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134 条记录 (耗时 0.033 秒)

    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE
    111.
    发明申请
    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE 审中-公开
    用于抑制目标基因表达的组合物

    公开(公告)号：US20120244210A1

    公开(公告)日：2012-09-27

    申请号：US13437428

    申请日：2012-04-02

    申请人： Fumikazu SHINOHARA ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    发明人： Fumikazu SHINOHARA ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    IPC分类号： A61K9/127 ,  A61P35/00 ,  A61P29/00 ,  A61K31/713

    CPC分类号： A61K9/0019 ,  A61K9/1271 ,  C12N15/1135 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32

    摘要： The present invention provides a composition that comprises a lipidparticle encapsulating a double-stranded nucleic acid molecule, wherein the antisense strand is a polynucleotide of 17 to 30 bases in which a sequence is complementary to the sequence of the 17 contiguous bases of a target gene's mRNA, the sense strand is a polynucleotide of 17 to 30 bases that contains a base sequence complementary to the base sequence of bases 1 to 17 in the 5′-end to 3′-end direction of the antisense strand, and a particular amount of the sugars binding to certain bases of the antisense strand and the sense strand are deoxyribose, or ribose whose hydroxyl group at the 2′ position is substituted by a modifying group, and wherein the lipidparticle contains a lipid bilayer membrane whose constituent component is a lipid conjugate, a fatty acid conjugate or an aliphatic hydrocarbon conjugate of a water-soluble substance.

    摘要翻译： 本发明提供了包含包封双链核酸分子的脂质粒子的组合物，其中，所述反义链是17〜30个碱基的多核苷酸，其中序列与靶基因的mRNA的17个连续碱基的序列互补 有义链是17〜30个碱基的多核苷酸，其含有与反义链的5'端至3'-端方向的碱基1至17的碱基序列互补的碱基序列，特定量的 与反义链和有义链的某些碱基结合的糖是脱氧核糖或其2'位的羟基被修饰基团取代的核糖，并且其中所述脂质颗粒含有脂质双层膜，其构成成分是脂质缀合物， 脂肪酸结合物或水溶性物质的脂族烃共轭物。

    SHOCK ABSORBER
    112.
    发明申请
    SHOCK ABSORBER 有权
    减震器

    公开(公告)号：US20120073920A1

    公开(公告)日：2012-03-29

    申请号：US13246284

    申请日：2011-09-27

    申请人： Jin Yamasaki ,  Shinichi Kagawa ,  Tetsuo Yoshida

    发明人： Jin Yamasaki ,  Shinichi Kagawa ,  Tetsuo Yoshida

    IPC分类号： F16F9/06 ,  F16F9/50 ,  F16F9/16

    CPC分类号： F16F9/32 ,  B60G17/08 ,  F16F9/18 ,  F16F9/325 ,  F16F9/34 ,  F16F9/46 ,  F16F9/465 ,  F16F9/48 ,  F16F9/50 ,  F16F2226/04

    摘要： A flow of hydraulic oil induced by sliding movement of a piston in a cylinder is controlled by a pilot-type main valve and a pilot valve, which is a pressure control valve, to generate a damping force. The pilot valve is adjusted in its valve-opening pressure with the thrust of a solenoid and adjusts the pressure in a back pressure chamber to control the valve-opening pressure of the main valve. A baffle plate is provided in a reservoir to isolate from each other the surface of hydraulic oil in the reservoir and an inlet port through which the hydraulic oil flows into the reservoir from a damping force generating mechanism, thereby suppressing the occurrence of aeration and cavitation. The baffle plate is secured by inserting a connecting port through a positioning opening and holding a separator tube with a pair of arm portions.

    摘要翻译： 通过活塞在气缸中的滑动运动而引起的液压油流由作为压力控制阀的先导式主阀和先导阀来控制，以产生阻尼力。 先导阀通过螺线管的推力调节其开阀压力，并调节背压室中的压力，以控制主阀的开阀压力。 在储存器中设置有挡板，以将容器中的液压油的表面与入口端口隔开，液压油通过该入口从阻尼力产生机构流入储存器，从而抑制曝气和气蚀的发生。 挡板通过将定位孔插入连接口并用一对臂部分保持分隔管来固定。

    NOVEL NUCLEIC ACID
    113.
    发明申请
    NOVEL NUCLEIC ACID 审中-公开
    新核酸

    公开(公告)号：US20100099746A1

    公开(公告)日：2010-04-22

    申请号：US12519960

    申请日：2007-12-18

    申请人： Yoji Yamada ,  Tatsuya Miyazawa ,  Tetsuo Yoshida ,  Haruo Nakano ,  Kyoko Kosaka

    发明人： Yoji Yamada ,  Tatsuya Miyazawa ,  Tetsuo Yoshida ,  Haruo Nakano ,  Kyoko Kosaka

    IPC分类号： A61K31/7088 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68 ,  A61P35/00

    CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2330/10

    摘要： The present invention provides a nucleic acid such as a micro-RNA or a micro-RNA precursor, having a novel sequence. The nucleic acid of the present invention is useful for detecting the expression or a mutation of a micro-RNA, separating cells, suppressing the expression of a gene having a target sequence, screening for a substance that promotes or suppresses a function of a micro-RNA, and diagnosing or treating a disease caused by a mast cell abnormality, a disease caused by an abnormality of mesenchymal stem cell proliferation or differentiation, cancers, and a disease caused by abnormal proliferation of cells, tissue hyperplasia or the like.

    摘要翻译： 本发明提供具有新序列的核酸如微RNA或微RNA前体。 本发明的核酸可用于检测微RNA的表达或突变，分离细胞，抑制具有靶序列的基因的表达，筛选促进或抑制微小RNA功能的物质， RNA，诊断或治疗由肥大细胞异常引起的疾病，由间充质干细胞增殖或分化异常引起的疾病，癌症和由细胞异常增殖，组织增生等引起的疾病。

    OSCILLATION TYPE ELECTROMAGNETIC POWER GENERATOR AND METHOD FOR MANUFACTURING OSCILLATION TYPE ELECTROMAGNETIC POWER GENERATOR
    114.
    发明申请
    OSCILLATION TYPE ELECTROMAGNETIC POWER GENERATOR AND METHOD FOR MANUFACTURING OSCILLATION TYPE ELECTROMAGNETIC POWER GENERATOR 有权
    振荡型电磁发电机及制造振荡式电磁发电机的方法

    公开(公告)号：US20100084928A1

    公开(公告)日：2010-04-08

    申请号：US12599036

    申请日：2007-09-20

    申请人： Tetsuo Yoshida ,  Yukio Aizawa ,  Shigemi Suganuma ,  Kentaro Masuda

    发明人： Tetsuo Yoshida ,  Yukio Aizawa ,  Shigemi Suganuma ,  Kentaro Masuda

    IPC分类号： H02K35/02 ,  H02K15/00

    CPC分类号： H02K35/02 ,  Y10T29/49009

    摘要： A specific condition for enhancing the power generation efficiency of an oscillation type electromagnetic power generator is disclosed. Solenoid coils constituting the oscillation type electromagnetic power generator are wound in directions opposite to each other with a predetermined coil gap therebetween. Adjacent magnets of a movable magnet are connected to each other via a spacer having a predetermined thickness in such a manner that poles with the same polarity are opposed to each other. A coil pitch which is the total dimension of the coil length of one solenoid coil and the coil gap and a magnet pitch which is the total dimension of the magnet length of one magnet of the movable magnet and the thickness of the spacer are almost equal to each other, and the coil length is shorter than the magnet length.

    摘要翻译： 公开了用于提高振荡型电磁发电机的发电效率的具体条件。 构成振荡型电磁发电机的电磁线圈以彼此相反的方向缠绕，其间具有预定的线圈间隙。 可动磁铁的相邻磁体通过具有预定厚度的间隔件彼此连接，使得具有相同极性的极彼此相对。 作为一个螺线管线圈的线圈长度和线圈间隙的总尺寸的线圈间距和作为可动磁铁的一个磁体的磁体长度的总尺寸的磁体间距和间隔件的厚度几乎等于 并且线圈长度比磁体长度短。

    Multilayered polyester film and process for producing the same
    117.
    发明授权
    Multilayered polyester film and process for producing the same 有权
    多层聚酯薄膜及其制造方法

    公开(公告)号：US07238411B2

    公开(公告)日：2007-07-03

    申请号：US10505048

    申请日：2003-02-10

    申请人： Tetsuo Yoshida ,  Tetsuo Ichihashi

    发明人： Tetsuo Yoshida ,  Tetsuo Ichihashi

    IPC分类号： B32B7/02 ,  B32B27/08 ,  B32B27/36 ,  B32B37/15 ,  B32B38/00

    CPC分类号： B32B7/02 ,  B29C55/023 ,  B29K2067/00 ,  B32B7/12 ,  B32B27/08 ,  B32B27/36 ,  B32B37/153 ,  B32B2038/0028 ,  B32B2250/40 ,  B32B2307/412 ,  B32B2307/734 ,  B32B2367/00 ,  B32B2425/00 ,  B32B2439/70 ,  Y10S428/91 ,  Y10T428/24942 ,  Y10T428/2495 ,  Y10T428/31786

    摘要： The present invention is a multilayer polyester film comprising a layer A and a layer B which are laminated alternately, the layer A constituting the outermost layer on both sides of the film, wherein (1) the layer A comprises a polyester A, and the layer B comprises a polyester B, (2) the melting point of the polyester A is higher than the melting point of the polyester B by at least 15° C., (3) the layer A is a layer having an oriented structure, and the layer B is a layer having a substantially unoriented structure, (4) the ratio (a/b) of the total thickness (a) of the layer A to the total thickness (b) of the layer B is 0.01 to 3, and (5) the in-plane tensile strength of the multilayer polyester film is 50 MPa or lower at a maximum, and the difference between its maximum value and minimum value is 20 MPa or smaller; and a method for producing the multilayer polyester film. According to the present invention, there is provided a film having excellent isotropy of in-plane tensile strength, excellent transparency, a low degree of thickness unevenness and excellent moldability.

    摘要翻译： 本发明是一种多层聚酯薄膜，其包括交替层压的层A和层B，层A构成膜两侧的最外层，其中（A）层A包含聚酯A，层 B包含聚酯B，（2）聚酯A的熔点比聚酯B的熔点高至少15℃，（3）层A是具有取向结构的层， 层B是具有基本上未取向结构的层，（4）层A的总厚度（a）与层B的总厚度（b）的比（a / b）为0.01〜3，（ 5）多层聚酯膜的面内拉伸强度最大为50MPa以下，其最大值与最小值的差为20MPa以下; 以及多层聚酯膜的制造方法。 根据本发明，提供了具有优异的面内拉伸强度，优异的透明性，低的不均匀度，成型性优异的薄膜。

    Seat weight measuring apparatus
    118.
    发明授权
    Seat weight measuring apparatus 有权
    座椅重量测量仪

    公开(公告)号：US07173198B2

    公开(公告)日：2007-02-06

    申请号：US10880593

    申请日：2004-07-01

    申请人： Tetsuo Yoshida

    发明人： Tetsuo Yoshida

    IPC分类号： G01G19/52

    CPC分类号： G01G19/4142

    摘要： A seat weight measuring apparatus capable of securely withstanding large force due to large load, such as force in the event of a vehicle collision, applied to a vehicle seat. Normally, a small force is applied to a rear pin bracket and the sleeves through which a pivot bolt is inserted do not substantially collide with the inner peripheries of holes. As a large force is applied to the rear pin bracket, a stopper bolt collides with a base frame and the rear pin bracket collides with the pivot bolt. The large force exerted on the rear pin bracket is shared and borne by portions of the frame thereby reducing the localized stresses in the frame.

    摘要翻译： 一种座椅重量测量装置，能够在车辆碰撞的情况下能够承受由于大的载荷而产生的较大的力，例如施加到车辆座椅上的力。 通常，将小力施加到后销支架上，并且通过枢轴螺栓插入的套筒基本上不与孔的内周碰撞。 由于向后销支架施加较大的力，止动螺栓与底座碰撞，后销支架与枢轴螺栓碰撞。 施加在后销支架上的大的力被共享并由框架的部分承担，从而减小了框架中的局部应力。

    Plasma etching apparatus
    119.
    发明申请
    Plasma etching apparatus 审中-公开
    等离子刻蚀装置

    公开(公告)号：US20060042754A1

    公开(公告)日：2006-03-02

    申请号：US11192029

    申请日：2005-07-29

    申请人： Ryoichi Yoshida ,  Tetsuo Yoshida ,  Michishige Saito ,  Toshikatsu Wakaki ,  Hayato Aoyama ,  Akira Obi ,  Hiroshi Suzuki

    发明人： Ryoichi Yoshida ,  Tetsuo Yoshida ,  Michishige Saito ,  Toshikatsu Wakaki ,  Hayato Aoyama ,  Akira Obi ,  Hiroshi Suzuki

    IPC分类号： H01L21/306

    CPC分类号： H01J37/32449 ,  H01J37/32091 ,  H01J37/3244 ,  H01L21/31116

    摘要： In order to improve a controllability of etching characteristics by way of precisely and freely controlling a flow or a density distribution of a processing gas introduced into a processing chamber, a plasma etching apparatus includes, as a gas inlet for introducing an etching gas into a plasma generation region PS in a chamber 10, an upper gas inlet (an upper central shower head 66a and an upper peripheral shower head 68a) for introducing a gas through an upper electrode 38; and a side gas inlet for introducing a gas through a sidewall of the chamber 10. The side gas inlet 104 has a side shower head 108 attached to the sidewall of the chamber 10.

    摘要翻译： 为了通过精确且自由地控制引入到处理室中的处理气体的流动或密度分布来提高蚀刻特性的可控性，等离子体蚀刻装置包括作为将蚀刻气体引入等离子体的气体入口 室10内的发生区域PS，通过上部电极38导入气体的上部气体入口（上部中央喷淋头66a和上部周边喷淋头68a） 以及用于将气体引入室10的侧壁的侧气体入口。 侧气体入口104具有附接到室10的侧壁的侧淋浴头108。