公开(公告)号：US09267964B2

公开(公告)日：2016-02-23

申请号：US14186657

申请日：2014-02-21

Applicant: Kansas State University Research Foundation

Inventor： Bret Flanders ,  Govind Paneru

IPC: G01Q60/38 ,  G01Q60/40 ,  G01Q70/12 ,  B82Y15/00 ,  B82Y35/00

CPC classification number: G01Q60/38 ,  B82Y15/00 ,  B82Y35/00 ,  G01Q60/40 ,  G01Q70/12 ,  Y10S977/762 ,  Y10T428/12389 ,  Y10T428/2976

Abstract: Nanowire apparatus and methods of using the same are disclosed. The apparatus include nanowires that are attached to and extend from varying substrates and can be used in the manipulation of cells and/or sensing of cellular and subcellular characteristics. The methods include using the apparatus to sense forces exerted by a single cell or using the apparatus to manipulate one or more cells.

Abstract translation: 公开了纳米线装置及其使用方法。 该装置包括连接到并且从不同底物延伸的纳米线，并且可以用于细胞的操纵和/或细胞和亚细胞特征的感测。 所述方法包括使用该装置来感测由单个电池施加的力或使用该装置来操纵一个或多个电池。

公开(公告)号：US20160030629A1

公开(公告)日：2016-02-04

申请号：US14434327

申请日：2013-12-06

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Xiuzhi S. Sun ,  Hongzhou Huang ,  Thu Annelise Nguyen

IPC: A61L26/00 ,  A61L27/52 ,  A61K47/48 ,  A61L27/26

CPC classification number: A61L26/008 ,  A61K9/06 ,  A61K9/7007 ,  A61K47/42 ,  A61K47/64 ,  A61K47/643 ,  A61K47/6903 ,  A61L26/0028 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0061 ,  A61L26/0066 ,  A61L27/22 ,  A61L27/227 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2300/602 ,  A61L2300/62 ,  A61L2400/06 ,  C07K14/76

Abstract: Peptide-albumin hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and albumin. The peptide comprises a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.

Abstract translation: 描述了具有自组装的三维纳米纤维基质的肽 - 白蛋白水凝胶。 纳米纤维基质包含两亲肽和白蛋白。 肽包含末端疏水区域，中心转移区域和末端亲水区域。 还描述了制备这种水凝胶的方法以及使用水凝胶作为组织工程的支架作为3维细胞培养物和用于药物递送，活性剂（治疗细胞，分子，药物，化合物），细胞的包封的方法 移植，细胞储存，病毒培养和储存。

公开(公告)号：US20130240830A1

公开(公告)日：2013-09-19

申请号：US13890316

申请日：2013-05-09

Applicant: MEMC ELECTRONIC MATERIALS, INC. ,  KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Michael R. Seacrist ,  Vikas Berry ,  Phong Tuan Nguyen

IPC: H01L21/02 ,  H01L29/16

CPC classification number: H01L21/02527 ,  B82Y30/00 ,  B82Y40/00 ,  H01L21/0237 ,  H01L21/02376 ,  H01L21/02381 ,  H01L21/02458 ,  H01L21/02488 ,  H01L21/02491 ,  H01L21/02502 ,  H01L21/02614 ,  H01L21/0262 ,  H01L29/1606 ,  H01L29/2003 ,  H01L29/267

Abstract: The invention generally related to a method for preparing a layer of graphene directly on the surface of a substrate, such as a semiconductor substrate. The layer of graphene may be formed in direct contact with the surface of the substrate, or an intervening layer of a material may be formed between the substrate surface and the graphene layer.

公开(公告)号：US20040136967A1

公开(公告)日：2004-07-15

申请号：US10647361

申请日：2003-08-25

Applicant: Kansas State University Research Foundation

Inventor： Mark L. Weiss ,  Deryl L. Troyer ,  Duane Davis ,  Kathy E. Mitchell

IPC: C12N005/08

CPC classification number: C12N5/0619 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0605 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2500/62 ,  C12N2501/135 ,  C12N2506/1369

Abstract: Stem cells from human sources can have a variety of useful applications in disease treatment and biotechnology. More particularly the umbilical cord matrix cell cultures of the invention have a variety of totipotent, pluripotent, or multipotent cells for a variety of end uses from a non-controversial, universally available, species-specific source. The technology can have application to any amniotic animal, including agricultural and laboratory animals and humans. The invention relates to isolating the stem cells, culturing the stem cells, maintaining the stem cells, transforming the stem cells into useful cell types using genetic or other transformation technologies, stem cell and tissue banking and using untransformed or transformed cells in disease treatment.

Abstract translation: 来自人源的干细胞可以在疾病治疗和生物技术中具有多种有用的应用。 更具体地，本发明的脐带基质细胞培养物具有各种全能，多能或多能细胞，用于从无争议的，普遍可用的物种特异性来源的各种最终用途。 该技术可以应用于任何羊膜动物，包括农业和实验动物和人类。 本发明涉及分离干细胞，培养干细胞，保持干细胞，使用遗传或其它转化技术将干细胞转化为有用的细胞类型，干细胞和组织库，以及在疾病治疗中使用未转化或转化的细胞。

公开(公告)号：US20030161818A1

公开(公告)日：2003-08-28

申请号：US10083779

申请日：2002-02-25

Applicant: Kansas State University Research Foundation

Inventor： Mark L. Weiss ,  Deryl L. Troyer ,  Duane Davis ,  Kathy E. Mitchell

IPC: A61K048/00 ,  C12N005/08

CPC classification number: C12N5/0607 ,  A61K35/12 ,  A61K48/00

Abstract: Stem cells from human sources can have a variety of useful applications in disease treatment and biotechnology. More particularly the umbilical cord matrix stem (UCMS) cell cultures of the invention have a variety of totipotent, pluriotent, or multipotent cells for a variety of end uses from a non-controversial, universally available, species-specific source. The technology can have application to any placental animal, including agricultural and laboratory animals and humans. The invention relates to isolating, culturing the stem cells, maintaining the stem cells, transforming the stem cells into useful cell types using genetic or other transformation technologies, stem cell and tissue banking and using untransformed or transformed cells in disease treatment.

Abstract translation: 来自人源的干细胞可以在疾病治疗和生物技术中具有多种有用的应用。 更具体地，本发明的脐带基质干细胞（UCMS）细胞培养物具有多种全能，多产或多能细胞，用于从无争议的，普遍可用的物种特异性来源的多种最终用途。 该技术可以应用于任何胎盘动物，包括农业和实验动物和人类。 本发明涉及分离，培养干细胞，保持干细胞，使用遗传或其他转化技术，干细胞和组织库，以及在疾病治疗中使用未转化或转化的细胞将干细胞转化为有用的细胞类型。

公开(公告)号：US20030072874A1

公开(公告)日：2003-04-17

申请号：US09977838

申请日：2001-10-15

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Kenneth J. Klabunde ,  Savka Stoeva ,  Christopher Sorensen

IPC: C09K003/00

CPC classification number: B82Y30/00 ,  B01J13/0043 ,  Y10S977/773 ,  Y10S977/896

Abstract: A method of forming ligated nanoparticles of the formula Y(Z)x, where Y is a nanoparticle selected from the group consisting of elemental metals having atomic numbers ranging from 21-34, 39-52, 57-83 and 89-102, all inclusive, the halides, oxides and sulfides of such metals, and the alkali metal and alkaline earth metal halides, and Z represents ligand moieties such as the alkyl thiols. In the method, a first colloidal dispersion is formed made up of nanoparticles solvated in a molar excess of a first solvent (preferably a ketone such as acetone), a second solvent different than the first solvent (preferably an organic aryl solvent such as toluene) and a quantity of ligand moieties; the first solvent is then removed under vacuum and the ligand moieties ligate to the nanoparticles to give a second colloidal dispersion of the ligated nanoparticles solvated in the second solvent. If substantially monodispersed nanoparticles are desired, the second dispersion is subjected to a digestive ripening process. Upon drying, the ligated nanoparticles may form a three-dimensional superlattice structure.

Abstract translation: 形成式Y（Z）x的连接纳米颗粒的方法，其中Y是选自原子序数范围为21-34,39-52,57-83和89-102的元素的纳米颗粒，全部 这些金属的卤化物，氧化物和硫化物以及碱金属和碱土金属卤化物，Z表示配体部分，例如烷基硫醇。 在该方法中，由摩尔过量的第一溶剂（优选酮如丙酮），不同于第一溶剂的第二溶剂（优选有机芳基溶剂如甲苯）溶剂化的纳米颗粒形成第一胶态分散体， 和一定数量的配体部分; 然后在真空下除去第一溶剂，并将配体部分连接到纳米颗粒上，得到在第二溶剂中溶剂化的连接的纳米颗粒的第二胶体分散体。 如果需要基本上单分散的纳米颗粒，则将第二分散体进行消化成熟过程。 干燥后，连接的纳米颗粒可形成三维超晶格结构。

公开(公告)号：US20250161426A1

公开(公告)日：2025-05-22

申请号：US18841203

申请日：2023-02-23

Applicant: Kansas State University Research Foundation

Inventor： Roman R. Ganta

IPC: A61K39/02 ,  A61K39/00

Abstract: The present disclosure provides an immunogenic composition against A. marginale wherein the composition generally includes a disrupted or deleted phtcp gene. Such compositions are useful in reducing the incidence, severity, transmission, and duration of infection with A. marginale.

公开(公告)号：US20250155433A1

公开(公告)日：2025-05-15

申请号：US18722025

申请日：2022-12-20

Applicant: Kansas State University Research Foundation

Inventor： Phillip E. KLEBBA ,  Salete M. NEWTON ,  Ashish KUMAR ,  Taihao YANG

IPC: G01N33/569 ,  G01N33/542 ,  G01N33/554

Abstract: Methods, kits, and devices for detecting microbes in various samples. The methods, kits, and devices utilize a high affinity protein-based sensor, wherein the high affinity protein-based sensor comprises a high affinity binding protein and/or bacteria engineered with such a protein, with a detectable label that generates a detectable signal. The high affinity binding protein is specific for a microbe-associated compound secreted or produced by the target microbe When a biological sample containing or suspected of containing a microbe is contacted with the sensor, the presence of the microbe can be detected due to changes in the detectable signal in the assay over time, which correspond to interaction of the microbe-associated compound with the high affinity binding protein.

公开(公告)号：US20250134984A1

公开(公告)日：2025-05-01

申请号：US18924027

申请日：2024-10-23

Applicant: The United States of America, as represented by the Secretary of Agriculture ,  Triad National Security, LLC ,  KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： AIDA E. RIEDER ,  KATHERINE M. PFLAUM ,  FAYNA C. DIAZ SAN SEGUNDO ,  WILLIAM M. FISCHER ,  IGNACIO FERNANDEZ SAINZ

IPC: A61K39/135 ,  A61K39/00 ,  A61P37/04 ,  C07K14/00 ,  C12N15/86

Abstract: Synthetic foot-and-mouth disease virus (FMDV) mosaic polypeptides, and nucleic acid molecules encoding the mosaic polypeptides, are described. When included as part of an FMDV genome, the mosaic polypeptides permit virus replication and assembly into FMDV particles. The mosaic polypeptide and nucleic acid compositions can be used to elicit immune responses that provide protection against a broad range of serotype Asia FMDV strains.

公开(公告)号：US12279545B2

公开(公告)日：2025-04-22

申请号：US17630206

申请日：2020-07-24

Applicant: Kansas State University Research Foundation

Inventor： Ajay Sharda ,  Sylvester Badua ,  Daniel Flippo

IPC: A01C7/10 ,  A01B79/00 ,  A01C5/06 ,  G05B19/4155

Abstract: A system for measuring real-time seed placement of seeds, such as corn seeds, during planting wherein the sensing and measurement (SAM) system comprises various elements selected from the group consisting of a high-speed camera, light-section sensor, potentiometer, GPS unit, data acquisition system, and a control computer. The SAM system measures seeding depth, seed spacing, and geo-location of the seed. It is mounted on a planter row unit located in between the closing wheels and the gauge wheels with the camera and light section sensor directly facing the furrow.