公开(公告)号：US20140343491A1

公开(公告)日：2014-11-20

申请号：US14280054

申请日：2014-05-16

Applicant: SurModics, Inc.

Inventor： Joram Slager

IPC: A61K31/436 ,  A61M25/10 ,  A61K9/16

CPC classification number: A61K31/436 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/145 ,  A61K9/1688 ,  A61K9/19 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5146 ,  A61L29/085 ,  A61L29/16 ,  Y02A50/402 ,  Y02A50/478 ,  Y10T428/2982

Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 μm to 10 μm, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.

Abstract translation: 本公开提供了大环内酯颗粒，其包括大环内酯治疗剂，例如高浓度颗粒物中的雷帕霉素。 在一种方法中，颗粒通过将包含聚氧乙烯失水山梨糖醇n-酰基酯，聚（乙烯亚胺）或烷基化季铵盐的组合物加入到溶解在醇如乙醇中的大环内酯的组合物中来制备。 在另一种方法中，通过将非溶剂组合物加入到包含大环内酯和溶解在醇如乙醇中的烷基取代的苯并二氢苯并三氢吡喃的组合物中来制备颗粒。 形成的大环内酯颗粒具有一种或多种所需性质，包括0.1μm至10μm范围内的尺寸，球形或近球形，低分散性和/或稳定性。 大环内酯颗粒可用于治疗组合物，或与可植入或可插入的医疗装置相关联，例如与装置上的聚合物涂层相关联。

公开(公告)号：US20140200411A1

公开(公告)日：2014-07-17

申请号：US14152667

申请日：2014-01-10

Applicant: SurModics, Inc.

Inventor： Bruce M. Jelle ,  Aleksey V. Kurdyumov ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother ,  Nathan A. Lockwood ,  Joseph Ventura ,  Sean M. Stucke

IPC: A61L31/10 ,  A61L31/14

CPC classification number: A61L31/10 ,  A61B2562/125 ,  A61L31/14 ,  A61N1/0404 ,  A61N1/05 ,  C07D495/04 ,  C07D519/00 ,  C08G61/02 ,  C08G61/124 ,  C08G61/126 ,  C08G73/0266 ,  C08G2261/1424 ,  C08G2261/1426 ,  C08G2261/1428 ,  C08G2261/143 ,  C08G2261/144 ,  C08G2261/145 ,  C08G2261/148 ,  C08G2261/3221 ,  C08G2261/3223 ,  C08G2261/3422 ,  C08G2261/43 ,  C08G2261/76 ,  C08G2261/77 ,  C08G2261/90 ,  C08G2261/94 ,  C09D5/24 ,  H01B1/127 ,  Y10T428/31507 ,  Y10T428/31533

Abstract: Disclosed herein are activatable conductive compositions and methods of making and using activatable conductive compositions. In particular, activatable conductive monomers polymers are described and electrically conductive coatings that include activatable conductive polymers.

Abstract translation: 本文公开了可激活的导电组合物和制备和使用可活化导电组合物的方法。 特别地，描述了可激活的导电单体聚合物和包括可激活的导电聚合物的导电涂层。

公开(公告)号：US20140193474A1

公开(公告)日：2014-07-10

申请号：US14148339

申请日：2014-01-06

Applicant: SURMODICS, INC

Inventor： DAVID E. BABCOCK ,  TIMOTHY M. KLOKE ,  JOSEPH S. MCGONIGLE

IPC: A61L29/14 ,  A61L29/16

CPC classification number: A61L29/14 ,  A61L29/041 ,  A61L29/085 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2420/08 ,  B05D7/54 ,  C10M107/28 ,  C10M107/42 ,  C10M107/46 ,  C10M107/48 ,  C10M107/50 ,  C10M135/36 ,  C10M169/04 ,  C10M177/00 ,  C10M2209/084 ,  C10M2209/0845 ,  C10M2217/0245 ,  C10M2217/0285 ,  C10N2220/02 ,  C10N2250/14 ,  C10N2250/141 ,  Y10T428/31573 ,  Y10T428/31699 ,  Y10T428/3175 ,  Y10T428/31928 ,  C10M2217/065 ,  C10M2209/1045 ,  C10M2221/025 ,  C10N2220/021 ,  C08L39/06 ,  C08L33/26 ,  C08L89/00

Abstract: Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including first and second coated layers. The first coated layer is between the second coated layer and the device surface and includes a vinyl pyrrolidone polymer and a photo reactive group. The second coated layer is in direct contact with the first coated layer and is a top coating that includes an acrylic acid polymer. The second coated layer can optionally include photoreactive groups. The coating was found to have a very low number of particulates (e.g., 10 μm or greater) which is very desirable for in vivo use.

Abstract translation: 本公开的实施方案包括润滑涂层。 在一个实施方案中，本公开包括用于包括第一和第二涂层的医疗装置的润滑涂层。 第一涂层位于第二涂层和装置表面之间，并且包括乙烯基吡咯烷酮聚合物和光反应性基团。 第二涂层与第一涂层直接接触，并且是包括丙烯酸聚合物的顶涂层。 第二涂层可以任选地包括光反应性基团。 发现涂层具有非常低数量的微粒（例如10μm或更大），这对于体内使用是非常理想的。

公开(公告)号：US20140180229A1

公开(公告)日：2014-06-26

申请号：US14055654

申请日：2013-10-16

Applicant: SurModics, Inc.

Inventor： Shawn Fuller ,  Bryan A. Claseman ,  Joram Slager ,  Jeffrey J. Missling ,  Gary Maharaj ,  Gary W. Opperman ,  Nathan Lockwood ,  Robert W. Hergenrother ,  Charles Olson

IPC: A61F13/84

CPC classification number: A61F13/00068 ,  A61F13/00021 ,  A61F13/00029 ,  A61F13/8405 ,  A61F2013/00153 ,  A61F2013/00327 ,  A61F2013/00331 ,  A61F2013/00357 ,  A61F2013/00557 ,  A61L15/22 ,  A61L15/44 ,  A61L15/60 ,  A61L2300/102 ,  A61L2300/208

Abstract: Embodiments of the invention include wound packing devices and methods of making and using the same. In an embodiment, the invention includes a wound packing device including a plurality of spacing elements capable of absorbing exudate, wherein the surface of the spacing elements resist colonization by microorganisms. The wound packing device can also include a connector connecting the plurality of spacing elements to one another. Other embodiments are also included herein.

Abstract translation: 本发明的实施例包括伤口包装装置及其制造和使用方法。 在一个实施方案中，本发明包括包含能够吸收渗出物的多个间隔元件的伤口包装装置，其中间隔元件的表面抵抗微生物的定居。 卷绕包装装置还可以包括将多个间隔元件彼此连接的连接器。 本文还包括其它实施例。

公开(公告)号：US20130261566A1

公开(公告)日：2013-10-03

申请号：US13855260

申请日：2013-04-02

Applicant: SURMODICS, INC.

Inventor： Nathan A. Lockwood ,  Bruce M. Jelle ,  Aleksey V. Kurdyumov

IPC: C09D5/22 ,  B05D3/06 ,  C09D5/00

CPC classification number: C09D5/22 ,  A61L29/085 ,  A61L29/14 ,  A61L29/18 ,  A61L2420/02 ,  B05D3/067 ,  C09D5/00 ,  Y10T428/31725 ,  Y10T428/31938 ,  C08L39/06

Abstract: The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.

Abstract translation: 本发明涉及医疗器械涂层，例如涂覆的导线和导管，其包含在环境或应用光下为涂层提供颜色的可视化部分。 涂层允许对涂层性能进行视觉或机器检查，例如覆盖的均匀性。 在一些实施方案中，涂层包括可视化部分和活化的UV光电子组，其用于在涂层中提供共价键合。 可视化部分可以是颗粒形式并夹带在涂层中，或者可以共价键合到亲水性聚合物主链上。 在其它实施方案中，可视化部分包括茋化学基团。 示例性涂层包括亲水性乙烯基吡咯烷酮聚合物，其可以提供对器件表面的润滑性以及着色性质。

公开(公告)号：US20130252261A1

公开(公告)日：2013-09-26

申请号：US13849056

申请日：2013-03-22

Applicant: SURMODICS, INC.

Inventor： Gary Opperman ,  Wendy Nelson

IPC: G01N21/78

CPC classification number: G01N33/581 ,  C12Q1/28 ,  G01N21/78 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558

Abstract: The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.

Abstract translation: 本发明提供用于进行比色分析的组合物，试剂盒和方法。 使底物反应生成显色反应产物，并加入作为磺酸的反应停止试剂以停止并稳定反应产物。 显色反应产物的吸光度特性可以在常规试剂和方法的显着更长的时间内保持。 磺酸可用于诸如ELISA的测定中，以便提供对生物样品中分析物的更准确和更安全的检测。

公开(公告)号：US20040137164A1

公开(公告)日：2004-07-15

申请号：US10745080

申请日：2003-12-23

Applicant: SURMODICS, INC.

Inventor： Dale G. Swan ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Ralph A. Chappa ,  Sean M. Stucke ,  Peter H. Duquette

IPC: C08G002/00

CPC classification number: C08J7/18 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/06 ,  A61L33/12 ,  B05D1/00 ,  B05D3/06 ,  B05D3/061 ,  B05D3/067 ,  B05D7/52 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/31855

Abstract: A method of forming a polymer layer on a support surface by the use of a coating agent and polymerizable compounds. The coating agent provides photoreactive groups adapted to attach the agent to the surface, as well as photoreactive groups adapted to remain unattached to the surface, and thus serve as photoinitiators for the activation of polymerizable compounds in order to form a polymer layer thereon. Also provided are coating agents, per se, as well as a method of using such agents and the resultant surfaces and devices fabricated therefrom.

Abstract translation: 通过使用涂布剂和可聚合化合物在支撑体表面上形成聚合物层的方法。 涂覆剂提供适于将试剂连接到表面的光反应性基团，以及适于保持不附着于表面的光反应性基团，因此用作活化可聚合化合物的光引发剂，以在其上形成聚合物层。 本发明还提供涂层剂，以及使用这种试剂的方法以及由其制造的所得表面和装置。

公开(公告)号：US20040062875A1

公开(公告)日：2004-04-01

申请号：US10256349

申请日：2002-09-27

Applicant: SurModics, Inc.

Inventor： Ralph A. Chappa ,  Mark F. Carlson

IPC: A61L002/00 ,  B05D001/02

CPC classification number: B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05D1/002 ,  B05D1/02

Abstract: A coating apparatus for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.

Abstract translation: 描述了一种用于涂覆可卷绕装置的涂覆装置，其包括具有一对辊和喷嘴的装置旋转体。 喷嘴产生喷涂的涂料，该喷涂材料指向一对间的间隙。 在涂布过程中，大部分没有沉积在可滚动装置上的喷雾通过辊之间的间隙。

公开(公告)号：US20030190420A1

公开(公告)日：2003-10-09

申请号：US10429019

申请日：2003-05-01

Applicant: Surmodics, Inc

Inventor： Ralph A. Chappa ,  Steven J. Porter

IPC: B05D003/12

CPC classification number: B05B13/0442 ,  B05B7/0416 ,  B05B13/0242 ,  B05B13/0405 ,  B05B15/70

Abstract: The invention provides a device for holding a substrate during deposition processes that includes a rotation member rotatable about a first, central axis, and a plurality of substrate holders positioned on the rotation member, the substrate holders being rotatable about second axes. In another aspect, the invention provides a method of applying a substantially uniform coating on a substrate including the steps of providing a device of the invention; mounting a substrate onto the substrate mounts; providing at least one substrate coating station in spaced relation to the substrate mounts; rotating the rotation member about a central axis to position one or more of the substrate mounts at the substrate coating station; supplying the coating through the nozzle; moving the nozzle of the coating station in a direction parallel to the substrate at a predetermined rate to apply a uniform coating on the substrate; and rotating the substrate mounts about the second axes during the coating process.

公开(公告)号：US20030129130A1

公开(公告)日：2003-07-10

申请号：US10261110

申请日：2002-09-30

Applicant: SurModics, Inc.

Inventor： Patrick E. Guire ,  Kristin S. Taton ,  John V. Wall

IPC: A61K051/00 ,  A61K049/00 ,  A61K009/14

CPC classification number: B82Y5/00 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/2081 ,  A61K9/5073 ,  A61K9/5078 ,  A61K47/6927 ,  A61K47/6957 ,  A61K49/0002 ,  A61K49/1821 ,  A61K51/1244 ,  A61L27/54 ,  A61L29/18 ,  A61L31/18 ,  A61L2300/44 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/622

Abstract: Surface coatings including microparticles immobilized in a matrix of polymeric material on a substrate are described. The microparticles can also include an agent which can be useful for various applications, such as medical applications. This invention relates to the field of surface coatings for use in various applications. More particularly, the invention relates to surface coating useful for drug delivery, imaging and other uses of microparticles immobilized via a polymeric matrix.

Abstract translation: 描述包括固定在基底上的聚合物材料基质中的微粒的表面涂层。 微粒还可以包括可用于各种应用例如医疗应用的试剂。 本发明涉及用于各种应用的表面涂层领域。 更具体地说，本发明涉及可用于通过聚合物基质固定的微粒的药物递送，成像和其它用途的表面涂层。