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    RESIDENCE STRUCTURES AND RELATED METHODS
    144.
    发明申请
    RESIDENCE STRUCTURES AND RELATED METHODS 有权

    公开(公告)号：US20230039421A1

    公开(公告)日：2023-02-09

    申请号：US17836972

    申请日：2022-06-09

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, JR. ,  Philip A. Eckhoff

    IPC: A61K9/00 ,  C08G18/73 ,  C08G63/08 ,  C08G18/42 ,  A61K47/58 ,  A61K47/69 ,  A61K9/48 ,  A61K31/357 ,  A61K31/65 ,  A61K31/7048 ,  C08G83/00 ,  A61K47/32 ,  C08L33/02 ,  C08L33/08 ,  C08L33/14 ,  A61K47/10 ,  A61K47/34 ,  A61K47/40 ,  A61K47/42 ,  A61M31/00

    Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

    Hydrogels and uses thereof
    145.
    发明授权
    Hydrogels and uses thereof 有权

    公开(公告)号：US11491228B2

    公开(公告)日：2022-11-08

    申请号：US16502551

    申请日：2019-07-03

    Applicant: Massachusetts Institute of Technology

    Inventor： Robert S. Langer ,  Owen Shea Fenton ,  Jason Andresen ,  Marion Paolini

    IPC: A61K47/34 ,  A61K9/06 ,  A61L27/18 ,  A61L27/38 ,  A61L27/52 ,  C08G65/00 ,  C08G18/64

    Abstract: Provided herein are polymers of Formula (I), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, compositions, and formulations thereof. The polymers described herein are biocompatible, non-toxic, water compatible, and operationally simple to formulate. Also provided are methods and kits involving the polymers described herein (e.g., methods of using polymers described herein for delivering agents (e.g., for therapeutic, diagnostic, prophylactic, imaging, ophthalmic, intraoperative, or cosmetic use) to a subject, cell, tissue, or biological sample, as part of materials (e.g., biodegradable materials, biocompatible materials, wound dressing (e.g., bandages), drug depots, coatings), or as scaffolds for tissue engineering. Provided are methods for synthesizing the polymers described herein, and polymers described herein synthesized by the synthetic methods described herein.

    SELF-RIGHTING SYSTEMS, METHODS, AND RELATED COMPONENTS
    148.
    发明申请
    SELF-RIGHTING SYSTEMS, METHODS, AND RELATED COMPONENTS 有权

    公开(公告)号：US20220080115A1

    公开(公告)日：2022-03-17

    申请号：US16614229

    申请日：2018-05-17

    Applicant: Massachusetts Institute of Technology ,  The Brigham and Woman's Hospital, Inc.

    Inventor： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

    IPC: A61M5/158 ,  A61M5/145 ,  A61M37/00

    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

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