)日:2007-06-07

    申请号:US11293040

    申请日:2005-12-02

    IPC分类号: A61K38/43 A61K38/44

    摘要: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.

    摘要翻译: 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物,装置,系统和方法 这小于光损伤阈值期。