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120 条记录 (耗时 0.034 秒)

    Nucleotide sequences coding for the sigM gene
    113.
    发明授权
    Nucleotide sequences coding for the sigM gene 失效
    编码sigM基因的核苷酸序列

    公开(公告)号：US06995000B2

    公开(公告)日：2006-02-07

    申请号：US09942935

    申请日：2001-08-31

    申请人： Brigitte Bathe ,  Christine Bastuck ,  Mike Farwick ,  Thomas Hermann ,  Walter Pfefferle

    发明人： Brigitte Bathe ,  Christine Bastuck ,  Mike Farwick ,  Thomas Hermann ,  Walter Pfefferle

    IPC分类号： C12P13/04

    CPC分类号： C07K14/34 ,  C12P13/08

    摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which encodes the sigma factor M (sigM) gene, and a host-vector system having a coryneform host bacterium in which the sigM gene is present in enhanced form and a vector which carries at least the sigM gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

    摘要翻译： 本发明涉及具有编码σ因子M（sigM）基因的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中sigM基因以增强形式存在的棒状细胞宿主细菌的宿主 - 载体系统和载体， 至少携带根据SEQ ID No 1的sigM基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

    Process for the production of L-amino acids using coryneform bacteria
    115.
    发明申请
    Process for the production of L-amino acids using coryneform bacteria 审中-公开
    使用棒状细菌生产L-氨基酸的方法

    公开(公告)号：US20050221454A1

    公开(公告)日：2005-10-06

    申请号：US11074025

    申请日：2005-03-08

    申请人： Brigitte Bathe

    发明人： Brigitte Bathe

    IPC分类号： C12P13/08 ,  C12N1/21 ,  C12N15/74

    CPC分类号： C12P13/08

    摘要： The pesent invention relates to a process for the production of L-amino acids, in which the following steps are carried out: a) fermentation of a coryneform bacteria producing the desired L-amino acid, in which bacteria at least the gene coding for the transcription regulator TipA is attenuated, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid.

    摘要翻译： 本发明涉及生产L-氨基酸的方法，其中进行以下步骤：a）产生所需L-氨基酸的棒状细菌的发酵，其中细菌至少编码 转录调节物TipA被减弱，b）在培养基或细菌细胞中浓度期望的L-氨基酸，和c）L-氨基酸的分离。

    Nucleotide sequences which code for the rpsL gene
    116.
    发明授权
    Nucleotide sequences which code for the rpsL gene 有权
    编码rpsL基因的核苷酸序列

    公开(公告)号：US06939695B2

    公开(公告)日：2005-09-06

    申请号：US10075460

    申请日：2002-02-15

    申请人： Bettina Moeckel ,  Brigitte Bathe ,  Stefan Hans ,  Caroline Kreutzer ,  Thomas Hermann ,  Walter Pfefferle ,  Michael Binder

    发明人： Bettina Moeckel ,  Brigitte Bathe ,  Stefan Hans ,  Caroline Kreutzer ,  Thomas Hermann ,  Walter Pfefferle ,  Michael Binder

    IPC分类号： C07K14/34 ,  C12N15/31 ,  C12P13/04 ,  C07H21/04

    CPC分类号： C07K14/34

    摘要： An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the rpsL gene is present in enhanced form, as well as the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

    摘要翻译： 一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸，b） 编码多肽的多核苷酸，其包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列，c）与a）或b）的多核苷酸互补的多核苷酸， 和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少存在rpsL基因 增强形式，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

    Nucleotide sequences encoding histidine kinase from corynebacterium glutamicum
    118.
    发明授权
    Nucleotide sequences encoding histidine kinase from corynebacterium glutamicum 失效
    编码来自谷氨酸棒杆菌的组氨酸激酶的核苷酸序列

    公开(公告)号：US06746854B2

    公开(公告)日：2004-06-08

    申请号：US09824551

    申请日：2001-08-01

    申请人： Brigitte Bathe ,  Caroline Kreutzer ,  Achim Marx ,  Walter Pfefferle

    发明人： Brigitte Bathe ,  Caroline Kreutzer ,  Achim Marx ,  Walter Pfefferle

    IPC分类号： C12P1308

    CPC分类号： C12N9/1223 ,  C12P13/08

    摘要： This invention relates to novel polynucleotide sequences encoding the histidine kinase luminescence expression sensor (luxS) gene from Corynebaclerium glutamicum, probes to the novel polynucleotide sequences encoding the luxS gene, vector and host cells containing the novel luxS polynucleotide sequences, the encoded Lux S polypeptide, and a process for the fermentative preparation of amino acids using bacteria which the luxS gene is attenuated.

    摘要翻译： 本发明涉及编码来自谷氨酸棒杆菌的组氨酸激酶发光表达传感器（luxS）基因的新型多核苷酸序列，探针编码luxS基因的新型多核苷酸序列，含有新型luxS多核苷酸序列的载体和宿主细胞，编码的Lux S多肽， 以及使用luxS基因减毒的细菌发酵制备氨基酸的方法。

    Nucleotide sequences which code for the zwa1 gene
    120.
    发明授权
    Nucleotide sequences which code for the zwa1 gene 失效
    编码zwa1基因的核苷酸序列

    公开(公告)号：US06632644B2

    公开(公告)日：2003-10-14

    申请号：US09731909

    申请日：2000-12-08

    申请人： Bettina Möckel ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    发明人： Bettina Möckel ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    IPC分类号： C12P1308

    CPC分类号： C07K14/34 ,  C12N9/00 ,  C12P13/08

    摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO 2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.

    摘要翻译： 本发明涉及一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码多肽的多核苷酸的程度相同的多核苷酸，所述多核苷酸包含氨基酸序列 b）编码多肽的多核苷酸，其包含与SEQ ID NO 2的氨基酸序列至少70％的程度相同的氨基酸序列，c） 与a）和b）和d）多核苷酸互补的多核苷酸，其包含a），b）或c），/或PTEXT的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及发酵 在使用棒状细菌中扩增zwa1基因的L-氨基酸的制备